The effect of high sugar intake on the development of periradicular lesions in rats with type 2 diabetes.

Abstract:

:Diabetes mellitus is associated with depression of natural defenses against infection and increases the risk of periodontal disease. However, the effects of diabetes on periradicular tissue, which differs structurally from periodontal tissue, are not known. In this study, we evaluated the effects of type 2 diabetes on the development of periradicular lesions after exposure of the pulp in the left mandibular first molar through the occlusal surface in rats. GK rats with spontaneous non-insulin-dependent diabetes mellitus and Wistar rats (controls) received a normal laboratory diet and either water or a 30% sucrose solution. At both 2 and 4 weeks after pulp exposure, histologic analysis showed that alveolar bone resorption was most severe and the periradicular lesions were largest in diabetic rats given the sucrose solution. These results suggest that the metabolic conditions produced by type 2 diabetes enhance the development of periradicular lesions in rats.

journal_name

J Dent Res

authors

Iwama A,Nishigaki N,Nakamura K,Imaizumi I,Shibata N,Yamasaki M,Nakamura H,Kameyama Y,Kapila Y

doi

10.1177/154405910308200416

keywords:

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

322-5

issue

4

eissn

0022-0345

issn

1544-0591

journal_volume

82

pub_type

杂志文章
  • A major gene effect controls resistance to caries.

    abstract::Despite recent advances revealing genetic factors influencing caries susceptibility, questions regarding the model of inheritance involved are yet to be addressed. We conducted a Complex Segregation Analysis on decayed teeth in a sample of homogenous, isolated families recruited from the Brazilian Amazon. A dominant, ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034510397614

    authors: Werneck RI,Lázaro FP,Cobat A,Grant AV,Xavier MB,Abel L,Alcaïs A,Trevilatto PC,Mira MT

    更新日期:2011-06-01 00:00:00

  • The measurement of the effect of toothbrushes on soft tissue abrasion.

    abstract::The effect of toothbrushes on soft tissue abrasion was measured using hamster cheek pouch tissue brushed mechanically for various intervals. The detection of protein removed during brushing was used as an index of tissue abrasion. The method was found to be sensitive in detecting the effects of brush load, number of s...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345770560070301

    authors: Alexander JF,Saffir AJ,Gold W

    更新日期:1977-07-01 00:00:00

  • The surface free energy of oral streptococci after being coated with saliva and its relation to adhesion in the mouth.

    abstract::Contact angle measurements on layers of bacteria were used to determine the bacterial surface free energy (gamma b) of a variety of oral streptococcal strains, both without and after being coated with human whole saliva. At least four isolates of each species, either freshly isolated or laboratory strains, were used. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345850640100501

    authors: Weerkamp AH,van der Mei HC,Busscher HJ

    更新日期:1985-10-01 00:00:00

  • Intra-oral models to assess cariogenicity: evaluation of oral fluoride and pH.

    abstract::The main purpose of this paper is to review the various methods used for evaluation of fluoride retention in saliva, plaque, and enamel following application of topical anti-caries treatments such as F dentifrices and F mouthwashes. Such methods monitor delivery of fluoride to the site of action, the mouth, and so can...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/002203459207100S29

    authors: Duckworth RM,Gilbert RJ

    更新日期:1992-04-01 00:00:00

  • Water aging reverses residual stresses in hydrophilic dental composites.

    abstract::Dental composites develop residual stresses during polymerization due to shrinkage. These stresses may change with time because of relaxation and water sorption in the oral environment. This phenomenon is likely dependent on the composition of the materials, specifically their hydrophilic characteristics, and could re...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034513513905

    authors: Park JW,Ferracane JL

    更新日期:2014-02-01 00:00:00

  • Effects of eugenol on polymorphonuclear cell migration and chemiluminescence.

    abstract::In this study, the effects of eugenol on human polymorphonuclear (PMN) cell migration and chemiluminescence were examined in vitro. Utilizing zymosan-activated serum or crude Bacteroides sonicate fractions as chemotractants, we found that eugenol inhibits PMN migration at 6.6 X 10(-2) to 6.6 X 10(-5) mol/L (P less tha...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345870660031401

    authors: Fotos PG,Woolverton CJ,Van Dyke K,Powell RL

    更新日期:1987-03-01 00:00:00

  • A new approach to the study of tooth wear.

