Abstract：
:Angiogenesis and biomineral substrates play major roles in bone development and regeneration. We hypothesized that macroporous scaffolds of biomineralized 85:15 poly(lactide-co-glycolide), which locally release vascular endothelial growth factor-165 (VEGF), would direct simultaneous regeneration of bone and vascular tissue. The presence of a bone-like biomineral substrate significantly increased regeneration of osteoid matrix (32 +/- 7% of total tissue area; mean +/- SD; p < 0.05) and mineralized tissue (14 +/- 2%; P < 0.05) within a rat cranium critical defect compared with a non-mineralized polymer scaffold (19 +/- 8% osteoid and 10 +/- 2% mineralized tissue). Further, the addition of VEGF to a mineralized substrate significantly increased the generation of mineralized tissue (19 +/- 4%; P < 0.05) compared with mineralized substrate alone. This appeared to be due to a significant increase in vascularization throughout VEGF-releasing scaffolds (52 +/- 9 vessels/mm(2); P < 0.05) compared with mineralized scaffolds without VEGF (34 +/- 4 vessels/mm(2)). Surprisingly, there was no significant difference in total osteoid between the two samples, suggesting that increased vascularization enhances mineralized tissue generation, but not necessarily osteoid formation. These results indicate that induced angiogenesis can enhance tissue regeneration, supporting the concept of therapeutic angiogenesis in tissue-engineering strategies.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Murphy WL,Simmons CA,Kaigler D,Mooney DJdoi
10.1177/154405910408300304keywords:
subject
Has Abstractpub_date
2004-03-01 00:00:00pages
204-10issue
3eissn
0022-0345issn
1544-0591journal_volume
83pub_type
杂志文章abstract：:Epstein-Barr virus (EBV), in addition to its transforming properties, contributes to the pathogenesis of several inflammatory diseases. Here, we investigated its involvement in oral lichen planus (OLP), a common autoimmune-like disease of unknown etiopathogenesis that can display a malignant potential. EBV-infected ce...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518788282
更新日期：2018-12-01 00:00:00
abstract：:The anticaries effect of professional fluoride (F) application has been attributed to calcium-fluoride-like deposits (CaF(2)) formed on enamel, but this has not been clearly demonstrated. We hypothesized that CaF(2) formed on plaque-free enamel by F application would reduce enamel demineralization due to the increase ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808701105
更新日期：2008-11-01 00:00:00
abstract：:In this study, the effects of eugenol on human polymorphonuclear (PMN) cell migration and chemiluminescence were examined in vitro. Utilizing zymosan-activated serum or crude Bacteroides sonicate fractions as chemotractants, we found that eugenol inhibits PMN migration at 6.6 X 10(-2) to 6.6 X 10(-5) mol/L (P less tha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660031401
更新日期：1987-03-01 00:00:00
abstract：:The tissue-implant interfaces of functional and non-functional endosseous dental implants were compared histologically for up to one year post-operatively. Nonmineralized connective tissue zones (a "fibrous capsule") existed in all functional interfaces. Direct, or nearly direct, bone apposition to implants occurred i...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580100201
更新日期：1979-10-01 00:00:00
abstract：:Molecular studies indicate that epigenetic events are important in determining how the internal enamel epithelium folds during odontogenesis. Since this process of folding leads to the subsequent arrangement of cusps on molar teeth, we hypothesized that intercuspal distances of human molar teeth would display greater ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200505
更新日期：2003-05-01 00:00:00
abstract：:Although a large body of scientific literature shows that background color and luminance affect color perception, previous measurements of tooth color difference thresholds have not taken the effects of viewing context into account. The present study tested the hypothesis that differences in skin/gingival color influe...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510376772
更新日期：2010-11-01 00:00:00
abstract：:The aim of this study was to assess the changes occurring in subgingival biofilm composition and in the periodontal clinical parameters of subjects with periodontitis and type 2 diabetes mellitus (DM) treated by means of scaling and root planing (SRP) only or combined with systemic metronidazole (MTZ) and amoxicillin ...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034516639274
更新日期：2016-07-01 00:00:00
