Enhanced collagenase activity in diabetic rat gingiva: in vitro and in vivo evidence.

Abstract:

:Gingiva from alloxan and streptozotocin-diabetic rats exhibited markedly enhanced collagenolytic activity in tissue culture. This effect was eliminated by puromycin or by repeated freeze-thawing of the tissue prior to incubation. Soluble extracts of the diabetic gingiva in situ were found to contain breakdown products of collagen similar in size to the reaction products generated by tissue collagenase. These fragments were not detected in the control tissue. This study indicates that experimental diabetes stimulates the synthesis of gingival collagenase in culture and that a similar effect occurs in vivo.

journal_name

J Dent Res

authors

Golub LM,Schneir M,Ramamurthy NS

doi

10.1177/00220345780570032101

subject

Has Abstract

pub_date

1978-03-01 00:00:00

pages

520-5

issue

3

eissn

0022-0345

issn

1544-0591

journal_volume

57

pub_type

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