Abstract：
:After cheek pouch carcinomas were induced in hamsters by the application of dimethylbenzanthracene (DMBA) to the right pouch for 13 weeks, the animals were divided into four groups and observed for seven more weeks. The control group received no further treatment, two experimental groups had incisional biopsies performed on tumors in their pouches, one of these also received injections of cortisone throughout the 20-week experimental period, and a fourth group received cortisone only. The wet weights of the cancerous cheek pouches were determined, and the submandibular and parotid salivary glands with associated cervical lymph nodes, the lungs, and the liver were examined with light microscopy. The cancerous pouches of the animals that received cortisone weighed significantly less than those of animals that received no cortisone but had incisional biopsies of the tumors. There was no significant difference in the degree of histodifferentiation of the tumors among the four groups. The animals in the two groups that received cortisone had significantly more tumors that were invasive than did the animals that did not receive cortisone. Cervical lymph node metastasis occurred in 21% to 38% of the animals but was not significantly different in the four groups. Distant metastases to the lungs or the liver were not found. Incisional biopsy of the tumors stimulated local growth of the cheek pouch tumors, and systemic cortisone administration produced more invasive cheek pouch tumors.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Tsiklakis K,Wood NK,Toto PD,Doemling DBdoi
10.1177/00220345860650061401subject
Has Abstractpub_date
1986-06-01 00:00:00pages
927-31issue
6eissn
0022-0345issn
1544-0591journal_volume
65pub_type
杂志文章abstract：:The histopathologic status of gingival tissue was assessed according to the criteria of Page and Schroeder.(5) Rhodamine-labeled bacteria were used to assess the antigenic specificity of plasma cells in the tissue. Examination of tissue sections revealed that 31.6% of plasma cells in the advanced lesions bound the lab...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034580059S213
更新日期：1980-11-01 00:00:00
abstract：:The number of molars selected for prophylactic removal varies widely among general dental practitioners and oral surgeons. To understand the basis for such variations, we investigated two hypotheses: (1) Individual judgment strategies will differ concerning the use of cues (items of information), and (2) few dentists ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790121101
更新日期：2000-12-01 00:00:00
abstract：:Recent functional animal studies have reported that the motor control of masticatory muscle function is bilaterally guided by both hemispheres, which may fundamentally differ from the cortical control of limb muscle function. In this study, we investigated whether unilateral cortical brain infarction induces different...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780120701
更新日期：1999-12-01 00:00:00
abstract：:The type of attachment that is used in oral rehabilitation by means of implant-retained mandibular overdentures may influence the retention and the stability of the denture. In this study, we examined the hypothesis that a better retention and stability of the denture improve the oral function. Eighteen edentulous sub...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/154405910208100305
更新日期：2002-03-01 00:00:00
abstract：:Repulsive magnetic appliances can intrude posterior teeth, but create a lateral shift of the mandible and also decrease in force as the mouth opens. To model their optimal use, the 3-D spatial force/displacement (F/D) and moment/displacement (M/D) diagrams of four magnetic repulsive appliances in diverse overlapping a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730010901
更新日期：1994-01-01 00:00:00
abstract：:Previous studies have demonstrated that antibodies against cholinoreceptors of exocrine glands correlate with dry mouth in persons with primary Sjögren syndrome (pSS). The aim of the present investigation was to establish if serum IgG antibodies (pSS IgG) were able to interact with cholinoreceptors in rat submandibula...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600905
更新日期：2007-09-01 00:00:00
abstract：:Information on the time-dependent release of fluoride from filled resins containing fluoride particles as a function of particle content and solution pH is limited. This study characterized the fluoride ion release from filled resins containing CaF2 particles as a function of filler content and pH. Urethane dimethacry...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910508400508
更新日期：2005-05-01 00:00:00