abstract：:The field of dental materials has undergone more of a revolution than an evolution over the past 100 y. The development of new products, especially in the past half century, has occurred at a staggering pace, and their introduction to the market has been equally impressive. The movement has mostly come in the area of ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518822808
更新日期：2019-03-01 00:00:00
abstract：:Periodontitis is a complex, multifactorial chronic disease involving continuous interactions among bacteria, host immune/inflammatory responses, and modifying genetic and environmental factors. More than any other cytokine family, the interleukin (IL)-1 family includes key signaling molecules that trigger and perpetua...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520945209
更新日期：2020-12-01 00:00:00
abstract：:Although osteoporosis is a major public health concern, the effect of this condition on oral bone has not been determined. Using the ovariectomized rat as a model, we examined whether acute estrogen depletion affects the mandible of the ovariectomized rat with and without maxillary molar extraction. Twenty-two ovariec...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730110901
更新日期：1994-11-01 00:00:00
abstract：:Much research has been devoted to the study of etched enamel, since it is critical to bonding. Currently, there are no precise data regarding the etched-enamel specific surface area. The aim of this study was to characterize, by two different methods, the surface of human dental enamel in vitro after being etched. It ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700607
更新日期：2008-06-01 00:00:00
abstract：:Early-onset periodontitis (EOP) is considered to have a genetic basis which has not been clearly defined. Genetic polymorphisms of the vitamin D receptor (VDR-B-b) and the immunoglobulin-Fc-gamma receptor IIIb (FcgammaRIIIb-NA1-NA2) are associated with bone metabolism and infectious diseases, respectively. The purpose...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800120501
更新日期：2001-12-01 00:00:00
abstract：:The term "artificial intelligence" (AI) refers to the idea of machines being capable of performing human tasks. A subdomain of AI is machine learning (ML), which "learns" intrinsic statistical patterns in data to eventually cast predictions on unseen data. Deep learning is a ML technique using multi-layer mathematical...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520915714
更新日期：2020-07-01 00:00:00
abstract：:The distribution, genetic relatedness, and peptidase activity in hydrolyzing N-benzoyl-L-arginine-p-nitroanilide by Capnocytophaga species isolated from calculus- and non-calculus-formers were determined in this study. The proportion and prevalence of Capnocytophaga species were higher in plaque samples from the calcu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700070601
更新日期：1991-07-01 00:00:00
abstract：:A full understanding of the key regulators controlling periodontal development and homeostasis is necessary for the design of improved periodontal regenerative therapies. Small leucine-rich proteoglycans (SLRPs) are extracellular matrix molecules suggested to regulate collagen organization and cell signaling. Mice wit...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514541126
更新日期：2014-08-01 00:00:00
abstract：:The biogenetic formation of mineral crystals, one aspect of biomineralization, is a multistep process of apatite formation throughout the growth of dentin tissue. An important step is the transformation of the non-mineralized predentin matrix to mineralizing dentin matrix and its biological control. In this study, the...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770081401
更新日期：1998-08-01 00:00:00
abstract：:Masticatory muscle silent periods were compared in normal subjects and in patients with MPD syndrome before and after a variety of psychological, physiological, and pharmacological forms of therapy. All patients initially showed prolonged silent periods in one or more of the muscles. There was a direct relationship be...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600030501
更新日期：1981-03-01 00:00:00
abstract：:Clinical evidence is lacking regarding the influence of the amount of residual coronal dentin and of post placement on the failure risk of endodontically compromised teeth. The aim of this prospective clinical trial was to assess whether these factors significantly affect the two-year survival of restored pulpless pre...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/154405910708600808
更新日期：2007-08-01 00:00:00
abstract：:When measured once, psychological stress predicts development of painful temporomandibular disorder (TMD). However, a single measurement fails to characterize the dynamic nature of stress over time. Moreover, effects of stress on pain likely vary according to biological susceptibility. We hypothesized that temporal es...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515595043
