Abstract:
:Gingiva from alloxan and streptozotocin-diabetic rats exhibited markedly enhanced collagenolytic activity in tissue culture. This effect was eliminated by puromycin or by repeated freeze-thawing of the tissue prior to incubation. Soluble extracts of the diabetic gingiva in situ were found to contain breakdown products of collagen similar in size to the reaction products generated by tissue collagenase. These fragments were not detected in the control tissue. This study indicates that experimental diabetes stimulates the synthesis of gingival collagenase in culture and that a similar effect occurs in vivo.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Golub LM,Schneir M,Ramamurthy NSdoi
10.1177/00220345780570032101subject
Has Abstractpub_date
1978-03-01 00:00:00pages
520-5issue
3eissn
0022-0345issn
1544-0591journal_volume
57pub_type
杂志文章abstract::Eugenol, in the 100 percent concentration in commercial use, was applied to a circumscribed area, 3 mm in diameter, of rat labial mucosa for 1 minute. Reaction periods of 15 minutes, 1, 2, 4 and 6 hours were then permitted. Using routine histological procedures for processing the experimental tissues, it was observed ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570110901
更新日期:1978-11-01 00:00:00
abstract::Dimensions and velocity of mandibular movement are important variables in the evaluation of masticatory and speech patterns. However, little information is available concerning elderly dentates and their oral motor function and behavior. Double recordings of a chewing period, from start to swallowing, were performed i...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690021101
更新日期:1990-02-01 00:00:00
abstract::Patients with restorations cemented with a reinforced zinc oxide-eugenol cement and a zinc phosphate cement were recalled after a four- to seven-year interval. No significant differences in clinical success were observed between restoration luted with the two cements. No significant difference in the incidence of cari...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550022201
更新日期:1976-03-01 00:00:00
abstract::The microstructures of (beta + gamma) silver-tin alloys are especially influenced by both homogenization temperature and subsequent heat treatment. When the alloy is cooled from homogenization temperatures above approximately 200 degrees C, lenticular regions of the ordered orthorhombic gamma phase precipitate from wi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640051501
更新日期:1985-05-01 00:00:00
abstract::Treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has posed significant challenges to maxillofacial surgeons because of the poor repair of BRONJ bone defects. Moreover, the pathological mechanisms remain unclear. Bone marrow stromal cells (BMSCs) play key roles during bone repair and bone regenerati...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034517691507
更新日期:2017-05-01 00:00:00
abstract::Dietary components rich in polyphenols-for example, tea and red wine-are thought to cause tooth staining. In the present study, hydroxyapatite was used as a model of enamel for study of the influence of salivary proteins on the binding of different polyphenols to hydroxyapatite in vitro. Neither salivary protein pelli...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910508400113
更新日期:2005-01-01 00:00:00
abstract::Wall-to-wall (WTW) polymerization contraction of filled and unfilled chemically and photo-initiated resins was studied in relation to the WTW distance. In an experimental set-up, the resins were bonded to two opposing disks, and the axial (WTW) displacement resulting from the polymerization shrinkage was measured cont...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680010701
更新日期:1989-01-01 00:00:00
abstract::In this study, we investigated whether selective activation of nociceptive primary afferent fibers by capsaicin would induce modulations on tooth-pulp-evoked sensory or inhibitory masseter reflex responses in healthy human subjects. The contribution of central N-methyl-D-aspartate (NMDA) receptor mechanisms in capsaic...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345970760090801
更新日期:1997-09-01 00:00:00
abstract::Dental caries can be described as a dysbiosis of the oral microbial community, in which acidogenic, aciduric, and acid-adapted bacterial species promote a pathogenic environment, leading to demineralization. Alkali generation by oral microbes, specifically via arginine catabolic pathways, is an essential factor in mai...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034517707512
更新日期:2017-07-01 00:00:00
abstract::Large mandibular defects are difficult to reconstruct with good functional and aesthetic outcomes because of the complex geometry of craniofacial bone. While the current gold standard is free tissue flap transfer, this treatment is limited in fidelity by the shape of the harvested tissue and can result in significant ...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034514547763
更新日期:2014-12-01 00:00:00
abstract::Previously, we reported that the rate (R) of hydroxyapatite dissolution in acetic, lactic, and phosphoric acid solutions is a function of the degree of saturation with respect to the dissolving mineral, DS (defined as the ratio of the mean ionic activity product for hydroxyapatite [Ca5OH(PO4)3] in solution to its solu...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345990780070701
更新日期:1999-07-01 00:00:00
abstract::In this study, we first investigated the expressions of Jagged1, Notch2, the receptor activator of nuclear factor-kappa B ligand (RANKL), and interleukin (IL)-6 in areas of root resorption during experimental tooth movement in rats in vivo. We then assessed the effects of compression force (CF) with or without GSI (an...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514555364
更新日期:2015-01-01 00:00:00
abstract::The reaction of the microvasculature in the periodontal ligament to mechanical pressure is considered a very important phenomenon with respect to the biological background to orthodontic tooth movement. For clarification of the microvascular reaction to mechanical pressure, an experimental model that incorporated a ha...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345920710060701
更新日期:1992-06-01 00:00:00
abstract::The surface enamel of fetal bovine teeth was stained with GBHA to indicate the position of bands of smooth-ended and ruffle-ended ameloblasts relative to the developing enamel. The boundaries of the bands were scored, under a dissecting microscope, and the bulk enamel under each band was collected. The enamel samples ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670060901
更新日期:1988-06-01 00:00:00
abstract::Polynomial and catenary equations were fit by least square error methods to the dentitions of seven children with "normal" occlusion. Mean and mean square error were then used to analyze accuracy of curve fits and asymmetries of arches. A lack of congruency for the "lines of occlusion" common to the maxilla and mandib...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345750540060501
更新日期:1975-11-01 00:00:00
abstract::During the 18th century, France was the leader in the field of dentistry, exemplified by Pierre Fauchard (1678-1761), who was given the title "the father of modern dentistry" for his comprehensive work, Le Chirurgien Dentiste. This paper examines an 18th century dental treatment in a barely 50-year-old male whose body...
