Abstract:
:Although osteoporosis is a major public health concern, the effect of this condition on oral bone has not been determined. Using the ovariectomized rat as a model, we examined whether acute estrogen depletion affects the mandible of the ovariectomized rat with and without maxillary molar extraction. Twenty-two ovariectomized and 20 sham-ovariectomized 90-day-old Sprague-Dawley rats were divided into the following groups: (1) sham-ovariectomized, baseline control; (2) ovariectomized, baseline control; (3) ovariectomized; (4) ovariectomized, tooth extraction; (5) sham-ovariectomized; and (6) sham-ovariectomized, tooth extraction. On day eight, sham-ovariectomized and ovariectomized rats had all their maxillary molars extracted, and the baseline control sham-ovariectomized and ovariectomized rats were killed. On day 35, the remaining animals were killed. After teeth were harvested, the right mandible was tested to failure in three-point bending. The bone mineral density of the left mandible was measured with dual-energy x-ray absorptiometry. The area fraction and area moment of inertia of a section of mandible were determined. Neither ovariectomy nor tooth extraction significantly affected the bone mineral density or structural properties of the rat mandible. However, there was an interaction between ovariectomy and maxillary molar extraction on the stiffness of the rat mandible (p < 0.008). Maxillary molar extraction decreased the stiffness of the mandible by 25% (p < 0.05) in the ovariectomized rat, whereas it did not do so in the sham-ovariectomized rat.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Elovic RP,Hipp JA,Hayes WCdoi
10.1177/00220345940730110901subject
Has Abstractpub_date
1994-11-01 00:00:00pages
1735-41issue
11eissn
0022-0345issn
1544-0591journal_volume
73pub_type
杂志文章abstract::The spatial relationship of the mandibular condyle to the temporal component of the TMJ is determined quantitatively from lateral tomograms using a new method of measuring specific areas of the joint space. Condyle position along the posteroanterior axis of the joint is expressed as a ratio of the posterior joint spac...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600010701
更新日期:1981-01-01 00:00:00
abstract::The composition of the degradable glasses used in commercial dental glass-ionomer cements determines their leaching behavior and hence the properties of the cement. The objective of the present study was to assess if the composition and leaching in acetic acid solutions are reflected in the x-ray diffraction character...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345010800081601
更新日期:2001-08-01 00:00:00
abstract::In an attempt to determine the degree of co-activation present in selected cervical muscles during clenching, we instructed 12 male subjects to produce four brief maximum voluntary contraction (MVC) efforts (clenching) in a position of maximum intercuspation. Surface EMG activity was recorded bilaterally from the mass...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720110701
更新日期:1993-11-01 00:00:00
abstract::Mixed or parotid saliva from caries-active individuals consistently supported better growth of Streptococcus mutans (type c) than that from caries-free individuals. Electrophoretic studies revealed that certain proteins in caries-active salivas were susceptible to microbial attack, but similar proteins in caries-free ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580101501
更新日期:1979-10-01 00:00:00
abstract::A multiple logistic regression analysis was used to compute the odds ratios for 11 common occlusal features for asymptomatic controls (n = 147) vs. five temporomandibular disorder groups: Disc Displacement with Reduction (n = 81), Disc Displacement without Reduction (n = 48), Osteoarthrosis with Disc Displacement Hist...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720061301
更新日期:1993-06-01 00:00:00
abstract::Previous studies have shown that therapeutic pulsed ultrasound (pulsed) has superior stimulatory effect on bone fracture healing compared with continuous ultrasound (continuous). Our predictive hypothesis was that pulsed ultrasound can produce better bone formation during mandibular osteodistraction than continuous ul...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808701018
更新日期:2008-10-01 00:00:00
abstract::Lactoferrin is one of a number of multifunctional proteins that are present in or on all mucosal surfaces throughout the body. Levels of lactoferrin are consistently elevated in inflammatory diseases such as arthritis, inflammatory bowel diseases, corneal disease, and periodontitis. Single-nucleotide polymorphisms (SN...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034515577413
更新日期:2015-06-01 00:00:00
