Epigenetic Modifications of Histones in Periodontal Disease.

Abstract:

:Periodontitis is a chronic infectious disease driven by dysbiosis, an imbalance between commensal bacteria and the host organism. Periodontitis is a leading cause of tooth loss in adults and occurs in about 50% of the US population. In addition to the clinical challenges associated with treating periodontitis, the progression and chronic nature of this disease seriously affect human health. Emerging evidence suggests that periodontitis is associated with mechanisms beyond bacteria-induced protein and tissue degradation. Here, we hypothesize that bacteria are able to induce epigenetic modifications in oral epithelial cells mediated by histone modifications. In this study, we found that dysbiosis in vivo led to epigenetic modifications, including acetylation of histones and downregulation of DNA methyltransferase 1. In addition, in vitro exposure of oral epithelial cells to lipopolysaccharides resulted in histone modifications, activation of transcriptional coactivators, such as p300/CBP, and accumulation of nuclear factor-κB (NF-κB). Given that oral epithelial cells are the first line of defense for the periodontium against bacteria, we also evaluated whether activation of pathogen recognition receptors induced histone modifications. We found that activation of the Toll-like receptors 1, 2, and 4 and the nucleotide-binding oligomerization domain protein 1 induced histone acetylation in oral epithelial cells. Our findings corroborate the emerging concept that epigenetic modifications play a role in the development of periodontitis.

journal_name

J Dent Res

authors

Martins MD,Jiao Y,Larsson L,Almeida LO,Garaicoa-Pazmino C,Le JM,Squarize CH,Inohara N,Giannobile WV,Castilho RM

doi

10.1177/0022034515611876

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

215-22

issue

2

eissn

0022-0345

issn

1544-0591

pii

0022034515611876

journal_volume

95

pub_type

杂志文章
  • Dental amalgam and antibiotic- and/or mercury-resistant bacteria.

    abstract::Mercury emitted from dental amalgam may select for increased numbers of antibiotic- or mercury-resistant commensal bacteria in patients and increase their risk for bacterial diseases that are resistant to common therapies. We hypothesized that the presence of dental amalgams would increase the level of mercury-, tetra...

    journal_title:Journal of dental research

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/154405910808700502

    authors: Roberts MC,Leroux BG,Sampson J,Luis HS,Bernardo M,Leitão J

    更新日期:2008-05-01 00:00:00

  • Double-layer color effects in porcelain systems.

    abstract::The color of an unshaded body porcelain was determined at three thicknesses on white, gray, and three chromatic backings. Spectral absorption and scattering coefficients of the porcelain were determined from the diffuse reflectance at one thickness on the white and gray backings. These optical coefficients, when utili...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345850640061801

    authors: O'Brien WJ,Johnston WM,Fanian F

    更新日期:1985-06-01 00:00:00

  • Clinical, radiographic, and genetic evaluation of a novel form of autosomal-dominant oligodontia.

    abstract::A frameshift mutation recently identified within the paired domain of the transcription factor, PAX9, has been linked to a unique form of oligodontia in a single, multigenerational family (Stockton et al., 2000). We now describe the phenotypic and segregation analyses of this remarkable kindred, the initial approach t...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345000790070701

    authors: Goldenberg M,Das P,Messersmith M,Stockton DW,Patel PI,D'Souza RN

    更新日期:2000-07-01 00:00:00

  • Fluoride inhibition of polymorphonuclear leukocytes.

    abstract::Significant inhibition of PMN metabolic activity by F- occurred at 0.1, 0.5 and 0.0 mM F- for O2- generation, 1-C14 CO2 release labeled glucose and NBT-reduction respectively. This inhibition resulted primarily from F- suppression of nonoxidative glucose metabolism. As the concentration of F- in the O2- generating sys...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345790580092101

    authors: Gabler WL,Leong PA

    更新日期:1979-09-01 00:00:00

  • Early detection of occlusal caries by measuring the electrical resistance of the tooth.

    abstract::The tooth resistance measuring instrument was compared to the traditional method of the explorer examination for the detection of occlusal carious lesions. The findings of the instrument were more sensitive as compared to the traditional method when verified by a histological examination. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345780570020801

    authors: White GE,Tsamtsouris A,Williams DL

    更新日期:1978-02-01 00:00:00

  • Functional characteristics of atrophic parotid acinar cells from rats after liquid feeding.

