Abstract:
:The rate of F absorption from the stomach is pH-dependent, with greater absorption at low pH. Since the rate of absorption is also strongly influenced by the rapidity of gastric emptying, we have compared the relative importance of gastric acidity and gastric emptying in overall F absorption. Male rats (350 g, n = 85) were pre-treated with cimetidine (to inhibit gastric acid secretion) or pentagastrin (to stimulate gastric acid secretion) or were untreated controls, and given 50 micrograms F by stomach intubation. The pH of the F-containing solution was varied in the cimetidine-pre-treated group (pH 1.5, 5.5, 8.5), and was 5.5 for the control and pentagastrin-pre-treated groups. Gastric emptying was measured by addition of 14C polyethylene glycol to the F solution as an unabsorbed marker of fluid movement. F absorption was measured after 10, 20, and 40 min. The rate of gastric emptying was unaffected by pre-treatment or pH of the intubating solution. Initially, F absorption was greatest at low pH. After 40 min, absorption was comparable in all groups, averaging approximately 70% of the initial dose. The extent of absorption from the stomach was inversely related to pH, but increased absorption from the small intestine compensated for the low gastric absorption at high pH.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Messer HH,Ophaug RHdoi
10.1177/00220345930720031101subject
Has Abstractpub_date
1993-03-01 00:00:00pages
619-22issue
3eissn
0022-0345issn
1544-0591journal_volume
72pub_type
杂志文章abstract::The whisker pad area (WP) is innervated by the second branch of the trigeminal nerve and experiences allodynia and hyperalgesia following transection of the mental nerve (MN; the third branch of the trigeminal nerve). However, the mechanisms of this extra-territorial pain remain unclear. The ionotropic P2X(7) ATP rece...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512474668
更新日期:2013-03-01 00:00:00
abstract::This paper discusses loosely bound fluoride and its role in dental caries and prevention. Loosely bound fluoride (abbr. by Fa) is fluoride adsorbed onto enamel mineral crystallites. Several recent studies indicate that a high total level of fluoride in enamel does not guarantee protection against caries. This leads to...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/00220345900690S118
更新日期:1990-02-01 00:00:00
abstract::The reaction of the microvasculature in the periodontal ligament to mechanical pressure is considered a very important phenomenon with respect to the biological background to orthodontic tooth movement. For clarification of the microvascular reaction to mechanical pressure, an experimental model that incorporated a ha...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345920710060701
更新日期:1992-06-01 00:00:00
abstract::Acculturation is a complex phenomenon that can serve as a proxy for cultural norms and behaviors affecting care-seeking, prevention behaviors, and, ultimately, health outcomes. The purpose of this study was to assess the effect of acculturation on the oral health of Haitian immigrants in New York City. We hypothesized...
journal_title:Journal of dental research
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doi:10.1177/154405910408300219
更新日期:2004-02-01 00:00:00
abstract::Lactoferrin is one of a number of multifunctional proteins that are present in or on all mucosal surfaces throughout the body. Levels of lactoferrin are consistently elevated in inflammatory diseases such as arthritis, inflammatory bowel diseases, corneal disease, and periodontitis. Single-nucleotide polymorphisms (SN...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034515577413
更新日期:2015-06-01 00:00:00
abstract::Excessive mechanical stress (MS) during hyperocclusion is known to result in disappearance of the alveolar hard line, enlargement of the periodontal ligament (PDL) space, and destruction of alveolar bone, leading to occlusal traumatism. We hypothesized that MS induces expression of osteoclastogenesis-associated chemok...
journal_title:Journal of dental research
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doi:10.1177/0022034511400742
更新日期:2011-06-01 00:00:00
abstract::TWIST1 plays a crucial role in dentinogenesis, and its activity depends on both a dimerization partner selection and phosphorylation. Other factors, like Id proteins, can affect the availability of dimerization partners for TWIST1, subsequently leading to diverse biological outcomes. The purpose of this study was to e...
