Abstract:
:Symphyseal secondary cartilage is important for mandibular development, but the molecular mechanisms underlying its formation remain largely unknown. Here we asked whether Indian hedgehog (Ihh) regulates symphyseal cartilage development and growth. By embryonic days 16.5 to 18.5, Sox9-expressing chondrocytes formed within condensed Tgfβ-1/Runx2-expressing mesenchymal cells at the prospective symphyseal joint site, and established a growth-plate-like structure with distinct Ihh, collagen X, and osteopontin expression patterns. In post-natal life, mesenchymal cells expressing the Ihh receptor Patched1 were present anterior to the Ihh-expressing secondary cartilage, proliferated, differentiated into chondrocytes, and contributed to anterior growth of alveolar bone. In Ihh-null mice, however, symphyseal development was defective, mainly because of enhanced chondrocyte maturation and reduced proliferation of chondroprogenitor cells. Proliferation was partially restored in dual Ihh;Gli3 mutants, suggesting that Gli3 is normally a negative regulator of symphyseal development. Thus, Ihh signaling is essential for symphyseal cartilage development and anterior mandibular growth.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Sugito H,Shibukawa Y,Kinumatsu T,Yasuda T,Nagayama M,Yamada S,Minugh-Purvis N,Pacifici M,Koyama Edoi
10.1177/0022034510397836subject
Has Abstractpub_date
2011-05-01 00:00:00pages
625-31issue
5eissn
0022-0345issn
1544-0591pii
0022034510397836journal_volume
90pub_type
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