Abstract：
:The expression of antimicrobial peptides at epithelial surfaces such as skin, lung, and intestine is thought to provide protection against infection. Cathelicidin antimicrobial peptides are essential for the protection of skin against invasive bacterial infection. To determine if cathelicidins are also present in the oral cavity, we examined the expression of both mRNA and protein in mice and human saliva. The murine cathelicidin (CRAMP) was detected in the adult by reverse-transcription/polymerase chain-reaction (RT-PCR), and in embryonic, newborn, and adult tissues by in situ hybridization and immunohistochemistry. CRAMP mRNA and protein were localized to the salivary glands, specifically in acinar cells of the submandibular gland and palatine minor glands, as well as in lingual epithelium and palatal mucosa. In man, the human cathelicidin LL-37 was detected in human saliva by Western blotting. These results indicate that cathelicidins are present in the salivary system, in some oral epithelia, and in saliva, contributing to broad-spectrum defense of the oral cavity.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Murakami M,Ohtake T,Dorschner RA,Gallo RLdoi
10.1177/154405910208101210keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
845-50issue
12eissn
0022-0345issn
1544-0591journal_volume
81pub_type
杂志文章abstract：:Although it has been shown that patients are more satisfied with prostheses supported by implants than with conventional dentures, there have been few direct comparisons of the various designs of implant-supported prostheses. This within-subject crossover clinical trial was designed to compare two forms of removable p...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345970760100901
更新日期：1997-10-01 00:00:00
abstract：:Studies on mechanisms underlying the differentiation of dental pulp stem cells are critical for the understanding of the biology of odontogenesis and for dental tissue engineering. Here, we tested the hypothesis that stem cells from exfoliated deciduous teeth (SHED) differentiate into functional odontoblasts and endot...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510368647
更新日期：2010-08-01 00:00:00
abstract：:Autonomic and behavioral responses to seven dental procedures were studied in 21 pedodontic patients aged six to 12. When mean pulse rate, pulse amplitude, absolute skin conductance, and skin-conductance responses were compared over all subjects, the injection of the local anesthetic consistently elicited the greatest...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620060801
更新日期：1983-06-01 00:00:00
abstract：:Various etching methods are examined with respect to their ability to induce the surface nucleation and growth of fluorapatite from solutions of low, sustained supersaturation with respect to hydroxyapatite and fluorapatite. The constant composition kinetics method enables the rates of remineralization to be precisely...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610091301
更新日期：1982-09-01 00:00:00
abstract：:We have investigated the role of the activation of nuclear poly(ADP-ribose) polymerase (PARP) enzyme, a mediator of downstream nitric oxide toxicity, using a combined approach of pharmacological inhibition and genetic disruption in a ligature-induced-periodontitis model in rats and mice. Immunohistochemical analysis r...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308201210
更新日期：2003-12-01 00:00:00
abstract：:The intent of this article is to review the numerous factors that affect the mechanical properties of particle- or fiber-filler-containing indirect dental resin composite materials. The focus will be on the effects of degradation due to aging in different media, mainly water and water and ethanol, cyclic loading, and ...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910808700802
更新日期：2008-08-01 00:00:00
abstract：:A procedure for measuring nasal airway resistance using posterior rhinorheometry is described. Baseline nasal airway resistances +/- 1 S.D. at an airflow of 0.5 L/sec were found to be 1.077 +/- 0.683 cm H2O for inhalation and 1.359 +/- 0.792 cm H2O for exhalation. Application of either cold water (4 to 6 C) or warm wa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560110301
更新日期：1977-11-01 00:00:00
abstract：:The discovery and implementation of fluoride in the prevention of dental caries is often praised as one of the most important achievements in health care. In the early 20th century, it took 30 y to identify fluoride as the cause of enamel mottling but also of reduced caries prevalence in a population drinking water co...
journal_title：Journal of dental research
pub_type： 历史文章,杂志文章
doi：10.1177/0022034519831604
更新日期：2019-07-01 00:00:00
abstract：:This study aims at modifying dual-cure composite cements by adding thio-urethane oligomers to improve mechanical properties, especially fracture toughness, and reduce polymerization stress. Thiol-functionalized oligomers were synthesized by combining 1,3-bis(1-isocyanato-1-methylethyl)benzene with trimethylol-tris-3-m...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514551768
更新日期：2014-12-01 00:00:00
abstract：:Tumor progression is often associated with altered glycosylation of the cell-surface proteins and lipids. The peripheral part of these cell-surface glycoconjugates often carries carbohydrate structures related to the ABO and Lewis blood-group antigens. The expression of histo-blood-group antigens in normal human tissu...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910508400103
更新日期：2005-01-01 00:00:00
abstract：:Heads of Swiss-Webster mouse fetuses of four ages spanning days 12-13 of gestation, were partially dissected by removing the brain (B), tongue (T) and mandible (M) alone or in combination (BT, BM, BTM). Preparations were suspended in a gassed, circulating culture system such that palatal closure must take place agains...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570024401
更新日期：1978-02-01 00:00:00
abstract：:Previous research, in which the bonding effectiveness of the 3 self-etch monomers HAEPA, EAEPA, and MAEPA was determined, showed that MAEPA was most effective. In this study, the molecular interactions of these monomers with hydroxyapatite and dentin were investigated by combining x-ray diffraction, infrared spectrosc...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510397197
更新日期：2011-05-01 00:00:00
abstract：:Growing interest in the treatment and prevention of Molar/Incisor Hypomineralization (MIH) warrants investigation into the protein composition of hypomineralized enamel. Hypothesizing abnormality akin to amelogenesis imperfecta, we profiled proteins in hypomineralized enamel from human permanent first molars using a b...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510375824
更新日期：2010-10-01 00:00:00
