Surface integrity governs the proteome of hypomineralized enamel.

abstract：:Recent evidence implicates endothelin in nociception, but it is unclear how endothelin activates trigeminal ganglion (TRG) neurons. In the present study, we investigated the expression of the endothelin receptors ETA and ETB and endothelin-induced responses in rat TRG neurons. Double-immunofluorescence studies demonst...

journal_title：Journal of dental research

authors： Yamamoto T,Ono K,Hitomi S,Harano N,Sago T,Yoshida M,Nunomaki M,Shiiba S,Watanabe S,Nakanishi O,Inenaga K

更新日期：2013-04-01 00:00:00

abstract：:Mixed or parotid saliva from caries-active individuals consistently supported better growth of Streptococcus mutans (type c) than that from caries-free individuals. Electrophoretic studies revealed that certain proteins in caries-active salivas were susceptible to microbial attack, but similar proteins in caries-free ...

journal_title：Journal of dental research

authors： Cowman RA,Schaefer SJ,Fitzgerald RJ,Rosner D,Shklair IL,Walter RG

更新日期：1979-10-01 00:00:00

abstract：:Previous investigations have shown a clear association between the presence of the enzyme aspartate aminotransferase (AST) in gingival crevicular fluid (GCF) and clinical evidence of periodontal disease in humans, as well as in the beagle dog model. This paper describes a 26-week study that uses the beagle dog model o...

journal_title：Journal of dental research

authors： Cohen RL,Alves ME,Crawford JM,McSwiggin T,Chambers DA

更新日期：1991-06-01 00:00:00

abstract：:The molecular mechanisms that maintain the equilibrium of odontoblast progenitor cells in dental pulp are unknown. Here we tested whether homeostasis in dental pulp is modulated by Twist-1, a nuclear protein that partners with Runx2 during osteoblast differentiation. Our analysis of Twist-1(+/-) mice revealed phenotyp...

journal_title：Journal of dental research

authors： Galler KM,Yasue A,Cavender AC,Bialek P,Karsenty G,D'Souza RN

更新日期：2007-10-01 00:00:00

abstract：:Successive active phases observed in periodontal diseases may be explained either by a sudden activation of the pro-forms of tissue-stored degradative enzymes such as metalloproteinases (MMPs) or by an imbalance between metalloproteinases and their tissue inhibitors (TIMPs). To discriminate between these two hypothese...

journal_title：Journal of dental research

authors： Soell M,Elkaim R,Tenenbaum H

更新日期：2002-03-01 00:00:00

abstract：:Previous studies show that both activin and Bmp4 act as crucial mesenchymal odontogenic signals during early tooth development. Remarkably, mice lacking activin-βA ( Inhba-/-) and mice with neural crest-specific inactivation of Bmp4 ( Bmp4ncko/ncko) both exhibit bud-stage developmental arrest of the mandibular molar t...

journal_title：Journal of dental research

authors： Kwon HE,Jia S,Lan Y,Liu H,Jiang R

更新日期：2017-09-01 00:00:00

abstract：:Tooth enamel is the most highly mineralized tissue in vertebrates. Enamel crystal formation and elongation should be well controlled to achieve an exceptional hardness and a compact microstructure. Enamel matrix calcification occurs with several matrix proteins, such as amelogenin, enamelin, and ameloblastin. Among th...

journal_title：Journal of dental research

authors： Cho ES,Kim KJ,Lee KE,Lee EJ,Yun CY,Lee MJ,Shin TJ,Hyun HK,Kim YJ,Lee SH,Jung HS,Lee ZH,Kim JW

更新日期：2014-10-01 00:00:00

abstract：:There is a large variability between and among individuals in the physiology of mastication, but it is not known whether this produces a similar variability in the particle sizes of food boluses at the end of the chewing process. Food boluses obtained just before swallowing were analyzed in ten subjects (aged 36.7 +/-...

journal_title：Journal of dental research

authors： Peyron MA,Mishellany A,Woda A

更新日期：2004-07-01 00:00:00

abstract：:Phosphorylated extracellular matrix proteins, including matrix extracellular phosphoprotein (MEPE), are involved in the formation and mineralization of dental tissues. In this study, we evaluated the potential of Dentonin, a synthetic peptide derived from MEPE, to promote the formation of reparative dentin. Agarose be...

journal_title：Journal of dental research

authors： Six N,Septier D,Chaussain-Miller C,Blacher R,DenBesten P,Goldberg M

更新日期：2007-08-01 00:00:00

abstract：:Chondroitin sulfate is up-regulated in granulation tissue during wound healing. To investigate the role of chondroitin sulfate in the wound-healing process after surgical repair of cleft palate, we isolated and cultured rabbit palatal fibroblasts. Treatment with chondroitin-6-sulfate resulted in a dose-dependent incre...

