Abstract：
:Locally applied bisphosphonates may improve the fixation of metal implants in bone. However, systemic bisphosphonate treatment is associated with a risk of osteonecrosis of the jaw (ONJ). We hypothesized that local delivery of bisphosphonate from the implant surface improves the fixation of dental implants without complications in a setting where systemic treatment induces ONJ. Forty rats were randomly allocated to 4 groups of 10. All groups received a titanium implant inserted in an extraction socket. Group I received the implants only. Group II received dexamethasone (0.5 mg/kg). Group III received dexamethasone as above plus alendronate (200 µg/kg). Group IV received zoledronate-coated implants and dexamethasone as above. The animals were sacrificed 2 weeks after tooth extraction. All 10 animals with systemic alendronate treatment developed large ONJ-like changes, while all with local treatment were completely healed. Implant removal torque was higher for the bisphosphonate-coated implants compared with the other groups (p < 0.03 for each comparison). Micro-computed tomography of the maxilla showed more bone loss in the systemic alendronate group compared with groups receiving local treatment (p = 0.001). Local bisphosphonate treatment appears to improve implant fixation in a setting where systemic treatment caused ONJ.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Abtahi J,Agholme F,Sandberg O,Aspenberg Pdoi
10.1177/0022034512472335subject
Has Abstractpub_date
2013-03-01 00:00:00pages
279-83issue
3eissn
0022-0345issn
1544-0591pii
0022034512472335journal_volume
92pub_type
杂志文章abstract：:Bacteria attach to teeth and oral mucosal surfaces in a surprisingly selective manner, and attachment appears to be the first step in the colonization process. Attachment is thought to involve lectin-like and/or hydrophobic ligands, called adhesins, often present in bacterial surface appendages which interact with rec...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630030401
更新日期：1984-03-01 00:00:00
abstract：:Periodontitis is a chronic infectious disease driven by dysbiosis, an imbalance between commensal bacteria and the host organism. Periodontitis is a leading cause of tooth loss in adults and occurs in about 50% of the US population. In addition to the clinical challenges associated with treating periodontitis, the pro...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515611876
更新日期：2016-02-01 00:00:00
abstract：:T6 antigen is a highly specific marker for human Langerhans cells (LC). Previous studies have demonstrated that Interleukin-1 (IL-1) and an IL-1 inhibitor (ILS) modulate LC T6 expression (T6E) in explant culture. The present study examined the in vitro modulation of T6E by two molecules: epidermal-cell-derived thymocy...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660031201
更新日期：1987-03-01 00:00:00
abstract：UNLABELLED:Excessive mechanical stress (MS) during hyperocclusion is known to result in disappearance of the alveolar hard line, enlargement of the periodontal ligament (PDL) space, and destruction of alveolar bone, leading to occlusal traumatism. We have recently reported that MS induces predominantly C-C chemokine li...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512467803
更新日期：2013-01-01 00:00:00
abstract：:Bisphosphonates are a class of agents used to treat osteoporosis and malignant bone metastases. The efficacy of these agents in treating and preventing the significant skeletal complications associated with these conditions has had a major positive impact for patients and is responsible for their widespread use in med...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910708601101
更新日期：2007-11-01 00:00:00
abstract：:During amelogenesis in the rat incisor, modulating ruffle-ended (RA) and smooth-ended (SA) ameloblasts are distributed as bands in the enamel organ of the maturation zone. This distribution of the two cell types has been shown to be precisely correlated with a banding of the underlying enamel, as shown by staining and...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680020101
更新日期：1989-02-01 00:00:00
abstract：:Streptococcus mutans produces 3 types of glucosyltransferase (GTF), whose cooperative action is considered to be essential for its cellular adherence to the tooth surface. However, the precise mechanisms for synthesizing adhesive glucans and the specific roles of each GTF in cellular adherence to smooth surfaces have ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800071401
更新日期：2001-07-01 00:00:00
abstract：:The amount of free water in 50 samples of air-dried enamel from permanent and deciduous teeth was measured by the Karl Fischer method. Samples included both contemporary and burial specimens. The mean values obtained showed that free water constituted about 1% of enamel mass. However, the range of individual values va...
