Abstract:
:The aim of this study was to assess the effect of chewing gum containing phosphoryl oligosaccharides of calcium (POs-Ca) and a low concentration of fluoride (F) on the hardness of enamel subsurface lesions, utilizing a double-blind, randomized, and controlled in situ model. Fifteen individuals wore removable lingual appliances with 3 bovine-enamel insets containing subsurface demineralized lesions. Three times a day for 14 days, they chewed one of the 3 chewing gums (placebo, POs-Ca, POs-Ca+F). After the treatment period, cross-sectional mineral content, nanoindentation hardness, and fluoride ion mapping by time-of-flight secondary ion mass spectrometry (TOF-SIMS) were evaluated. Although there were no statistical differences in overall mineral content and hardness recovery rates between POs-Ca and POs-Ca+F subsurface lesions (p > 0.05), nanoindentation at 1-μm distance increments from the surface showed statistical differences in hardness recovery rate between POs-Ca and POs-Ca+F in the superficial 20-μm region (p < 0.05). Fluoride mapping revealed distribution of the ion up to 20 μm from the surface in the POs-Ca+F group. Nanoindentation and TOF-SIMS results highlighted the benefits of bioavailability of fluoride ion on reinforcement of the superficial zone of subsurface lesions in situ (NCT01377493).
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Kitasako Y,Sadr A,Hamba H,Ikeda M,Tagami Jdoi
10.1177/0022034512439716subject
Has Abstractpub_date
2012-04-01 00:00:00pages
370-5issue
4eissn
0022-0345issn
1544-0591pii
0022034512439716journal_volume
91pub_type
杂志文章,随机对照试验abstract::The effect of enamel matrix proteins on the seeded growth of enamel apatite crystals was studied in stable supersaturated solutions at pH 7.4 and 37 degrees C. Of the two major protein classes in the enamel matrix, the enamelins were considerably more effective than the amelogenins in retarding seeded growth. However,...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630021801
更新日期:1984-02-01 00:00:00
abstract::The universally accepted concept of delay-loaded dental implants has recently been challenged. This study hypothesizes that early loading (decreased implant healing time) leads to increased bone formation and decreased crestal bone loss. We used 17 minipigs to study implants under a controlled load, with non-loaded im...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200803
更新日期:2003-08-01 00:00:00
abstract::A/Jax mice were injected with 50 muCi of 3H cortisol and 10 mg of cortisone acetate on day 12 of gestation. At various intervals after injection, the maternal liver, placenta, yolk sac, and the fetal jaws were removed and analyzed by thin-layer chromatography in conjunction with oxidative combustion and liquid scintil...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345750540051101
更新日期:1975-09-01 00:00:00
abstract::The sensitizing potential of three periodontal dressing materials was evaluated by the guinea pig maximization test. The results indicated a difference in the sensitization rate of the three materials. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570110801
更新日期:1978-11-01 00:00:00
abstract::In sham-operated and TPTX animals, F treatment did not affect final body weight, or serum Ca and P. In sham-treated rats, serum iPTH was not affected by F treatment. At the periosteum, F increased bone formation rate and bone and matrix apposition rates. At the endosteum, F treatment decreased forming surface, bone fo...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560031601
更新日期:1977-03-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is a potent inducer of angiogenesis, vascular permeability, and edema. Up-regulation of VEGF expression in the dental pulp may result in increased intra-pulpal pressure, and contribute to pain and irreversible tissue damage. Lipoteichoic acid (LTA) is an amphiphilic molecule f...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200612
更新日期:2003-06-01 00:00:00
abstract::A radiotracer technique was used to study silver and gold diffusion into dental porcelain under experimental conditions close to the real conditions in prosthetic laboratories for porcelain bakes. It was clearly shown that these non-oxidizable elements were able to diffuse into the ceramic as well as oxidizable ones. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660120401
更新日期:1987-12-01 00:00:00
abstract::The purpose of this study was to investigate the mechanism of surface layer formation in artificial white spots. Two nondestructive nuclear micro-analysis techniques were employed to analyze windows of human dental enamel at progressive stages of an artificial lesion. Fluoride concentrations were measured to a depth o...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620091001
更新日期:1983-09-01 00:00:00
abstract::Smoking is a major risk of periodontal diseases. At the site of first contact, the gingiva is exposed to aromatic amines and polycyclic hydrocarbons. These are metabolized by the N-acetyltransferases (NAT), leading to local detoxification and/or activation reactions contributing to the risk of periodontal destruction ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910208100512
更新日期:2002-05-01 00:00:00
abstract::Lysis of cell wall preparations from strains representing serotypes a - g of Streptococcus mutans has provided a convenient and efficient means of obtaining the typing antigens in a soluble undegraded form, and has demonstrated that, in each case, the antigen is a cell wall component in the strict sense of a component...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620100401
更新日期:1983-10-01 00:00:00
abstract::Porcine dentin sialophosphoprotein (DSPP) is the most abundant non-collagenous protein in dentin. It is processed by proteases into 3 independent proteins: dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP). We fractionated DPP and DSP along with TGF-β activity by ion exchange (IE) c...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514534690
更新日期:2014-07-01 00:00:00
abstract::A quantitative microprobe analysis was conducted on three commercial amalgams to determine the nature of the phases present. The presence of tin in the Ag-Hg phase (gamma1) was confirmed and Cu-3Sn was found in the original alloy particles. In the dispersant amalgam studied, little Sn-Hg phase (gamma-2) was found and ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract::The purpose of the study was to determine the exposure times needed to harden a light-activated composite cement through various thicknesses of porcelain. A negative exponential model was developed with which the relative hardness of a composite could be predicted from the product of the exposure time and the square r...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680030801
更新日期:1989-03-01 00:00:00
