Characterization of a novel periodontal ligament-specific periostin isoform.

Abstract:

:Periostin is a mesenchymal cell marker predominantly expressed in collagen-rich fibrous connective tissues, including heart valves, tendons, perichondrium, periosteum, and periodontal ligament (PDL). Knockdown of periostin expression in mice results in early-onset periodontitis and failure of cardiac healing after acute myocardial infarction, suggesting that periostin is essential for connective tissue homeostasis and regeneration. However, its role(s) in periodontal tissues has not yet been fully defined. In this study, we describe a novel human isoform of periostin (PDL-POSTN). Isoform-specific analysis by reverse-transcription polymerase chain-reaction (RT-PCR) revealed that PDL-POSTN was predominantly expressed in the PDL, with much lower expression in other tissues and organs. A PDL cell line transfected with PDL-POSTN showed enhanced alkaline phosphatase (ALPase) activity and calcified nodule formation, compared with cells transfected with the full-length periostin isoform. A neutralizing antibody against integrin-αv inhibited both ALPase activity and calcified nodule formation in cells transfected with PDL-POSTN. Furthermore, co-immunoprecipitation assays revealed that PDL-POSTN bound to integrin αvβ3 more strongly than the common isoform of periostin, resulting in strong activation of the integrin αvβ3-focal adhesion kinase (FAK) signaling pathway. These results suggest that PDL-POSTN positively regulates cytodifferentiation and mineralization in PDL cells through integrin αvβ3.

journal_name

J Dent Res

authors

Yamada S,Tauchi T,Awata T,Maeda K,Kajikawa T,Yanagita M,Murakami S

doi

10.1177/0022034514543015

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

891-7

issue

9

eissn

0022-0345

issn

1544-0591

pii

0022034514543015

journal_volume

93

pub_type

杂志文章
  • Urinary catecholamine levels in children with and without dental caries.

    abstract::Urinary catecholamines have been used to measure emotionally stressful states which may affect the development of dental caries. This study investigates the hypothesis that children with and without dental caries do not differ significantly in the mean values of urinary catecholamines such as epinephrine, norepinephri...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345950740100801

    authors: Vanderas AP,Manetas C,Papagiannoulis L

    更新日期:1995-10-01 00:00:00

  • Early detection of occlusal caries by measuring the electrical resistance of the tooth.

    abstract::The tooth resistance measuring instrument was compared to the traditional method of the explorer examination for the detection of occlusal carious lesions. The findings of the instrument were more sensitive as compared to the traditional method when verified by a histological examination. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345780570020801

    authors: White GE,Tsamtsouris A,Williams DL

    更新日期:1978-02-01 00:00:00

  • Role of Bone Marrow Stromal Cells in Impaired Bone Repair from BRONJ Osseous Lesions.

    abstract::Treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has posed significant challenges to maxillofacial surgeons because of the poor repair of BRONJ bone defects. Moreover, the pathological mechanisms remain unclear. Bone marrow stromal cells (BMSCs) play key roles during bone repair and bone regenerati...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034517691507

    authors: He LH,Xiao E,An JG,He Y,Chen S,Zhao L,Zhang T,Zhang Y

    更新日期:2017-05-01 00:00:00

  • Antibacterial susceptibility of plaque bacteria.

    abstract::Selected anaerobic, capnophilic and facultative bacteria isolated from patients with various forms of periodontal health and disease were tested for their susceptibility to antibiotics and antimicrobial agents. Specific bactericidal and minimum inhibitory concentrations were compared to disc zone diameters, thereby ge...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345790580071401

    authors: Newman MG,Hulem C,Colgate J,Anselmo C

    更新日期:1979-07-01 00:00:00

  • Altered enamelin phosphorylation site causes amelogenesis imperfecta.

    abstract::Defects in the enamelin gene (ENAM) cause amelogenesis imperfecta (AI). Our objective was to identify the genetic etiology of enamel hypoplasia in a Caucasian proband. Our hypothesis was that ENAM was defective. The proband and his father have an AG insertion (g.13185_13186insAG; p.422FsX448) in ENAM previously identi...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034510365662

    authors: Chan HC,Mai L,Oikonomopoulou A,Chan HL,Richardson AS,Wang SK,Simmer JP,Hu JC