journal_title：Journal of dental research
pub_type： 历史文章,杂志文章
doi：10.1177/00220345880670051701
更新日期：1988-05-01 00:00:00
abstract：:Known antimalarial compunds from several chemical classes were tested for their ability to inhibit in vitro growth of microorganisms causing dental plaque and to prevent the development of plaque in a hamster model. Approximately a third of the compounds tested inhibited in vitro growth; however, none prevented develo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345750540030901
更新日期：1975-05-01 00:00:00
abstract：:Studies have shown that prevention of mutans streptococci (MS) colonization in early childhood can lead to prevention of dental decay. In the microbiological part of the present study in Ylivieska, Finland, with 195 mothers with high salivary MS levels, regular maternal use of xylitol chewing gum resulted in a statist...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/00220345000790111201
更新日期：2000-11-01 00:00:00
abstract：:Mucous membrane pemphigoid or cicatricial pemphigoid is a mucocutaneous blistering disease characterized by autoantibodies to different molecules in the basement membrane zone. Our objectives were to identify the target antigen recognized by sera from 20 untreated patients with pemphigoid disease limited to the oral c...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345010800080601
更新日期：2001-08-01 00:00:00
abstract：:It was recently reported that human periapical cysts (hPCys), a commonly occurring odontogenic cystic lesion of inflammatory origin, contain mesenchymal stem cells (MSCs) with the capacity for self-renewal and multilineage differentiation. In this study, periapical inflammatory cysts were compared with dental pulp to ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515570316
更新日期：2015-06-01 00:00:00
abstract：:Fibroblast cultures derived from uninjured and reparative rabbit buccal mucosa were compared in terms of extracellular glycosaminoglycan (GAG) content and cellular response to interleukin-1 (IL-1). Under identical growth conditions, proliferation of both cell lines was the same. Both lines incorporated [3H]-glucosamin...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680010801
更新日期：1989-01-01 00:00:00
abstract：:The etiology of dental caries reflects a complex interplay of biochemical, microbial, genetic, social and physical environmental, and health-influencing behavioral factors. This review updates the literature on the efficacy of behavioral approaches to caries prevention for children up to 18 y of age. Included were stu...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034515609034
更新日期：2016-01-01 00:00:00
abstract：:The treatment of periodontitis/peri-implantitis involves the reduction/eradication of periopathogens. After therapy, beneficial and pathogenic species recolonize the subgingival area. The dynamics of recolonization and especially the role of the supragingival environment in this process are still not well-understood. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910508400409
更新日期：2005-04-01 00:00:00
abstract：:Tritiated proline was administered to domestic cats during the development of their permanent dentition. The amount of residual radioactivity was determined autoradiographically at various times after cavity preparation in mature molars and premolars. Two wk after cavity preparation, the amount of radiolabel beneath t...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610090101
更新日期：1982-09-01 00:00:00
abstract：:Composite resin restorations in cavities are generally associated with the development of a contraction gap during the first minutes after insertion. Enamel-Bond-Concise composite restoration were placed on both approximal sides of extracted pre-molars. The cervical walls of all cavities extended beyond the enamel-cem...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630051501
更新日期：1984-05-01 00:00:00
abstract：:We examined 102 children born and reared in an area of rural Kenya with 2 ppm fluoride in the drinking water for dental fluorosis, using the index developed by Thylstrup and Fejerskov (1978). The prevalence of dental fluorosis was 100%, 92% of all teeth exhibited a TFI score of 4 or higher, and 50% of the children had...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650050501
更新日期：1986-05-01 00:00:00
abstract：:Lingual amylase and lingual lipase, two digestive enzymes that are secreted from lingual serous glands (von Ebner's), were simultaneously purified from rat lingual serous glands with hydrophobic chromatography used as the final step. This method, previously developed for the purification of lingual lipase, includes ho...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680020801
