Abstract:
:The universally accepted concept of delay-loaded dental implants has recently been challenged. This study hypothesizes that early loading (decreased implant healing time) leads to increased bone formation and decreased crestal bone loss. We used 17 minipigs to study implants under a controlled load, with non-loaded implants for comparison. Radiographic and histological assessments were made of the osseointegrated bone changes for 3 healing times (between implant insertion and loading), following 5 months of loading. The effect of loading on crestal bone loss depended on the healing time. Early loading preserved the most crestal bone. Delayed loading had significantly more crestal bone loss compared with the non-loaded controls (2.4 mm vs. 0.64 mm; P < 0.05). The histological assessment and biomechanical analyses of the healing bone suggested that loading and bioactivities of osteoblasts exert a synergistic effect on osseointegration that is likely to support the hypothesis that early loading produces more favorable osseointegration.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Ko CC,Douglas WH,DeLong R,Rohrer MD,Swift JQ,Hodges JS,An KN,Ritman ELdoi
10.1177/154405910308200803keywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
585-91issue
8eissn
0022-0345issn
1544-0591journal_volume
82pub_type
杂志文章abstract::Caries of the permanent first molars of 5-year-old children was found to be associated with caries of their diciduous teeth. The sample consisted of 220 children whose permanent first molars had erupted. They were selected out of 965 children who were a representative sample of children attending compulsory kindergart...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550062001
更新日期:1976-11-01 00:00:00
abstract::TWIST1 plays a crucial role in dentinogenesis, and its activity depends on both a dimerization partner selection and phosphorylation. Other factors, like Id proteins, can affect the availability of dimerization partners for TWIST1, subsequently leading to diverse biological outcomes. The purpose of this study was to e...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514530164
更新日期:2014-06-01 00:00:00
abstract::The aim of this study was to investigate whether the release of fluoride and the antimicrobial effect of freshly mixed glass ionomers could be prolonged by application of fluoride on aged material. Test slabs of freshly mixed and aged (14 d in water) conventional and silver glass ionomer (Ketac-Fil and Ketac-Silver, E...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720090901
更新日期:1993-09-01 00:00:00
abstract::Cleidocranial dysplasia (CCD) is a skeletal dysplasia caused by heterozygous mutations of RUNX2, a gene that is essential for the mineralization of bone and tooth. We isolated primary dental pulp cells from a 10-y-old patient and tested their proliferative capacity, alkaline phosphatase activity, and ability to form m...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514566655
更新日期:2015-04-01 00:00:00
abstract::The aim of this systematic review and network meta-analysis was to summarize the direct and indirect clinical evidence on the effectiveness of professionally applied and self-applied topical fluorides in preventing dental root caries. Controlled clinical trials with any follow-up duration were included. MEDLINE, PubMe...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520906384
更新日期:2020-05-01 00:00:00
abstract::Wall-to-wall (WTW) polymerization contraction of filled and unfilled chemically and photo-initiated resins was studied in relation to the WTW distance. In an experimental set-up, the resins were bonded to two opposing disks, and the axial (WTW) displacement resulting from the polymerization shrinkage was measured cont...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680010701
更新日期:1989-01-01 00:00:00
abstract::This randomized controlled trial aimed to evaluate the duration and outcome quality of orthodontic treatment with a customized fixed appliance system versus a noncustomized system. Patients ( n = 180) were randomized and received orthodontic treatment with the Insignia customized orthodontic system or the Damon Q nonc...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/0022034517720913
更新日期:2017-12-01 00:00:00
abstract::Several studies have shown that surgical detachment of marginal gingiva close to the cervical cementum of molar teeth in a rat mandible is a distinct stimulus for alveolar bone resorption. Recently, we found that P2X4, an ATP-receptor, is significantly up-regulated in marginal gingival cells soon after surgery. We hyp...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708600214
更新日期:2007-02-01 00:00:00
abstract::The field of dental materials has undergone more of a revolution than an evolution over the past 100 y. The development of new products, especially in the past half century, has occurred at a staggering pace, and their introduction to the market has been equally impressive. The movement has mostly come in the area of ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034518822808
更新日期:2019-03-01 00:00:00
abstract::Pain and discomfort are common problems for patients undergoing orthodontic treatment. We have demonstrated that cortical excitation propagation in the somatosensory and insular cortices (IC) induced by electrical stimulation of the periodontal ligament (PDL) is facilitated 1 d after experimental tooth movement (ETM)....
