Abstract:
:While dental pulp appears to be able to form mineralized matrices that do not always resemble dentin, the precise characteristics of the hard tissue and the mechanism of its induction remain unknown. Therefore, we evaluated hard tissue induced by transplantation of pulp into subcutaneous tissue. Seven days after transplantation, initial hard tissue was formed at the inner periphery of the pulp. After 14 days, this hard tissue expanded inwardly. Mineralized matrix was immunopositive for osteocalcin, osteopontin, and bone sialoprotein, but negative for dentin sialoprotein. Transplantation of GFP-labeled pulp into wild-type rats showed these formative cells to have been derived from the transplant. TEM observation revealed apatite crystals within necrotic cells and matrix vesicles at the initial stage of calcification. These results indicate that pulp cells possess the ability to form a bone- or cementum-like matrix. Calcification of the matrix may occur in necrotic cells and matrix vesicles, followed by collagenous calcification.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Hosoya A,Nakamura H,Ninomiya T,Hoshi K,Yoshiba K,Yoshiba N,Takahashi M,Okabe T,Sahara N,Yamada H,Kasahara E,Ozawa Hdoi
10.1177/154405910708600515subject
Has Abstractpub_date
2007-05-01 00:00:00pages
469-74issue
5eissn
0022-0345issn
1544-0591pii
86/5/469journal_volume
86pub_type
杂志文章abstract::The acquired enamel pellicle is an oral, fluid-derived protein layer that forms on the tooth surface. It is a biologically and clinically important integument that protects teeth against enamel demineralization, and abrasion. Tooth surfaces are exposed to different proteinaceous microenvironments depending on the enam...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034516680771
更新日期:2017-04-01 00:00:00
abstract::The purpose of the study was to determine the exposure times needed to harden a light-activated composite cement through various thicknesses of porcelain. A negative exponential model was developed with which the relative hardness of a composite could be predicted from the product of the exposure time and the square r...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680030801
更新日期:1989-03-01 00:00:00
abstract::Previous studies have indicated that tooth-bleaching agents contain potentially hazardous chemicals. The present study evaluates the acute toxicity of a commercially available tooth-bleaching agent and carbamide peroxide, which is the active bleaching ingredient. Rats were dosed by stomach gavage, i.e., via a stomach ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345950740021401
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abstract::Previous studies of tooth size in twins and their families have suggested a high degree of genetic control, although there have been difficulties separating the various genetic and environmental effects. A genetic analysis of variation in crown size of the permanent incisors of South Australian twins was carried out, ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345950740071101
更新日期:1995-07-01 00:00:00
abstract::Previously, in vitro differentiation of odontoblasts was shown for dental pulp stem cells (DPSCs) transfected with bone morphogenetic protein-2 (Bmp2). For this study, we hypothesized that such cells also show potential for mineralized tissue formation in vivo. DPSCs were transfected with Bmp2 and seeded onto a cerami...
journal_title:Journal of dental research
pub_type: 杂志文章
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更新日期:2009-11-01 00:00:00
abstract::Cytotoxicity of fine cut amalgam was persistent until 24 hours after trituration in vitro, whereas cytotoxicity of spherical amalgam diminished more quickly. Increasing mercury content in spherical amalgam increased cytotoxicity. Possible reactions for the diminution of cytotoxicity of amalgams with time are discussed...
journal_title:Journal of dental research
pub_type: 杂志文章
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更新日期:1975-03-01 00:00:00
abstract::There are no prospective studies investigating the effects of sugar-related feeding practices on changes in dental caries from early childhood to young adulthood. The aim of this study was to assess whether sugar-related feeding practices affect dental caries between the ages of 6 and 18 y. This birth cohort study was...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515625907
更新日期:2016-04-01 00:00:00
abstract::Three strain combinations of in-bred mice representing strong and moderate histocompatibility barriers were used to determine if tooth allotransplants evoked strong or weak immunologic memory as measured by the second-set donor-strain skin graft technique. At issue was whether the anatomic site of engraftment could in...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630010901
更新日期:1984-01-01 00:00:00
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journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345820610030801
更新日期:1982-03-01 00:00:00
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journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570021501
更新日期:1978-02-01 00:00:00
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journal_title:Journal of dental research
pub_type: 历史文章,杂志文章
doi:10.1177/00220345880670051701
更新日期:1988-05-01 00:00:00
abstract::Periodontitis is a chronic inflammatory disease affecting oral tissues. The continuous, high production of cytokines by host cells triggered by periodontopathogens is thought to be responsible for the destruction of tooth-supporting tissues. Macrophages play a critical role in this host inflammatory response to period...
