Abstract:
:Previous investigations have shown a clear association between the presence of the enzyme aspartate aminotransferase (AST) in gingival crevicular fluid (GCF) and clinical evidence of periodontal disease in humans, as well as in the beagle dog model. This paper describes a 26-week study that uses the beagle dog model of ligature-induced periodontitis in which GCF-AST (corrected for collection time) was correlated with microscopic evidence of tissue destruction in the periodontium at the sites of fluid collection. GCF and clinical data were collected at baseline, at optimal gingival health, during gingivitis, and after ligation. A cross-mouth design was implemented so that six premolar teeth in each dog were ligated for periods up to five weeks. Formalin-fixed tissues from the sites of GCF collection were prepared for light microscopy and evaluated for the presence of epithelial ulceration, bone resorption, and inflammatory cell infiltration. The relationship between GCF-AST levels and microscopic findings was analyzed by calculation of sensitivity and specificity and by plots of Receiver Operating Characteristics. These data revealed a correlation between elevated enzyme concentration and microscopic evidence of disease activity. Taken together with human studies, these results provide support for the use of AST as a marker of periodontal disease progression.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Cohen RL,Alves ME,Crawford JM,McSwiggin T,Chambers DAdoi
10.1177/00220345910700061501subject
Has Abstractpub_date
1991-06-01 00:00:00pages
984-7issue
6eissn
0022-0345issn
1544-0591journal_volume
70pub_type
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journal_title:Journal of dental research
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journal_title:Journal of dental research
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journal_title:Journal of dental research
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journal_title:Journal of dental research
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journal_title:Journal of dental research
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journal_title:Journal of dental research
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journal_title:Journal of dental research
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journal_title:Journal of dental research
pub_type: 杂志文章
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journal_title:Journal of dental research
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journal_title:Journal of dental research
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journal_title:Journal of dental research
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abstract::The type of attachment that is used in oral rehabilitation by means of implant-retained mandibular overdentures may influence the retention and the stability of the denture. In this study, we examined the hypothesis that a better retention and stability of the denture improve the oral function. Eighteen edentulous sub...
journal_title:Journal of dental research
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journal_title:Journal of dental research
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journal_title:Journal of dental research
pub_type: 杂志文章,meta分析,评审
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