journal_title:Journal of dental research
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doi:10.1177/0022034514530164
更新日期:2014-06-01 00:00:00
abstract::Streptococcus mutans strain JH1005 is a mutant that produces levels of bacteriocin activity three-fold-elevated than those produced by its parent, JH1001. A single infection regimen with JH1005 was found to result in persistent colonization of the teeth of all three adult subjects tested. This is a significant improve...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660060101
更新日期:1987-06-01 00:00:00
abstract::Previous studies of tooth size in twins and their families have suggested a high degree of genetic control, although there have been difficulties separating the various genetic and environmental effects. A genetic analysis of variation in crown size of the permanent incisors of South Australian twins was carried out, ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345950740071101
更新日期:1995-07-01 00:00:00
abstract::Molar teeth of four groups of Osborne-Mendel rats, kept on a cariogenic diet, were treated once per day for 48 days with either distilled water (solution C), a solution containing 0.05% chlorhexidine gluconate and 0.04% NaF, pH 5.8 (solution CXF), CXF plus 1000 ppm Sr (solution CXFS), or CXFS plus 1000 ppm Zn (solutio...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630100401
更新日期:1984-10-01 00:00:00
abstract::A simple in vitro method has been described for quantitatively measuring the rate at which isotopically labeled substances permeate through dentin in occlusal cavity preparations. The presence or absence of pulp tissue had only a minor effect on the kinetics of permeation. As the dentin was made thinner there was a re...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560011601
更新日期:1977-01-01 00:00:00
abstract::Ammoniacal silver stain showed that there was a decrease in nucleohistones in zinc-deficient rat buccal hyperplastic epithelium as compared to control. Autoradiographic study showed that there was decreased incorporation of 3H-arginine and 3H-lysine in the hyperplastic epithelium. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560122501
更新日期:1977-12-01 00:00:00
abstract::Disks of dentin taken from extracted human teeth demonstrated the optical property of the magnification/reduction effect. When images were transmitted from a pulpal-to-occlusal direction, the images were magnified. When the disks were inverted, the images were reduced in size. The images were slightly distorted but cl...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550041601
更新日期:1976-07-01 00:00:00
abstract::In 1984, a four-year mixed-longitudinal study of oral health was begun in Morogoro Town and Morogoro District, Tanzania. Its main goal was to detect a possible upward trend in prevalence of caries in child cohorts in this developing country. The sample consisted of 722 seven- to nine-year-olds in 1984, 833 seven- to 1...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680121101
更新日期:1989-12-01 00:00:00
abstract::The role of Streptococcus mutans in the initiation of dental caries has been recognized and attributed, at least in part, to its ability to colonize the tooth surface. Therefore, factors which prevent S. mutans attachment to hydroxyapatite (HA) are of considerable interest for the prophylaxis of this infectious diseas...
journal_title:Journal of dental research
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doi:10.1177/00220345970760020701
更新日期:1997-02-01 00:00:00
abstract::Previous studies have demonstrated that antibodies against cholinoreceptors of exocrine glands correlate with dry mouth in persons with primary Sjögren syndrome (pSS). The aim of the present investigation was to establish if serum IgG antibodies (pSS IgG) were able to interact with cholinoreceptors in rat submandibula...
journal_title:Journal of dental research
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doi:10.1177/154405910708600905
更新日期:2007-09-01 00:00:00
abstract::Focusing public insurance programs on interceptive orthodontics (IO) may increase access for low-income children. This report presents outcomes from a randomized clinical trial (RCT) comparing IO with comprehensive orthodontics (CO) in Medicaid patients. One hundred seventy pre-adolescents with Medicaid-eligible maloc...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/0022034512448663
更新日期:2012-07-01 00:00:00
abstract::Van der Woude syndrome (VWS) is an autosomal-dominant oral facial disorder. To find a gene mutation in a Japanese family using fingernail DNA samples, we performed this study. We hypothesized that a gene mutation in IRF6 might be involved in VWS, and that fingernail DNA samples may be valuable for detecting such mutat...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608501215
更新日期:2006-12-01 00:00:00
abstract::Calcitonin gene-related peptide (CGRP) plays a crucial role in the modulation of orofacial pain, and we hypothesized that CGRP mediated a neuron-glia crosstalk in orofacial pain. The objective of this study was to elucidate the mechanisms whereby CGRP mediated trigeminal neuron-glia crosstalk in modulating orofacial p...
