Abstract:
:Intra-oral wounds, like wounds in children, demonstrate privileged healing when compared with adult wounds at extra-oral sites. This study investigated whether this preferential healing is related to an increased ability of oral mucosal fibroblasts to reorganize extracellular matrix (ECM) when compared with their dermal counterparts. ECM reorganization was investigated by means of a fibroblast-populated collagen lattice (FPCL) system. The effect of donor age was also investigated in this system. Differences in ECM reorganization and FPCL contraction were evident: FPCL contraction was more rapid by oral mucosal fibroblasts than dermal fibroblasts (p < 0.01). FPCL contraction was also greater in child (donor < 10 years) than adult (donor > 18 years) oral mucosal fibroblasts (p < 0.01). These differences were not related to phenotypic differences in cell viability (p > 0.5), DNA synthesis (p > 0.05), and cell number (p > 0.5) within the FPCLs, or cellular attachment to collagen (p > 0.07). FPCL contraction was not stimulated by the addition of conditioned medium from oral mucosal or dermal fibroblasts (p > 0.05). These data show that the significantly increased ability of oral mucosal fibroblasts to reorganize ECM in vitro, when compared with dermal fibroblasts, represents a distinct phenotypic contractile difference, rather than differences in their production of soluble mediators or cell attachment to ECM.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Stephens P,Davies KJ,al-Khateeb T,Shepherd JP,Thomas DWdoi
10.1177/00220345960750060601subject
Has Abstractpub_date
1996-06-01 00:00:00pages
1358-64issue
6eissn
0022-0345issn
1544-0591journal_volume
75pub_type
杂志文章abstract::In 1986, the first nationwide epidemiological survey of adult oral health and attitudes to oral health care was carried out in The Netherlands. One of the aims of this study was to evaluate the prevalence and the quality (in terms of need for replacement) of amalgam and composite restorations in the Dutch adult popula...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690060901
更新日期:1990-06-01 00:00:00
abstract::Despite the recognized link between aging and cancer, most preclinical studies in experimental tumor models are conducted with 6- to 8-wk-old rodents. The goal of the present study was to examine the impact of age on tumor incidence, growth, and microenvironmental characteristics in mouse models of head and neck squam...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034518775736
更新日期:2018-10-01 00:00:00
abstract::Bacteroides forysthus has been shown to be prevalent among patients with periodontitis. Conventional microbiological methods used to identify this bacterium, however, are laborious and time-consuming and are therefore not well-suited for screening purposes. We have developed a polymerase chain-reaction (PCR) method wh...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345970760070701
更新日期:1997-07-01 00:00:00
abstract::Physico-chemical investigations of enamel from deciduous teeth of a small number of children with and without pre-natal fluoride supplementation (PNF) exhibited the following differences between the PNF and non-PNF enamel, with the former showing: (a) more homogeneous and less extensive patterns of acid-etching; (b) d...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640031601
更新日期:1985-03-01 00:00:00
abstract::Elemental analysis of two precious alloyceramic systems revealed the accumulation of Sn atoms within the interaction zone of couples subjected to a range of metal oxidation time; and varying total firing times. The source of Sn atoms which accumulated within the interaction zone was the opaque porcelain layer which co...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560090301
更新日期:1977-09-01 00:00:00
abstract::The biochemical function, adenylate energy charge (AEC), correlates with the viable count of S. mutans. AEC may be used to estimate the percent viable fraction of bacteria in dental plaque samples. An interactive computer program designed to process the AEC data is described. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/002203457905800410011
更新日期:1979-11-01 00:00:00
abstract::Dentin Matrix Protein 1 (DMP1) is highly expressed in alveolar bone and cementum, which are important components of the periodontium. Therefore, we hypothesized that Dmp1 is critical for the integrity of the periodontium, and that deletion may lead to increased susceptibility to disease. An early-onset periodontal def...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808700708
更新日期:2008-07-01 00:00:00
abstract::This study describes the formation of a calcium polyacrylate-hydroxyapatite cement. Our hypothesis was that calcium phosphates would rapidly hydrolyze in the presence of polyacrylic acid (PAA) to form a cement. PAA, tetracalcium phosphate (TetCP), and dicalcium phosphate (DCP) were reacted together and formed calcium ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345940730030501
更新日期:1994-03-01 00:00:00
abstract::Dental implants have become an increasingly popular treatment choice for replacing missing teeth. Yet, little is known about the prevalence and sociodemographic distribution of dental implant use in the United States. To address this knowledge gap, we analyzed data from 7 National Health and Nutrition Examination Surv...
