Fibroblastic subpopulations in uninjured and wounded rabbit oral mucosa.

Abstract:

:Fibroblast cultures derived from uninjured and reparative rabbit buccal mucosa were compared in terms of extracellular glycosaminoglycan (GAG) content and cellular response to interleukin-1 (IL-1). Under identical growth conditions, proliferation of both cell lines was the same. Both lines incorporated [3H]-glucosamine into GAG in cellular, pericellular, and medium fractions, with the majority of incorporated label residing in the medium. Dermatan sulfate (DS) was the predominant GAG in the medium fraction of both normal and wound fibroblast cultures; however, the two cell lines differed in the identity of the medium fraction's secondary GAG: chondroitin sulfate (CS) for normal fibroblasts and hyaluronic acid (HA) for wound-derived cells. The GAG content of the pericellular matrix for all cultures was the same regardless of the tissue of origin: heparan sulfate (HS) accompanied by a very small amount of CS. Exposure to IL-1 produced limited but highly specific effects: It was not mitogenic for either cell line but did cause a quantitative change (increase) in overall incorporation into GAG for medium and pericellular fractions for both cell lines. Further, IL-1 induced a qualitative change in GAG composition for normal mucosal fibroblastic medium fractions by causing the synthesis/release of heparan sulfate (HS) and a variant form of DS. These data support the hypothesis that different fibroblastic substrains can populate a given oral site as a function of variables such as injury and/or healing status.

journal_name

J Dent Res

authors

Bronson RE,Treat JA,Bertolami CN

doi

10.1177/00220345890680010801

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

51-8

issue

1

eissn

0022-0345

issn

1544-0591

journal_volume

68

pub_type

杂志文章
  • Natural defenses against Candida colonization breakdown in the oral cavities of the elderly.

    abstract::Candida colonization of the oral cavity increases in the elderly. A major predisposing condition is denture use, which also increases in the elderly. To test whether the increase in colonization is age-related in a fashion independent of denture use, we analyzed the frequency (incidence) of carriage, the intensity of ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345990780040601

    authors: Lockhart SR,Joly S,Vargas K,Swails-Wenger J,Enger L,Soll DR

    更新日期:1999-04-01 00:00:00

  • Glass-ionomer cement formulations. II. The synthesis of novel polycarobxylic acids.

    abstract::The synthesis of many polycarboxylic acids is reported. An account is given of their stability in aqueous solution and the properties of cements formed by their reaction with ion-leachable glasses. A copolymer of acrylic and itaconic acids was found to combine several favorable characteristics. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345800590060801

    authors: Crisp S,Kent BE,Lewis BG,Ferner AJ,Wilson AD

    更新日期:1980-06-01 00:00:00

  • The biocompatibility of dental implant materials measured in an animal model.

    abstract::The biocompatibility of two implant materials, vitallium and poly-methyl methacrylate (PMMA), was evaluated in an animal model in which bone formation and resorption are independent of each other. Neither material accelerated resorption, but formation was inhibited 12% by vitallium and 38% by PMMA. When three PMMA pre...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345810600010801

    authors: Garcia DA,Sullivan TM,O'Neill DM

    更新日期:1981-01-01 00:00:00

  • Assessing tooth color differences in digital facial portraits.

    abstract::Although a large body of scientific literature shows that background color and luminance affect color perception, previous measurements of tooth color difference thresholds have not taken the effects of viewing context into account. The present study tested the hypothesis that differences in skin/gingival color influe...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034510376772

    authors: Lindsey DT,Wee AG

    更新日期:2010-11-01 00:00:00

  • Thio-urethanes improve properties of dual-cured composite cements.

    abstract::This study aims at modifying dual-cure composite cements by adding thio-urethane oligomers to improve mechanical properties, especially fracture toughness, and reduce polymerization stress. Thiol-functionalized oligomers were synthesized by combining 1,3-bis(1-isocyanato-1-methylethyl)benzene with trimethylol-tris-3-m...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034514551768

    authors: Bacchi A,Dobson A,Ferracane JL,Consani R,Pfeifer CS

    更新日期:2014-12-01 00:00:00

  • An epidemiological investigation into the relative importance of age and oral hygiene status as determinants of periodontitis.

