Abstract:
:Sjögren's syndrome is a common autoimmune rheumatic disease. The most common symptoms of Sjögren's syndrome are extreme tiredness, along with dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia). Saliva plays an essential role in numerous functions of the mouth. Xerostomia can be caused by medications, chronic diseases like Sjögren's syndrome, and medical treatments, such as radiation therapy and bone marrow transplant. Xerostomia can eventually lead to difficulty in swallowing, severe and progressive tooth decay, or oral infections. Despite having excellent oral hygiene, individuals with Sjögren's syndrome have elevated levels of dental caries, along with the loss of many teeth, early in the disease. Sjögren's syndrome alters the protein profile and brings about a change in the composition of saliva. There is an increase in the levels of lactoferrin, beta(2)-microglobulin, sodium, lysozyme C, and cystatin C, and a decrease in salivary amylase and carbonic anhydrase. Up to 90% of individuals with Sjögren's syndrome have antibodies targeting the Ro 60 and La autoantigens. Natural aging, regardless of Sjögren's syndrome, is also another factor that brings about a significant change in the composition of saliva. The most prevailing cause of xerostomia in elderly persons is the use of anticholinergic medications. Currently, there is no cure for Sjögren's syndrome, and treatment is mainly palliative.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Mathews SA,Kurien BT,Scofield RHdoi
10.1177/154405910808700411subject
Has Abstractpub_date
2008-04-01 00:00:00pages
308-18issue
4eissn
0022-0345issn
1544-0591pii
87/4/308journal_volume
87pub_type
杂志文章,评审abstract::Extracellular matrix (ECM) mineralization is regulated by mineral ion availability, proteins, and other molecular determinants. To investigate protein regulation of mineralization in tooth dentin and cementum, and in alveolar bone, we expressed matrix Gla protein (MGP) ectopically in bones and teeth in mice, using an ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808700907
更新日期:2008-09-01 00:00:00
abstract::Fluoride content of drinking water is an important criterion in prescribing fluoride supplements. The majority of practicing dentists and physicians prescribe fluoride supplements, yet many apparently are unaware of the fluoride levels in their patients' drinking water. Characteristics of North Carolina (NC) dentists,...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650011301
更新日期:1986-01-01 00:00:00
abstract::Using a pin-on-disc sliding-wear test apparatus, the wear behavior of a typical composite restorative vs. styli fashioned from human enamel, sintered alumina, and magnesium fluoride was examined. The rates of restorative wear were found to be identical, within the experimental error of the measurements, for tests usin...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630062501
更新日期:1984-06-01 00:00:00
abstract::One of the main goals of bone tissue engineering is to identify and develop new biomaterials and scaffolds for structural support and controlled cell growth, which allow for formation or replacement of bone tissue. Recently, carbon nanotubes (CNT) have emerged as a potential candidate for bone tissue engineering. CNT ...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034513490957
更新日期:2013-07-01 00:00:00
abstract::The importance of assessing the impact of treatments for chronic conditions on an individual's quality of life has been well-established. In this randomized clinical trial, oral-health-related quality of life, measured with the Oral Health Impact Profile (OHIP), was compared between two groups of edentulous patients. ...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/00220345000790090401
更新日期:2000-09-01 00:00:00
abstract::Using a hydraulic bellows system mounted on a maxillary partial denture, continuous force-displacement data were taken in an edentulous area in the maxillary bicuspid-molar region on ten adults. Both loading and unloading force-displacement curves showed three segments. Two visco-elastic properties - hysteresis and re...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630101901
更新日期:1984-10-01 00:00:00
abstract::Primary cilia regulate several developmental processes and mediate hedgehog signaling. To study their roles in cranial base development, we created conditional mouse mutants deficient in Polaris, a critical primary cilium component, in cartilage. Mutant post-natal cranial bases were deformed, and their synchondrosis g...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509337775
更新日期:2009-06-01 00:00:00
abstract::The kinetics of subsurface demineralization of tooth sections has been studied in real-time by scanning microradiography (SMR). Demineralization was carried out: (1) with a large volume of solution buffered to pH = 4 to maintain a constant composition; and (2) in a small constant volume (approximately 3 mL), buffered ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720051401
更新日期:1993-05-01 00:00:00
abstract::Extracellular vesicles (EVs), several tens to hundreds of nanometers in size, are vesicles secreted by cells for intercellular communication. EVs released from mesenchymal stem cells (MSC-EVs) have the potential to treat multiple diseases. This study aimed to determine the effects of MSC-EVs on bisphosphonate-related ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520906793
更新日期:2020-05-01 00:00:00
abstract::The effects of demineralized dentin and bone matrix on dental ectomesenchymal cells were evaluated after observation periods of two or three weeks. Autogenous dentin and bone matrix, obtained from the crowns of primary molars or maxillary cortical bone, respectively, were demineralized with 3% acetic acid and implante...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690011301
更新日期:1990-01-01 00:00:00
abstract::This study contains the first part of a research project in which the applicability of fracture mechanics parameters to predict failure of a restored tooth was investigated. Fracture mechanics parameters have been used in dental research before, but were restricted to comparative studies between various brands of comp...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670060601
更新日期:1988-06-01 00:00:00
abstract::It has been shown that a release of periosteal tension may augment the growth of a long bone; however, similar experiments in the mandible have produced equivocal results. For further definition of the role of periosteal tension in the growth of the mandibular condyle, 80 young female Sprague-Dawley rats were randomly...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690090201
更新日期:1990-09-01 00:00:00
abstract::Mixed or parotid saliva from caries-active individuals consistently supported better growth of Streptococcus mutans (type c) than that from caries-free individuals. Electrophoretic studies revealed that certain proteins in caries-active salivas were susceptible to microbial attack, but similar proteins in caries-free ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580101501
