Involvement of autoimmunity in the pathogenesis of aggressive periodontitis.

Abstract:

:The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modified by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.

journal_name

J Dent Res

authors

Hendler A,Mulli TK,Hughes FJ,Perrett D,Bombardieri M,Houri-Haddad Y,Weiss EI,Nissim A

doi

10.1177/0022034510381903

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1389-94

issue

12

eissn

0022-0345

issn

1544-0591

pii

0022034510381903

journal_volume

89

pub_type

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