Abstract：
:Phosphorylated extracellular matrix proteins, including matrix extracellular phosphoprotein (MEPE), are involved in the formation and mineralization of dental tissues. In this study, we evaluated the potential of Dentonin, a synthetic peptide derived from MEPE, to promote the formation of reparative dentin. Agarose beads, either soaked with Dentonin or unloaded, were implanted into the pulps of rat molars, and examined 8, 15, and 30 days after treatment. At day 8, Dentonin promoted the proliferation of pulp cells, as visualized by PCNA-labeling. RP59-positive osteoblast progenitors were located around the Dentonin-soaked beads. PCNA- and RP59-labeling were decreased at day 15, while osteopontin, weakly labeled at day 8, was increased at 15 days, but dentin sialoprotein was undetectable at any time. At 8 days, precocious reparative dentin formation occurred in pulps containing Dentonin-soaked beads, with formation slowing after 15 days. These results suggest that Dentonin affects primarily the initial cascade of events leading to pulp healing.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Six N,Septier D,Chaussain-Miller C,Blacher R,DenBesten P,Goldberg Mdoi
10.1177/154405910708600818subject
Has Abstractpub_date
2007-08-01 00:00:00pages
780-5issue
8eissn
0022-0345issn
1544-0591pii
86/8/780journal_volume
86pub_type
杂志文章abstract：:The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510381903
更新日期：2010-12-01 00:00:00
abstract：:Severe early childhood caries (S-ECC) is a multifactorial disease that can lead to suffering and reduced oral health-related quality of life in young children. The bacterial and fungal composition of dental plaque and how children's sex is associated with S-ECC are largely unknown. In this study, V4-16S rRNA and ITS1 ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520908595
更新日期：2020-06-01 00:00:00
abstract：:Caries of the permanent first molars of 5-year-old children was found to be associated with caries of their diciduous teeth. The sample consisted of 220 children whose permanent first molars had erupted. They were selected out of 965 children who were a representative sample of children attending compulsory kindergart...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550062001
更新日期：1976-11-01 00:00:00
abstract：:Glass-ionomer cements (GICs) are regarded as aqueous gels made up of polyalkenoic acid salts containing ion-leachable glass fillers. The consequence of water permeation across the GIC-dentin interface is unknown. This study used SEM, field-emission/environmental SEM (FE-ESEM), and TEM to examine the ultrastructure of ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300403
更新日期：2004-04-01 00:00:00
abstract：:The limited durability of resin-dentin bonds severely compromises the lifetime of tooth-colored restorations. Bond degradation occurs via hydrolysis of suboptimally polymerized hydrophilic resin components and degradation of water-rich, resin-sparse collagen matrices by matrix metalloproteinases (MMPs) and cysteine ca...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034510391799
更新日期：2011-08-01 00:00:00
abstract：:This study contains the first part of a research project in which the applicability of fracture mechanics parameters to predict failure of a restored tooth was investigated. Fracture mechanics parameters have been used in dental research before, but were restricted to comparative studies between various brands of comp...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670060601
更新日期：1988-06-01 00:00:00
abstract：:Four classes of elastomeric impression materials (polysulfide, polyether, silicone, and agar-agar) were evaluated on the basis of linear dimensional stability as a function of time between taking and pouring an impression of mounted teeth. Four polysulfide materials produced dies which were larger than the teeth and g...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590071001
更新日期：1980-07-01 00:00:00
abstract：:Cultures of Streptococcus mutans MFe28 (serotype h) were grown with differing extracellular polysaccharide (EPS) content. Biochemical and physicochemical characteristics considered relevant to caries were measured. Acid production parameters measured in a pH-stat were: Vm = 0.76 +/- 0.14 mumol/g/sec (wet weight); appa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670060101
更新日期：1988-06-01 00:00:00
abstract：:Large mandibular defects are difficult to reconstruct with good functional and aesthetic outcomes because of the complex geometry of craniofacial bone. While the current gold standard is free tissue flap transfer, this treatment is limited in fidelity by the shape of the harvested tissue and can result in significant ...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034514547763
更新日期：2014-12-01 00:00:00
abstract：:The rate of F absorption from the stomach is pH-dependent, with greater absorption at low pH. Since the rate of absorption is also strongly influenced by the rapidity of gastric emptying, we have compared the relative importance of gastric acidity and gastric emptying in overall F absorption. Male rats (350 g, n = 85)...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720031101
更新日期：1993-03-01 00:00:00
abstract：:Oral bacteria, including Streptococcus mutans and Streptococcus salivarius, contribute to tooth decay and plaque formation; therefore, it is essential to develop strategies to prevent dental caries and plaque formation. We recently showed that organo-selenium compounds covalently attached to different biomaterials inh...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513482141
更新日期：2013-05-01 00:00:00
abstract：:Dental implants have become an increasingly popular treatment choice for replacing missing teeth. Yet, little is known about the prevalence and sociodemographic distribution of dental implant use in the United States. To address this knowledge gap, we analyzed data from 7 National Health and Nutrition Examination Surv...