abstract::T6 antigen is a highly specific marker for human Langerhans cells (LC). Previous studies have demonstrated that Interleukin-1 (IL-1) and an IL-1 inhibitor (ILS) modulate LC T6 expression (T6E) in explant culture. The present study examined the in vitro modulation of T6E by two molecules: epidermal-cell-derived thymocy...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660031201
更新日期:1987-03-01 00:00:00
abstract::Because bone reconstruction in irradiated sites is less than ideal, we applied a regenerative gene therapy method in which a cell-signaling virus was localized to biomaterial scaffolds to regenerate wounds compromised by radiation therapy. Critical-sized defects were created in rat calvariae previously treated with ra...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509352151
更新日期:2010-01-01 00:00:00
abstract::Protease-activated receptors (PARs) are G protein-coupled receptors, which are activated by proteolytical cleavage of the amino-terminus and act as sensors for extracellular proteases. We hypothesized that PAR-1 and PAR-2 can be modulated by inflammatory stimulus in human dental pulp cells. PAR-1 and PAR-2 gene expres...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034517719415
更新日期:2017-12-01 00:00:00
abstract::The Global Burden of Disease (GBD) 2010 Study produced comparable estimates of the burden of 291 diseases and injuries in 1990, 2005, and 2010. This article reports on the global burden of untreated caries, severe periodontitis, and severe tooth loss in 2010 and compares those figures with new estimates for 1990. We u...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513490168
更新日期:2013-07-01 00:00:00
abstract::Our observations confirm the previously reported observation that multinucleated cells develop within a two-week period in cat bone-marrow cultures. Calcitonin induces cytoplasmic contraction in these multinucleated cells, which indicates that they resemble osteoclasts. After seven days of culture, cat bone-marrow cul...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650070201
更新日期:1986-07-01 00:00:00
abstract::While dental pulp appears to be able to form mineralized matrices that do not always resemble dentin, the precise characteristics of the hard tissue and the mechanism of its induction remain unknown. Therefore, we evaluated hard tissue induced by transplantation of pulp into subcutaneous tissue. Seven days after trans...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708600515
更新日期:2007-05-01 00:00:00
abstract::The present investigation demonstrates that direct application of a composite resin on an acid-etched, vital dentin surface is hazardous to the pulp in monkey teeth. This indicates that exposed dentin should be protected before treating the tooth with a restorative technique including acid etching. A ca(OH)2-containin...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550022001
更新日期:1976-03-01 00:00:00
abstract::The field of dental materials has undergone more of a revolution than an evolution over the past 100 y. The development of new products, especially in the past half century, has occurred at a staggering pace, and their introduction to the market has been equally impressive. The movement has mostly come in the area of ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034518822808
更新日期:2019-03-01 00:00:00
abstract::Early childhood caries (ECC) is a chronic disease affecting the oral health of children globally. This disease is multifactorial, but a primary factor is cariogenic microorganisms such as Streptococcus mutans. Biosynthetic gene clusters (BGCs) encode small molecules with diverse biological activities that influence th...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520914519
更新日期:2020-07-01 00:00:00
abstract::The rate of F absorption from the stomach is pH-dependent, with greater absorption at low pH. Since the rate of absorption is also strongly influenced by the rapidity of gastric emptying, we have compared the relative importance of gastric acidity and gastric emptying in overall F absorption. Male rats (350 g, n = 85)...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720031101
更新日期:1993-03-01 00:00:00
abstract::A sintered hydroxyapatite (HAP) ceramic for use in wear studies was prepared from a commercial tricalcium phosphate. The sintered HAP had physical properties close to those of human enamel. The coefficient of friction and wear of the sintered HAP ceramic as characterized by tangential force, track width, and surface f...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570070401
更新日期:1978-07-01 00:00:00
abstract::The dental phenolic medicaments, eugenol and guaiacol, are partly similar in chemical structure to capsaicin, the pungent constituent of chili peppers, which selectively activates sensory neurons via a specific receptor. We have previously demonstrated that these phenolic compounds show capsaicin-like action. In the p...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345970760040501
