Abstract：
:The discovery and implementation of fluoride in the prevention of dental caries is often praised as one of the most important achievements in health care. In the early 20th century, it took 30 y to identify fluoride as the cause of enamel mottling but also of reduced caries prevalence in a population drinking water containing fluoride. Similarly, from 1960 to 1990, it took major efforts to unravel the working mode of fluoride in such detail that a rational scheme of caries prevention could be formulated. This article describes the scientific struggle leading to a consensus on the topic. For a historic purpose, the field, the actors, and their main research achievements are described. Ultimately it was generally agreed that the effect of fluoride is primarily topical by fluorides in the oral fluids rather than systemic by incorporation of fluoride in the enamel mineral crystals. Fluoride concentrations, even <1 mg/L, enhance the deposition of calcium phosphates during remineralization of enamel (and dentin). Similarly, such low levels of fluoride are effective in reducing the dissolution of the calcified tissues. This understanding has led to the development of fluoride-containing caries-preventive products that had an undisputed beneficial effect on the levels of dental caries.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Ten Cate JM,Buzalaf MARdoi
10.1177/0022034519831604subject
Has Abstractpub_date
2019-07-01 00:00:00pages
725-730issue
7eissn
0022-0345issn
1544-0591journal_volume
98pub_type
历史文章,杂志文章abstract：:An intra-oral model system has been developed which uses a single-section technique for before-and-after measurements on the same tissue. This model allows for placement of sections of enamel at both buccal and approximal sites. These sections may be sound or possess white-spot lesions. This allows for the evaluation ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660091401
更新日期：1987-09-01 00:00:00
abstract：:Smoking is a major risk of periodontal diseases. At the site of first contact, the gingiva is exposed to aromatic amines and polycyclic hydrocarbons. These are metabolized by the N-acetyltransferases (NAT), leading to local detoxification and/or activation reactions contributing to the risk of periodontal destruction ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910208100512
更新日期：2002-05-01 00:00:00
abstract：:Data from the actual private practices of two dentists were compared with respective data from the participation of the same two dentists in a laboratory model of private practice conducted in the University of North Carolina Dental Research Center. The findings show that a laboratory model can be established which ac...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540032501
更新日期：1975-05-01 00:00:00
abstract：:Stable fluoride-resistant mutants of Streptococcus mutans GS-5 were isolated on Todd-Hewitt agar by a step-wise selection procedure. Resistance is defined here as the ability to form colonies in 48 hr. First-step mutants demonstrated six different levels of resistance, ranging from 400 to 1000 micrograms/mL sodium flu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660101701
更新日期：1987-10-01 00:00:00
abstract：:In a three-year study of 145 adolescent males in a boarding school in Wisconsin, there were no statistically significant differences in dental caries experience between a group consuming phosphates added to pre-sweetened and non-presweetened ready-to-eat cereals, and the control group, or between cereal eaters and non...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345790580090201
更新日期：1979-09-01 00:00:00
abstract：:The biocompatibility of two implant materials, vitallium and poly-methyl methacrylate (PMMA), was evaluated in an animal model in which bone formation and resorption are independent of each other. Neither material accelerated resorption, but formation was inhibited 12% by vitallium and 38% by PMMA. When three PMMA pre...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600010801
更新日期：1981-01-01 00:00:00
abstract：:It has often been hypothesized that a large tongue leads to an enlargement of the mandible and therefore contributes to the development of mandibular prognathism. We examined (1) whether the tongue volume in human subjects with mandibular prognathism was larger than that in subjects with good occlusion and (2) whether...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750120701
更新日期：1996-12-01 00:00:00
abstract：:Cleft palate is among the most common structural birth defects in humans. Previous studies have shown that mutations in FOXF2 are associated with cleft palate in humans and mice and that Foxf2 acts in a Shh-Foxf-Fgf18-Shh molecular network controlling palatal shelf growth. In this study, we combined RNA-seq and ChIP-s...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520904018
更新日期：2020-04-01 00:00:00
abstract：:The human dentition is a complex adaptive system that is influenced by genetic, epigenetic, and environmental factors. Within this system, is sexual dimorphism related to the growth promotion of the Y chromosome, or to hormonal influences, or both? This study is the first to investigate both primary and permanent toot...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513484934
更新日期：2013-05-01 00:00:00
abstract：:The effect of enamel matrix proteins on the seeded growth of enamel apatite crystals was studied in stable supersaturated solutions at pH 7.4 and 37 degrees C. Of the two major protein classes in the enamel matrix, the enamelins were considerably more effective than the amelogenins in retarding seeded growth. However,...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630021801
更新日期：1984-02-01 00:00:00
abstract：:Lipopolysaccharide (LPS) has been shown to be a prominent pathogenic factor in inflammatory bone loss. However, knowledge of the mechanisms involved is limited. The role of the SDF-1/CXCR4 (Stromal-derived factor-1 and its unique chemokine receptor) axis in LPS-induced bone loss has not been studied. The aim of this s...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510379019
更新日期：2011-02-01 00:00:00
abstract：:Inflammatory conditions as they occur during periodontal disease often result in decreased alveolar bone levels and a loss of connective tissue homeostasis. Here we have focused on the effect of microRNA-138 (miR-138) as a potential regulator of periodontal stem cells as they affect homeostasis during inflammatory con...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515613043
更新日期：2016-02-01 00:00:00
abstract：:Synovial hyperplasia is a feature of degenerative temporomandibular joint (TMJ) disease. However, the mechanism by which hyperplasia progresses in the TMJ is unknown. Based on the hypothesis that the oxidative stress generated by mechanical loading causes degenerative changes in the TMJ synovium, we investigated the g...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300807
更新日期：2004-08-01 00:00:00