    更新日期:2010-07-01 00:00:00

  • A rheological study of the role of additives on the setting of glass-ionomer cements.

    abstract::The effects of various additives on the setting of the glass-ionomer cement system was studied by means of cone and plate viscometry. The action of (+)-tartaric acid, the most important additive, on the setting reaction depended on its concentration. Low concentrations accelerated the development of viscosity of the c...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345880670120101

    authors: Hill RG,Wilson AD

    更新日期:1988-12-01 00:00:00

  • Protective effect of the dental pellicle against erosive challenges in situ.

    abstract::The acquired dental pellicle helps prevent erosion, but the protection level is unknown. This in situ study tested whether a two-hour pellicle protects against different erosive challenges by orange juice. Subjects wore palatal appliances loaded with either enamel or dentin specimens. Pellicle was allowed to form, or ...

    journal_title:Journal of dental research

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/154405910608500706

    authors: Hara AT,Ando M,González-Cabezas C,Cury JA,Serra MC,Zero DT

    更新日期:2006-07-01 00:00:00

  • Prevalence and need for replacement of amalgam and composite restorations in Dutch adults.

    abstract::In 1986, the first nationwide epidemiological survey of adult oral health and attitudes to oral health care was carried out in The Netherlands. One of the aims of this study was to evaluate the prevalence and the quality (in terms of need for replacement) of amalgam and composite restorations in the Dutch adult popula...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345900690060901

    authors: Kroeze HJ,Plasschaert AJ,van 't Hof MA,Truin GJ

    更新日期:1990-06-01 00:00:00

  • FT-Raman Spectroscopy Study of the Remineralization of Microwave-Exposed Artificial Caries.

    abstract::Dental caries is a microbially mediated disease that can result in significant tooth structure degradation. Although the preponderance of lesions is treated by surgical intervention, various strategies have been developed for its noninvasive management. Here, we use a novel approach for noninvasive treatment based on ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515619370

    authors: Kerr JE,Arndt GD,Byerly DL,Rubinovitz R,Theriot CA,Stangel I

    更新日期:2016-03-01 00:00:00

  • Late elongation of the cranial base.

    abstract::A single logistic curve was fitted to serial data for three cranial base lengths (S-N, Ba-N, and Ba-S) in 33 boys and 26 girls. Elongation during pubescence plus adolescence is greater in boys than girls for each length. The maximum rate of pubescent elongation occurs earliest in Ba-N. There are no consistent sex diff...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345770560071501

    authors: Roche AF,Lewis AB,Wainer H,McCartin R

    更新日期:1977-07-01 00:00:00

  • Reversal of compromised bonding in bleached enamel.

    abstract::Oxygen inhibits polymerization of resin-based materials. We hypothesized that compromised bonding to bleached enamel can be reversed with sodium ascorbate, an anti-oxidant. Sandblasted human enamel specimens were treated with distilled water (control) and 10% carbamide peroxide gel with or without further treatment wi...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910208100709

    authors: Lai SC,Tay FR,Cheung GS,Mak YF,Carvalho RM,Wei SH,Toledano M,Osorio R,Pashley DH

    更新日期:2002-07-01 00:00:00

  • Human and macaque mastication: a quantitative study.

    abstract::Significant differences exist between human and Macaca fascicularis patterns of mandibular movement during mastication. Macaque patterns display less asymmetry, more uniformity, and limited lateral excursions when compared to humans for mastication of the same food. Different anatomical structures between the two spec...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345780570071301

    authors: Byrd KE,Milberg DJ,Luschei ES

    更新日期:1978-07-01 00:00:00

  • Investigation of possible solvents for extracellular polysaccharides from Streptococcus mutans and Streptococcus sanguis.

    abstract::The solubilities of extracellular polysaccharide fractions produced by 14 oral streptococcal strains were compared in water, aqueous lithium and guanidine salt solutions, dimethyl sulfoxide (DMSO), and a 9:1 DMSO-water mixture. The best results for solubilizing the fractions were obtained with the DMSO-water mixture p...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345750540042601

    authors: Lamberts BL,Meyer TS,Simonson LG

    更新日期:1975-07-01 00:00:00

  • Finite element method simulation of bone resorption beneath a complete denture.

