Abstract：
:Extracellular matrix (ECM) mineralization is regulated by mineral ion availability, proteins, and other molecular determinants. To investigate protein regulation of mineralization in tooth dentin and cementum, and in alveolar bone, we expressed matrix Gla protein (MGP) ectopically in bones and teeth in mice, using an osteoblast/odontoblast-specific 2.3-kb Col1a1 promoter. Mandibles were analyzed by radiography, micro-computed tomography, light microscopy, histomorphometry, and transmission electron microscopy. While bone and tooth ECMs were established in the Col1a1-Mgp mice, extensive hypomineralization was observed, with values of unmineralized ECM from four- to eight-fold higher in dentin and alveolar bone when compared with that in wild-type tissues. Mineralization was virtually absent in tooth root dentin and cellular cementum, while crown dentin showed "breakthrough" areas of mineralization. Acellular cementum was lacking in Col1a1-Mgp teeth, and unmineralized osteodentin formed within the pulp. These results strengthen the view that bone and tooth mineralization is critically regulated by mineralization inhibitors.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Kaipatur NR,Murshed M,McKee MDdoi
10.1177/154405910808700907subject
Has Abstractpub_date
2008-09-01 00:00:00pages
839-44issue
9eissn
0022-0345issn
1544-0591pii
87/9/839journal_volume
87pub_type
杂志文章abstract：:Degradation of dentin matrix components within caries dentin has been correlated with the activity of host-derived proteases, such as matrix metalloproteases (MMPs) and cysteine cathepsins (CTs). Since this relationship has not been fully established, we hypothesized that the abundance of MMPs and CTs in caries-affect...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513516979
更新日期：2014-03-01 00:00:00
abstract：:The composition of the degradable glasses used in commercial dental glass-ionomer cements determines their leaching behavior and hence the properties of the cement. The objective of the present study was to assess if the composition and leaching in acetic acid solutions are reflected in the x-ray diffraction character...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800081601
更新日期：2001-08-01 00:00:00
abstract：:The adsorption isotherms of benzoic acid on synthetic hydroxyapatite (containing about 1.5 monolayers of physisorbed water) were studied from ethanol, dimethylsulfoxide, p-dioxane, methylene chloride, and benzene to discern the role of solvent in the process. The adsorption is reversible from the first three solvents ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650051601
更新日期：1986-05-01 00:00:00
abstract：:Local administrations of prostaglandins E1 or E2 combined with orthodontic tooth movement can approximately double the rate of tooth movement in monkeys compared to that of the control. Macroscopically, no side-effect was observed in the gingiva and associated structures. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610121401
更新日期：1982-12-01 00:00:00
abstract：:This study contains the first part of a research project in which the applicability of fracture mechanics parameters to predict failure of a restored tooth was investigated. Fracture mechanics parameters have been used in dental research before, but were restricted to comparative studies between various brands of comp...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670060601
更新日期：1988-06-01 00:00:00
abstract：:Enamel fluorosis can occur following either an acute or chronic exposure to fluoride during tooth formation. Fluorosed enamel is characterized by a retention of amelogenins in the early-maturation stage, and by the formation of a more porous enamel with a subsurface hypomineralization. The mechanisms by which fluoride...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/00220345920710051701
更新日期：1992-05-01 00:00:00
abstract：:Weanling rice rats were fed either standard laboratory chow or Diet 2000. The animals were sacrificed at 4, 8, 12, and 15 weeks. There was an increasing amount of exposed root surface and root surface caries with age in the animals fed Diet 2000. There was exposed root surface but no caries in the animals fed laborato...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560091701
更新日期：1977-09-01 00:00:00
abstract：:Polynomial and catenary equations were fit by least square error methods to the dentitions of seven children with "normal" occlusion. Mean and mean square error were then used to analyze accuracy of curve fits and asymmetries of arches. A lack of congruency for the "lines of occlusion" common to the maxilla and mandib...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540060501
更新日期：1975-11-01 00:00:00
abstract：:Eighteen different Streptococcus strains including S mutans, sanguis, mitis, salivarius, bovis, and 2F2, were assayed for their relative adsorption to synthetic hydroxyapatite and for quantities of lactic acid produced while in the adsorbed state. The results indicated that all S mutans and some S sanguis have an enha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560101401
更新日期：1977-10-01 00:00:00
abstract：:The incorporation of polymerizable cationic monomers has been attempted to generate dental resinous materials with antibacterial activity. This study tested the hypothesis that a dental adhesive containing a cationic monomer, methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB), would influence biofilm format...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509334499
更新日期：2009-04-01 00:00:00
abstract：:The lack of a reliable bond test has hindered the elucidation of the mechanism for porcelain-metal bonding in dental systems, because a test capable of detecting differences among porcelain-metal bonds of various qualities is required before the reasons for these differences may be ascertained. A method was developed ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670020801
更新日期：1988-02-01 00:00:00
abstract：:We evaluated the histopathological response of the periodontal membrane to intentionally-replanted teeth carrying composite (experimental) and silver amalgam (control) restorations in the middle third of each root. The study revealed that the amalgam produced, in the periodontal tissues, an initial localized inflammat...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620011801
更新日期：1983-01-01 00:00:00
abstract：:The main goal of peri-implantitis treatment is to control infection and arrest bone loss, which requires the removal of polymicrobial biofilms on the implant surface and the reduction of tissue invasion. Additionally, prognosis can be improved if reosseointegration occurs on previously contaminated implants. To evalua...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520913873
更新日期：2020-07-01 00:00:00
abstract：:At the present time, peri-implantitis has become a global burden that occurs with a frequency from 1% to 47% at implant level. Therefore, we aimed herein at assessing the impact of peri-implant maintenance therapy (PIMT) on the prevention of peri-implant diseases. Electronic and manual literature searches were conduct...