journal_title:Journal of dental research
pub_type: 历史文章,杂志文章
doi:10.1177/0022034518792567
更新日期:2018-12-01 00:00:00
abstract::The cariostatic benefit from water fluoridation is indisputable, but the knowledge of possible adverse effects on bone and fracture risk due to fluoride exposure is ambiguous. The association between long-term (chronic) drinking water fluoride exposure and hip fracture (ICD-7-9: '820' and ICD-10: 'S72.0-S72.2') was as...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513506443
更新日期:2013-11-01 00:00:00
abstract::Frequent consumption of cariogenic foods and bacterial infection are risk factors for early childhood caries (ECC). This study hypothesized that a short diet survey focused on frequency of foods, categorized by putative cariogenicity, would differentiate severe ECC (S-ECC) from caries-free children. Children's diets w...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510376543
更新日期:2010-11-01 00:00:00
abstract::A series of 4,6-dichloro-1,3,5-triazines [e.g., 2-allylamino-(ADT), diallylamino-(DADT), 2-N-p-allyloxyphenylamino-, 2-N-allyl-N-phenylamino-, and 2-N-allyl-N-p-tolylamino-4,6-dichloro-1,3,5-triazine] was synthesized and characterized by IR, NMR, and mass spectrometry. These monomers have chlorine atoms that can react...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650120401
更新日期:1986-12-01 00:00:00
abstract::As the use of adhesive restorative materials has increased during the last several years, interest in adhesive materials that release fluoride has also grown. The purpose of this study was to measure fluoride release from several adhesive restorative materials and to evaluate its effect on dentin resistance to deminer...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345990780101001
更新日期:1999-10-01 00:00:00
abstract::In an attempt to make a dynamic study of the isoelectric point and the chargeability of human dental enamel, an electrochemical approach was utilized. Zeta potential of three kinds of the enamel was measured by a streaming potential method. As a result, these isoelectric points could be decided. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570022701
更新日期:1978-02-01 00:00:00
abstract::The resin-dentin interdiffusion zone produced by a dentin-adhesive system that removes the smear layer and concurrently decalcifies superficial dentin was morphologically examined by both scanning and transmission electron microscopy. Cross-sectioned resin-bonded dentin discs were etched with an argon-ion beam to make...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720020501
更新日期:1993-02-01 00:00:00
abstract::The mechanism of formation of nodular material on the surface of a Pd-Ag-based alloy for porcelain during pre-porcelainization heat treatment was investigated using scanning electron microscopy, x-ray diffraction, quantitative metallography, and Auger electron spectroscopy. The nodules were found to form by a Nabarro-...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620121201
更新日期:1983-12-01 00:00:00
abstract::The range of substrates transported by the sugar-binding protein-dependent msm (multiple sugar metabolism) system of S. mutans was investigated. By determining the ability of unlabeled sugar to compete with radiolabeled melibiose transport, we have demonstrated that the transported sugars included a number of carbohyd...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720100701
更新日期:1993-10-01 00:00:00
abstract::In an earlier paper on bench-scale simulation of the caries process, it was shown that the passage of ions through ion-permselective barriers could have profound effects on the composition of the solution within the "lesion" at steady state. As indicated in earlier papers, these changes are produced by unequal rates o...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650090201
更新日期:1986-09-01 00:00:00
abstract::Changes in stimulated and non-stimulated whole saliva flow rates were measured in 11 Hodgkin's disease patients who received therapeutic doses of radiation to a mantle field at the M. D. Anderson Hospital in Houston, Texas. Salivary flow rates were examined before, during, and after radiotherapy. Mean flow rate reduct...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670021801
更新日期:1988-02-01 00:00:00