更新日期：1989-02-01 00:00:00
abstract：:Local administrations of prostaglandins E1 or E2 combined with orthodontic tooth movement can approximately double the rate of tooth movement in monkeys compared to that of the control. Macroscopically, no side-effect was observed in the gingiva and associated structures. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610121401
更新日期：1982-12-01 00:00:00
abstract：:Sjögren's syndrome is a common autoimmune rheumatic disease. The most common symptoms of Sjögren's syndrome are extreme tiredness, along with dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia). Saliva plays an essential role in numerous functions of the mouth. Xerostomia can be caused by medications, chr...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910808700411
更新日期：2008-04-01 00:00:00
abstract：:Enamel abraders used in two-body wear tests suffer the disadvantage that standardization is difficult or impossible to obtain. The aim of this study was to test whether steatite (a ceramic material with a Vickers Hardness similar to that of enamel) could be used as a satisfactory human enamel analogue. The friction an...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730091001
更新日期：1994-09-01 00:00:00
abstract：:The tooth resistance measuring instrument was compared to the traditional method of the explorer examination for the detection of occlusal carious lesions. The findings of the instrument were more sensitive as compared to the traditional method when verified by a histological examination. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570020801
更新日期：1978-02-01 00:00:00
abstract：:During the maintenance of bone marrow-derived mesenchymal stem cells (BMMSCs), suspended cells are discarded normally. We noted the osteogenic potential of these cells to be like that of anchorage-dependent BMMSCs. Therefore, we characterized suspended BMMSCs from rabbit bone marrow by bioengineering and applied the s...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514548706
更新日期：2014-10-01 00:00:00
abstract：:The remodeling of gingival tissue was measured by determining the incorporation of tritiated proline and the disappearance of tritium activity from proline and hydroxyproline for 18 days after administration of label. There was a rapid decrease in the tritium activity from gingiva which was paralleled by a decrease in...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570023101
更新日期：1978-02-01 00:00:00
abstract：:A silver-plating technique was developed in an effort to produce good mechanical bonding characteristics between stainless steel pins and amalgam. Metallographic microscope and scanning electron microscope (SEM) studies were made to assess the presence, or otherwise, of such a bond between (a) the silver layer plating...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590020301
更新日期：1980-02-01 00:00:00
abstract：:Genetic influences are important in the determination of mandibular morphology, and growth hormone receptor (GHR) is believed to have an important influence on the growth of craniofacial bone. In this study, we used quantitative trait locus methods to evaluate the relationship between craniofacial morphology and singl...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910508401116
更新日期：2005-11-01 00:00:00
abstract：:A complex feedback mechanism between parathyroid hormone (PTH), 1,25(OH)2D3 (1,25D), and fibroblast growth factor 23 (FGF-23) maintains mineral homeostasis, in part by regulating calcium and phosphate absorption/reabsorption. Previously, we showed that 1,25D regulates mineral homeostasis by repressing dentin matrix pr...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515599726
更新日期：2015-10-01 00:00:00
abstract：:The effect of a topical fluoride regimen consisting of a four-minute pre-treatment with a saturated dicalcium phosphate dihydrate (DCPD) solution followed by a four-minute application of APF was compared with that of a four-minute application of APF alone with respect to the deposition of fluoride in enamel in an apat...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650030201
更新日期：1986-03-01 00:00:00
abstract：:The purpose of this study was to evaluate the Bruxcore Plate (BP) as a dependent measure of nocturnal bruxing activity. As part of a bruxism treatment study, we evaluated 100 nocturnal bruxers for bruxing activity before, during, and immediately after treatment and again at a six-month recall. The first 40 subjects wo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680061101
更新日期：1989-06-01 00:00:00
