In vitro modulation of T6 expression on gingival Langerhans cells by interleukin-1 inhibitors and ETAF.

abstract：:Periodontitis is a chronic infectious disease driven by dysbiosis, an imbalance between commensal bacteria and the host organism. Periodontitis is a leading cause of tooth loss in adults and occurs in about 50% of the US population. In addition to the clinical challenges associated with treating periodontitis, the pro...

journal_title：Journal of dental research

authors： Martins MD,Jiao Y,Larsson L,Almeida LO,Garaicoa-Pazmino C,Le JM,Squarize CH,Inohara N,Giannobile WV,Castilho RM

更新日期：2016-02-01 00:00:00

abstract：:Periodontal disease is a bacterial infection that results in inflammatory destruction of tissues that support the teeth, including connective tissue and bone. In this study, we report that transgenic mice that overexpress the 17-kDa form of IL-1alpha in the basal layer of oral mucosal epithelium develop a syndrome tha...

journal_title：Journal of dental research

authors： Dayan S,Stashenko P,Niederman R,Kupper TS

更新日期：2004-10-01 00:00:00

abstract：:Jaw displacement tremor was investigated. Both tremor amplitude and tremor frequency were found to increase with increasing muscle activation. Co-contraction of jaw elevator and jaw depressor muscles was employed in order to vary muscle activation levels without the teeth being in occlusion. Reproducibility of tremor ...

journal_title：Journal of dental research

authors： McCarroll RS,De Vries JH

更新日期：1988-08-01 00:00:00

abstract：:In two separate experiments, none of the 14 subunits examined consistently ranked dentifrices similarly to the ranking obtained when the individual rat was used as the experimental unit. Arbitrarily dividing the rat into subunits and then comparing results among these subunits may lead to false conclusions since the r...

journal_title：Journal of dental research

authors： Briner WW

更新日期：1976-05-01 00:00:00

abstract：:In the rat parotid acinar cell, methacholine caused an increase in [Ca2+]i as determined by quin-2 fluorescence. The increase in [Ca2+]i was initially independent of, and subsequently dependent on, the presence of extracellular Ca2+, indicating mobilization of intracellular Ca2+, as well as activation of Ca2+ entry. M...

journal_title：Journal of dental research

authors： Aub DL,Putney JW Jr

更新日期：1987-02-01 00:00:00

abstract：:Dickkopf-related protein 1 (DKK1) is a potent inhibitor of Wnt/β-catenin signaling. Dkk1-null mutant embryos display severe defects in head induction. Conversely, targeted expression of Dkk1 in dental epithelial cells leads to the formation of dysfunctional enamel knots and subsequent tooth defects during embryonic de...

journal_title：Journal of dental research

authors： Han XL,Liu M,Voisey A,Ren YS,Kurimoto P,Gao T,Tefera L,Dechow P,Ke HZ,Feng JQ

更新日期：2011-11-01 00:00:00

abstract：:Smoking has been established as an important risk factor for periodontal disease and tooth loss. The purpose of this study was a prospective evaluation of the effects of smoking on dental care utilization and its costs, based on data from 5712 males aged 20-59 yrs. Age, dental health behavior, and history of diabetes ...

journal_title：Journal of dental research

authors： Ide R,Hoshuyama T,Wilson D,Takahashi K,Higashi T

更新日期：2009-01-01 00:00:00

abstract：:Molecular studies indicate that epigenetic events are important in determining how the internal enamel epithelium folds during odontogenesis. Since this process of folding leads to the subsequent arrangement of cusps on molar teeth, we hypothesized that intercuspal distances of human molar teeth would display greater ...

journal_title：Journal of dental research

authors： Townsend G,Richards L,Hughes T

更新日期：2003-05-01 00:00:00

abstract：:Early-onset periodontitis (EOP) is considered to have a genetic basis which has not been clearly defined. Genetic polymorphisms of the vitamin D receptor (VDR-B-b) and the immunoglobulin-Fc-gamma receptor IIIb (FcgammaRIIIb-NA1-NA2) are associated with bone metabolism and infectious diseases, respectively. The purpose...