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520962465
更新日期:2020-10-08 00:00:00
abstract::Monolayers of feline parotid acinar cells were infected with feline rhinotracheitis herpes virus. Membrane potentials and input resistances were measured before and during infection. Uninfected acinar cells had an average membrane potential of -51 mV and resistances from 6 to 120 mega-ohms; cells infected for more tha...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600121001
更新日期:1981-12-01 00:00:00
abstract::Angiogenesis and biomineral substrates play major roles in bone development and regeneration. We hypothesized that macroporous scaffolds of biomineralized 85:15 poly(lactide-co-glycolide), which locally release vascular endothelial growth factor-165 (VEGF), would direct simultaneous regeneration of bone and vascular t...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408300304
更新日期:2004-03-01 00:00:00
abstract::Streptococcus mutans strain JH1005 is a mutant that produces levels of bacteriocin activity three-fold-elevated than those produced by its parent, JH1001. A single infection regimen with JH1005 was found to result in persistent colonization of the teeth of all three adult subjects tested. This is a significant improve...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660060101
更新日期:1987-06-01 00:00:00
abstract::Although pulp fibroblasts are a major cell type in dental pulp, their roles in microbial recognition and pulpal inflammation are not well-understood. Considering the pivotal role of Toll-like receptors (TLRs) in the recognition of micro-organisms, we hypothesized that TLRs on pulp fibroblasts may induce inflammatory s...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509354720
更新日期:2010-02-01 00:00:00
abstract::MMP-20 (enamelysin), the matrix metalloproteinase family member discovered in the enamel organ, has also been detected in odontoblasts during dentin formation. We studied the presence and localization of MMP-20 in mature human teeth in health and disease. In immunohistochemistry, MMP-20-positive staining was observed ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910208100905
更新日期:2002-09-01 00:00:00
abstract::The human mandibular condyle has a parasagittal plate-like trabecular structure. We tested the hypothesis that this structure reflects the mechanical loading of the condyle. We developed a finite element model of the condyle to analyze the strains occurring during static compressive loading. The principal strains in t...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910208101010
更新日期:2002-10-01 00:00:00
abstract::This study has identified and characterized class II (Ia) antigen-expressing cells in the normal rat incisor pulp by immunohistochemistry and flow cytometry. Two types of Ia-expressing cells occurred: one with a pronounced dendritic appearance located primarily in the periphery of the pulp, and one with morphological ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670100301
更新日期:1988-10-01 00:00:00
abstract::1. A method has been developed and described for obtaining accurate thermal diffusivity values for dental cements and other restorative materials. This method employs specimens of a short cylindrical geometry which are readily fabricated from simply-constructed molds. 2. Results obtained for polycarboxylate and glass-...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600120801
更新日期:1981-12-01 00:00:00
abstract::The discovery of the phenomenon "osseointegration," or functional ankylosis, has led to the development of oral implants with high clinical performance. Consequently, the placement of titanium implants has changed the paradigms of restorative dentistry. Implants are used to prevent placing reconstructions anchored on ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034519853574
更新日期:2019-11-01 00:00:00
abstract::Growing interest in the treatment and prevention of Molar/Incisor Hypomineralization (MIH) warrants investigation into the protein composition of hypomineralized enamel. Hypothesizing abnormality akin to amelogenesis imperfecta, we profiled proteins in hypomineralized enamel from human permanent first molars using a b...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510375824
更新日期:2010-10-01 00:00:00
abstract::Mixtures containing two bacterial species were analyzed using flow cytometric techniques. Light scattering characteristics of Streptococcus mutans and Actinomyces viscosus show unique profiles for pure cultures. However, the light scatter analysis of a mixture containing these two species demonstrates overlapping near...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630080501
更新日期:1984-08-01 00:00:00
abstract::The acquired enamel pellicle is an oral, fluid-derived protein layer that forms on the tooth surface. It is a biologically and clinically important integument that protects teeth against enamel demineralization, and abrasion. Tooth surfaces are exposed to different proteinaceous microenvironments depending on the enam...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034516680771
更新日期:2017-04-01 00:00:00
abstract::Diabetes mellitus is associated with depression of natural defenses against infection and increases the risk of periodontal disease. However, the effects of diabetes on periradicular tissue, which differs structurally from periodontal tissue, are not known. In this study, we evaluated the effects of type 2 diabetes on...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200416
更新日期:2003-04-01 00:00:00
abstract::The effect of a topical fluoride regimen consisting of a four-minute pre-treatment with a saturated dicalcium phosphate dihydrate (DCPD) solution followed by a four-minute application of APF was compared with that of a four-minute application of APF alone with respect to the deposition of fluoride in enamel in an apat...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650030201
更新日期:1986-03-01 00:00:00
abstract::Cleft palate is among the most common structural birth defects in humans. Previous studies have shown that mutations in FOXF2 are associated with cleft palate in humans and mice and that Foxf2 acts in a Shh-Foxf-Fgf18-Shh molecular network controlling palatal shelf growth. In this study, we combined RNA-seq and ChIP-s...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520904018
更新日期:2020-04-01 00:00:00
abstract::Debonding rates of 164 resin-bonded prostheses (RBP) placed from 1974 to 1985 were examined at recall. The yearly debond rates were calculated, the cumulative probability of failure was determined for the debonded RBPs, and Weibull distribution parameters were determined. For perforated prostheses, there was a high in...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720081401
更新日期:1993-08-01 00:00:00
abstract::Odontoblasts and fibroblasts are suspected to influence the innate immune response triggered in the dental pulp by micro-organisms that progressively invade the human tooth during the caries process. To determine whether they differ in their responses to oral pathogens, we performed a systematic comparative analysis o...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808700304
更新日期:2008-03-01 00:00:00
abstract::Significant differences exist between human and Macaca fascicularis patterns of mandibular movement during mastication. Macaque patterns display less asymmetry, more uniformity, and limited lateral excursions when compared to humans for mastication of the same food. Different anatomical structures between the two spec...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570071301
更新日期:1978-07-01 00:00:00
abstract::Saliva plays a major role in maintaining oral health. Patients with salivary hypofunction exhibit difficulty in chewing and swallowing foods, tooth decay, periodontal disease, and microbial infections. At this time, treatments for hyposalivation are limited to medications (e.g., muscarinic receptor agonists: pilocarpi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515600157
更新日期:2015-11-01 00:00:00
abstract::We report a clinical study that examines whether HIV infection affects Streptococcus mutans colonization in the oral cavity. Whole stimulated saliva samples were collected from 46 HIV-seropositive individuals and 69 HIV-seronegative control individuals. The level of S. mutans colonization was determined by conventiona...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512454298
更新日期:2012-09-01 00:00:00