Abstract：
:A water-soluble lipopolysaccharide from Salmonella enteritidis and a phenol-soluble lipopolysaccharide from Leptotrichia buccalis were applied topically to the healthy marginal gingivae of beagle dogs. Saline was applied to contralateral areas as an internal control. Increases in vascular permeability were monitored by measurement of gingival fluid, and the collected gingival fluid samples were assayed for kininogenase and kinin activities. Both lipopolysaccharides induced an inflammatory response, as indicated by increased gingival fluid flow. Kininogenase-kinin activities paralleled the increases in gingival fluid flow, with the highest values being associated with peak increases in gingival fluid. The results indicate that both lipopolysaccharides, although different in lipid solubility, penetrate healthy sulcular epithelium and initiate an inflammatory response which is mediated in part by the kallikrein-kinin system. Interrelationships between this system and other inflammatory mediators suggest that kinin generation not only plays a role in the early phases of acute gingival inflammation, but may also contribute to the activation of other mediators appearing later in the response and in chronic inflammatory lesions.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Montgomery EH,White RRdoi
10.1177/00220345860650020301subject
Has Abstractpub_date
1986-02-01 00:00:00pages
113-7issue
2eissn
0022-0345issn
1544-0591journal_volume
65pub_type
杂志文章abstract：:Epstein-Barr virus (EBV), in addition to its transforming properties, contributes to the pathogenesis of several inflammatory diseases. Here, we investigated its involvement in oral lichen planus (OLP), a common autoimmune-like disease of unknown etiopathogenesis that can display a malignant potential. EBV-infected ce...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518788282
更新日期：2018-12-01 00:00:00
abstract：:A frameshift mutation recently identified within the paired domain of the transcription factor, PAX9, has been linked to a unique form of oligodontia in a single, multigenerational family (Stockton et al., 2000). We now describe the phenotypic and segregation analyses of this remarkable kindred, the initial approach t...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790070701
更新日期：2000-07-01 00:00:00
abstract：:Bacteroides forysthus has been shown to be prevalent among patients with periodontitis. Conventional microbiological methods used to identify this bacterium, however, are laborious and time-consuming and are therefore not well-suited for screening purposes. We have developed a polymerase chain-reaction (PCR) method wh...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760070701
更新日期：1997-07-01 00:00:00
abstract：:Little is known about the oral health of the frail and home-living elderly. The effects of dentogenic infections on the general condition of the elderly are also unknown. We therefore set out to investigate 191 elderly patients referred to an acute geriatric hospital due to sudden worsening of their general health. Th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760060601
更新日期：1997-06-01 00:00:00
abstract：:Squamous cell carcinoma (SCC) of the head and neck is the sixth most frequent cancer worldwide. The survival rate is among the lowest of the major cancers and has not improved significantly in the past two decades. Extensive local invasion and regional lymph node metastasis are, in large part, responsible for the poor...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780061001
更新日期：1999-06-01 00:00:00
abstract：:The fatigue crack growth resistance of dentin was characterized as a function of depth from the dentino-enamel junction. Compact tension (CT) specimens were prepared from the crowns of third molars in the deep, middle, and peripheral dentin. The microstructure was quantified in terms of the average tubule dimensions a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034511408429
更新日期：2011-08-01 00:00:00
abstract：:The dental phenolic medicaments, eugenol and guaiacol, are partly similar in chemical structure to capsaicin, the pungent constituent of chili peppers, which selectively activates sensory neurons via a specific receptor. We have previously demonstrated that these phenolic compounds show capsaicin-like action. In the p...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760040501
更新日期：1997-04-01 00:00:00
abstract：:Stereologic studies of trabecular architecture suggest that the pig mandibular condyle is strongest when loaded supero-inferiorly, and that stress is concentrated in the antero-inferior region (Teng and Herring, 1995). To test these hypotheses, we investigated the uni-axial mechanical properties of 22 pig mandibular c...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750110501
更新日期：1996-11-01 00:00:00
abstract：:Smoking has been established as an important risk factor for periodontal disease and tooth loss. The purpose of this study was a prospective evaluation of the effects of smoking on dental care utilization and its costs, based on data from 5712 males aged 20-59 yrs. Age, dental health behavior, and history of diabetes ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034508327523
更新日期：2009-01-01 00:00:00
abstract：:In this study, we analyzed the influence of prosthetic abutment height on marginal bone loss (MBL) around implants in the posterior maxilla. In this retrospective cohort study, the radiographically determined MBL was related to the height of the abutments of internal conical connection implants at 6 and 18 months post...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513519800
更新日期：2014-07-01 00:00:00
abstract：:The human temporalis and masseter muscles are not activated homogeneously during static bite force tasks. In this study, we studied the possible existence of regional differences in these muscles under dynamic conditions. Electromyographic (EMG) activity was recorded by means of bipolar fine-wire electrodes. Six elect...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345950740061201
更新日期：1995-06-01 00:00:00
abstract：:Fluoride content of drinking water is an important criterion in prescribing fluoride supplements. The majority of practicing dentists and physicians prescribe fluoride supplements, yet many apparently are unaware of the fluoride levels in their patients' drinking water. Characteristics of North Carolina (NC) dentists,...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650011301
更新日期：1986-01-01 00:00:00
abstract：:Previous studies suggest that salivary and pulp-derived host enzymes, matrix metalloproteinases (MMPs), may be involved in dentin caries pathogenesis. To study the inhibition of acid-activated human salivary MMPs by non-antimicrobial chemically modified tetracyclines (CMTs), we used a functional activity assay with 12...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800061301
更新日期：2001-06-01 00:00:00