journal_title：Journal of dental research
pub_type： 历史文章,杂志文章
doi：10.1177/0022034518792567
更新日期：2018-12-01 00:00:00
abstract：:Rotational freedom of the implant-abutment connection influences its screw joint stability; for optimization, influential factors need to be evaluated based on a previously developed closed formula. The underlying hypothesis is that the manufacturing tolerances, geometric pattern, and dimensions of the index do not in...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509341243
更新日期：2009-08-01 00:00:00
abstract：:It has not been established whether transmission of mutans streptococci occurs between unrelated children older than 4 years of age. The aim of the study was to investigate the possible transmission of mutans streptococci genotypes from child to child in kindergarten. We studied 96 children (ages 5-6 yrs) in three San...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509353400
更新日期：2010-01-01 00:00:00
abstract：:Sjögren's syndrome is a common autoimmune rheumatic disease. The most common symptoms of Sjögren's syndrome are extreme tiredness, along with dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia). Saliva plays an essential role in numerous functions of the mouth. Xerostomia can be caused by medications, chr...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910808700411
更新日期：2008-04-01 00:00:00
abstract：:Calcitonin gene-related peptide (CGRP) plays a crucial role in the modulation of orofacial pain, and we hypothesized that CGRP mediated a neuron-glia crosstalk in orofacial pain. The objective of this study was to elucidate the mechanisms whereby CGRP mediated trigeminal neuron-glia crosstalk in modulating orofacial p...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520950296
更新日期：2021-01-01 00:00:00
abstract：:Sensitivity or pain of the mucoperiosteum covering the mandibular edentulous ridge is often thought to limit bite forces in complete-denture wearers. Therefore, bite forces with mandibular implant-retained overdentures may depend on the degree of implant support. This study analyzed the effects of different degrees of...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/00220345980770101101
更新日期：1998-10-01 00:00:00
abstract：:The dentition in zebrafish is extremely and richly vascularized, but the function of the vasculature, in view of the continuous replacement of the teeth, remains elusive. Through application of SU5416, a vascular endothelial growth factor receptor inhibitor, we studied the role of the blood vessels in the dentition of...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514557156
更新日期：2015-01-01 00:00:00
abstract：:Pilocarpine (P) is of potential utility in the treatment of xerostomia. Because optimal development of P dosage forms for humans requires that its pharmacokinetics and pharmacodynamics be defined, this intravenous study of its disposition and associated salivary responses was performed. In a hospital setting, two heal...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345950740120701
更新日期：1995-12-01 00:00:00
abstract：:Previous studies show that both activin and Bmp4 act as crucial mesenchymal odontogenic signals during early tooth development. Remarkably, mice lacking activin-βA ( Inhba-/-) and mice with neural crest-specific inactivation of Bmp4 ( Bmp4ncko/ncko) both exhibit bud-stage developmental arrest of the mandibular molar t...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517713710
更新日期：2017-09-01 00:00:00
abstract：:The pathophysiology of painful temporomandibular disorders is not fully understood, but evidence suggests that muscle pain modulates motor function in characteristic ways. This study tested the hypothesis that activation of nociceptive muscle afferent fibers would be linked to an increased excitability of the human ja...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910208100915
更新日期：2002-09-01 00:00:00
abstract：:Squamous cell carcinoma (SCC) of the head and neck is the sixth most frequent cancer worldwide. The survival rate is among the lowest of the major cancers and has not improved significantly in the past two decades. Extensive local invasion and regional lymph node metastasis are, in large part, responsible for the poor...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780061001
更新日期：1999-06-01 00:00:00
abstract：:A radiotracer technique was used to study silver and gold diffusion into dental porcelain under experimental conditions close to the real conditions in prosthetic laboratories for porcelain bakes. It was clearly shown that these non-oxidizable elements were able to diffuse into the ceramic as well as oxidizable ones. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660120401
更新日期：1987-12-01 00:00:00
abstract：:Heads of Swiss-Webster mouse fetuses of four ages spanning days 12-13 of gestation, were partially dissected by removing the brain (B), tongue (T) and mandible (M) alone or in combination (BT, BM, BTM). Preparations were suspended in a gassed, circulating culture system such that palatal closure must take place agains...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570024401
更新日期：1978-02-01 00:00:00
abstract：:The tongue exerts crucial functions in our daily life. However, we know very little about the regulatory mechanisms of mammalian tongue development. In this review, we summarize recent findings of the molecular and cellular mechanisms that control tissue-tissue interactions during tongue morphogenesis. Specifically, c...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034511434055
更新日期：2012-06-01 00:00:00
abstract：:Recent advances in molecular biology have facilitated analyses of the oral microbiome ("Who are they?"); however, its functions (e.g., metabolic activities) are poorly understood ("What are they doing?"). This review aims to summarize our current understanding of the metabolism of the oral microbiome. Saccharolytic ba...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034515606045
更新日期：2015-12-01 00:00:00
abstract：:Defined sets of transcriptional factors can reprogram human somatic cells to induced pluripotent stem (iPS) cells. However, many types of human cells are not easily accessible to minimally invasive procedures. Here we evaluated dental pulp cells (DPCs) as an optimal source of iPS cells, since they are easily obtained ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510366846
更新日期：2010-08-01 00:00:00
abstract：:Incisors of Mg-deficient rats showed a marked inhibition of eruption and a decrease in mitoses of apical tissues. Cortisone administration resulted in some increase in eruption rate and cell division though these remained below the values of Mg-supplemented controls. An improvement in gross condition and a less severe...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560122901
更新日期：1977-12-01 00:00:00
abstract：:In mineralizing hamster molars, the influence of several inhibitors on p-NPP-ase has been demonstrated, and compared with their effect on PPi-ase, known to belong to the same enzyme. Whereas the latter activity is much more physiological, p-NPP is a better substrate to distinguish between the effects of bivalent catio...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560102701
更新日期：1977-10-01 00:00:00
abstract：:The effect of different doses of polyadenylic and polyuridylic acids (poly A:U) was studied in control rats and in rats exposed to hypoxia. In the control rats, administration of different doses of poly A:U did not change the thickness of the epiphyseal plate or increase the incorporation of 3H-phenylalanine as judged...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550041701
更新日期：1976-07-01 00:00:00