    abstract::Rat parotid atrophy, induced by liquid feeding over 10 days, was manifested as gland weight loss (40%) and histologically as acinar shrinkage. Acinar secretory function was investigated in the same glands using enzymatically dispersed cell preparations and superfused gland slices. Results were normalized for the acina...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345940730060901

    authors: Scott J,Gunn DL

    更新日期:1994-06-01 00:00:00

  • Mandibulofacial adaptations in a juvenile animal model of temporomandibular joint arthritis.

    abstract::Juvenile rheumatoid arthritis (JRA) is a chronic systemic disease of childhood that affects synovial joints including the temporomandibular joint (TMJ). Individuals with JRA of the TMJ frequently show aberrations in mandibulofacial development. Since the basis for these developmental perturbations is poorly understood...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345990780080801

    authors: Tavakkoli-Jou M,Miller AJ,Kapila S

    更新日期:1999-08-01 00:00:00

  • Comparative SEM and TEM examination of the ultrastructure of the resin-dentin interdiffusion zone.

    abstract::The resin-dentin interdiffusion zone produced by a dentin-adhesive system that removes the smear layer and concurrently decalcifies superficial dentin was morphologically examined by both scanning and transmission electron microscopy. Cross-sectioned resin-bonded dentin discs were etched with an argon-ion beam to make...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345930720020501

    authors: Van Meerbeek B,Dhem A,Goret-Nicaise M,Braem M,Lambrechts P,VanHerle G

    更新日期:1993-02-01 00:00:00

  • Quantitative changes in amylase activity in the salivary glands, pancreas, saliva, and serum after administration of isoproterenol, pilocarpine, and acetylcholine.

    abstract::Amylase activity in various tissues--i.e., submandibular/sublingual and parotid glands, the pancreas, saliva, and serum--in rats was measured after injection of isoproterenol, pilocarpine, and acetylcholine. All agents reduced amylase activity in the parotid gland and increased the enzyme activity in the submandibular...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345830620011201

    authors: Ikeno T,Nasu J,Kuzuya H

    更新日期:1983-01-01 00:00:00

  • Matrix Gla protein inhibition of tooth mineralization.

    abstract::Extracellular matrix (ECM) mineralization is regulated by mineral ion availability, proteins, and other molecular determinants. To investigate protein regulation of mineralization in tooth dentin and cementum, and in alveolar bone, we expressed matrix Gla protein (MGP) ectopically in bones and teeth in mice, using an ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910808700907

    authors: Kaipatur NR,Murshed M,McKee MD

    更新日期:2008-09-01 00:00:00

  • Antigens and surface components associated with virulence of Actinomyces viscosus.

    abstract::We have isolated a specific cell wall antigen of high molecular weight which appears to be unique to virulent strains of A viscosus and A naeslundii. The antigen is composed of two parts: a polysaccharide moiety containing 6-DOT as the major sugar and determinant of serologic specificity, and a small peptide bearing s...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/002203457605500111011

    authors: Hammond BF,Steel CF,Peindl KS

    更新日期:1976-01-01 00:00:00

  • Site-specific expression of collagen I and XII mRNAs in the rat periodontal ligament at two developmental stages.

    abstract::In mammals, the periodontal ligament (PDL) is a highly specialized tissue which facilitates tooth eruption and lends mechanical support to the tooth once in occlusion. The PDL extracellular matrix fibers play a major role in such functions. During its development, the spatial arrangement of the PDL extracellular matri...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345920710070201

    authors: Karimbux NY,Rosenblum ND,Nishimura I

    更新日期:1992-07-01 00:00:00

  • Transport of sugars, including sucrose, by the msm transport system of Streptococcus mutans.

    abstract::The range of substrates transported by the sugar-binding protein-dependent msm (multiple sugar metabolism) system of S. mutans was investigated. By determining the ability of unlabeled sugar to compete with radiolabeled melibiose transport, we have demonstrated that the transported sugars included a number of carbohyd...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345930720100701

    authors: Tao L,Sutcliffe IC,Russell RR,Ferretti JJ

    更新日期:1993-10-01 00:00:00

  • Disrupted IRF6-NME1/2 Complexes as a Cause of Cleft Lip/Palate.