abstract：:An in vitro model has been developed for measurement of initial attachment of 3H-labeled human gingival fibroblasts (HGF) and periodontal ligament cells (HPDL cells) to sieved dentin powder. Reproducible attachment was obtained and was closely related to the number of plated cells, the amount of dentin powder, the tem...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720030901
更新日期：1993-03-01 00:00:00
abstract：:Acute or chronic inflammation comprises a highly prevalent type of orofacial pain and is mediated by the generation of endogenous agonists that activate numerous receptors expressed on terminals of trigeminal (TG) nociceptive afferent neurons. One such studied receptor is transient receptor potential vanilloid subtype...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034516653751
更新日期：2016-09-01 00:00:00
abstract：:Dental pulp regeneration therapy for the pulpless tooth has attracted recent attention, and clinical trial studies are underway with the tissue engineering approach. However, there remain many concerns, including the extended period for regenerating the dental pulp. In addition, the use of scaffolds increases the risk...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518772260
更新日期：2018-09-01 00:00:00
abstract：:The rate of F absorption from the stomach is pH-dependent, with greater absorption at low pH. Since the rate of absorption is also strongly influenced by the rapidity of gastric emptying, we have compared the relative importance of gastric acidity and gastric emptying in overall F absorption. Male rats (350 g, n = 85)...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720031101
更新日期：1993-03-01 00:00:00
abstract：:The periodontium contains heterogeneous mesenchymal cell populations with various differentiation potentials. The capacity of these cells for tissue formation as well as the origin of their precursors are still not entirely defined. In this study, cells originating from different periodontal tissues were cultured in v...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345950740051201
更新日期：1995-05-01 00:00:00
abstract：:Application of an incisal bite plane for as little as three d caused a significant increase in the size of the sublingual glands of rats, with some evidence of hyperplasia and hypertrophy of the acinar cells. The enlargement had few effects on salivary secretion, and the gland changes were reversible. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620060501
更新日期：1983-06-01 00:00:00
abstract：:The aim of this study was to test effects of preventive regimes using fluoride and chlorhexidine to prevent caries and periodontal diseases in 34 patients with overdentures. The patients, who were treated with immediate overdentures, were distributed at random into three experimental groups. In these groups, different...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/00220345870660101301
更新日期：1987-10-01 00:00:00
abstract：:This 24-mo randomized controlled trial was based on a double-blind parallel design, and it compared the effectiveness of 2 fluoride application protocols in arresting dentine caries in primary teeth. Three-year-old children with active dentine caries were recruited and randomly allocated to 2 treatment groups. Childre...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520952031
更新日期：2021-01-01 00:00:00
abstract：:Four disclosant dyes were tested for antimicrobial activity against 27 oral reference strains and five non-oral human pathogens. Erythrosine and fluorescein inhibited most gram-positive and gram-negative organisms associated with dental plaque, and were bactericidal to selected strains. Fast green and brilliant blue d...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620071601
更新日期：1983-07-01 00:00:00
abstract：:Clinical evidence is lacking regarding the influence of the amount of residual coronal dentin and of post placement on the failure risk of endodontically compromised teeth. The aim of this prospective clinical trial was to assess whether these factors significantly affect the two-year survival of restored pulpless pre...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/154405910708600808
更新日期：2007-08-01 00:00:00
abstract：:The tongue plays an important role in mastication and swallowing by its contact with the hard palate. Using an experimental palatal plate with 7 pressure sensors, and recording jaw movement using mandibular kinesiography, we assessed, in healthy subjects, the coordination of tongue and jaw movements during the entire ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500214
更新日期：2006-02-01 00:00:00
abstract：:Although a secular decline is being seen in coronal caries in children in industrialized countries, there appears to be a relatively high prevalence of root caries, with chronologically older adults exhibiting the highest prevalences. This paper reviews the descriptive and analytical epidemiology of root caries as fou...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/00220345900690051901
更新日期：1990-05-01 00:00:00
abstract：:A search was made for expression of genes for proline-rich proteins (PRPs) and other salivary-type proteins, including statherin and histatins, in taste-bud tissues of mice and primates because of previous genetic findings in mice (Azen et al., 1986) that Prp and taste genes for certain bitter substances are either th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690110401
更新日期：1990-11-01 00:00:00
abstract：:The effect of different doses of polyadenylic and polyuridylic acids (poly A:U) was studied in control rats and in rats exposed to hypoxia. In the control rats, administration of different doses of poly A:U did not change the thickness of the epiphyseal plate or increase the incorporation of 3H-phenylalanine as judged...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550041701
更新日期：1976-07-01 00:00:00
abstract：:This study's objective was to identify, in a statistically valid and efficient manner, the risk factors associated with dental implant failure. We hypothesize that factors exist which can be modified by clinicians to enhance outcome. A retrospective cohort study design was used. Cohort members had >or= one implant pla...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910208100814
更新日期：2002-08-01 00:00:00
abstract：:Pulpal blood flow was determined in 32 dogs ranging in age from 6 weeks to 18 months by the isotope fractionation method incorporating diffusible and nondiffusible tracers. Dogs were placed into selected age groups by the developmental status of the canine teeth. For the teeth sampled, the maxillary first, second, and...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560102601
更新日期：1977-10-01 00:00:00
abstract：:The kinetics of growth of calcium phosphates on synthetic hydroxyapatite (HAP), human enamel, whole dentin, and human calculus has been studied at 37 C at pH values from 4.97 to 5.10 held constant by the pH-stat addition of base. Following an initial induction period, dicalcium phosphate dihydrate (DCPD) crystallizati...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570010901
更新日期：1978-01-01 00:00:00