    abstract::Human tooth wear occurs so slowly that traditionally it has needed months or years to be measurable. This study showed that microscopic changes in wear patterns on human teeth could be detected in a matter of days and could be used as indicators of rates of wear. Thus, daily or weekly changes in rates of wear can be d...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345910700030901

    authors: Teaford MF,Tylenda CA

    更新日期:1991-03-01 00:00:00

  • Identification of Bacteroides forsythus in subgingival dental plaque with the aid of a rapid PCR method.

    abstract::Bacteroides forysthus has been shown to be prevalent among patients with periodontitis. Conventional microbiological methods used to identify this bacterium, however, are laborious and time-consuming and are therefore not well-suited for screening purposes. We have developed a polymerase chain-reaction (PCR) method wh...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345970760070701

    authors: Meurman JH,Wahlfors J,Korhonen A,Alakuijala P,Väisänen P,Torkko H,Jänne J

    更新日期:1997-07-01 00:00:00

  • Osterix regulates tooth root formation in a site-specific manner.

    abstract::Bone and dentin share similar biochemical compositions and physiological properties. Dentin, a major tooth component, is formed by odontoblasts; in contrast, bone is produced by osteoblasts. Osterix (Osx), a zinc finger-containing transcription factor, has been identified as an essential regulator of osteoblast differ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034514565647

    authors: Kim TH,Bae CH,Lee JC,Kim JE,Yang X,de Crombrugghe B,Cho ES

    更新日期:2015-03-01 00:00:00

  • Epigenetic Modifications of Histones in Periodontal Disease.

    abstract::Periodontitis is a chronic infectious disease driven by dysbiosis, an imbalance between commensal bacteria and the host organism. Periodontitis is a leading cause of tooth loss in adults and occurs in about 50% of the US population. In addition to the clinical challenges associated with treating periodontitis, the pro...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515611876

    authors: Martins MD,Jiao Y,Larsson L,Almeida LO,Garaicoa-Pazmino C,Le JM,Squarize CH,Inohara N,Giannobile WV,Castilho RM

    更新日期:2016-02-01 00:00:00

  • 4-META opaque resin--a new resin strongly adhesive to nickel-chromium alloy.

    abstract::1) A new adhesive opaque resin containing a reactive monomer, 4-methacryloxy-ethyl trimellitate anhydride (4-META), was prepared, and its application to thermosetting acrylic resin veneer crowns was studied. 2) The 4-META opaque resin was applied to a variety of nickel-chromium dental alloy specimens which had undergo...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345810600091101

    authors: Tanaka T,Nagata K,Takeyama M,Atsuta M,Nakabayashi N,Masuhara E

    更新日期:1981-09-01 00:00:00

  • Clonal persistence of oral Fusobacterium nucleatum in infancy.

    abstract::Once established, early-colonizing bacterial species tend to persist in the mouth. To obtain detailed information on the population dynamics of early-colonizing oral anaerobes, we examined the clonal diversity and persistence of clones among oral Fusobacterium nucleatum populations during the first 2 yrs of life. Cons...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910408300613

    authors: Haraldsson G,Holbrook WP,Könönen E

    更新日期:2004-06-01 00:00:00

  • Increased wall-to-wall curing contraction in thin bonded resin layers.

    abstract::Wall-to-wall (WTW) polymerization contraction of filled and unfilled chemically and photo-initiated resins was studied in relation to the WTW distance. In an experimental set-up, the resins were bonded to two opposing disks, and the axial (WTW) displacement resulting from the polymerization shrinkage was measured cont...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345890680010701

    authors: Feilzer AJ,De Gee AJ,Davidson CL

    更新日期:1989-01-01 00:00:00

  • Transcriptome Reveals Cathepsin K in Periodontal Ligament Differentiation.

    abstract::Periodontal ligaments (PDLs) play an important role in remodeling the alveolar bond and cementum. Characterization of the periodontal tissue transcriptome remains incomplete, and an improved understanding of PDL features could aid in developing new regenerative therapies. Here, we aimed to generate and analyze a large...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034516645796

    authors: Yamada S,Ozaki N,Tsushima K,Yamaba S,Fujihara C,Awata T,Sakashita H,Kajikawa T,Kitagaki J,Yamashita M,Yanagita M,Murakami S