    abstract::The objective of this study was to assess the relative effects of age and oral hygiene on the progression of periodontitis by estimating incidence from age-specific prevalence. This study analyzed data from a representative national sample of 14,690 dentate Americans, aged from 15 to 74, seen in the first National Hea...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345870660010201

    authors: Abdellatif HM,Burt BA

    更新日期:1987-01-01 00:00:00

  • Curing light-activated composite cement through porcelain.

    abstract::The purpose of the study was to determine the exposure times needed to harden a light-activated composite cement through various thicknesses of porcelain. A negative exponential model was developed with which the relative hardness of a composite could be predicted from the product of the exposure time and the square r...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345890680030801

    authors: Chan KC,Boyer DB

    更新日期:1989-03-01 00:00:00

  • Genetic association of ARHGAP21 gene variant with mandibular prognathism.

    abstract::Mandibular prognathism (MP) is a recognizable phenotype associated with dentoskeletal class III malocclusion. MP is a complex genetic trait, although familial recurrence also suggests the contribution of single inherited variations. To date, the genetic causes of MP have been investigated using linkage analysis or ass...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515572190

    authors: Perillo L,Monsurrò A,Bonci E,Torella A,Mutarelli M,Nigro V

    更新日期:2015-04-01 00:00:00

  • HIV infection affects Streptococcus mutans levels, but not genotypes.

    abstract::We report a clinical study that examines whether HIV infection affects Streptococcus mutans colonization in the oral cavity. Whole stimulated saliva samples were collected from 46 HIV-seropositive individuals and 69 HIV-seronegative control individuals. The level of S. mutans colonization was determined by conventiona...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034512454298

    authors: Liu G,Saxena D,Chen Z,Norman RG,Phelan JA,Laverty M,Fisch GS,Corby PM,Abrams W,Malamud D,Li Y

    更新日期:2012-09-01 00:00:00

  • Biological mechanisms of fluorosis and level and timing of systemic exposure to fluoride with respect to fluorosis.

    abstract::Enamel fluorosis can occur following either an acute or chronic exposure to fluoride during tooth formation. Fluorosed enamel is characterized by a retention of amelogenins in the early-maturation stage, and by the formation of a more porous enamel with a subsurface hypomineralization. The mechanisms by which fluoride...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/00220345920710051701

    authors: DenBesten PK,Thariani H

    更新日期:1992-05-01 00:00:00

  • Damage maps of veneered zirconia under simulated mastication.

    abstract::Zirconia-based restorations often fracture from chipping and/or delamination of the porcelain veneers. We hypothesized that veneer chipping/delamination is a result of the propagation of near-contact-induced partial cone cracks on the occlusal surface under mastication. Masticatory loading involves the opposing tooth ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910808701210

    authors: Kim JW,Kim JH,Janal MN,Zhang Y

    更新日期:2008-12-01 00:00:00

  • A numerical model of temporomandibular joint loading.

    abstract::A numerical model of the mandible, its articulating surfaces, and the forces exerted by the primary masticatory muscles has been developed for the purpose of investigating loading of the temporomandibular joint. Evidence is presented which shows that the temporomandibular joint. Evidence is presented which shows that ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345860650080201

    authors: Smith DM,McLachlan KR,McCall WD Jr

    更新日期:1986-08-01 00:00:00

  • Enamel silicon and fluoride relationships demonstrating a surface silicon effect that facilitates fluoride uptake.

    abstract::This study indicated that a clear relationship exists between silicon and fluoride. We have also demonstrated a probable surface enamel silicon effect that increases fluoride uptake. The complex set of relationships described in the surface chemistry of calcium, tin, and zirconium with fluoride, hydroxide, phosphate, ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345760550050601

    authors: Levy JS,Koritzer RT

    更新日期:1976-09-01 00:00:00

  • The influence of various attachment types in mandibular implant-retained overdentures on maximum bite force and EMG.

    abstract::The type of attachment that is used in oral rehabilitation by means of implant-retained mandibular overdentures may influence the retention and the stability of the denture. In this study, we examined the hypothesis that a better retention and stability of the denture improve the oral function. Eighteen edentulous sub...