journal_title：Journal of dental research

authors： Zou XH,Foong WC,Cao T,Bay BH,Ouyang HW,Yip GW

更新日期：2004-11-01 00:00:00

abstract：:Using glycoproteins and milk oligosaccharides as substrate acceptors, we demonstrated at least two fucosyltransferases in human parotid saliva. One enzyme transferred L-fucose from GDP-fucose to the C-3 position of N-acetylglucosamine or glucose residue of oligosaccharide chains, and the other transferred to the C-4 p...

journal_title：Journal of dental research

authors： Tamagawa H,Inoshita E,Shibata S,Shizukuishi S,Tsunemitsu A

更新日期：1983-07-01 00:00:00

abstract：:The inhibitory activity of 2-phosphono-butane 1,2,4 tricarboxylic acid (PBTA) in the formation of hydroxyapatite (HA) was studied in vitro and in vivo. PBTA, at 4 ppm, inhibited the spontaneous formation of HA in vitro from a supersaturated solution. PBTA, at 2 ppm, completely inhibited the crystal growth of HA; at lo...

journal_title：Journal of dental research

authors： Gaffar A,Moreno EC

更新日期：1985-01-01 00:00:00

abstract：:Resin composites currently available are not suitable for use as large stress-bearing posterior restorations involving cusps due to their tendencies toward excessive fracture and wear. The glass fillers in composites provide only limited reinforcement because of the brittleness and low strength of glass. The aim of th...

journal_title：Journal of dental research

authors： Xu HH,Martin TA,Antonucci JM,Eichmiller FC

更新日期：1999-02-01 00:00:00

abstract：:Our observations confirm the previously reported observation that multinucleated cells develop within a two-week period in cat bone-marrow cultures. Calcitonin induces cytoplasmic contraction in these multinucleated cells, which indicates that they resemble osteoclasts. After seven days of culture, cat bone-marrow cul...

journal_title：Journal of dental research

authors： Pharoah MJ,Heersche JN

更新日期：1986-07-01 00:00:00

abstract：:Periodontal ligaments (PDLs) play an important role in remodeling the alveolar bond and cementum. Characterization of the periodontal tissue transcriptome remains incomplete, and an improved understanding of PDL features could aid in developing new regenerative therapies. Here, we aimed to generate and analyze a large...

journal_title：Journal of dental research

authors： Yamada S,Ozaki N,Tsushima K,Yamaba S,Fujihara C,Awata T,Sakashita H,Kajikawa T,Kitagaki J,Yamashita M,Yanagita M,Murakami S

更新日期：2016-08-01 00:00:00

abstract：:The diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection relies on the detection of viral RNA by real-time reverse transcription polymerase chain reaction (rRT-PCR) performed with respiratory specimens, especially nasopharyngeal swabs. However, this procedure requires specialized medical...

journal_title：Journal of dental research

authors： Azzi L,Maurino V,Baj A,Dani M,d'Aiuto A,Fasano M,Lualdi M,Sessa F,Alberio T

更新日期：2021-02-01 00:00:00

abstract：:Because bone reconstruction in irradiated sites is less than ideal, we applied a regenerative gene therapy method in which a cell-signaling virus was localized to biomaterial scaffolds to regenerate wounds compromised by radiation therapy. Critical-sized defects were created in rat calvariae previously treated with ra...

journal_title：Journal of dental research

authors： Hu WW,Ward BB,Wang Z,Krebsbach PH

更新日期：2010-01-01 00:00:00

abstract：:Knoop hardness measurements of UV-polymerized dental composites showed that, at a certain depth below the surface, the degree of cure rapidly decreases. The depth of cure was found to be critically dependent on the UV source and exposure time used. A theoretical model was derived which was in quantitative accord with ...

journal_title：Journal of dental research

authors： Cook WD

更新日期：1980-05-01 00:00:00

abstract：:The type of attachment that is used in oral rehabilitation by means of implant-retained mandibular overdentures may influence the retention and the stability of the denture. In this study, we examined the hypothesis that a better retention and stability of the denture improve the oral function. Eighteen edentulous sub...

journal_title：Journal of dental research

authors： van Kampen FM,van der Bilt A,Cune MS,Bosman F

更新日期：2002-03-01 00:00:00

abstract：:Matrix metalloproteinase (MMP) inhibition has been shown to reduce adhesive bond degradation when applied as a pre-conditioner, adding to clinical steps in the placement of adhesives, but their incorporation within dental adhesives has not been fully explored. This study examined the effect of including 2 MMP inhibito...

