Abstract:
:A search was made for expression of genes for proline-rich proteins (PRPs) and other salivary-type proteins, including statherin and histatins, in taste-bud tissues of mice and primates because of previous genetic findings in mice (Azen et al., 1986) that Prp and taste genes for certain bitter substances are either the same or closely linked. Taste-bud tissues and other tissues were tested for specific mRNAs with labeled DNA probes by Northern blotting and in situ hybridization. It was found that PRP mRNAs were present in von Ebner's glands of mice and macaques, and that there was a much greater degree of PRP mRNA induction in mouse parotid (16-fold) than in von Ebner's gland (two-fold) after in vivo isoproterenol stimulation. This difference may be due, in part, to differences in autonomic nerve innervation. Statherin and histatin mRNAs were found in macaque taste-bud tissues containing von Ebner's gland, and statherin protein was found in human von Ebner's gland by immunohistochemistry. The finding of PRP gene expression in von Ebner's gland, whose secretions have been suggested to play a role in taste stimulation, adds further support to a possible function of PRPs in bitter tasting. The possible functions of statherin and histatins in von Ebner's gland secretions may be related to statherin's regulation of salivary calcium and histatins' antibacterial and antifungal properties.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Azen EA,Hellekant G,Sabatini LM,Warner TFdoi
10.1177/00220345900690110401subject
Has Abstractpub_date
1990-11-01 00:00:00pages
1724-30issue
11eissn
0022-0345issn
1544-0591journal_volume
69pub_type
杂志文章abstract::Although a secular decline is being seen in coronal caries in children in industrialized countries, there appears to be a relatively high prevalence of root caries, with chronologically older adults exhibiting the highest prevalences. This paper reviews the descriptive and analytical epidemiology of root caries as fou...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/00220345900690051901
更新日期:1990-05-01 00:00:00
abstract::It has been shown that a release of periosteal tension may augment the growth of a long bone; however, similar experiments in the mandible have produced equivocal results. For further definition of the role of periosteal tension in the growth of the mandibular condyle, 80 young female Sprague-Dawley rats were randomly...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690090201
更新日期:1990-09-01 00:00:00
abstract::Autosomal dominant mutations in PTH1R segregate with primary failure of eruption (PFE), marked by clinical eruption failure of adult teeth without mechanical obstruction. While the diagnosis of PFE conveys a poor dental prognosis, there are no reports of PFE patients who carry PTH1R mutations and exhibit any other ske...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513513588
更新日期:2014-02-01 00:00:00
abstract::Stress analyses are presented for a second mandibular premolar with a class 1 amalgam restoration. The effects of amalgam setting and thermal expansions are examined. An axisymmetric representation of the structure is used and the analyses are carried out by the finite element method. Lined and unlined restorations ar...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570051101
更新日期:1978-05-01 00:00:00
abstract::The oral cavity contains a rich consortium of exopolysaccharide-producing microbes. These extracellular polysaccharides comprise a major component of the oral biofilm. Together with extracellular proteins, DNA, and lipids, they form the biofilm matrix, which contributes to bacterial colonization, biofilm formation and...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034519845001
更新日期:2019-07-01 00:00:00
abstract::Four classes of elastomeric impression materials (polysulfide, polyether, silicone, and agar-agar) were evaluated on the basis of linear dimensional stability as a function of time between taking and pouring an impression of mounted teeth. Four polysulfide materials produced dies which were larger than the teeth and g...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345800590071001
更新日期:1980-07-01 00:00:00
abstract::Chemical bonding between dental porcelains and alloys results from interdiffusion of porcelain and metal ions. An interfacial diffusion zone is created which, most likely, has properties different from those of bulk materials. The changed interface might affect experimental measurements of thermo-mechanical strain. To...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620051701
更新日期:1983-05-01 00:00:00