    journal_title:Journal of dental research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1177/154405910208100305

    authors: van Kampen FM,van der Bilt A,Cune MS,Bosman F

    更新日期:2002-03-01 00:00:00

  • Magnification--a new look at a long-known optical property of dentin.

    abstract::Light propagation in human dentin exhibits a strong directional dependence featuring the long-known optical magnification property. We hypothesized that this anisotropic effect is caused by multiple scattering at the dentin tubules, and not by fiberoptic effects, as had been previously assumed. We performed measuremen...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910608501017

    authors: Kienle A,Michels R,Hibst R

    更新日期:2006-10-01 00:00:00

  • Validation of an in vitro biofilm model of supragingival plaque.

    abstract::The study of biofilm structure and function mandates the use of model systems for which a host of environmental variables can be rigorously controlled. We describe a model of supragingival plaque containing Actinomyces naeslundii, Veillonella dispar, Fusobacterium nucleatum, Streptococcus sobrinus, and Streptococcus o...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345010800011201

    authors: Guggenheim B,Giertsen E,Schüpbach P,Shapiro S

    更新日期:2001-01-01 00:00:00

  • Enamel Surface with Pit and Fissure Sealant Containing 45S5 Bioactive Glass.

    abstract::Enamel demineralization adjacent to pit and fissure sealants leads to the formation of marginal caries, which can necessitate the replacement of existing sealants. Dental materials with bioactive glass, which releases ions that inhibit dental caries, have been studied. The purpose of this study was to evaluate the ena...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515626116

    authors: Yang SY,Kwon JS,Kim KN,Kim KM

    更新日期:2016-05-01 00:00:00

  • Sex-Based Diverse Plaque Microbiota in Children with Severe Caries.

    abstract::Severe early childhood caries (S-ECC) is a multifactorial disease that can lead to suffering and reduced oral health-related quality of life in young children. The bacterial and fungal composition of dental plaque and how children's sex is associated with S-ECC are largely unknown. In this study, V4-16S rRNA and ITS1 ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034520908595

    authors: de Jesus VC,Shikder R,Oryniak D,Mann K,Alamri A,Mittermuller B,Duan K,Hu P,Schroth RJ,Chelikani P

    更新日期:2020-06-01 00:00:00

  • Refractive index mismatch and monomer reactivity influence composite curing depth.

    abstract::Limited cure depth is a drawback of light-activated composites. We hypothesize that curing light transmission and cure depth are influenced by monomer reactivity and filler/resin refractive index mismatch. Light transmission throughout cure was recorded for composites based on strontium (refractive index 1.51) or bari...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910808700115

    authors: Shortall AC,Palin WM,Burtscher P

    更新日期:2008-01-01 00:00:00

  • A two-body frictional wear test.

    abstract::Enamel abraders used in two-body wear tests suffer the disadvantage that standardization is difficult or impossible to obtain. The aim of this study was to test whether steatite (a ceramic material with a Vickers Hardness similar to that of enamel) could be used as a satisfactory human enamel analogue. The friction an...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345940730091001

    authors: Wassell RW,McCabe JF,Walls AW

    更新日期:1994-09-01 00:00:00

  • The effect of fluoride application on fluoride release and the antibacterial action of glass ionomers.

    abstract::The aim of this study was to investigate whether the release of fluoride and the antimicrobial effect of freshly mixed glass ionomers could be prolonged by application of fluoride on aged material. Test slabs of freshly mixed and aged (14 d in water) conventional and silver glass ionomer (Ketac-Fil and Ketac-Silver, E...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345930720090901

    authors: Seppä L,Forss H,Ogaard B

    更新日期:1993-09-01 00:00:00

  • Characteristics of mandibular masticatory movement in young and elderly dentate subjects.

    abstract::Dimensions and velocity of mandibular movement are important variables in the evaluation of masticatory and speech patterns. However, little information is available concerning elderly dentates and their oral motor function and behavior. Double recordings of a chewing period, from start to swallowing, were performed i...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345900690021101

    authors: Karlsson S,Carlsson GE

    更新日期:1990-02-01 00:00:00

  • The three-dimensional active envelope of jaw border movement and its determinants.