    abstract::Mutations and common polymorphisms in interferon regulatory factor 6 ( IRF6) are associated with both syndromic and nonsyndromic forms of cleft lip/palate (CLP). To date, much of the focus on this transcription factor has been on identifying its direct targets and the gene regulatory network in which it operates. Nota...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034517723615

    authors: Parada-Sanchez MT,Chu EY,Cox LL,Undurty SS,Standley JM,Murray JC,Cox TC

    更新日期:2017-10-01 00:00:00

  • Capsaicin-induced muscle pain alters the excitability of the human jaw-stretch reflex.

    abstract::The pathophysiology of painful temporomandibular disorders is not fully understood, but evidence suggests that muscle pain modulates motor function in characteristic ways. This study tested the hypothesis that activation of nociceptive muscle afferent fibers would be linked to an increased excitability of the human ja...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910208100915

    authors: Wang K,Arendt-Nielsen L,Svensson P

    更新日期:2002-09-01 00:00:00

  • Self-perceived oral health status, psychological well-being, and life satisfaction in an older adult population.

    abstract::Numerous studies have demonstrated that many older adults have problems chewing, pain, difficulties in eating, and problems in social relationships because of oral disorders. However, it is not clear if these functional and psychosocial outcomes affect broader psychological well-being and life satisfaction. Consequent...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345000790041301

    authors: Locker D,Clarke M,Payne B

    更新日期:2000-04-01 00:00:00

  • Impact of Age on Disease Progression and Microenvironment in Oral Cancer.

    abstract::Despite the recognized link between aging and cancer, most preclinical studies in experimental tumor models are conducted with 6- to 8-wk-old rodents. The goal of the present study was to examine the impact of age on tumor incidence, growth, and microenvironmental characteristics in mouse models of head and neck squam...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034518775736

    authors: Vincent-Chong VK,DeJong H,Rich LJ,Patti A,Merzianu M,Hershberger PA,Seshadri M

    更新日期:2018-10-01 00:00:00

  • Carbon nanotubes: directions and perspectives in oral regenerative medicine.

    abstract::One of the main goals of bone tissue engineering is to identify and develop new biomaterials and scaffolds for structural support and controlled cell growth, which allow for formation or replacement of bone tissue. Recently, carbon nanotubes (CNT) have emerged as a potential candidate for bone tissue engineering. CNT ...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/0022034513490957

    authors: Martins-Júnior PA,Alcântara CE,Resende RR,Ferreira AJ

    更新日期:2013-07-01 00:00:00

  • Fibroblastic subpopulations in uninjured and wounded rabbit oral mucosa.

    abstract::Fibroblast cultures derived from uninjured and reparative rabbit buccal mucosa were compared in terms of extracellular glycosaminoglycan (GAG) content and cellular response to interleukin-1 (IL-1). Under identical growth conditions, proliferation of both cell lines was the same. Both lines incorporated [3H]-glucosamin...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345890680010801

    authors: Bronson RE,Treat JA,Bertolami CN

    更新日期:1989-01-01 00:00:00

  • Nitric oxide signaling contributes to ectopic orofacial neuropathic pain.

    abstract::Inferior alveolar nerve (IAN) injury induces persistent ectopic pain which spreads to a wide area in the orofacial region. Its exact mechanism remains unclear. We investigated the involvement of nitric oxide (NO) in relation to ectopic orofacial pain caused by IAN transection (IANX). We assessed the changes in mechani...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034513509280

    authors: Sugiyama T,Shinoda M,Watase T,Honda K,Ito R,Kaji K,Urata K,Lee J,Ohara K,Takahashi O,Echizenya S,Iwata K

    更新日期:2013-12-01 00:00:00

  • Host response in experimental periodontal disease.

    abstract::Experiments were performed to determine the role of the immune response in rat periodontal disease. Germ-free rats were fed defined antigen-free liquid diets or a diet containing ovalbumin(OVA) as a prototype antigen. The OVA-fed rats demonstrated increased gingival lymphocytes (mainly T at early times), OVA-sensitize...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345840630031801

    authors: Taubman MA,Yoshie H,Ebersole JL,Smith DJ,Olson CL

    更新日期:1984-03-01 00:00:00

  • Comparative anatomic study of mandibular growth in rats after bilateral resections of superficial masseter, posterior temporal, and anterior digastric muscles.

