Abstract:
:Genetic influences are important in the determination of mandibular morphology, and growth hormone receptor (GHR) is believed to have an important influence on the growth of craniofacial bone. In this study, we used quantitative trait locus methods to evaluate the relationship between craniofacial morphology and single-nucleotide polymorphisms (SNPs) in GHR in an unselected healthy Chinese population. We systematically screened the 10 exons and nearby introns of GHR and identified 6 SNPs. Using 4 SNPs as markers, we studied the relationships between genotypes and craniofacial linear measurements. Individuals with the genotype CC of polymorphism I526L had a significantly greater mandibular ramus length (condylion-gonion/ articulare-gonion) than those with genotype AC or AA. Haplotype analysis showed that there were also significant differences between the long and short mandibular height groups in an extreme population. Our results indicate that the GHR gene polymorphism I526L is associated with mandibular height in the Chinese population.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Zhou J,Lu Y,Gao XH,Chen YC,Lu JJ,Bai YX,Shen Y,Wang BKdoi
10.1177/154405910508401116keywords:
subject
Has Abstractpub_date
2005-11-01 00:00:00pages
1052-6issue
11eissn
0022-0345issn
1544-0591pii
84/11/1052journal_volume
84pub_type
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