abstract：:The microstructure of the set glass-polyalkenoate cement has not been undertaken beyond a study where an Electron Probe Micro Analyser was used. The purpose of this investigation was to determine the ion distribution in matrix parts of the set cement by means of Secondary Ion Mass Spectrometry (SIMS). Among the techni...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780011301
更新日期：1999-01-01 00:00:00
abstract：:Periostin is a mesenchymal cell marker predominantly expressed in collagen-rich fibrous connective tissues, including heart valves, tendons, perichondrium, periosteum, and periodontal ligament (PDL). Knockdown of periostin expression in mice results in early-onset periodontitis and failure of cardiac healing after acu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514543015
更新日期：2014-09-01 00:00:00
abstract：:Amylase activity in various tissues--i.e., submandibular/sublingual and parotid glands, the pancreas, saliva, and serum--in rats was measured after injection of isoproterenol, pilocarpine, and acetylcholine. All agents reduced amylase activity in the parotid gland and increased the enzyme activity in the submandibular...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620011201
更新日期：1983-01-01 00:00:00
abstract：:Fluorides are present in the environment. Excessive systemic exposure to fluorides can lead to disturbances of bone homeostasis (skeletal fluorosis) and enamel development (dental/enamel fluorosis). The severity of dental fluorosis is also dependent upon fluoride dose and the timing and duration of fluoride exposure. ...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034510384626
更新日期：2011-05-01 00:00:00
abstract：:In a previous experiment, we found that masseter muscle spindles show functional plasticity after 5 to 15 days under increased occlusal vertical dimension (iOVD). In the present study, we hypothesized that spindle function would eventually recover if longer observation periods were allowed. Therefore, in this study we...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500914
更新日期：2006-09-01 00:00:00
abstract：:The monomer triethyleneglycoldimethacrylate (TEGDMA) is used as a diluent in many resin-based dental materials. It was previously shown in vitro that TEGDMA was released into the adjacent biophase from such materials during the first days after placement. In this study, the uptake, distribution, and excretion of 14C-T...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800050501
更新日期：2001-05-01 00:00:00
abstract：:The pathophysiology of painful temporomandibular disorders is not fully understood, but evidence suggests that muscle pain modulates motor function in characteristic ways. This study tested the hypothesis that activation of nociceptive muscle afferent fibers would be linked to an increased excitability of the human ja...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910208100915
更新日期：2002-09-01 00:00:00
abstract：:Cellular hypoxia may be a useful indication of tissue distress in the dental pulp that could be used to investigate the early stages of pulpal responses. Tritiated misonidazole (3H-MISO) is a marker which preferentially labels cells with decreased oxygen tension (hypoxia). The experiments reported here were carried ou...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750100801
更新日期：1996-10-01 00:00:00
abstract：:Selected strains of oral Streptococcus and Actinomyces have been tested for their ability to grow in the presence of mercury. Strains were tested for growth on a semi-defined medium with low mercury-binding characteristics. Sensitivities were initially measured on agar plates, and subsequently, selected strains were g...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720091201
更新日期：1993-09-01 00:00:00
abstract：:Chondroitin sulfate is up-regulated in granulation tissue during wound healing. To investigate the role of chondroitin sulfate in the wound-healing process after surgical repair of cleft palate, we isolated and cultured rabbit palatal fibroblasts. Treatment with chondroitin-6-sulfate resulted in a dose-dependent incre...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408301111
更新日期：2004-11-01 00:00:00
abstract：:Although osteoporosis is a major public health concern, the effect of this condition on oral bone has not been determined. Using the ovariectomized rat as a model, we examined whether acute estrogen depletion affects the mandible of the ovariectomized rat with and without maxillary molar extraction. Twenty-two ovariec...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730110901
更新日期：1994-11-01 00:00:00
abstract：:In previous studies, light-cured glass-ionomer cements have been shown to evoke cytotoxic reactions. It was the purpose of this investigation (a) to determine the nature of the ingredients released into an aqueous medium from 2 light-cured glass-ionomer cements (GICs) and 3 compomers; (b) to evaluate the cytotoxicity ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770121001