journal_title:Journal of dental research
pub_type: 历史文章,杂志文章
doi:10.1177/0022034508329872
更新日期:2009-03-01 00:00:00
abstract::Epstein-Barr virus (EBV), in addition to its transforming properties, contributes to the pathogenesis of several inflammatory diseases. Here, we investigated its involvement in oral lichen planus (OLP), a common autoimmune-like disease of unknown etiopathogenesis that can display a malignant potential. EBV-infected ce...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034518788282
更新日期:2018-12-01 00:00:00
abstract::The aim of this study was to test the hypothesis that the chewing of xylitol- or xylitol/sorbitol-containing chewing gum reduces plaque formation and the acidogenic potential of dental plaque. Thirty healthy volunteers aged from 19 to 28 yrs were randomly allocated to one of three test groups, chewing either xylitol-,...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/00220345980770071001
更新日期:1998-07-01 00:00:00
abstract::The objectives of the study were to describe the oral health status and treatment needs of the 5- to 6-year-old and 12-year-old children in Southern China; to describe the patterns of oral health behaviors, knowledge, and attitudes among the 12-year-olds; and to assess the effects of socio-behavioral factors on the 12...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345010800051501
更新日期:2001-05-01 00:00:00
abstract::Dental porcelains rely on the high-thermal-expansion mineral leucite to elevate their bulk thermal expansion to levels compatible with dental PFM alloys. The microcracks that form around these leucite particles when cooled during porcelain manufacture are a potential source of change in bulk porcelain thermal expansio...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750070801
更新日期:1996-07-01 00:00:00
abstract::Antigenic alterations to the dentin organic matrix may be detected by an immunohistochemical approach. We hypothesized that alterations in the antigenicity of type I collagen and proteoglycans occur in sclerotic dentin under caries lesions. Transverse sections were prepared from carious teeth in the sclerotic zone and...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608500204
更新日期:2006-02-01 00:00:00
abstract::The regulation of blood flow of the dental pulp was investigated in dogs and rats anesthetized with sodium pentobarbital. Pulpal blood flow was altered by variations of local and systemic hemodynamics. Variation in pulpal hemodynamics was attained by means of close intra-arterial injections of adrenergic agonists (NE ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/002203458506400415
更新日期:1985-04-01 00:00:00
abstract::Lactoferrin is one of a number of multifunctional proteins that are present in or on all mucosal surfaces throughout the body. Levels of lactoferrin are consistently elevated in inflammatory diseases such as arthritis, inflammatory bowel diseases, corneal disease, and periodontitis. Single-nucleotide polymorphisms (SN...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034515577413
更新日期:2015-06-01 00:00:00
abstract::Dynamic changes of pulpal blood flow (PBF) and gingival blood flow (GBF) induced by intra-venous injection of two kinds of vasoactive drugs were observed in dogs by means of Laser Doppler Velocimetry. Intra-venous injection of norepinephrine caused PBF to increase, corresponding to the blood pressure (BP) increase, wh...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680050701
更新日期:1989-05-01 00:00:00
abstract::Previous reports have linked the prevalence of tooth abnormalities with high caries experience in the different types of epidermolysis bullosa (EB). However, it is not known to what extent the apparent susceptibility to enamel caries is due to disease-related altered enamel chemistry in these cases. The aim of this st...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750090901
更新日期:1996-09-01 00:00:00
abstract::Previous studies have shown that fluoride affected the formation of apatite in spontaneous precipitations from unstable calcium phosphate solutions partly through its effect on the stability of such nonapatitic precursors as octacalcium phosphate, Ca8H2(PO4)6.5 H2O. The present study shows that fluoride had a comparab...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345800590021401
更新日期:1980-02-01 00:00:00
abstract::Jaw displacement tremor was investigated. Both tremor amplitude and tremor frequency were found to increase with increasing muscle activation. Co-contraction of jaw elevator and jaw depressor muscles was employed in order to vary muscle activation levels without the teeth being in occlusion. Reproducibility of tremor ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670080401
更新日期:1988-08-01 00:00:00
abstract::The role of Streptococcus mutans in the initiation of dental caries has been recognized and attributed, at least in part, to its ability to colonize the tooth surface. Therefore, factors which prevent S. mutans attachment to hydroxyapatite (HA) are of considerable interest for the prophylaxis of this infectious diseas...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345970760020701
更新日期:1997-02-01 00:00:00
abstract::A new hydroxyapatite ceramic implant material for restoration of atrophic edentulous ridges was tested in a canine animal model. The structure of this material is unique, in that it is produced from the skeleton of a coral, and in that it is penetrated by a uniform network of interconnected pores. Results indicate tha...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620021301
更新日期:1983-02-01 00:00:00
abstract::A plaque growth chamber was developed for long-term growth of five separate plaques from the same plaque or saliva sample under identical conditions of temperature and gas phase. Reagent addition and growth conditions for each plaque could be independently controlled, and each was accessible for sequential sampling an...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700110301
更新日期:1991-11-01 00:00:00