The growth hormone receptor gene is associated with mandibular height in a Chinese population.

Abstract:

:Genetic influences are important in the determination of mandibular morphology, and growth hormone receptor (GHR) is believed to have an important influence on the growth of craniofacial bone. In this study, we used quantitative trait locus methods to evaluate the relationship between craniofacial morphology and single-nucleotide polymorphisms (SNPs) in GHR in an unselected healthy Chinese population. We systematically screened the 10 exons and nearby introns of GHR and identified 6 SNPs. Using 4 SNPs as markers, we studied the relationships between genotypes and craniofacial linear measurements. Individuals with the genotype CC of polymorphism I526L had a significantly greater mandibular ramus length (condylion-gonion/ articulare-gonion) than those with genotype AC or AA. Haplotype analysis showed that there were also significant differences between the long and short mandibular height groups in an extreme population. Our results indicate that the GHR gene polymorphism I526L is associated with mandibular height in the Chinese population.

journal_name

J Dent Res

authors

Zhou J,Lu Y,Gao XH,Chen YC,Lu JJ,Bai YX,Shen Y,Wang BK

doi

10.1177/154405910508401116

keywords:

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

1052-6

issue

11

eissn

0022-0345

issn

1544-0591

pii

84/11/1052

journal_volume

84

pub_type

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