Abstract：
:Once established, early-colonizing bacterial species tend to persist in the mouth. To obtain detailed information on the population dynamics of early-colonizing oral anaerobes, we examined the clonal diversity and persistence of clones among oral Fusobacterium nucleatum populations during the first 2 yrs of life. Consecutive salivary samples from 12 infants, collected at 2, 6, 12, 18, and 24 mos of age, yielded a total of 546 F. nucleatum isolates for clonal typing with arbitrarily primed PCR (AP-PCR). Up to 7 AP-PCR types were simultaneously detected in each sample. In 11 out of the 12 infants examined, AP-PCR types persisted for up to 1 yr. Strain turnover rate was high during the first year of life, but then the occurrence of persistent clones increased. This study indicates a wide genetic diversity within the species and provides evidence for the increasing persistence of F. nucleatum clones in the oral cavity with age.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Haraldsson G,Holbrook WP,Könönen Edoi
10.1177/154405910408300613keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
500-4issue
6eissn
0022-0345issn
1544-0591journal_volume
83pub_type
杂志文章abstract：:Macrophage colony-stimulating factor (CSF-1) is a key regulatory cytokine for amelogenesis, and ameloblasts synthesize CSF-1. We hypothesized that PDGF stimulates DNA synthesis and regulates CSF-1 in these cells. We determined the effect of PDGF on CSF-1 expression using MEOE-3M ameloblasts as a model. By RT-PCR, MEOE...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700105
更新日期：2008-01-01 00:00:00
abstract：:Although pulp fibroblasts are a major cell type in dental pulp, their roles in microbial recognition and pulpal inflammation are not well-understood. Considering the pivotal role of Toll-like receptors (TLRs) in the recognition of micro-organisms, we hypothesized that TLRs on pulp fibroblasts may induce inflammatory s...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509354720
更新日期：2010-02-01 00:00:00
abstract：:The fatigue crack growth resistance of dentin was characterized as a function of depth from the dentino-enamel junction. Compact tension (CT) specimens were prepared from the crowns of third molars in the deep, middle, and peripheral dentin. The microstructure was quantified in terms of the average tubule dimensions a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034511408429
更新日期：2011-08-01 00:00:00
abstract：:The creatinine-adjusted urinary concentration of mercury in 73 schoolchildren with a mean age of 12 years was determined. In addition, the number of amalgam restorations and their size, prevalence of allergy, and days absent from school due to illness were recorded for each individual. A significant positive correlati...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660061701
更新日期：1987-06-01 00:00:00
abstract：:The accelerating activity of N,N-substituted aminoethyl methacrylates on the curing of methyl methacrylate and composite resins with benzoyl peroxide is somewhat smaller than that of dimethyl-p-toluidine. Tesins cured with aminoethyl methacrylates containing a p-tolyl and 3,5-xylyl substituent on the nitrogen atom tur...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540041301
更新日期：1975-07-01 00:00:00
abstract：:Previous studies have demonstrated that antibodies against cholinoreceptors of exocrine glands correlate with dry mouth in persons with primary Sjögren syndrome (pSS). The aim of the present investigation was to establish if serum IgG antibodies (pSS IgG) were able to interact with cholinoreceptors in rat submandibula...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600905
更新日期：2007-09-01 00:00:00
abstract：:The accumulated posteruptive tooth age was calculated for 212 children with Down's syndrome and 124 of their unaffected sibs. Posteruptive tooth age was shown to vary widely with different morphological permanent tooth types at the same chronological age. Girls in both groups had greater accumulated posteruptive tooth...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540033001
更新日期：1975-05-01 00:00:00
abstract：:Although osteoporosis is a major public health concern, the effect of this condition on oral bone has not been determined. Using the ovariectomized rat as a model, we examined whether acute estrogen depletion affects the mandible of the ovariectomized rat with and without maxillary molar extraction. Twenty-two ovariec...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730110901
更新日期：1994-11-01 00:00:00
abstract：:The linear electrochemical polarization method was used to provide quantitative in vitro measurements of corrosion rates as a function of exposure time for Cu-Ni-Mn, Cu-Ni-Mn-Au, Cu-Ni-Mn-Ag, and Cu-Ni-Mn-Au-Ag alloys in artificial saliva. Both Au and Ag additives to dental-cast Cu-Ni-Mn alloys lowered the corrosion r...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590040701
更新日期：1980-04-01 00:00:00
abstract：:We investigated whether oral health, represented by missing teeth, was associated with an increased risk of cardiovascular disease, including myocardial infarction (MI), heart failure (HF), stroke, and all-cause mortality. Subjects who underwent routine dental examinations and health checkups provided by the Korean Na...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518814829
更新日期：2019-02-01 00:00:00
abstract：:The incisor dentin of hypophosphatemic (Hyp) mice was examined histopathologically to determine whether the multiple occurrences of interglobular dentin would be influenced by the serum phosphate level. Both normal and Hyp mice (12 weeks of age) were divided into two groups. The mice in one group were given a control ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345920710031101
更新日期：1992-03-01 00:00:00
abstract：:Dispersed salivary acini isolated from the rat submandibular gland by enzymatic digestion were used to study the effects of alpha-receptor stimulation on transmembrane transport of 36Cl. In the absence of secretagogue, the tracer accumulated in the cells in a time-dependent manner until a steady-state content of 6.8 +...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670030701
更新日期：1988-03-01 00:00:00
abstract：:Acculturation is a complex phenomenon that can serve as a proxy for cultural norms and behaviors affecting care-seeking, prevention behaviors, and, ultimately, health outcomes. The purpose of this study was to assess the effect of acculturation on the oral health of Haitian immigrants in New York City. We hypothesized...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300219
更新日期：2004-02-01 00:00:00
abstract：:A detailed understanding of the complexity of root canal systems is imperative to ensure successful root canal preparation. The aim of this study was to evaluate the potential and accuracy of a three-dimensional, non-destructive technique for detailing root canal geometry by means of high-resolution tomography. The an...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790060901