    abstract::Bilateral resections of the superficial masseter, posterior temporal, and anterior digastric muscles of rats were done to determine their effects on mandibular growth. The macroscopic findings support the functional matrix theory of mandibular growth. The analysis of body weight and the statistical two-way analysis of...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345760550052301

    authors: Lifshitz J

    更新日期:1976-09-01 00:00:00

  • Veneer vs. core failure in adhesively bonded all-ceramic crown layers.

    abstract::Joining a brittle veneer to a strong ceramic core with an adhesive offers potential benefits over current fabrication methods for all-ceramic crowns. We tested the hypothesis that such joining can withstand subsurface radial cracking in the veneer, from enhanced flexure in occlusal loading, as well as in the core. Cri...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910808700408

    authors: Lee JJ,Kwon JY,Bhowmick S,Lloyd IK,Rekow ED,Lawn BR

    更新日期:2008-04-01 00:00:00

  • A study of in vivo fluoride uptake by dental tissues from fluoride-containing silver amalgams.

    abstract::Teeth to be extracted for orthodontic reasons were filled in vivo with regular and fine-cut silver amalgams containing 1% and 5% SnF2. The teeth were extracted after 15 or 30 d, and the in vivo fluoride release and uptake by the dental tissues were studied using an electron microprobe analysis technique. The obtained ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345810600020101

    authors: Souganidis DJ,Athanassouli TM,Papastathopoulos DS

    更新日期:1981-02-01 00:00:00

  • Vitamin D and periodontal health in older men.

    abstract::Vitamin D, an anti-inflammatory mediator, has potential benefits for physical and oral health. Although it is produced endogenously, some individuals have a greater need for dietary and supplemental sources. This repeated-measures cross-sectional study assessed associations between total vitamin D intake and periodont...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034513495239

    authors: Alshouibi EN,Kaye EK,Cabral HJ,Leone CW,Garcia RI

    更新日期:2013-08-01 00:00:00

  • Metabolism of gingival collagen in a rat.

    abstract::The remodeling of gingival tissue was measured by determining the incorporation of tritiated proline and the disappearance of tritium activity from proline and hydroxyproline for 18 days after administration of label. There was a rapid decrease in the tritium activity from gingiva which was paralleled by a decrease in...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345780570023101

    authors: Orlowski WA

    更新日期:1978-02-01 00:00:00

  • Prevalence and need for replacement of amalgam and composite restorations in Dutch adults.

    abstract::In 1986, the first nationwide epidemiological survey of adult oral health and attitudes to oral health care was carried out in The Netherlands. One of the aims of this study was to evaluate the prevalence and the quality (in terms of need for replacement) of amalgam and composite restorations in the Dutch adult popula...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345900690060901

    authors: Kroeze HJ,Plasschaert AJ,van 't Hof MA,Truin GJ

    更新日期:1990-06-01 00:00:00

  • microRNA-21 Contributes to Orthodontic Tooth Movement.

    abstract::microRNAs could be mechanosensitive and emerge as critical posttranscriptional regulators in the bone-remodeling process. During orthodontic tooth movement (OTM), the application of mechanical force induces alveolar bone remodeling, but whether microRNAs respond to orthodontic force and contribute to OTM is unknown. m...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034516657043

    authors: Chen N,Sui BD,Hu CH,Cao J,Zheng CX,Hou R,Yang ZK,Zhao P,Chen Q,Yang QJ,Jin Y,Jin F

    更新日期:2016-11-01 00:00:00

  • The Microbiome in Populations with a Low and High Prevalence of Caries.

    abstract::The oral microbiota was compared between Romanian adolescents with a high prevalence of caries and no dental care and Swedish caries-active and caries-free adolescents in caries prevention programs and with a low prevalence of caries. Biofilm samples were analyzed by FLX+ pyrosequencing of the V1 to V4 hypervariable r...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515609554

    authors: Johansson I,Witkowska E,Kaveh B,Lif Holgerson P,Tanner AC

    更新日期:2016-01-01 00:00:00

  • Etching patterns of Co-Cr alloys for bonded cast restorations.

    abstract::Resin-bonded bridges may replace missing teeth and act as splints in periodontal treatment. The objective of this study was to investigate the etch pattern after electrolytic etching of selected Co-Cr alloys in hydrochloric acid and to assess the changes in alloy composition after different etching times. The alloys i...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345870660091301

    authors: Ekstrand K,Ruyter IE

    更新日期:1987-09-01 00:00:00