Epigenetic Modifications of Histones in Periodontal Disease.

abstract：:Periodontal disease is a bacterial infection that results in inflammatory destruction of tissues that support the teeth, including connective tissue and bone. In this study, we report that transgenic mice that overexpress the 17-kDa form of IL-1alpha in the basal layer of oral mucosal epithelium develop a syndrome tha...

journal_title：Journal of dental research

authors： Dayan S,Stashenko P,Niederman R,Kupper TS

更新日期：2004-10-01 00:00:00

abstract：:The number of molars selected for prophylactic removal varies widely among general dental practitioners and oral surgeons. To understand the basis for such variations, we investigated two hypotheses: (1) Individual judgment strategies will differ concerning the use of cues (items of information), and (2) few dentists ...

journal_title：Journal of dental research

authors： Knutsson K,Lysell L,Rohlin M

更新日期：2000-12-01 00:00:00

abstract：:Fibroblast cultures derived from uninjured and reparative rabbit buccal mucosa were compared in terms of extracellular glycosaminoglycan (GAG) content and cellular response to interleukin-1 (IL-1). Under identical growth conditions, proliferation of both cell lines was the same. Both lines incorporated [3H]-glucosamin...

journal_title：Journal of dental research

authors： Bronson RE,Treat JA,Bertolami CN

更新日期：1989-01-01 00:00:00

abstract：:Since edentate subjects have a reduced masticatory function, it can be expected that the morphology of the cancellous bone of their mandibular condyles has changed according to the altered mechanical environment. In the present study, the morphology of cylindrical cancellous bone specimens of the mandibular condyles o...

journal_title：Journal of dental research

authors： Giesen EB,Ding M,Dalstra M,van Eijden TM

更新日期：2004-03-01 00:00:00

abstract：:The cariostatic benefit from water fluoridation is indisputable, but the knowledge of possible adverse effects on bone and fracture risk due to fluoride exposure is ambiguous. The association between long-term (chronic) drinking water fluoride exposure and hip fracture (ICD-7-9: '820' and ICD-10: 'S72.0-S72.2') was as...

journal_title：Journal of dental research

authors： Näsman P,Ekstrand J,Granath F,Ekbom A,Fored CM

更新日期：2013-11-01 00:00:00

abstract：:The oral microbiome consists of a planktonic microbiome residing in saliva and an adhering microbiome (the biofilm adhering to oral hard and soft tissues). Here we hypothesized that possible differences in microbial composition of the planktonic and adhering oral microbiome on teeth can be related to the forces by whi...

journal_title：Journal of dental research

authors： Wessel SW,Chen Y,Maitra A,van den Heuvel ER,Slomp AM,Busscher HJ,van der Mei HC

更新日期：2014-01-01 00:00:00

abstract：:Occlusal alterations may result in changes in the functional performance of masticatory muscles. In this study, we set up an experimental model in rats to examine whether masticatory muscle abnormalities occur after a malocclusion is induced. Rats underwent unilateral amputation of the molar cusps to simulate an occlu...

journal_title：Journal of dental research

authors： Bani D,Bani T,Bergamini M

更新日期：1999-11-01 00:00:00

abstract：:A number of studies have been made investigating the properties of dental prosthodontic soft polymer materials. In such materials, which are used as short-term denture soft liners, the polymer component is complexed with one or more plasticizers. This lowers the glass transition temperature, Tg, of the polymer by allo...

journal_title：Journal of dental research

authors： Jones DW,Hall GC,Sutow EJ,Langman MF,Robertson KN

更新日期：1991-05-01 00:00:00

abstract：:Primary cilia regulate several developmental processes and mediate hedgehog signaling. To study their roles in cranial base development, we created conditional mouse mutants deficient in Polaris, a critical primary cilium component, in cartilage. Mutant post-natal cranial bases were deformed, and their synchondrosis g...

journal_title：Journal of dental research

authors： Ochiai T,Nagayama M,Nakamura T,Morrison T,Pilchak D,Kondo N,Hasegawa H,Song B,Serra R,Pacifici M,Koyama E

更新日期：2009-06-01 00:00:00

abstract：:Molecular studies indicate that epigenetic events are important in determining how the internal enamel epithelium folds during odontogenesis. Since this process of folding leads to the subsequent arrangement of cusps on molar teeth, we hypothesized that intercuspal distances of human molar teeth would display greater ...

