Abstract:
:Mucous membrane pemphigoid or cicatricial pemphigoid is a mucocutaneous blistering disease characterized by autoantibodies to different molecules in the basement membrane zone. Our objectives were to identify the target antigen recognized by sera from 20 untreated patients with pemphigoid disease limited to the oral cavity, and to determine the pathogenicity of autoantibodies in oral pemphigoid, with an organ culture model. We conducted indirect immunofluorescence, immunoblot, and immunoprecipitation assays, with accompanying absorption experiments, using normal human skin, conjunctiva and gingiva, bovine gingiva and a tumor cell line, which were reacted with sera from patients with oral pemphigoid, anti-alpha6 antibody, and control sera. Sera of oral pemphigoid patients selectively and specifically bound to human alpha6 integrin, a 120-kDa protein present in gingiva and the tumor cell line. Oral pemphigoid sera and anti-alpha6 antibody produced separation of epithelium from basement membrane (blister formation) of normal human buccal mucosa, after 48 hours, in organ culture.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Bhol KC,Goss L,Kumari S,Colon JE,Ahmed ARdoi
10.1177/00220345010800080601keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
1711-5issue
8eissn
0022-0345issn
1544-0591journal_volume
80pub_type
杂志文章abstract::Multiple interactions occur among major determinants of dental caries. We have studied the bacterial flora and pH-lowering capacity of the same dental plaques in relation to caries. The findings on the plaque flora are reported here. The buccal surfaces of upper teeth in each subject were selected for study. A low-car...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345000790021201
更新日期:2000-02-01 00:00:00
abstract::There is a large variability between and among individuals in the physiology of mastication, but it is not known whether this produces a similar variability in the particle sizes of food boluses at the end of the chewing process. Food boluses obtained just before swallowing were analyzed in ten subjects (aged 36.7 +/-...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章
doi:10.1177/154405910408300713
更新日期:2004-07-01 00:00:00
abstract::The oral microbiota was compared between Romanian adolescents with a high prevalence of caries and no dental care and Swedish caries-active and caries-free adolescents in caries prevention programs and with a low prevalence of caries. Biofilm samples were analyzed by FLX+ pyrosequencing of the V1 to V4 hypervariable r...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515609554
更新日期:2016-01-01 00:00:00
abstract::The distribution, genetic relatedness, and peptidase activity in hydrolyzing N-benzoyl-L-arginine-p-nitroanilide by Capnocytophaga species isolated from calculus- and non-calculus-formers were determined in this study. The proportion and prevalence of Capnocytophaga species were higher in plaque samples from the calcu...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700070601
更新日期:1991-07-01 00:00:00
abstract::The recording of multiple interval-censored failure times is common in dental research. Modeling multilevel data has been a difficult task. This paper aims to use the Bayesian approach to analyze a set of multilevel clustered interval-censored data from a clinical study to investigate the effectiveness of silver diami...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/154405910508400907
更新日期:2005-09-01 00:00:00
abstract::Submandibular glands from young adult and aged male and female rats have been examined and various descriptive parameters obtained. Several sex differences were observed with tissue from young and old animals. Sex differences were found in the gland contents of DNA, protein, and sialic acid and in some protein compone...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600051501
更新日期:1981-05-01 00:00:00
abstract::Four classes of elastomeric impression materials (polysulfide, polyether, silicone, and agar-agar) were evaluated on the basis of linear dimensional stability as a function of time between taking and pouring an impression of mounted teeth. Four polysulfide materials produced dies which were larger than the teeth and g...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345800590071001
更新日期:1980-07-01 00:00:00
abstract::Because bone reconstruction in irradiated sites is less than ideal, we applied a regenerative gene therapy method in which a cell-signaling virus was localized to biomaterial scaffolds to regenerate wounds compromised by radiation therapy. Critical-sized defects were created in rat calvariae previously treated with ra...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509352151
更新日期:2010-01-01 00:00:00
abstract::Sense of coherence (SOC) has been related to oral health behaviors and oral-health-related quality of life (OHRQoL) in observational studies. This cluster-randomized trial aimed to test the effect of an intervention to enhance SOC on OHRQoL in children. Twelve primary schools were randomly allocated to intervention an...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/0022034512459757
更新日期:2013-01-01 00:00:00
abstract::Samples of a base mental alloy were cast and welded together using a conventional welding procedure. The joints were loaded and placed either in a corrosive environment or in air for varying time periods. The tensile and shear strength of the joints was unaffected by the corrosive environment, and the joints, despite ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600021101
更新日期:1981-02-01 00:00:00
abstract::Six subjects wore intra-oral devices carrying eight bovine enamel blocks which were covered with a layer of S. mutans. They rinsed their mouths for five sec, one min, or multiples of one min with a 5 or 10% glucose (G) solution. Demineralization was measured after 45 min by determining the change in iodide permeabilit...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650021001
更新日期:1986-02-01 00:00:00
abstract::The biochemical function, adenylate energy charge (AEC), correlates with the viable count of S. mutans. AEC may be used to estimate the percent viable fraction of bacteria in dental plaque samples. An interactive computer program designed to process the AEC data is described. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/002203457905800410011
更新日期:1979-11-01 00:00:00
abstract::Smoking has been established as an important risk factor for periodontal disease and tooth loss. The purpose of this study was a prospective evaluation of the effects of smoking on dental care utilization and its costs, based on data from 5712 males aged 20-59 yrs. Age, dental health behavior, and history of diabetes ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034508327523
更新日期:2009-01-01 00:00:00