journal_title:Journal of dental research
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doi:10.1177/0022034520950296
更新日期:2021-01-01 00:00:00
abstract::Medication-related osteonecrosis of the jaw (MRONJ), although initially believed to be exclusively associated with bisphosphonates, has been implicated in recent reports with additional drugs, especially the bone antiresorptive denosumab. The pathophysiology has not been fully elucidated, and no causal association bet...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
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更新日期:2015-04-01 00:00:00
abstract::This paper aims to present a simple overview of potential new diagnostic methods for dental caries. There are several novel methods of caries detection (with potential application to diagnosis) which have been proposed in the last few years, in addition to those that are gaining some commercial exposure and clinical a...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/154405910408301s18
更新日期:2004-01-01 00:00:00
abstract::Local administrations of prostaglandins E1 or E2 combined with orthodontic tooth movement can approximately double the rate of tooth movement in monkeys compared to that of the control. Macroscopically, no side-effect was observed in the gingiva and associated structures. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345820610121401
更新日期:1982-12-01 00:00:00
abstract::We examined 102 children born and reared in an area of rural Kenya with 2 ppm fluoride in the drinking water for dental fluorosis, using the index developed by Thylstrup and Fejerskov (1978). The prevalence of dental fluorosis was 100%, 92% of all teeth exhibited a TFI score of 4 or higher, and 50% of the children had...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650050501
更新日期:1986-05-01 00:00:00
abstract::There are no prospective studies investigating the effects of sugar-related feeding practices on changes in dental caries from early childhood to young adulthood. The aim of this study was to assess whether sugar-related feeding practices affect dental caries between the ages of 6 and 18 y. This birth cohort study was...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515625907
更新日期:2016-04-01 00:00:00
abstract::Lipopolysaccharide (LPS) has been shown to be a prominent pathogenic factor in inflammatory bone loss. However, knowledge of the mechanisms involved is limited. The role of the SDF-1/CXCR4 (Stromal-derived factor-1 and its unique chemokine receptor) axis in LPS-induced bone loss has not been studied. The aim of this s...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510379019
更新日期:2011-02-01 00:00:00
abstract::The influence of the molecular weight of the poly(acrylic acid) component on some properties of glass-ionomer cement has been investigated. The results can be explained by treatment of glass-ionomer cements as thermoplastic composites. Many of the concepts of polymer science can be applied successfully in a qualitativ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680021401
更新日期:1989-02-01 00:00:00
abstract::The Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is a cell-surface receptor of the immunoglobulin superfamily, involved in the propagation of the inflammatory response to bacterial challenge. Soluble (s)TREM-1 is released from the cell surface during the course of infection and is a useful inflammatory bi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512470691
更新日期:2013-02-01 00:00:00
abstract::We evaluated the histopathological response of the periodontal membrane to intentionally-replanted teeth carrying composite (experimental) and silver amalgam (control) restorations in the middle third of each root. The study revealed that the amalgam produced, in the periodontal tissues, an initial localized inflammat...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620011801
更新日期:1983-01-01 00:00:00
abstract::Mucous membrane pemphigoid or cicatricial pemphigoid is a mucocutaneous blistering disease characterized by autoantibodies to different molecules in the basement membrane zone. Our objectives were to identify the target antigen recognized by sera from 20 untreated patients with pemphigoid disease limited to the oral c...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345010800080601
更新日期:2001-08-01 00:00:00
abstract::Stem cells from exfoliated deciduous teeth (SHED) possess multipotent differentiation and immunomodulatory properties. They have been used for orofacial bone regeneration and autoimmune disease treatment. In this study, we show that acetylsalicylic acid (ASA) treatment is able to significantly improve SHED-mediated os...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514557672
更新日期:2015-01-01 00:00:00