journal_title：Journal of dental research

authors： Townsend G,Richards L,Hughes T

更新日期：2003-05-01 00:00:00

abstract：:Hereditary diseases affecting the skeleton are heterogeneous in etiology and severity. Though many of these conditions are individually rare, the total number of people affected is great. These disorders often include dental-oral-craniofacial (DOC) manifestations, but the combination of the rarity and lack of in-depth...

journal_title：Journal of dental research

authors： Foster BL,Ramnitz MS,Gafni RI,Burke AB,Boyce AM,Lee JS,Wright JT,Akintoye SO,Somerman MJ,Collins MT

更新日期：2014-07-01 00:00:00

abstract：:Previous reports have linked the prevalence of tooth abnormalities with high caries experience in the different types of epidermolysis bullosa (EB). However, it is not known to what extent the apparent susceptibility to enamel caries is due to disease-related altered enamel chemistry in these cases. The aim of this st...

journal_title：Journal of dental research

authors： Kirkham J,Robinson C,Strafford SM,Shore RC,Bonass WA,Brookes SJ,Wright JT

更新日期：1996-09-01 00:00:00

abstract：:Mesenchymal stem cells isolated from different dental tissues have been described to have osteogenic/odontogenic-like differentiation capacity, but little attention has been paid to the biochemical composition of the material that each produces. Here, we used Raman spectroscopy to analyze the mineralized materials pro...

journal_title：Journal of dental research

authors： Volponi AA,Gentleman E,Fatscher R,Pang YW,Gentleman MM,Sharpe PT

更新日期：2015-11-01 00:00:00

abstract：:We have previously reported the clinical and radiographic findings of a trial in dogs of a new dental implant system after a functional period of eight months. The present report consists of the corresponding qualitative and quantitative histological data. The implant system was fabricated from Ti-6A1-4V and employed ...

journal_title：Journal of dental research

authors： Deporter DA,Watson PA,Pilliar RM,Howley TP,Winslow J

更新日期：1988-09-01 00:00:00

abstract：:The effect of different doses of polyadenylic and polyuridylic acids (poly A:U) was studied in control rats and in rats exposed to hypoxia. In the control rats, administration of different doses of poly A:U did not change the thickness of the epiphyseal plate or increase the incorporation of 3H-phenylalanine as judged...

journal_title：Journal of dental research

authors： Koo CS,Kim MK,Han SS

更新日期：1976-07-01 00:00:00

abstract：:Significant differences exist between human and Macaca fascicularis patterns of mandibular movement during mastication. Macaque patterns display less asymmetry, more uniformity, and limited lateral excursions when compared to humans for mastication of the same food. Different anatomical structures between the two spec...

journal_title：Journal of dental research

authors： Byrd KE,Milberg DJ,Luschei ES

更新日期：1978-07-01 00:00:00

abstract：:Successive active phases observed in periodontal diseases may be explained either by a sudden activation of the pro-forms of tissue-stored degradative enzymes such as metalloproteinases (MMPs) or by an imbalance between metalloproteinases and their tissue inhibitors (TIMPs). To discriminate between these two hypothese...

journal_title：Journal of dental research

authors： Soell M,Elkaim R,Tenenbaum H

更新日期：2002-03-01 00:00:00

abstract：:Monolayers of feline parotid acinar cells were infected with feline rhinotracheitis herpes virus. Membrane potentials and input resistances were measured before and during infection. Uninfected acinar cells had an average membrane potential of -51 mV and resistances from 6 to 120 mega-ohms; cells infected for more tha...

journal_title：Journal of dental research

authors： Weigel RJ,Fritz ME,Nahmias AJ

更新日期：1981-12-01 00:00:00

abstract：:Restriction endonuclease analysis (REA) was performed on the total cellular DNA from each of 396 strains of mutans streptococci (1) to determine its potential usefulness for the study of transmission of the organism and (2) to document the proportions and variety of strains harbored by members of a small group of fami...

journal_title：Journal of dental research

authors： Kulkarni GV,Chan KH,Sandham HJ

更新日期：1989-07-01 00:00:00

abstract：:In cases of pulp exposure due to deep dental caries or severe traumatic injuries, existing pulp-capping materials have a limited ability to reconstruct dentin-pulp complexes and can result in pulpectomy because of their low potentials to accelerate dental pulp cell activities, such as migration, proliferation, and dif...

journal_title：Journal of dental research

authors： Yoshida S,Wada N,Hasegawa D,Miyaji H,Mitarai H,Tomokiyo A,Hamano S,Maeda H