    更新日期:2016-08-01 00:00:00

  • Clustering tooth surfaces into biologically informative caries outcomes.

    abstract:UNLABELLED:Dental caries affects most adults worldwide; however, the risk factors for dental caries do not necessarily exert their effects uniformly across all tooth surfaces. Instead, the actions of some risk factors may be limited to a subset of teeth/surfaces. Therefore, we used hierarchical clustering on tooth surf...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034512463241

    authors: Shaffer JR,Feingold E,Wang X,Weeks DE,Weyant RJ,Crout R,McNeil DW,Marazita ML

    更新日期:2013-01-01 00:00:00

  • Effects of craniofacial structures on mouse palatal closure in vitro.

    abstract::Heads of Swiss-Webster mouse fetuses of four ages spanning days 12-13 of gestation, were partially dissected by removing the brain (B), tongue (T) and mandible (M) alone or in combination (BT, BM, BTM). Preparations were suspended in a gassed, circulating culture system such that palatal closure must take place agains...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345780570024401

    authors: Brinkley L,Basehoar G,Avery J

    更新日期:1978-02-01 00:00:00

  • Patterns of enamel maturation.

    abstract::Investigations of the maturation pattern of rat incisor enamel by quantitative electron microscopy and electron-probe microanalysis indicate that mineralization of rat enamel can be regarded, as in humans, as a regular and progressive process pattern of enamel matrix formation. The species variations that have been pr...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345790580024201

    authors: Glick PL

    更新日期:1979-03-01 00:00:00

  • Enamel demineralization and the length of intra-oral exposure to different concentrations of glucose or sucrose.

    abstract::Six subjects wore intra-oral devices carrying eight bovine enamel blocks which were covered with a layer of S. mutans. They rinsed their mouths for five sec, one min, or multiples of one min with a 5 or 10% glucose (G) solution. Demineralization was measured after 45 min by determining the change in iodide permeabilit...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345860650021001

    authors: Tehrani A,Goulet D,Brudevold F,Attarzadeh F

    更新日期:1986-02-01 00:00:00

  • Dentists' judgment strategies on prophylactic removal of mandibular third molars.

    abstract::The number of molars selected for prophylactic removal varies widely among general dental practitioners and oral surgeons. To understand the basis for such variations, we investigated two hypotheses: (1) Individual judgment strategies will differ concerning the use of cues (items of information), and (2) few dentists ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345000790121101

    authors: Knutsson K,Lysell L,Rohlin M

    更新日期:2000-12-01 00:00:00

  • Relationship among mutans streptococci, "low-pH" bacteria, and lodophilic polysaccharide-producing bacteria in dental plaque and early enamel caries in humans.

    abstract::Multiple interactions occur among major determinants of dental caries. We have studied the bacterial flora and pH-lowering capacity of the same dental plaques in relation to caries. The findings on the plaque flora are reported here. The buccal surfaces of upper teeth in each subject were selected for study. A low-car...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345000790021201

    authors: van Ruyven FO,Lingström P,van Houte J,Kent R

    更新日期:2000-02-01 00:00:00

  • Chemical and molecular weight analyses of prosthodontic soft polymers.

    abstract::A number of studies have been made investigating the properties of dental prosthodontic soft polymer materials. In such materials, which are used as short-term denture soft liners, the polymer component is complexed with one or more plasticizers. This lowers the glass transition temperature, Tg, of the polymer by allo...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345910700050201

    authors: Jones DW,Hall GC,Sutow EJ,Langman MF,Robertson KN

    更新日期:1991-05-01 00:00:00

  • Hard tissue formation in subcutaneously transplanted rat dental pulp.

    abstract::While dental pulp appears to be able to form mineralized matrices that do not always resemble dentin, the precise characteristics of the hard tissue and the mechanism of its induction remain unknown. Therefore, we evaluated hard tissue induced by transplantation of pulp into subcutaneous tissue. Seven days after trans...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910708600515

    authors: Hosoya A,Nakamura H,Ninomiya T,Hoshi K,Yoshiba K,Yoshiba N,Takahashi M,Okabe T,Sahara N,Yamada H,Kasahara E,Ozawa H