journal_title：Journal of dental research

authors： Almahdy A,Koller G,Sauro S,Bartsch JW,Sherriff M,Watson TF,Banerjee A

更新日期：2012-06-01 00:00:00

abstract：:Dental caries is a microbially mediated disease that can result in significant tooth structure degradation. Although the preponderance of lesions is treated by surgical intervention, various strategies have been developed for its noninvasive management. Here, we use a novel approach for noninvasive treatment based on ...

journal_title：Journal of dental research

authors： Kerr JE,Arndt GD,Byerly DL,Rubinovitz R,Theriot CA,Stangel I

更新日期：2016-03-01 00:00:00

abstract：:The universally accepted concept of delay-loaded dental implants has recently been challenged. This study hypothesizes that early loading (decreased implant healing time) leads to increased bone formation and decreased crestal bone loss. We used 17 minipigs to study implants under a controlled load, with non-loaded im...

journal_title：Journal of dental research

authors： Ko CC,Douglas WH,DeLong R,Rohrer MD,Swift JQ,Hodges JS,An KN,Ritman EL

更新日期：2003-08-01 00:00:00

abstract：:In 1992 and 1997, all US and Canadian dental schools were surveyed by mail regarding the preferred initial radiographic examination prescribed for non-emergency, comprehensive-care patients (dentulous adults, edentulous adults, and children). In both survey years, a minority of US and Canadian dental schools reported ...

journal_title：Journal of dental research

authors： Kantor ML

更新日期：2000-07-01 00:00:00

abstract：:Cell therapies utilizing mesenchymal stem cells (MSCs) could overcome limitations of traditional treatments for reconstructing craniofacial tissues. This large-scale study explored a standardized methodology for the isolation and clinical-scale expansion of alveolar bone marrow-derived MSCs (aBMSCs). We harvested 103 ...

journal_title：Journal of dental research

authors： Mason S,Tarle SA,Osibin W,Kinfu Y,Kaigler D

更新日期：2014-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent inducer of angiogenesis, vascular permeability, and edema. Up-regulation of VEGF expression in the dental pulp may result in increased intra-pulpal pressure, and contribute to pain and irreversible tissue damage. Lipoteichoic acid (LTA) is an amphiphilic molecule f...

journal_title：Journal of dental research

authors： Telles PD,Hanks CT,Machado MA,Nör JE

更新日期：2003-06-01 00:00:00

abstract：:Purinergic signaling is involved in pain generation and modulation in the nociceptive sensory nervous system. Adenosine triphosphate (ATP) induces pain via activation of ionotropic P2X receptors while adenosine mediates analgesia via activation of metabotropic P1 receptors. These purinergic signaling are determined by...

journal_title：Journal of dental research

authors： Liu X,Ma L,Zhang S,Ren Y,Dirksen RT

更新日期：2017-06-01 00:00:00

abstract：:Previously, in vitro differentiation of odontoblasts was shown for dental pulp stem cells (DPSCs) transfected with bone morphogenetic protein-2 (Bmp2). For this study, we hypothesized that such cells also show potential for mineralized tissue formation in vivo. DPSCs were transfected with Bmp2 and seeded onto a cerami...

journal_title：Journal of dental research

authors： Yang X,van der Kraan PM,Bian Z,Fan M,Walboomers XF,Jansen JA

更新日期：2009-11-01 00:00:00

abstract：:The adsorption isotherms of benzoic acid on synthetic hydroxyapatite (containing about 1.5 monolayers of physisorbed water) were studied from ethanol, dimethylsulfoxide, p-dioxane, methylene chloride, and benzene to discern the role of solvent in the process. The adsorption is reversible from the first three solvents ...

journal_title：Journal of dental research

authors： Misra DN

更新日期：1986-05-01 00:00:00

abstract：:Although the tripeptides Glu-O-Phosphoserine-Tyr and Glu-O-Phosphoserine-Leu have been identified in embryonic bovine enamel proteins, 1, 2 the issue of whether both sequences occur in each of the phosphopeptides, or whether certain sequences occur in specific peptides only, has recently been resolved by isolating hom...

journal_title：Journal of dental research

authors： Glimcher MJ

更新日期：1979-03-01 00:00:00

abstract：:When one uses composite resins, the curing contraction, the stiffness of the material, and the strength of the vulnerable dentinal bond are important factors in determining the marginal adaptation of the restoration. Calculations based on these intrinsic material properties have indicated that both bulk placement and ...

journal_title：Journal of dental research

authors： Kemp-Scholte CM,Davidson CL

更新日期：1988-05-01 00:00:00