更新日期:1997-04-01 00:00:00
abstract::The color of an unshaded body porcelain was determined at three thicknesses on white, gray, and three chromatic backings. Spectral absorption and scattering coefficients of the porcelain were determined from the diffuse reflectance at one thickness on the white and gray backings. These optical coefficients, when utili...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640061801
更新日期:1985-06-01 00:00:00
abstract::The firing pattern of the motor units (MUs) in jaw-elevator muscles was studied within a wide range of isometric contraction levels by means of changes in the frequency and broadness of the primary peak in the low-frequency (5-40 Hz) power spectral density function of the surface EMG. EMG was recorded from both masset...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345940730051501
更新日期:1994-05-01 00:00:00
abstract::Autoimmune responses to heat-shock protein 60 (HSP60) contribute to the progression of atherosclerosis, whereas immunization with HSP60 may induce atheroprotective responses. We assessed the capacity of an atheroprotective vaccine that targeted a recombinant HSP60 from Porphyromonas gingivalis (rGroEL) to induce a pro...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514523784
更新日期:2014-04-01 00:00:00
abstract::Large mandibular defects are difficult to reconstruct with good functional and aesthetic outcomes because of the complex geometry of craniofacial bone. While the current gold standard is free tissue flap transfer, this treatment is limited in fidelity by the shape of the harvested tissue and can result in significant ...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034514547763
更新日期:2014-12-01 00:00:00
abstract::We placed an MOD preparation in each of 12 permanent molars, then restored each tooth with a posterior composite resin by means of six different application techniques (I-polymerization as one complete unit; II--polymerization as one complete unit with glass inserts; III--polymerization in gingivo-occlusal increments;...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680080401
更新日期:1989-08-01 00:00:00
abstract::Although the tripeptides Glu-O-Phosphoserine-Tyr and Glu-O-Phosphoserine-Leu have been identified in embryonic bovine enamel proteins, 1, 2 the issue of whether both sequences occur in each of the phosphopeptides, or whether certain sequences occur in specific peptides only, has recently been resolved by isolating hom...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580023101
更新日期:1979-03-01 00:00:00
abstract::Zirconia-based restorations often fracture from chipping and/or delamination of the porcelain veneers. We hypothesized that veneer chipping/delamination is a result of the propagation of near-contact-induced partial cone cracks on the occlusal surface under mastication. Masticatory loading involves the opposing tooth ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808701210
更新日期:2008-12-01 00:00:00
abstract::Oral bacteria, including Streptococcus mutans and Streptococcus salivarius, contribute to tooth decay and plaque formation; therefore, it is essential to develop strategies to prevent dental caries and plaque formation. We recently showed that organo-selenium compounds covalently attached to different biomaterials inh...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513482141
更新日期:2013-05-01 00:00:00
abstract::Dissolution of mercury from the Ag-Hg matrix phase of dental amalgam is distilled water and synthetic saliva, and the mercury evaporation from the solutions, were studied in vitro. The main objectives of the study were to evaluate the factors that affect the results of the mercury release tests, and to consider the po...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690050901
更新日期:1990-05-01 00:00:00
abstract::Wavelength-independent Microradiography (WIM), described in this paper, used polychromatic, high-energy (less than or equal to 60 kV) x-rays for determination of mineral concentrations in tooth material non-destructively. This was done with the aid of a reference step-wedge made of 94% aluminum, 6% zinc. The mass atte...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690081501
更新日期:1990-08-01 00:00:00
abstract::The acquired dental pellicle helps prevent erosion, but the protection level is unknown. This in situ study tested whether a two-hour pellicle protects against different erosive challenges by orange juice. Subjects wore palatal appliances loaded with either enamel or dentin specimens. Pellicle was allowed to form, or ...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/154405910608500706
更新日期:2006-07-01 00:00:00