更新日期：1998-12-01 00:00:00
abstract：:The adsorption isotherms of benzoic acid on synthetic hydroxyapatite (containing about 1.5 monolayers of physisorbed water) were studied from ethanol, dimethylsulfoxide, p-dioxane, methylene chloride, and benzene to discern the role of solvent in the process. The adsorption is reversible from the first three solvents ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650051601
更新日期：1986-05-01 00:00:00
abstract：:Cell kinetics of rat molar periodontal ligament (PDL) during orthodontically-induced osteogenesis revealed: 1) primary growth fraction of 59%, 2) proliferating cells from throughout the PDL migrate toward the bone surface, 3) preosteoblasts, capable of forming osteoblasts without synthesizing DNA, are present in the P...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600021501
更新日期：1981-02-01 00:00:00
abstract：:Weanling rice rats were fed either standard laboratory chow or Diet 2000. The animals were sacrificed at 4, 8, 12, and 15 weeks. There was an increasing amount of exposed root surface and root surface caries with age in the animals fed Diet 2000. There was exposed root surface but no caries in the animals fed laborato...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560091701
更新日期：1977-09-01 00:00:00
abstract：:This 24-mo randomized controlled trial was based on a double-blind parallel design, and it compared the effectiveness of 2 fluoride application protocols in arresting dentine caries in primary teeth. Three-year-old children with active dentine caries were recruited and randomly allocated to 2 treatment groups. Childre...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520952031
更新日期：2021-01-01 00:00:00
abstract：:It is shown that the creep behavior of a commercial dispersant-amalgam containing copper is improved by the addition of a manganese-containing alloy. This improvement is apparently obtained without any serious changes in corrosion resistance, provided that no more than 20% of the Mn alloy is added. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570090601
更新日期：1978-09-01 00:00:00
abstract：:ATP-degrading enzyme activities in pulps of healthy and carious human teeth were quantitatively analyzed using the bioluminescence method. The patterns of both Ca2+- and MG2+-activated ATP hydrolysis resembled each other. Increased enzyme activities were observed during injured states. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600020601
更新日期：1981-02-01 00:00:00
abstract：:A previously reported technique for staining areas of degradation in dental composite restorations was evaluated in 51 removed restorations. The staining reagent was silver nitrate, which penetrated the degraded subsurface as ionic silver and was subsequently developed into colored deposits of metallic silver. Several...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700031201
更新日期：1991-03-01 00:00:00
abstract：:Previous studies suggest that salivary and pulp-derived host enzymes, matrix metalloproteinases (MMPs), may be involved in dentin caries pathogenesis. To study the inhibition of acid-activated human salivary MMPs by non-antimicrobial chemically modified tetracyclines (CMTs), we used a functional activity assay with 12...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800061301
更新日期：2001-06-01 00:00:00
abstract：:The presence and kinetics of bone-resorbing activity in periapical lesions were studied with a rat model system. Lesions were found to expand most rapidly between induction on day 0 and day 15 ("active phase"), with enlargement occurring at a slower rate thereafter (days 20 and 30, "chronic phase"), as assessed by mea...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700100901
更新日期：1991-10-01 00:00:00
abstract：:Studies have shown that prevention of mutans streptococci (MS) colonization in early childhood can lead to prevention of dental decay. In the microbiological part of the present study in Ylivieska, Finland, with 195 mothers with high salivary MS levels, regular maternal use of xylitol chewing gum resulted in a statist...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/00220345000790111201
更新日期：2000-11-01 00:00:00
abstract：:Eugenol, in the 100 percent concentration in commercial use, was applied to a circumscribed area, 3 mm in diameter, of rat labial mucosa for 1 minute. Reaction periods of 15 minutes, 1, 2, 4 and 6 hours were then permitted. Using routine histological procedures for processing the experimental tissues, it was observed ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570110901
更新日期：1978-11-01 00:00:00