    abstract::The sagittal and frontal active envelope of border movement is applied regularly as a clinical tool in functional examinations of the human masticatory system. In contrast, the three-dimensional movement area has hardly been examined. Furthermore, the determinants of this area are not established unambiguously. In the...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345010800100901

    authors: Koolstra JH,Naeije M,van Eijden TM

    更新日期:2001-10-01 00:00:00

  • Odontoblastic Exosomes Attenuate Apoptosis in Neighboring Cells.

    abstract::Each odontoblast is tightly linked to other odontoblasts. They form a line of defense and are capable of withstanding external stimuli, particularly the inflammation caused by caries. Thus, we investigated exosomes derived from odontoblasts as an intercellular mechanism by which inflamed odontoblasts are protected fro...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034519869580

    authors: Wang HS,Yang FH,Wang YJ,Pei F,Chen Z,Zhang L

    更新日期:2019-10-01 00:00:00

  • Effect of Aging on Periodontal Inflammation, Microbial Colonization, and Disease Susceptibility.

    abstract::Periodontitis is a chronic inflammatory disease induced by a biofilm that forms on the tooth surface. Increased periodontal disease is associated with aging. We investigated the effect of aging on challenge by oral pathogens, examining the host response, colonization, and osteoclast numbers in aged versus young mice. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515625962

    authors: Wu Y,Dong G,Xiao W,Xiao E,Miao F,Syverson A,Missaghian N,Vafa R,Cabrera-Ortega AA,Rossa C Jr,Graves DT

    更新日期:2016-04-01 00:00:00

  • Alteration of conserved alternative splicing in AMELX causes enamel defects.

    abstract::Tooth enamel is the most highly mineralized tissue in vertebrates. Enamel crystal formation and elongation should be well controlled to achieve an exceptional hardness and a compact microstructure. Enamel matrix calcification occurs with several matrix proteins, such as amelogenin, enamelin, and ameloblastin. Among th...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034514547272

    authors: Cho ES,Kim KJ,Lee KE,Lee EJ,Yun CY,Lee MJ,Shin TJ,Hyun HK,Kim YJ,Lee SH,Jung HS,Lee ZH,Kim JW

    更新日期:2014-10-01 00:00:00

  • Finite element method simulation of bone resorption beneath a complete denture.

    abstract::Bone resorption beneath a maxillary complete denture was simulated by the finite element method, assuming that a threshold of compressive strain exists in the alveolar bone above which the resorption occurred. The pattern of predicted resorption was observed when 100 N of force was applied to three positions occlusall...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345890680091601

    authors: Maeda Y,Wood WW

    更新日期:1989-09-01 00:00:00

  • Oral infections in home-living elderly patients admitted to an acute geriatric ward.

    abstract::Little is known about the oral health of the frail and home-living elderly. The effects of dentogenic infections on the general condition of the elderly are also unknown. We therefore set out to investigate 191 elderly patients referred to an acute geriatric hospital due to sudden worsening of their general health. Th...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345970760060601

    authors: Meurman JH,Pajukoski H,Snellman S,Zeiler S,Sulkava R

    更新日期:1997-06-01 00:00:00

  • Axonal Degeneration in Dental Pulp Precedes Human Primary Teeth Exfoliation.

    abstract::The dental pulp in human primary teeth is densely innervated by a plethora of nerve endings at the coronal pulp-dentin interface. This study analyzed how the physiological root resorption (PRR) process affects dental pulp innervation before exfoliation of primary teeth. Forty-four primary canine teeth, classified into...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034515593055

    authors: Suzuki K,Lovera M,Schmachtenberg O,Couve E

    更新日期:2015-10-01 00:00:00

  • Site-specific expression of collagen I and XII mRNAs in the rat periodontal ligament at two developmental stages.

    abstract::In mammals, the periodontal ligament (PDL) is a highly specialized tissue which facilitates tooth eruption and lends mechanical support to the tooth once in occlusion. The PDL extracellular matrix fibers play a major role in such functions. During its development, the spatial arrangement of the PDL extracellular matri...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345920710070201

    authors: Karimbux NY,Rosenblum ND,Nishimura I

    更新日期:1992-07-01 00:00:00