更新日期：2000-06-01 00:00:00
abstract：:The term "artificial intelligence" (AI) refers to the idea of machines being capable of performing human tasks. A subdomain of AI is machine learning (ML), which "learns" intrinsic statistical patterns in data to eventually cast predictions on unseen data. Deep learning is a ML technique using multi-layer mathematical...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520915714
更新日期：2020-07-01 00:00:00
abstract：:The biocompatibility of two implant materials, vitallium and poly-methyl methacrylate (PMMA), was evaluated in an animal model in which bone formation and resorption are independent of each other. Neither material accelerated resorption, but formation was inhibited 12% by vitallium and 38% by PMMA. When three PMMA pre...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600010801
更新日期：1981-01-01 00:00:00
abstract：:An analysis of the relationship between creep and microstructural characteristics of several gamma2-containing amalgams showed the grain size of the Ag-Hg phase (gamma1) to be a predominant factor influencing creep. When gamma1 grain size is increased, creep is reduced. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560121401
更新日期：1977-12-01 00:00:00
abstract：:Genetic approaches are rapidly yielding new information about our sense of taste. This information comes from both molecular studies of genes encoding taste receptors and other taste-signaling components, and from studies of inherited variation in taste abilities. Our understanding of bitter taste has advanced by comb...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910408300603
更新日期：2004-06-01 00:00:00
abstract：:The main purpose of this paper is to review the various methods used for evaluation of fluoride retention in saliva, plaque, and enamel following application of topical anti-caries treatments such as F dentifrices and F mouthwashes. Such methods monitor delivery of fluoride to the site of action, the mouth, and so can...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/002203459207100S29
更新日期：1992-04-01 00:00:00
abstract：:Clinical evidence is lacking regarding the influence of the amount of residual coronal dentin and of post placement on the failure risk of endodontically compromised teeth. The aim of this prospective clinical trial was to assess whether these factors significantly affect the two-year survival of restored pulpless pre...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/154405910708600808
更新日期：2007-08-01 00:00:00
abstract：:The feasibility of immunizing monkeys with enzymes from oral streptococci in an attempt to reduce dental caries was investigated. Forty rhesus monkeys, Macaca mulatta, were used. Cariogenic streptococci, S mutans, were implanted into all the monkeys' mouths. There was no pathological effect resulting from immunization...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560123001
更新日期：1977-12-01 00:00:00
abstract：:The cariostatic benefit from water fluoridation is indisputable, but the knowledge of possible adverse effects on bone and fracture risk due to fluoride exposure is ambiguous. The association between long-term (chronic) drinking water fluoride exposure and hip fracture (ICD-7-9: '820' and ICD-10: 'S72.0-S72.2') was as...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513506443
更新日期：2013-11-01 00:00:00
abstract：:To date, the precise etiology of molar-incisor hypomineralization (MIH) is uncertain. Vitamin D plays a key role in hard tissue formation. Therefore, this study aimed to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) status and dental health data obtained from 1,048 children in a 10-year follow-...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514561657
更新日期：2015-02-01 00:00:00
abstract：:The objectives of the study were to describe the oral health status and treatment needs of the 5- to 6-year-old and 12-year-old children in Southern China; to describe the patterns of oral health behaviors, knowledge, and attitudes among the 12-year-olds; and to assess the effects of socio-behavioral factors on the 12...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800051501
更新日期：2001-05-01 00:00:00
abstract：:The extent of dental tissue destruction during the treatment of white spot lesions (WSLs) increases with the severity of the lesion. If the depth and shape of WSLs can be predicted with a noninvasive diagnostic method before dental caries treatment, more conservative interventions can be planned. Given the superiority...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518811642
更新日期：2019-03-01 00:00:00
abstract：:Periodontal diseases are initiated by bacteria that accumulate in a biofilm on the tooth surface and affect the adjacent periodontal tissue. Systemic diseases such as diabetes, rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) increase susceptibility to destructive periodontal diseases. In human studie...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034518805739
更新日期：2019-02-01 00:00:00
abstract：:Since 1935, various mechanisms have been suggested for the formation of subsurface lesions and, in particular, the surface layer covering enamel lesions. The relatively intact mineral-rich and porous surface layer is most likely caused by kinetic events. The suggested mineral-rich outer layer in sound enamel, the orga...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/00220345860650010201
更新日期：1986-01-01 00:00:00
abstract：:An indirect extrusion capillary viscometer has been developed. This has been tested for nonsetting Newtonian fluids and was found to give results close to, but slightly lower than the actual viscosity. The same apparatus has been successfully applied to a non-Newtonian fluid to determine the dependence of viscosity on...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550021001
更新日期：1976-03-01 00:00:00
abstract：:The universally accepted concept of delay-loaded dental implants has recently been challenged. This study hypothesizes that early loading (decreased implant healing time) leads to increased bone formation and decreased crestal bone loss. We used 17 minipigs to study implants under a controlled load, with non-loaded im...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200803
更新日期：2003-08-01 00:00:00
abstract：:The goal of nonrestorative or non- and microinvasive caries treatment (fluoride- and nonfluoride-based interventions) is to manage the caries disease process at a lesion level and minimize the loss of sound tooth structure. The purpose of this systematic review and network meta-analysis was to summarize the available ...
journal_title：Journal of dental research
pub_type： 杂志文章,meta分析
doi：10.1177/0022034518800014
更新日期：2019-01-01 00:00:00