journal_title:Journal of dental research
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doi:10.1177/154405910608500306
更新日期:2006-03-01 00:00:00
abstract::The aim of this study was to compare the effectiveness of dexamethasone administration following arthrocentesis of the temporomandibular joint (TMJ) with a placebo (saline). Twenty-eight participants with TMJ arthralgia were randomly assigned to two groups of a parallel double-blind RCT. In both groups, an arthrocente...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/0022034511431260
更新日期:2012-02-01 00:00:00
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journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345010800120501
更新日期:2001-12-01 00:00:00
abstract::It is shown that the creep behavior of a commercial dispersant-amalgam containing copper is improved by the addition of a manganese-containing alloy. This improvement is apparently obtained without any serious changes in corrosion resistance, provided that no more than 20% of the Mn alloy is added. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570090601
更新日期:1978-09-01 00:00:00
abstract::The inhibitory activity of 2-phosphono-butane 1,2,4 tricarboxylic acid (PBTA) in the formation of hydroxyapatite (HA) was studied in vitro and in vivo. PBTA, at 4 ppm, inhibited the spontaneous formation of HA in vitro from a supersaturated solution. PBTA, at 2 ppm, completely inhibited the crystal growth of HA; at lo...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640011201
更新日期:1985-01-01 00:00:00
abstract::Silver cations generated by passing low intensity direct current through pure silver electrodes were found to be sufficiently antibacterial to cause sterilization of samples of infected dentin. The optimal procedure involved a 5 microA current applied for 20 minutes with the anode then left in contact with the sample....
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570091901
更新日期:1978-09-01 00:00:00
abstract::The effect of a topical fluoride regimen consisting of a four-minute pre-treatment with a saturated dicalcium phosphate dihydrate (DCPD) solution followed by a four-minute application of APF was compared with that of a four-minute application of APF alone with respect to the deposition of fluoride in enamel in an apat...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650030201
更新日期:1986-03-01 00:00:00
abstract::In sham-operated and TPTX animals, F treatment did not affect final body weight, or serum Ca and P. In sham-treated rats, serum iPTH was not affected by F treatment. At the periosteum, F increased bone formation rate and bone and matrix apposition rates. At the endosteum, F treatment decreased forming surface, bone fo...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560031601
更新日期:1977-03-01 00:00:00
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journal_title:Journal of dental research
pub_type: 杂志文章
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journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550052301
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journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560050501
更新日期:1977-05-01 00:00:00
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journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200915
更新日期:2003-09-01 00:00:00
abstract::A sintered hydroxyapatite (HAP) ceramic for use in wear studies was prepared from a commercial tricalcium phosphate. The sintered HAP had physical properties close to those of human enamel. The coefficient of friction and wear of the sintered HAP ceramic as characterized by tangential force, track width, and surface f...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570070401
更新日期:1978-07-01 00:00:00
abstract::Although it has been shown that patients are more satisfied with prostheses supported by implants than with conventional dentures, there have been few direct comparisons of the various designs of implant-supported prostheses. This within-subject crossover clinical trial was designed to compare two forms of removable p...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章
doi:10.1177/00220345970760100901
更新日期:1997-10-01 00:00:00
abstract::Four disclosant dyes were tested for antimicrobial activity against 27 oral reference strains and five non-oral human pathogens. Erythrosine and fluorescein inhibited most gram-positive and gram-negative organisms associated with dental plaque, and were bactericidal to selected strains. Fast green and brilliant blue d...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620071601
更新日期:1983-07-01 00:00:00
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journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514557672
更新日期:2015-01-01 00:00:00
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journal_title:Journal of dental research
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650061401
更新日期:1986-06-01 00:00:00
abstract::This study describes the formation of a calcium polyacrylate-hydroxyapatite cement. Our hypothesis was that calcium phosphates would rapidly hydrolyze in the presence of polyacrylic acid (PAA) to form a cement. PAA, tetracalcium phosphate (TetCP), and dicalcium phosphate (DCP) were reacted together and formed calcium ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345940730030501
更新日期:1994-03-01 00:00:00