    abstract::Bone resorption beneath a maxillary complete denture was simulated by the finite element method, assuming that a threshold of compressive strain exists in the alveolar bone above which the resorption occurred. The pattern of predicted resorption was observed when 100 N of force was applied to three positions occlusall...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345890680091601

    authors: Maeda Y,Wood WW

    更新日期:1989-09-01 00:00:00

  • Multiple dendritic cell (DC) subpopulations in human gingiva and association of mature DCs with CD4+ T-cells in situ.

    abstract::Gingival epithelium is a site of active trafficking of Langerhans cells (LCs), while the lamina propria in chronic periodontitis (CP) contains CD83+ mature dendritic cells (mDCs) and CD4+ T-cells. The immune cells that contribute to the mDCs, and whether mDCs engage with T-cells in situ, are unclear. Using several imm...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910308200915

    authors: Jotwani R,Cutler CW

    更新日期:2003-09-01 00:00:00

  • Water absorption and water solubility of soft lining materials for acrylic dentures.

    abstract::Soft lining materials undergo two processes when immersed in water. Plasticizers and other soluble materials are leached into the water, and water is absorbed by the polymer. The balance between these two processes affects both the compliance and dimensional stability of the materials. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345830620061601

    authors: Braden M,Wright PS

    更新日期:1983-06-01 00:00:00

  • Damage maps of veneered zirconia under simulated mastication.

    abstract::Zirconia-based restorations often fracture from chipping and/or delamination of the porcelain veneers. We hypothesized that veneer chipping/delamination is a result of the propagation of near-contact-induced partial cone cracks on the occlusal surface under mastication. Masticatory loading involves the opposing tooth ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910808701210

    authors: Kim JW,Kim JH,Janal MN,Zhang Y

    更新日期:2008-12-01 00:00:00

  • Decellularized Human Dental Pulp as a Scaffold for Regenerative Endodontics.

    abstract::Teeth undergo postnatal organogenesis relatively late in life and only complete full maturation a few years after the crown first erupts in the oral cavity. At this stage, development can be arrested if the tooth organ is damaged by either trauma or caries. Regenerative endodontic procedures (REPs) are a treatment alt...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034517693606

    authors: Song JS,Takimoto K,Jeon M,Vadakekalam J,Ruparel NB,Diogenes A

    更新日期:2017-06-01 00:00:00

  • Low metacarpal bone density, tooth loss, and periodontal disease in Japanese women.

    abstract::The relationship between periodontitis and systemic bone mineral density in Japanese women is undetermined. We tested the hypothesis that periodontitis was more frequent in women with low metacarpal bone mineral density (m-BMD). Subjects were 190 Japanese women (89 premenopausal, 101 post-menopausal). Periodontal stat...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345010800090901

    authors: Inagaki K,Kurosu Y,Kamiya T,Kondo F,Yoshinari N,Noguchi T,Krall EA,Garcia RI

    更新日期:2001-09-01 00:00:00

  • Clonal persistence of oral Fusobacterium nucleatum in infancy.

    abstract::Once established, early-colonizing bacterial species tend to persist in the mouth. To obtain detailed information on the population dynamics of early-colonizing oral anaerobes, we examined the clonal diversity and persistence of clones among oral Fusobacterium nucleatum populations during the first 2 yrs of life. Cons...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910408300613

    authors: Haraldsson G,Holbrook WP,Könönen E

    更新日期:2004-06-01 00:00:00

  • Fluoridated Water Modifies the Effect of Breastfeeding on Dental Caries.

    abstract::Breastfeeding is important for health and development. Yet, the interaction between breastfeeding duration and usage of fluoridated water on caries experience has not been investigated. This study examined exposure to fluoridation as an effect modifier of the association between breastfeeding duration and caries. The ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034519843487

    authors: Ha DH,Spencer AJ,Peres KG,Rugg-Gunn AJ,Scott JA,Do LG

    更新日期:2019-07-01 00:00:00

  • A histological evaluation of a functional endosseous, porous-surfaced, titanium alloy dental implant system in the dog.

    abstract::We have previously reported the clinical and radiographic findings of a trial in dogs of a new dental implant system after a functional period of eight months. The present report consists of the corresponding qualitative and quantitative histological data. The implant system was fabricated from Ti-6A1-4V and employed ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345880670090801

    authors: Deporter DA,Watson PA,Pilliar RM,Howley TP,Winslow J

    更新日期:1988-09-01 00:00:00

  • Capsaicin-induced muscle pain alters the excitability of the human jaw-stretch reflex.