abstract::Restriction endonuclease analysis (REA) was performed on the total cellular DNA from each of 396 strains of mutans streptococci (1) to determine its potential usefulness for the study of transmission of the organism and (2) to document the proportions and variety of strains harbored by members of a small group of fami...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680070401
更新日期:1989-07-01 00:00:00
abstract::The oral microbiota was compared between Romanian adolescents with a high prevalence of caries and no dental care and Swedish caries-active and caries-free adolescents in caries prevention programs and with a low prevalence of caries. Biofilm samples were analyzed by FLX+ pyrosequencing of the V1 to V4 hypervariable r...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515609554
更新日期:2016-01-01 00:00:00
abstract::Amelogenin and ameloblastin, the major enamel matrix proteins, are important for enamel mineralization. To identify their synergistic roles in enamel development, we generated Amel X(-/-)/Ambn(-/-) mice. These mice showed additional enamel defects in comparison with Amel X(-/-) or Ambn(-/-) mice. In 7-day-old Amel X(-...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509334749
更新日期:2009-04-01 00:00:00
abstract::Symphyseal secondary cartilage is important for mandibular development, but the molecular mechanisms underlying its formation remain largely unknown. Here we asked whether Indian hedgehog (Ihh) regulates symphyseal cartilage development and growth. By embryonic days 16.5 to 18.5, Sox9-expressing chondrocytes formed wi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510397836
更新日期:2011-05-01 00:00:00
abstract::Intracystic fluid pressure is thought to be involved in odontogenic cyst growth. In this study, we investigated the effects of positive pressure on the expression of interleukin-1alpha (IL-1alpha), matrix metalloproteinases (MMPs), and prostaglandin E2 (PGE2) in odontogenic keratocysts to determine whether this pressu...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910508401008
更新日期:2005-10-01 00:00:00
abstract::Our long-term objective is to devise methods to improve osteotomy site preparation and, in doing so, facilitate implant osseointegration. As a first step in this process, we developed a standardized oral osteotomy model in ovariectomized rats. There were 2 unique features to this model: first, the rats exhibited an os...
journal_title:Journal of dental research
pub_type: 杂志文章,多中心研究
doi:10.1177/0022034517742631
更新日期:2018-04-01 00:00:00
abstract::Class II major histocompatilibity complex (MHC)-expressing cells are usually distributed in dental pulp, and it was postulated that the colony-stimulating factor (CSF) derived from dental pulp fibroblasts contributes to the migration of class II MHC-expressing cells into pulp tissue. This study aimed to investigate th...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200204
更新日期:2003-02-01 00:00:00
abstract::Although the occlusal vertical dimension (OVD) is strictly controlled, the neuronal mechanism of its regulation is still unclear. We hypothesize that neurons in the trigeminal mesencephalic nucleus (MesV) play an important role in the regulation of the OVD, because the MesV receives the projection from jaw-closing mus...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200715
更新日期:2003-07-01 00:00:00
abstract::Eighteen different Streptococcus strains including S mutans, sanguis, mitis, salivarius, bovis, and 2F2, were assayed for their relative adsorption to synthetic hydroxyapatite and for quantities of lactic acid produced while in the adsorbed state. The results indicated that all S mutans and some S sanguis have an enha...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560101401
更新日期:1977-10-01 00:00:00
abstract::Transglutaminase-2 (TGM-2) stabilizes extracellular matrix (ECM) proteins by cross-linking and has been implicated in several fibrotic disorders. Arecoline present in betel quid has been proposed as one of the causative factors for oral submucous fibrosis (OSMF). Hence, we hypothesize that arecoline may regulate TGM-2...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034508329633
更新日期:2009-02-01 00:00:00
abstract::Caries increment is affected by sugar-sweetened beverage (SSB) consumption. Taxing SSBs could reduce sugar consumption and caries increment. The authors aimed to estimate the impact of a 20% SSB sales tax on caries increment and associated treatment costs (as well as the resulting tax revenue) in the context of German...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034516660278
更新日期:2016-11-01 00:00:00
abstract::This study contains the first part of a research project in which the applicability of fracture mechanics parameters to predict failure of a restored tooth was investigated. Fracture mechanics parameters have been used in dental research before, but were restricted to comparative studies between various brands of comp...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670060601