journal_title：Journal of dental research
pub_type： 杂志文章,meta分析,评审
doi：10.1177/0022034515622432
更新日期：2016-04-01 00:00:00
abstract：:Phosphatases are involved in bone and tooth mineralization, but their mechanisms of action are not completely understood. Tissue-nonspecific alkaline phosphatase (TNAP, ALPL) regulates inhibitory extracellular pyrophosphate through its pyrophosphatase activity to control mineral propagation in the matrix; mice without...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513490958
更新日期：2013-08-01 00:00:00
abstract：:Pain and discomfort are common problems for patients undergoing orthodontic treatment. We have demonstrated that cortical excitation propagation in the somatosensory and insular cortices (IC) induced by electrical stimulation of the periodontal ligament (PDL) is facilitated 1 d after experimental tooth movement (ETM)....
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520962465
更新日期：2020-10-08 00:00:00
abstract：:Biological mediators have been used to enhance periodontal regeneration. The aim of this prospective randomized controlled study was to evaluate the safety and effectiveness of 3 doses of fibroblast growth factor 2 (FGF-2) when combined with a β-tricalcium phosphate (β-TCP) scaffold carrier placed in vertical infrabon...
journal_title：Journal of dental research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/0022034516632497
更新日期：2016-05-01 00:00:00
abstract：:It is claimed that dental fluorosis in both deciduous and permanent teeth is increasing in fluoridated and non-fluoridated communities. What is unclear is whether fluoride-induced enamel opacities in the deciduous dentition are associated with the subsequent appearance of enamel defects in the permanent dentition. The...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750040301
更新日期：1996-04-01 00:00:00
abstract：:Stress-relaxation measurements were performed on specimens of radicular human dentin. The relaxation modulus showed a linear dependence on the logarithm of time and the approximation to the logarithmic distribution function of relaxation times was used to predict the behavior of other viscoelastic properties. This exp...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540061801
更新日期：1975-11-01 00:00:00
abstract：:Despite recent advances revealing genetic factors influencing caries susceptibility, questions regarding the model of inheritance involved are yet to be addressed. We conducted a Complex Segregation Analysis on decayed teeth in a sample of homogenous, isolated families recruited from the Brazilian Amazon. A dominant, ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510397614
更新日期：2011-06-01 00:00:00
abstract：:Saliva plays a major role in maintaining oral health. Patients with salivary hypofunction exhibit difficulty in chewing and swallowing foods, tooth decay, periodontal disease, and microbial infections. At this time, treatments for hyposalivation are limited to medications (e.g., muscarinic receptor agonists: pilocarpi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515600157
更新日期：2015-11-01 00:00:00
abstract：:The main purpose of this paper is to review the various methods used for evaluation of fluoride retention in saliva, plaque, and enamel following application of topical anti-caries treatments such as F dentifrices and F mouthwashes. Such methods monitor delivery of fluoride to the site of action, the mouth, and so can...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/002203459207100S29
更新日期：1992-04-01 00:00:00
abstract：:Enamel demineralization adjacent to pit and fissure sealants leads to the formation of marginal caries, which can necessitate the replacement of existing sealants. Dental materials with bioactive glass, which releases ions that inhibit dental caries, have been studied. The purpose of this study was to evaluate the ena...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515626116
更新日期：2016-05-01 00:00:00
abstract：:Spontaneously occurring bacteriophage-resistant mutants of Actinomyces viscosus were isolated. The mutants exhibited altered coaggregation patterns with streptococci. From analysis of the data, it appears that a cell surface structure on A. viscosus may function both as a phage receptor and as a binding site for co-ag...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620111801
更新日期：1983-11-01 00:00:00
abstract：:The mechanism of formation of nodular material on the surface of a Pd-Ag-based alloy for porcelain during pre-porcelainization heat treatment was investigated using scanning electron microscopy, x-ray diffraction, quantitative metallography, and Auger electron spectroscopy. The nodules were found to form by a Nabarro-...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620121201
更新日期：1983-12-01 00:00:00
abstract：:Sintered samples of modifying porcelains of various colors and manufacturers were analyzed using reflectance spectrophotometry. Color designations are reported according to practices of the Commission Internationale de l'Eclairage (International Commission for Illumination), and color names were assigned based on a me...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610030801
更新日期：1982-03-01 00:00:00
abstract：:It is generally accepted that glass ionomers inhibit secondary caries in vivo, and data from in vitro studies support this effect. The aim of this review was a systematic assessment, from the literature, of clinical evidence for the ability of glass-ionomer restoratives to inhibit secondary caries at the restoration m...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/00220345990780020101
更新日期：1999-02-01 00:00:00
abstract：:This study demonstrated a correlation between silicon x-ray counts and area fractions of adherent porcelain as determined by point-counting. This correlation has allowed a method to be devised for measuring area fractions of porcelain adherent to porcelain-fused-to-metal (PFM) fracture surfaces. The described method, ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620081801
更新日期：1983-08-01 00:00:00
abstract：:The effect of a topical fluoride regimen consisting of a four-minute pre-treatment with a saturated dicalcium phosphate dihydrate (DCPD) solution followed by a four-minute application of APF was compared with that of a four-minute application of APF alone with respect to the deposition of fluoride in enamel in an apat...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650030201
更新日期：1986-03-01 00:00:00
abstract：:The objectives of this study were 1) to provide an estimate of the value of the intraclass correlation coefficient (ICC) for dental caries data at tooth and surface level, 2) to provide an estimate of the design effect (DE) to be used in the determination of sample size estimates for future dental surveys, and 3) to e...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514559408
更新日期：2015-02-01 00:00:00