abstract::The clearance of glucose from saliva was compared with that from spaces located in an intra-oral appliance. The spaces (N = 8) were similar in shape and size to posterior interdental spaces and could be sampled with a microsyringe without removing the appliance from the mouth. The subjects (N = 5) rinsed their mouths ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640030301
更新日期:1985-03-01 00:00:00
abstract::Debonding rates of 164 resin-bonded prostheses (RBP) placed from 1974 to 1985 were examined at recall. The yearly debond rates were calculated, the cumulative probability of failure was determined for the debonded RBPs, and Weibull distribution parameters were determined. For perforated prostheses, there was a high in...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720081401
更新日期:1993-08-01 00:00:00
abstract::Ten cats were immunized with subcutaneous injections of keyhole limpet hemocyanin (KLH). After it was determined that the experimental animals had developed circulating antibodies to KLH, challenge doses of KLH were administered via the root canal system. The radiographic and histologic findings suggest that antigen-a...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345800590011601
更新日期:1980-01-01 00:00:00
abstract::In previous studies, human dental pulp stem cells (hDPSCs) were mainly isolated from adults. In this present study, we characterized hDPSCs isolated from an earlier developmental stage to evaluate the potential usage of these cells for tissue-regenerative therapy. hDPSCs isolated at the crown-completed stage showed a ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910808700716
更新日期:2008-07-01 00:00:00
abstract::In vitro wear data were determined for nine experimental composites and compared with two-year clinical data. The in vitro tests included single-pass wear and two-body abrasion. The in vivo data were obtained between 1978 and 1980 for 54 class 2 posterior composite restorations in 25 patients. Correlations between the...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620101801
更新日期:1983-10-01 00:00:00
abstract::Previous studies showed that residual compressive stresses induced by thermal tempering retarded the growth of surface cracks in bilayered porcelain disks. The objectives of the present study were: (1) to determine whether thermal tempering by air blasting reduces the length of cracks induced by microhardness indentat...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750020301
更新日期:1996-02-01 00:00:00
abstract::Caries increment is affected by sugar-sweetened beverage (SSB) consumption. Taxing SSBs could reduce sugar consumption and caries increment. The authors aimed to estimate the impact of a 20% SSB sales tax on caries increment and associated treatment costs (as well as the resulting tax revenue) in the context of German...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034516660278
更新日期:2016-11-01 00:00:00
abstract::Recent advances in molecular biology have facilitated analyses of the oral microbiome ("Who are they?"); however, its functions (e.g., metabolic activities) are poorly understood ("What are they doing?"). This review aims to summarize our current understanding of the metabolism of the oral microbiome. Saccharolytic ba...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034515606045
更新日期:2015-12-01 00:00:00
abstract::The range of substrates transported by the sugar-binding protein-dependent msm (multiple sugar metabolism) system of S. mutans was investigated. By determining the ability of unlabeled sugar to compete with radiolabeled melibiose transport, we have demonstrated that the transported sugars included a number of carbohyd...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720100701
更新日期:1993-10-01 00:00:00
abstract::A number of studies have been made investigating the properties of dental prosthodontic soft polymer materials. In such materials, which are used as short-term denture soft liners, the polymer component is complexed with one or more plasticizers. This lowers the glass transition temperature, Tg, of the polymer by allo...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700050201
更新日期:1991-05-01 00:00:00
abstract::A series of in vitro studies have been performed to study the release of tin and fluoride from an experimental prophylactic cup and the influence of this release on the fluoride content of enamel. It has been found that the release of fluoride from the prophy cup during a simulated prophylaxis results in a significant...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550030801
更新日期:1976-05-01 00:00:00
abstract::Erupting first permanent molars of 5 1/2 to 6 1/2 year-olds are eminently suited for the clinical testing of potential caries-inhibiting techniques. Due to the rapid onset of caries in these teeth, accurate monitoring of new materials/regimes can be instituted and meaningful data obtained within one year of trial comm...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章
doi:10.1177/002203457705600301011
更新日期:1977-10-01 00:00:00
abstract::The lack of a reliable bond test has hindered the elucidation of the mechanism for porcelain-metal bonding in dental systems, because a test capable of detecting differences among porcelain-metal bonds of various qualities is required before the reasons for these differences may be ascertained. A method was developed ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670020801
更新日期:1988-02-01 00:00:00
abstract::An analysis of the relationship between creep and microstructural characteristics of several gamma2-containing amalgams showed the grain size of the Ag-Hg phase (gamma1) to be a predominant factor influencing creep. When gamma1 grain size is increased, creep is reduced. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560121401
更新日期:1977-12-01 00:00:00
abstract::The tissue-implant interfaces of functional and non-functional endosseous dental implants were compared histologically for up to one year post-operatively. Nonmineralized connective tissue zones (a "fibrous capsule") existed in all functional interfaces. Direct, or nearly direct, bone apposition to implants occurred i...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580100201
更新日期:1979-10-01 00:00:00
abstract::When one uses composite resins, the curing contraction, the stiffness of the material, and the strength of the vulnerable dentinal bond are important factors in determining the marginal adaptation of the restoration. Calculations based on these intrinsic material properties have indicated that both bulk placement and ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670050901
更新日期:1988-05-01 00:00:00
abstract::Significant inhibition of PMN metabolic activity by F- occurred at 0.1, 0.5 and 0.0 mM F- for O2- generation, 1-C14 CO2 release labeled glucose and NBT-reduction respectively. This inhibition resulted primarily from F- suppression of nonoxidative glucose metabolism. As the concentration of F- in the O2- generating sys...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580092101
更新日期:1979-09-01 00:00:00