Blocking VEGF signaling delays development of replacement teeth in zebrafish.

Abstract:

:The dentition in zebrafish is extremely and richly vascularized, but the function of the vasculature, in view of the continuous replacement of the teeth, remains elusive. Through application of SU5416, a vascular endothelial growth factor receptor inhibitor, we studied the role of the blood vessels in the dentition of the zebrafish. We were unable to show an effect on the development of first-generation teeth as well as first tooth replacement. However, in juvenile fish, a delay was observed in the developmental state of the replacement tooth compared with what was expected based on the maturation state of the functional tooth. Furthermore, we observed a difference between treated and nontreated fish in the distance between blood vessels and developing replacement teeth. In conclusion, our results provide support for a nutritive, rather than an inductive, function of the vasculature in the process of tooth development and replacement.

journal_name

J Dent Res

authors

Crucke J,Huysseune A

doi

10.1177/0022034514557156

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

157-65

issue

1

eissn

0022-0345

issn

1544-0591

pii

0022034514557156

journal_volume

94

pub_type

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