更新日期：2015-09-01 00:00:00
abstract：:The purpose of this investigation was to examine the inhibitory effects of aqueous extracts derived from the bark-containing sticks (Neem stick) of Azadirachta indica upon bacterial aggregation, growth, adhesion to hydroxyapatite, and production of insoluble glucan, which may affect in vitro plaque formation. Neem sti...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750021301
更新日期：1996-02-01 00:00:00
abstract：:Local anesthetic agents may be classified according to their intrinsic anesthetic potency and duration of activity. Procaine and chloroprocaine are relatively weak, short-acting drugs. Lidocaine, mepivacaine, and prilocaine represent agents of intermediate potency and duration of action. Tetracaine, bupivacaine, and e...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600080903
更新日期：1981-08-01 00:00:00
abstract：:The bactericidal effect of hexylresorcinol was assessed using bacterial aggregates. Increased drug concentration resulted in decreased survival of bacteria when the aggregates were exposed to hexylresorcinol for at least eight hours. This indicates that this drug may be effective against dental plaque only when availa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580111501
更新日期：1979-11-01 00:00:00
abstract：:Fibroblast growth factor receptor 2 (FGFR2) in craniofacial bones mediates osteoprogenitor proliferation, differentiation, and apoptosis. The distortion of proper craniofacial bone growth may cause class II and class III skeletal malocclusion and result in compromised function and aesthetics. Here, we investigated the...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519872951
更新日期：2019-11-01 00:00:00
abstract：:Breastfeeding is important for health and development. Yet, the interaction between breastfeeding duration and usage of fluoridated water on caries experience has not been investigated. This study examined exposure to fluoridation as an effect modifier of the association between breastfeeding duration and caries. The ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519843487
更新日期：2019-07-01 00:00:00
abstract：:Interleukin (IL)-23 is an essential cytokine involved in expansion of the Th17 lineage, which is associated with many immune-related destructive tissue diseases. We hypothesized that the IL-23-induced Th17 pathway plays a role in periodontal pathology and examined the expression of cytokines, and related molecules, in...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509339889
更新日期：2009-07-01 00:00:00
abstract：:Previous studies have suggested that information provided by periodontal mechanoreceptors is particularly important for the fine motor control of the mandible, i.e., when humans hold and carefully manipulate food particles between the teeth with low biting forces. In the present study, we further evaluated this hypoth...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770041001
更新日期：1998-04-01 00:00:00
abstract：:The complexity of human oral functional movements has not been studied in detail quantitatively, and only recently have studies begun to evaluate whether such movements contain sex-specific characteristics. Therefore, the purposes of this study were: (1) to quantify in detail the jaw movements and associated masticato...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760031301
更新日期：1997-03-01 00:00:00
abstract：:The classic stimulus for cellular cytokine production is bacterial lipopolysaccharide (endotoxin). It was therefore hypothesized that tumor necrosis factor-alpha (TNF-alpha) may be responsible for pericoronitis. TNF-alpha and its receptors were detected by immunohistochemical staining in third molar pericoronitis in t...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910508401216
更新日期：2005-12-01 00:00:00
abstract：:The work described considers the effects on calcified tissues of those concentrations of fluoride which are not overtly cyto-toxic, i.e., in the general region of up to 1-2 mumol/L. Plasma fluoride concentrations or those of the cellular environment are considered rather than dietary levels. The effect of fluoride ion...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/00220345900690S134
更新日期：1990-02-01 00:00:00
abstract：:We explored the potential to diagnose Zika virus (ZIKV) infection by analyzing peptides in saliva during a convalescent phase of infection, long after resolution of acute disease. A 25-y-old woman clinically diagnosed with Zika fever in the first trimester was enrolled with her dizygotic twins for a 3-mo postnatal sam...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517723325
更新日期：2017-09-01 00:00:00