更新日期:1979-10-01 00:00:00
abstract::Diet is recognized as one of the most important factors affecting the equilibrium of the oral bacterial flora. Studies related to dental caries development have focused mainly on the effect of carbohydrates. In the present work, using swabbing coupled with an immuno-colony-blot assay, we followed the indigenous oral b...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690030801
更新日期:1990-03-01 00:00:00
abstract::The universally accepted concept of delay-loaded dental implants has recently been challenged. This study hypothesizes that early loading (decreased implant healing time) leads to increased bone formation and decreased crestal bone loss. We used 17 minipigs to study implants under a controlled load, with non-loaded im...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200803
更新日期:2003-08-01 00:00:00
abstract::Class II major histocompatilibity complex (MHC)-expressing cells are usually distributed in dental pulp, and it was postulated that the colony-stimulating factor (CSF) derived from dental pulp fibroblasts contributes to the migration of class II MHC-expressing cells into pulp tissue. This study aimed to investigate th...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200204
更新日期:2003-02-01 00:00:00
abstract::Enamel abraders used in two-body wear tests suffer the disadvantage that standardization is difficult or impossible to obtain. The aim of this study was to test whether steatite (a ceramic material with a Vickers Hardness similar to that of enamel) could be used as a satisfactory human enamel analogue. The friction an...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345940730091001
更新日期:1994-09-01 00:00:00
abstract::Recent reports have suggested functional interactions between the masticatory and head motor systems. However, the neurophysiological mechanisms behind these phenomena have not been thoroughly investigated. In this study, the motor unit activity was recorded bilaterally from the dorsal neck splenius muscles (SPL) whil...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200515
更新日期:2003-05-01 00:00:00
abstract::A new type of hydraulic cement has been developed. This cement consists of a mixture of cement powder and setting agent powder and therefore has only to be kneaded with a little amount of water when being used. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580050601
更新日期:1979-05-01 00:00:00
abstract::The biogenetic formation of mineral crystals, one aspect of biomineralization, is a multistep process of apatite formation throughout the growth of dentin tissue. An important step is the transformation of the non-mineralized predentin matrix to mineralizing dentin matrix and its biological control. In this study, the...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345980770081401
更新日期:1998-08-01 00:00:00
abstract::Samples of human dental plaque were pooled from several "white spot" smooth tooth surface areas as well as from several clinically-sound tooth surface areas in each of 12 caries-positive college students. Each of the two samples from each subject was used for the determination of: (1) pH-lowering potential in vitro in...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700120501
更新日期:1991-12-01 00:00:00
abstract::The most frequent complaints registered against composite restorations are stained margins and a rough surface. The stained margins have many causes such as (1) fracturing or crazing of enamel during preparation of the cavity, (2) using a composite having an excessive curing shrinkage, (3) manipulating too slowly, whi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580052101
更新日期:1979-05-01 00:00:00
abstract::Teeth develop through distinct morphological stages. At the cap stage, a compactly clustered and concentrically arranged cell mass, the enamel knot, appears at the tip of the enamel organ. Cells in this knot express sets of key molecules, and as such have been proposed to act as a signaling center directing tooth morp...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514525784
更新日期:2014-05-01 00:00:00
abstract::Bilateral resections of the superficial masseter, posterior temporal, and anterior digastric muscles of rats were done to determine their effects on mandibular growth. The macroscopic findings support the functional matrix theory of mandibular growth. The analysis of body weight and the statistical two-way analysis of...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550052301
更新日期:1976-09-01 00:00:00
abstract::The clearance of glucose from saliva was compared with that from spaces located in an intra-oral appliance. The spaces (N = 8) were similar in shape and size to posterior interdental spaces and could be sampled with a microsyringe without removing the appliance from the mouth. The subjects (N = 5) rinsed their mouths ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640030301
更新日期:1985-03-01 00:00:00
abstract::Intra-oral wounds, like wounds in children, demonstrate privileged healing when compared with adult wounds at extra-oral sites. This study investigated whether this preferential healing is related to an increased ability of oral mucosal fibroblasts to reorganize extracellular matrix (ECM) when compared with their derm...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750060601
更新日期:1996-06-01 00:00:00
abstract::PAX9 is a transcription factor expressed in the tooth mesenchyme during tooth morphogenesis. In Pax9-null mice, tooth development is arrested at the bud stage. In humans, heterozygous mutations in PAX9 have been associated with non-syndromic tooth agenesis, predominantly in the molars. Here, we report 2 novel mutation...
journal_title:Journal of dental research
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doi:10.1177/0022034513519801
更新日期:2014-03-01 00:00:00
abstract::Urinary catecholamines have been used to measure emotionally stressful states which may affect the development of dental caries. This study investigates the hypothesis that children with and without dental caries do not differ significantly in the mean values of urinary catecholamines such as epinephrine, norepinephri...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345950740100801
更新日期:1995-10-01 00:00:00
abstract::Enamel fluorosis can occur following either an acute or chronic exposure to fluoride during tooth formation. Fluorosed enamel is characterized by a retention of amelogenins in the early-maturation stage, and by the formation of a more porous enamel with a subsurface hypomineralization. The mechanisms by which fluoride...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/00220345920710051701
更新日期:1992-05-01 00:00:00
abstract::As the use of adhesive restorative materials has increased during the last several years, interest in adhesive materials that release fluoride has also grown. The purpose of this study was to measure fluoride release from several adhesive restorative materials and to evaluate its effect on dentin resistance to deminer...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345990780101001
更新日期:1999-10-01 00:00:00