abstract：:Growing evidence suggests that individual genetic susceptibility may influence the host's response to infections. The aim of this project was to study whether gene polymorphisms of inflammatory markers are associated with the presence of viable periodontopathogenic bacteria. We extracted genomic DNA from 45 young adul...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600505
更新日期：2007-05-01 00:00:00
abstract：:Pilocarpine (P) is of potential utility in the treatment of xerostomia. Because optimal development of P dosage forms for humans requires that its pharmacokinetics and pharmacodynamics be defined, this intravenous study of its disposition and associated salivary responses was performed. In a hospital setting, two heal...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345950740120701
更新日期：1995-12-01 00:00:00
abstract：:Lactoferrin is one of a number of multifunctional proteins that are present in or on all mucosal surfaces throughout the body. Levels of lactoferrin are consistently elevated in inflammatory diseases such as arthritis, inflammatory bowel diseases, corneal disease, and periodontitis. Single-nucleotide polymorphisms (SN...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034515577413
更新日期：2015-06-01 00:00:00
abstract：:Patients with cleft lip/palate (CLP) have been reported, in some studies, to exhibit an increased prevalence of caries, although the underlying cause for this increase is unknown. In genetically defined mouse models, studies of postnatal sequelae associated with CLP have been hampered by neonatal lethality. Using a co...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516679376
更新日期：2017-03-01 00:00:00
abstract：:Since edentate subjects have a reduced masticatory function, it can be expected that the morphology of the cancellous bone of their mandibular condyles has changed according to the altered mechanical environment. In the present study, the morphology of cylindrical cancellous bone specimens of the mandibular condyles o...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300314
更新日期：2004-03-01 00:00:00
abstract：:Tritiated proline was administered to domestic cats during the development of their permanent dentition. The amount of residual radioactivity was determined autoradiographically at various times after cavity preparation in mature molars and premolars. Two wk after cavity preparation, the amount of radiolabel beneath t...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610090101
更新日期：1982-09-01 00:00:00
abstract：:There is a large variability between and among individuals in the physiology of mastication, but it is not known whether this produces a similar variability in the particle sizes of food boluses at the end of the chewing process. Food boluses obtained just before swallowing were analyzed in ten subjects (aged 36.7 +/-...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/154405910408300713
更新日期：2004-07-01 00:00:00
abstract：:MMP-20 (enamelysin), the matrix metalloproteinase family member discovered in the enamel organ, has also been detected in odontoblasts during dentin formation. We studied the presence and localization of MMP-20 in mature human teeth in health and disease. In immunohistochemistry, MMP-20-positive staining was observed ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910208100905
更新日期：2002-09-01 00:00:00
abstract：:To identify salivary biomarkers of periodontal diseases, we used plaque-resistant and -susceptible rats as animal models. The levels of salivary cystatin S in saliva, salivary glands, and gingiva were tested in Nembutal-anesthetized young and adult plaque-resistant and -susceptible rats of both sexes with and without ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770110801
更新日期：1998-11-01 00:00:00
abstract：:The effect of pH on the growth and proteolytic activity of the type strain and fresh isolates of Porphyromonas gingivalis and Bacteroides intermedius was investigated. B. intermedius strains grew with and without glucose at a pH as low as 5.0. These bacteria grew almost as well as Streptococcus mutans at pH 5.0 and be...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690060801
更新日期：1990-06-01 00:00:00
abstract：:Using a hydraulic bellows system mounted on a maxillary partial denture, continuous force-displacement data were taken in an edentulous area in the maxillary bicuspid-molar region on ten adults. Both loading and unloading force-displacement curves showed three segments. Two visco-elastic properties - hysteresis and re...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630101901
更新日期：1984-10-01 00:00:00
abstract：:Fluid transudation through simplified dentin adhesives can occur in bonded vital crown dentin, since these adhesives behave as permeable membranes after polymerization. The effect of adhesive permeability in endodontically treated teeth is unknown. This study examined the hypothesis that in vivo fluid movement through...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/154405910508400303
更新日期：2005-03-01 00:00:00
abstract：:In periodontal surgery, healing after guided tissue regeneration (GTR) may be explained by differences in functional activities of gingival and periodontal ligament fibroblasts (GF and PDLF). Several studies in vitro have supported this hypothesis, but much remains to be defined. In the present work, gingival and peri...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750030601
更新日期：1996-03-01 00:00:00
abstract：:The size of a bolus determines how it will be manipulated in the mouth and swallowed. We hypothesized that mucosal sensitivity would be important for masticatory function. The accuracy of solid object size perception, spatial acuity, and food particle size reduction during mastication were measured in 22 healthy adult...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300507
更新日期：2004-05-01 00:00:00
abstract：UNLABELLED:We have previously shown that the resin monomer 2-hydroxyethylmethacrylate (HEMA) affects mouse B-lymphocyte activity, leading to increased IgG1 antibody production in vivo. In the present study, we tested, in vitro, the hypothesis that HEMA also affects human B-lymphocyte activity. The in vitro production o...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510378522
更新日期：2010-12-01 00:00:00
abstract：:Early-onset periodontitis (EOP) is considered to have a genetic basis which has not been clearly defined. Genetic polymorphisms of the vitamin D receptor (VDR-B-b) and the immunoglobulin-Fc-gamma receptor IIIb (FcgammaRIIIb-NA1-NA2) are associated with bone metabolism and infectious diseases, respectively. The purpose...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800120501
更新日期：2001-12-01 00:00:00
abstract：:It is claimed that dental fluorosis in both deciduous and permanent teeth is increasing in fluoridated and non-fluoridated communities. What is unclear is whether fluoride-induced enamel opacities in the deciduous dentition are associated with the subsequent appearance of enamel defects in the permanent dentition. The...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750040301
更新日期：1996-04-01 00:00:00
