Novel OK-432-conjugated tumor vaccines induce tumor-specific immunity against murine tongue cancer.

Abstract:

:Priming with tumor antigens is one of the most important strategies in cancer immunotherapy. To enhance tumor antigenicity, OK-432, a streptococcal preparation, was coupled to squamous cell carcinoma (KLN-205) by means of a 0.2% glutaraldehyde method. The purpose of this study was to investigate whether OK-432-conjugated tumor vaccines could induce tumor-specific immunity. Our originally developed mouse tongue cancer model was used throughout this work for the analysis of antitumor effects. Prepared OK-432-conjugated KLN-205 vaccines were immunized 3 times to DBA/2 mice. The results showed that the KLN-205 vaccines induced cytolytic activity and strongly suppressed both KLN-205 tumor incidence and growth, and survival of the mice was improved. Moreover, the histological results showed that a greater number of lymphocytes had infiltrated around tumor cells by 24 hours after tumor inoculation in the vaccine group. These results suggest that immunizations with KLN-205 vaccines increase the antitumor effects against tongue cancer.

journal_name

J Dent Res

authors

Li X,Bukawa H,Hirota M,Tsuyuki Y,Omura S,Fujita K

doi

10.1177/154405910308200813

keywords:

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

636-40

issue

8

eissn

0022-0345

issn

1544-0591

journal_volume

82

pub_type

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