    更新日期:2007-05-01 00:00:00

  • Root surface caries in the molar teeth of rice rats. II. Quantitation of lesions induced by high sucrose diet.

    abstract::Weanling rice rats were fed either standard laboratory chow or Diet 2000. The animals were sacrificed at 4, 8, 12, and 15 weeks. There was an increasing amount of exposed root surface and root surface caries with age in the animals fed Diet 2000. There was exposed root surface but no caries in the animals fed laborato...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345770560091701

    authors: Doff RS,Rosen S,App G

    更新日期:1977-09-01 00:00:00

  • The formation and remineralization of artificial white spot lesions: a constant composition approach.

    abstract::Artificial white spot lesions have been prepared on bovine enamel surfaces by the controlled addition of lactate buffer containing methylhydroxydiphosphonate ions. The rates of remineralization have been measured using a constant composition method in solutions of calcium phosphate of low supersaturation. Deposition o...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345840630061001

    authors: de Rooij JF,Nancollas GH

    更新日期:1984-06-01 00:00:00

  • Experimental ridge augmentation with porous hydroxyapatite implants.

    abstract::A new hydroxyapatite ceramic implant material for restoration of atrophic edentulous ridges was tested in a canine animal model. The structure of this material is unique, in that it is produced from the skeleton of a coral, and in that it is penetrated by a uniform network of interconnected pores. Results indicate tha...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345830620021301

    authors: Piecuch JF,Topazian RG,Skoly S,Wolfe S

    更新日期:1983-02-01 00:00:00

  • The control of morphogenesis in Candida albicans.

    abstract::Morphogenesis (germ-tube formation) in Candida albicans was induced gratuitously by N-acetylhexosamine derivatives (N-acetyl-glucosamine covalently linked to agarose, N-acetylmannosamine, hyaluronic acid, colloidal chitin, and mucin). These compounds were not taken up by the yeast cells and did not support growth. 2-D...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345840630031501

    authors: Shepherd MG,Sullivan PA

    更新日期:1984-03-01 00:00:00

  • Compressive viscoelastic properties of human dentin: I. Stress-relaxation behavior.

    abstract::Stress-relaxation measurements were performed on specimens of radicular human dentin. The relaxation modulus showed a linear dependence on the logarithm of time and the approximation to the logarithmic distribution function of relaxation times was used to predict the behavior of other viscoelastic properties. This exp...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345750540061801

    authors: Duncanson MG Jr,Korostoff E

    更新日期:1975-11-01 00:00:00

  • Interaction of glass-ionomer cements with moist dentin.

    abstract::Glass-ionomer cements (GICs) are regarded as aqueous gels made up of polyalkenoic acid salts containing ion-leachable glass fillers. The consequence of water permeation across the GIC-dentin interface is unknown. This study used SEM, field-emission/environmental SEM (FE-ESEM), and TEM to examine the ultrastructure of ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910408300403

    authors: Yiu CK,Tay FR,King NM,Pashley DH,Sidhu SK,Neo JC,Toledano M,Wong SL

    更新日期:2004-04-01 00:00:00

  • "Gum bug, leave my heart alone!"--epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis.

    abstract::Evidence from epidemiologic studies suggests that periodontal infections are independently associated with subclinical and clinical atherosclerotic vascular disease. Although the strength of the reported associations is modest, the consistency of the data across diverse populations and a variety of exposure and outcom...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/0022034510375281

    authors: Kebschull M,Demmer RT,Papapanou PN

    更新日期:2010-09-01 00:00:00

  • The effect of rotary instrumentation on the permeability of dentin.

    abstract::The filtration and diffusion of tritiated water through dentin disks were measured ina split-chamber diffusion cell. The dentin had been cut with a diamond disk and the surfaces modified with a carbide fissure bur or diamond bur. Disks were given a secondary burnishing treatment with a blank bur or a modified blank bu...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345810600061101

    authors: Boyer DB,Svare CW

    更新日期:1981-06-01 00:00:00