    abstract::The pathophysiology of painful temporomandibular disorders is not fully understood, but evidence suggests that muscle pain modulates motor function in characteristic ways. This study tested the hypothesis that activation of nociceptive muscle afferent fibers would be linked to an increased excitability of the human ja...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910208100915

    authors: Wang K,Arendt-Nielsen L,Svensson P

    更新日期:2002-09-01 00:00:00

  • Caries management strategies for primary molars: 1-yr randomized control trial results.

    abstract::Minimal invasive approaches to managing caries, such as partial caries removal techniques, are showing increasing evidence of improved outcomes over the conventional complete caries removal. There is also increasing interest in techniques where no caries is removed. We present the 1-yr results of clinical efficacy for...

    journal_title:Journal of dental research

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/0022034514550717

    authors: Santamaria RM,Innes NP,Machiulskiene V,Evans DJ,Splieth CH

    更新日期:2014-11-01 00:00:00

  • Disrupted IRF6-NME1/2 Complexes as a Cause of Cleft Lip/Palate.

    abstract::Mutations and common polymorphisms in interferon regulatory factor 6 ( IRF6) are associated with both syndromic and nonsyndromic forms of cleft lip/palate (CLP). To date, much of the focus on this transcription factor has been on identifying its direct targets and the gene regulatory network in which it operates. Nota...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034517723615

    authors: Parada-Sanchez MT,Chu EY,Cox LL,Undurty SS,Standley JM,Murray JC,Cox TC

    更新日期:2017-10-01 00:00:00

  • Thermal stimulation of the oral mucosa and nasal airway resistance.

    abstract::A procedure for measuring nasal airway resistance using posterior rhinorheometry is described. Baseline nasal airway resistances +/- 1 S.D. at an airflow of 0.5 L/sec were found to be 1.077 +/- 0.683 cm H2O for inhalation and 1.359 +/- 0.792 cm H2O for exhalation. Application of either cold water (4 to 6 C) or warm wa...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345770560110301

    authors: Martin JS,Tansy MF

    更新日期:1977-11-01 00:00:00

  • Chlorhexide and fluoride in prevention of plaque and caries in hamsters.

    abstract::The effect of combined administration of chlorhexidine and fluoride in the drinking water of hamsters on plaque and caries prevention was studied. Plaque indices of the hamsters receiving chlorhexidine either alone or simultaneously with fluoride were significantly lower than those of the control and fluoride only tre...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345770560111401

    authors: Brayer L,Gedalia I,Gover A

    更新日期:1977-11-01 00:00:00

  • Accuracy of Kubelka-Munk reflectance theory applied to human dentin and enamel.

    abstract::The Kubelka-Munk (K-M) theory provides a reflectance model for translucent materials placed on backings of different colors. We hypothesize that Kubelka-Munk (K-M) theoretical diffuse reflectance spectra of dentin and enamel are in good agreement with observed diffuse reflectance. The aim of this study was to measure ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345010800020901

    authors: Ragain JC Jr,Johnston WM

    更新日期:2001-02-01 00:00:00

  • Microbial aspects of preventive regimes in patients with overdentures.

    abstract::The aim of this study was to test effects of preventive regimes using fluoride and chlorhexidine to prevent caries and periodontal diseases in 34 patients with overdentures. The patients, who were treated with immediate overdentures, were distributed at random into three experimental groups. In these groups, different...

    journal_title:Journal of dental research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1177/00220345870660101301

    authors: Keltjens HM,Schaeken MJ,Van der Hoeven JS

    更新日期:1987-10-01 00:00:00

  • Trends in Dental Implant Use in the U.S., 1999-2016, and Projections to 2026.

    abstract::Dental implants have become an increasingly popular treatment choice for replacing missing teeth. Yet, little is known about the prevalence and sociodemographic distribution of dental implant use in the United States. To address this knowledge gap, we analyzed data from 7 National Health and Nutrition Examination Surv...

    journal_title:Journal of dental research

    pub_type: 历史文章,杂志文章

    doi:10.1177/0022034518792567

    authors: Elani HW,Starr JR,Da Silva JD,Gallucci GO

    更新日期:2018-12-01 00:00:00