abstract::Vietnamese immigrant and Norwegian children, matched according to caries experience, age, and sex, were compared with respect to S. mutans in dental plaque and in saliva. Regardless of ethnic group, S. mutans prevalence was highest in plaque over caries lesions and from fissures, and lowest in plaque from smooth surfa...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630120801
更新日期:1984-12-01 00:00:00
abstract::Although the contribution of the oral microbiota to oral malodor is well-documented, the potential role of Gram-positive micro-organisms is unclear. In the current study, we tested the hypothesis that Gram-positive micro-organisms contribute to malodor production by deglycosylating oral glycoproteins, rendering them s...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608501007
更新日期:2006-10-01 00:00:00
abstract::Extracellular vesicles (EVs), several tens to hundreds of nanometers in size, are vesicles secreted by cells for intercellular communication. EVs released from mesenchymal stem cells (MSC-EVs) have the potential to treat multiple diseases. This study aimed to determine the effects of MSC-EVs on bisphosphonate-related ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520906793
更新日期:2020-05-01 00:00:00
abstract::Cleft palate is among the most common structural birth defects in humans. Previous studies have shown that mutations in FOXF2 are associated with cleft palate in humans and mice and that Foxf2 acts in a Shh-Foxf-Fgf18-Shh molecular network controlling palatal shelf growth. In this study, we combined RNA-seq and ChIP-s...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520904018
更新日期:2020-04-01 00:00:00
abstract::A search was made for expression of genes for proline-rich proteins (PRPs) and other salivary-type proteins, including statherin and histatins, in taste-bud tissues of mice and primates because of previous genetic findings in mice (Azen et al., 1986) that Prp and taste genes for certain bitter substances are either th...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690110401
更新日期:1990-11-01 00:00:00
abstract::Investigators have used chemotherapeutic agents topically for plaque control without knowing the drug concentration necessary to inhibit the growth of odontopathic microorganisms. S mutans, S sanguis, A viscosus and A naeslundii are important components of the plaque flora. The minimal inhibitory concentrations (MIC) ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550040401
更新日期:1976-07-01 00:00:00
abstract::Periodontal diseases are initiated by bacteria that accumulate in a biofilm on the tooth surface and affect the adjacent periodontal tissue. Systemic diseases such as diabetes, rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) increase susceptibility to destructive periodontal diseases. In human studie...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034518805739
更新日期:2019-02-01 00:00:00
abstract::To understand the role of betel quid (BQ) in the pathogenesis of oral submucous fibrosis (OSF) and oral cancer, we used DNA damage, cytotoxicity, and cell proliferation assays to study the pathobiological effects of aqueous extracts of three BQ constituents [betel nut (Areca catechu, BN), inflorescence of Piper betle ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345940730050501
更新日期:1994-05-01 00:00:00
abstract::A water-soluble lipopolysaccharide from Salmonella enteritidis and a phenol-soluble lipopolysaccharide from Leptotrichia buccalis were applied topically to the healthy marginal gingivae of beagle dogs. Saline was applied to contralateral areas as an internal control. Increases in vascular permeability were monitored b...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650020301
更新日期:1986-02-01 00:00:00
abstract::Autonomic and behavioral responses to seven dental procedures were studied in 21 pedodontic patients aged six to 12. When mean pulse rate, pulse amplitude, absolute skin conductance, and skin-conductance responses were compared over all subjects, the injection of the local anesthetic consistently elicited the greatest...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620060801
更新日期:1983-06-01 00:00:00
abstract::This study describes the formation of a calcium polyacrylate-hydroxyapatite cement. Our hypothesis was that calcium phosphates would rapidly hydrolyze in the presence of polyacrylic acid (PAA) to form a cement. PAA, tetracalcium phosphate (TetCP), and dicalcium phosphate (DCP) were reacted together and formed calcium ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345940730030501
更新日期:1994-03-01 00:00:00
abstract::Synovial hyperplasia is a feature of degenerative temporomandibular joint (TMJ) disease. However, the mechanism by which hyperplasia progresses in the TMJ is unknown. Based on the hypothesis that the oxidative stress generated by mechanical loading causes degenerative changes in the TMJ synovium, we investigated the g...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408300807
更新日期:2004-08-01 00:00:00
abstract::There are no prospective studies investigating the effects of sugar-related feeding practices on changes in dental caries from early childhood to young adulthood. The aim of this study was to assess whether sugar-related feeding practices affect dental caries between the ages of 6 and 18 y. This birth cohort study was...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515625907
更新日期:2016-04-01 00:00:00
abstract::Previous studies have shown that therapeutic pulsed ultrasound (pulsed) has superior stimulatory effect on bone fracture healing compared with continuous ultrasound (continuous). Our predictive hypothesis was that pulsed ultrasound can produce better bone formation during mandibular osteodistraction than continuous ul...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808701018
更新日期:2008-10-01 00:00:00
abstract::The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors and tyrosine kinases. DDRs regulate cell functions, and their extracellular domains affect collagen fibrillogenesis and mineralization. Based on the collagenous nature of dentoalveolar tissues, we hypothesized that DDR1 plays an importan...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034519881136
更新日期:2019-12-01 00:00:00
abstract::Cardiovascular disease is a common cause of morbidity and premature mortality. Cardiovascular disease can be prevented when risk factors are identified early. Calcified carotid artery atheromas (CCAAs), detected in panoramic radiographs, and periodontitis have both been associated with increased risk of cardiovascular...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034519885362
更新日期:2020-01-01 00:00:00
abstract::Several studies indicated that serotype/biotype c strains are the most common on a global basis, but that regional differences may occur relative to other serotype/biotypes. Of particular interest is the observation that individuals residing in the Middle East have higher incidences of serotype e and d strains relativ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630011201
更新日期:1984-01-01 00:00:00