Cleft palate induction: quantitative studies of 3H corticoids in A/Jax mouse tissues after maternal injections of 3H cortisol.

Abstract:

:A/Jax mice were injected with 50 muCi of 3H cortisol and 10 mg of cortisone acetate on day 12 of gestation. At various intervals after injection, the maternal liver, placenta, yolk sac, and the fetal jaws were removed and analyzed by thin-layer chromatography in conjunction with oxidative combustion and liquid scintillation counting to identify and measure the amount of labeled corticoid metabolites. The results support the thesis that these corticoids may induce clefts by an individual or combined direct action on the fetal jaws and palatal shelf tissue.

journal_name

J Dent Res

authors

Spain KM,Kisieleski W,Wood NK

doi

10.1177/00220345750540051101

keywords:

subject

Has Abstract

pub_date

1975-09-01 00:00:00

pages

1069-77

issue

5

eissn

0022-0345

issn

1544-0591

journal_volume

54

pub_type

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