更新日期：2016-10-01 00:00:00

abstract：:Blood cortisol levels of oral surgery patients were analyzed to objectively determine the effect of intravenous sedation on surgical stress. Results showed a measure of sedation but did not adequately reflect the stress of oral surgery or the changes produced by intravenous sedation. ...

journal_title：Journal of dental research

authors： Bunch FL,Allen GD,Jorgensen NB

更新日期：1975-09-01 00:00:00

abstract：:In the rat parotid acinar cell, methacholine caused an increase in [Ca2+]i as determined by quin-2 fluorescence. The increase in [Ca2+]i was initially independent of, and subsequently dependent on, the presence of extracellular Ca2+, indicating mobilization of intracellular Ca2+, as well as activation of Ca2+ entry. M...

journal_title：Journal of dental research

authors： Aub DL,Putney JW Jr

更新日期：1987-02-01 00:00:00

abstract：:An infrared spectroscopic study has been made of the development of crystallinity (hopeite) in dental zinc phosphate cements. Crystallization in the bulk of a cement is prevented only by the incorporation, in the liquid, of aluminum which forms complexes with phosphoric acid. The development of surface crystallinity i...

journal_title：Journal of dental research

authors： Crisp S,O'Neill IK,Prosser HJ,Stuart B,Wilson AD

更新日期：1978-02-01 00:00:00

abstract：:A conceptual means of obtaining improved bonding between filler particles and the polymeric binders of composites is presented. It involves preparing glass particles that separate into two interconnected vitreous phases when heated to an appropriate temperature, and then etching these to produce a porous surface layer...

journal_title：Journal of dental research

authors： Bowen RL,Reed LE

更新日期：1976-09-01 00:00:00

abstract：:Dental caries can be described as a dysbiosis of the oral microbial community, in which acidogenic, aciduric, and acid-adapted bacterial species promote a pathogenic environment, leading to demineralization. Alkali generation by oral microbes, specifically via arginine catabolic pathways, is an essential factor in mai...

journal_title：Journal of dental research

authors： Agnello M,Cen L,Tran NC,Shi W,McLean JS,He X

更新日期：2017-07-01 00:00:00

abstract：:Tooth agenesis is one of the most common developmental anomalies affecting function and esthetics. The paired-domain transcription factor, Pax9, is critical for patterning and morphogenesis of tooth and taste buds. Mutations of PAX9 have been identified in patients with tooth agenesis. Despite significant progress in ...

journal_title：Journal of dental research

authors： Wong SW,Han D,Zhang H,Liu Y,Zhang X,Miao MZ,Wang Y,Zhao N,Zeng L,Bai B,Wang YX,Liu H,Frazier-Bowers SA,Feng H

更新日期：2018-02-01 00:00:00

abstract：:This study investigated the association between caries status and sealant need at a prior survey and subsequent sealant use in a Medicaid program. Clinical data from a 1986-87 statewide epidemiological survey (N = 8026) representative of North Carolina (NC) schoolchildren (grades K-12) were linked with all NC Medicaid...

journal_title：Journal of dental research

authors： Robison VA,Rozier RG,Weintraub JA,Koch GG

更新日期：1997-12-01 00:00:00

abstract：:Dental caries is initiated by demineralization of the tooth surface through acid production by sugar metabolism of supragingival plaque microflora. To elucidate the sugar metabolic system, we used CE-MS to perform metabolomics of the central carbon metabolism, the EMP pathway, the pentose-phosphate pathway, and the TC...

journal_title：Journal of dental research

authors： Takahashi N,Washio J,Mayanagi G

更新日期：2010-12-01 00:00:00

abstract：:The diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection relies on the detection of viral RNA by real-time reverse transcription polymerase chain reaction (rRT-PCR) performed with respiratory specimens, especially nasopharyngeal swabs. However, this procedure requires specialized medical...

journal_title：Journal of dental research

authors： Azzi L,Maurino V,Baj A,Dani M,d'Aiuto A,Fasano M,Lualdi M,Sessa F,Alberio T

更新日期：2021-02-01 00:00:00

abstract：:The human temporalis and masseter muscles are not activated homogeneously during static bite force tasks. In this study, we studied the possible existence of regional differences in these muscles under dynamic conditions. Electromyographic (EMG) activity was recorded by means of bipolar fine-wire electrodes. Six elect...

journal_title：Journal of dental research

authors： Blanksma NG,van Eijden TM

更新日期：1995-06-01 00:00:00