更新日期:1988-06-01 00:00:00
abstract::Previous studies have clearly established the down-regulating effect of a sucrose-rich diet on primary dentinogenesis in rat molars. Earlier observation of the negative effect of a high-sucrose diet on a parotid function involved in the control of intradentinal solute movement led us to hypothesize that parotid gland ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910208100407
更新日期:2002-04-01 00:00:00
abstract::The effects of oral rinses on enamel fluoride uptake, caries, and plaque pH in rats were investigated by use of (1) an acidic calcium phosphate solution (CPS) saturated with dicalcium phosphate dihydrate (DCPD) and (2) a 1% fluoride solution. Osborne-Mendel rats, 19 days of age, were randomly assigned to one of four m...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670061401
更新日期:1988-06-01 00:00:00
abstract::Limited cure depth is a drawback of light-activated composites. We hypothesize that curing light transmission and cure depth are influenced by monomer reactivity and filler/resin refractive index mismatch. Light transmission throughout cure was recorded for composites based on strontium (refractive index 1.51) or bari...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808700115
更新日期:2008-01-01 00:00:00
abstract::Artificial white spot lesions have been prepared on bovine enamel surfaces by the controlled addition of lactate buffer containing methylhydroxydiphosphonate ions. The rates of remineralization have been measured using a constant composition method in solutions of calcium phosphate of low supersaturation. Deposition o...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630061001
更新日期:1984-06-01 00:00:00
abstract::The aim of this study was to assess the effect of chewing gum containing phosphoryl oligosaccharides of calcium (POs-Ca) and a low concentration of fluoride (F) on the hardness of enamel subsurface lesions, utilizing a double-blind, randomized, and controlled in situ model. Fifteen individuals wore removable lingual a...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/0022034512439716
更新日期:2012-04-01 00:00:00
abstract::Extracellular vesicles (EVs), several tens to hundreds of nanometers in size, are vesicles secreted by cells for intercellular communication. EVs released from mesenchymal stem cells (MSC-EVs) have the potential to treat multiple diseases. This study aimed to determine the effects of MSC-EVs on bisphosphonate-related ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520906793
更新日期:2020-05-01 00:00:00
abstract::The aim of this study was to examine the association between the bone mass (bone mineral content [BMC]) and hypomineralized second primary molars (HSPMs)/molar incisor hypomineralization (MIH) in 6-y-old children. This cross-sectional study was embedded in the Generation R Study, a population-based prospective cohort ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515625470
更新日期:2016-04-01 00:00:00
abstract::Genetic studies of early-onset periodontitis (EOP) are hampered by several factors. These include delayed onset of the trait, an upper age limit of expression of the disease, and lack of phenotypic information for edentulous family members. Segregation analyses of families with EOP support a major locus hypothesis but...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345000790031201
更新日期:2000-03-01 00:00:00
abstract::Mandibular prognathism is a common dentofacial phenotype with a substantial genetic component; however, few susceptibility loci have been mapped. Ethnicity is a risk factor for mandibular prognathism, and a relatively high prevalence is observed in Asian populations. The hypothesis of this study suggested that a speci...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510382546
更新日期:2011-01-01 00:00:00
abstract::Dissolution of mercury from the Ag-Hg matrix phase of dental amalgam is distilled water and synthetic saliva, and the mercury evaporation from the solutions, were studied in vitro. The main objectives of the study were to evaluate the factors that affect the results of the mercury release tests, and to consider the po...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690050901
更新日期:1990-05-01 00:00:00
abstract::Minimal invasive approaches to managing caries, such as partial caries removal techniques, are showing increasing evidence of improved outcomes over the conventional complete caries removal. There is also increasing interest in techniques where no caries is removed. We present the 1-yr results of clinical efficacy for...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/0022034514550717
更新日期:2014-11-01 00:00:00