abstract：:This paper aims to present a simple overview of potential new diagnostic methods for dental caries. There are several novel methods of caries detection (with potential application to diagnosis) which have been proposed in the last few years, in addition to those that are gaining some commercial exposure and clinical a...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910408301s18
更新日期：2004-01-01 00:00:00
abstract：:Short-chain carboxylic acids (e.g., lactic acid, propionic acid, butyric acid) are metabolic by-products of bacterial metabolism which can accumulate in the gingival crevice. It is of no small consequence, therefore, that 1- to 5-mM concentrations of these acids exhibit significant biological activity, including the a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760010801
更新日期：1997-01-01 00:00:00
abstract：:We report a clinical study that examines whether HIV infection affects Streptococcus mutans colonization in the oral cavity. Whole stimulated saliva samples were collected from 46 HIV-seropositive individuals and 69 HIV-seronegative control individuals. The level of S. mutans colonization was determined by conventiona...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512454298
更新日期：2012-09-01 00:00:00
abstract：:The acute effects of smokeless tobacco (ST) on buccal mucosal transport and barrier function were studied by means of in vivo and in vitro techniques. In humans, in vivo exposure to 0.5 g ST transiently increased the transmural electrical potential difference (PD). However, despite continued exposure, PD returned to b...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670111101
更新日期：1988-11-01 00:00:00
abstract：:Although a large body of scientific literature shows that background color and luminance affect color perception, previous measurements of tooth color difference thresholds have not taken the effects of viewing context into account. The present study tested the hypothesis that differences in skin/gingival color influe...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510376772
更新日期：2010-11-01 00:00:00
abstract：:Recent evidence implicates endothelin in nociception, but it is unclear how endothelin activates trigeminal ganglion (TRG) neurons. In the present study, we investigated the expression of the endothelin receptors ETA and ETB and endothelin-induced responses in rat TRG neurons. Double-immunofluorescence studies demonst...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513478428
更新日期：2013-04-01 00:00:00
abstract：:1) A new adhesive opaque resin containing a reactive monomer, 4-methacryloxy-ethyl trimellitate anhydride (4-META), was prepared, and its application to thermosetting acrylic resin veneer crowns was studied. 2) The 4-META opaque resin was applied to a variety of nickel-chromium dental alloy specimens which had undergo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600091101
更新日期：1981-09-01 00:00:00
abstract：:Amelogenin gene organization varies from 6 exons (1,2,3,5,6,7) in amphibians and sauropsids to 10 in rodents. The additional exons are exons 4, 8, 9, and "4b", the latter being as yet unidentified in AMELX transcripts. To learn more about the evolutionary origin of these exons, we used an in silico approach to find th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034511423399
更新日期：2012-01-01 00:00:00
abstract：:Excessive mechanical stress (MS) during hyperocclusion is known to result in disappearance of the alveolar hard line, enlargement of the periodontal ligament (PDL) space, and destruction of alveolar bone, leading to occlusal traumatism. We hypothesized that MS induces expression of osteoclastogenesis-associated chemok...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034511400742
更新日期：2011-06-01 00:00:00
abstract：:Because of the greater sensitivity of commonly used dental films near 40 kv and the inherently greater contrast between bone and other oral tissues that is achieved at lower energies than those conventionally used, a considerable reduction of radiation exposure can be obtained by the use of those quasimonochromatic ph...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550010801
更新日期：1976-01-01 00:00:00
abstract：:Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) nanocomplexes incorporated into sugar-free chewing gum have been shown to remineralize enamel subsurface lesions in situ. The aim of this study was to compare the ability of CPP-ACP, with that of other forms of calcium, to be retained in supragingival plaque ...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/154405910308200311
更新日期：2003-03-01 00:00:00
abstract：:Occlusal alterations may result in changes in the functional performance of masticatory muscles. In this study, we set up an experimental model in rats to examine whether masticatory muscle abnormalities occur after a malocclusion is induced. Rats underwent unilateral amputation of the molar cusps to simulate an occlu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780111101
更新日期：1999-11-01 00:00:00
abstract：:Synovitis in internal derangement of the temporomandibular joint (TMJ) is accompanied by the growth of new blood vessels. Fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) are well-characterized angiogenic factors. The objective of this study was to elucidate the correlation between the ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200406
更新日期：2003-04-01 00:00:00
abstract：:A detailed understanding of the complexity of root canal systems is imperative to ensure successful root canal preparation. The aim of this study was to evaluate the potential and accuracy of a three-dimensional, non-destructive technique for detailing root canal geometry by means of high-resolution tomography. The an...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790060901
更新日期：2000-06-01 00:00:00
abstract：:Chondroitin sulfate is up-regulated in granulation tissue during wound healing. To investigate the role of chondroitin sulfate in the wound-healing process after surgical repair of cleft palate, we isolated and cultured rabbit palatal fibroblasts. Treatment with chondroitin-6-sulfate resulted in a dose-dependent incre...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408301111
更新日期：2004-11-01 00:00:00
abstract：:Periostin is a mesenchymal cell marker predominantly expressed in collagen-rich fibrous connective tissues, including heart valves, tendons, perichondrium, periosteum, and periodontal ligament (PDL). Knockdown of periostin expression in mice results in early-onset periodontitis and failure of cardiac healing after acu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514543015
更新日期：2014-09-01 00:00:00
abstract：:Periodontitis is characterized by periodontal tissue destruction. Since interleukin-17 (IL-17) has been reported to up-regulate IL-1beta and tumor necrosis factor-alpha (TNF-alpha), it was hypothesized that it is increased in periodontitis and up-regulates these cytokines and tissue-destructive matrix metalloproteinas...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600409
更新日期：2007-04-01 00:00:00