abstract::Stress-induced changes imparted in a 'dentin-bonded-crown' material during sintering, annealing, pre-cementation surface modification, and resin coating have been visualized by profilometry. The hypothesis tested was that operative techniques modify the stressing pattern throughout the material thickness. We polished ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509354049
更新日期:2010-01-01 00:00:00
abstract::Chemical bonding between dental porcelains and alloys results from interdiffusion of porcelain and metal ions. An interfacial diffusion zone is created which, most likely, has properties different from those of bulk materials. The changed interface might affect experimental measurements of thermo-mechanical strain. To...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620051701
更新日期:1983-05-01 00:00:00
abstract::Using glycoproteins and milk oligosaccharides as substrate acceptors, we demonstrated at least two fucosyltransferases in human parotid saliva. One enzyme transferred L-fucose from GDP-fucose to the C-3 position of N-acetylglucosamine or glucose residue of oligosaccharide chains, and the other transferred to the C-4 p...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620070701
更新日期:1983-07-01 00:00:00
abstract::Contact angle measurements on layers of bacteria were used to determine the bacterial surface free energy (gamma b) of a variety of oral streptococcal strains, both without and after being coated with human whole saliva. At least four isolates of each species, either freshly isolated or laboratory strains, were used. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640100501
更新日期:1985-10-01 00:00:00
abstract::The initiator of calculus matrix calcification, in vitro, was isolated. Crude phospholipid, known to contain the factor, was separated into five fractions by column chromatography. A single protein-containing fraction induced apatite formation during incubation. The nucleating fraction was indentified as a proteolipid...
journal_title:Journal of dental research
pub_type: 历史文章,杂志文章
doi:10.1177/00220345770560020701
更新日期:1977-02-01 00:00:00
abstract::Previous studies of tooth size in twins and their families have suggested a high degree of genetic control, although there have been difficulties separating the various genetic and environmental effects. A genetic analysis of variation in crown size of the permanent incisors of South Australian twins was carried out, ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345950740071101
更新日期:1995-07-01 00:00:00
abstract::The ability of adhesive resins to restore the physical properties of demineralized dentin has not been well-documented. The unfilled resins that are used for adhesion have relatively low moduli of elasticity and limited ability to increase dentin stiffness, although they may increase the ultimate tensile strength of d...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345950740041001
更新日期:1995-04-01 00:00:00
abstract::Levels of mutans streptococci in plaque samples from margins of Class II amalgam (Dispersalloy), composite (P-10), and glass-ionomer (Ketac Silver) restorations were compared. Fifty-one children, each having one of the restorations in a permanent first molar, were part of an inter-individual comparison, giving 17 rest...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690030601
更新日期:1990-03-01 00:00:00
abstract::This systematic review and meta-analysis assessed the efficacy of lasers in reducing dentin hypersensitivity (DH) as compared with placebo or no treatment. Seven electronic databases and a manual search resulted in 2,538 unique publications. After selection, 13 studies were included in the meta-analysis. A CONSORT-bas...
journal_title:Journal of dental research
pub_type: 杂志文章,meta分析,评审
doi:10.1177/0022034513487212
更新日期:2013-06-01 00:00:00
abstract::Bone remodeling is a complex process regulated by several mediators. Recent work has revealed that cytokines and growth factors have significant effects on bone cell metabolism. However, little information is available concerning the production of cytokines during orthodontic tooth movement in human subjects, and ther...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750010801
更新日期:1996-01-01 00:00:00
abstract::Glass-ionomer cements (GICs) are regarded as aqueous gels made up of polyalkenoic acid salts containing ion-leachable glass fillers. The consequence of water permeation across the GIC-dentin interface is unknown. This study used SEM, field-emission/environmental SEM (FE-ESEM), and TEM to examine the ultrastructure of ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408300403
更新日期:2004-04-01 00:00:00