journal_title：Journal of dental research

authors： Yoshihara A,Sugita N,Yamamoto K,Kobayashi T,Miyazaki H,Yoshi H

更新日期：2001-12-01 00:00:00

abstract：:Dental caries is initiated by demineralization of the tooth surface through acid production by sugar metabolism of supragingival plaque microflora. To elucidate the sugar metabolic system, we used CE-MS to perform metabolomics of the central carbon metabolism, the EMP pathway, the pentose-phosphate pathway, and the TC...

journal_title：Journal of dental research

authors： Takahashi N,Washio J,Mayanagi G

更新日期：2010-12-01 00:00:00

abstract：:The dentition in zebrafish is extremely and richly vascularized, but the function of the vasculature, in view of the continuous replacement of the teeth, remains elusive. Through application of SU5416, a vascular endothelial growth factor receptor inhibitor, we studied the role of the blood vessels in the dentition of...

journal_title：Journal of dental research

authors： Crucke J,Huysseune A

更新日期：2015-01-01 00:00:00

abstract：:Growing evidence suggests that individual genetic susceptibility may influence the host's response to infections. The aim of this project was to study whether gene polymorphisms of inflammatory markers are associated with the presence of viable periodontopathogenic bacteria. We extracted genomic DNA from 45 young adul...

journal_title：Journal of dental research

authors： Nibali L,Ready DR,Parkar M,Brett PM,Wilson M,Tonetti MS,Griffiths GS

更新日期：2007-05-01 00:00:00

abstract：:The pathomechanics of degenerative joint disease of the temporomandibular joint (TMJ) may involve fatigue produced by mechanical work on the articulating tissues. This study tested the hypotheses that mechanical work in the TMJ (i) varies with the type of mandibular activity, and (ii) is evenly distributed over TMJ su...

journal_title：Journal of dental research

authors： Gallo LM,Chiaravalloti G,Iwasaki LR,Nickel JC,Palla S

更新日期：2006-11-01 00:00:00

abstract：:Interfacial bond strengths of light-activated composites were measured as a function of age using a transverse strength test. Bond strength between layers decreased with the age of the initial layer and reflected the setting curves of the composites. The highly-filled composites exhibited the greatest bond strengths. ...

journal_title：Journal of dental research

authors： Boyer DB,Chan KC,Reinhardt JW

更新日期：1984-10-01 00:00:00

abstract：:During the maintenance of bone marrow-derived mesenchymal stem cells (BMMSCs), suspended cells are discarded normally. We noted the osteogenic potential of these cells to be like that of anchorage-dependent BMMSCs. Therefore, we characterized suspended BMMSCs from rabbit bone marrow by bioengineering and applied the s...

journal_title：Journal of dental research

authors： Zheng RC,Park YK,Cho JJ,Kim SK,Heo SJ,Koak JY,Lee JH

更新日期：2014-10-01 00:00:00

abstract：:The objectives of this study were 1) to provide an estimate of the value of the intraclass correlation coefficient (ICC) for dental caries data at tooth and surface level, 2) to provide an estimate of the design effect (DE) to be used in the determination of sample size estimates for future dental surveys, and 3) to e...

journal_title：Journal of dental research

authors： Masood M,Masood Y,Newton JT

更新日期：2015-02-01 00:00:00

abstract：:Branching morphogenesis is essential for the formation of salivary glands, kidneys, lungs, and many other organs during development, but the mechanisms underlying this process are not adequately understood. Microarray and other gene expression methods have been powerful approaches for identifying candidate genes that ...

journal_title：Journal of dental research

authors： Hsu JC,Di Pasquale G,Harunaga JS,Onodera T,Hoffman MP,Chiorini JA,Yamada KM

更新日期：2012-02-01 00:00:00

abstract：:A water-soluble lipopolysaccharide from Salmonella enteritidis and a phenol-soluble lipopolysaccharide from Leptotrichia buccalis were applied topically to the healthy marginal gingivae of beagle dogs. Saline was applied to contralateral areas as an internal control. Increases in vascular permeability were monitored b...

journal_title：Journal of dental research

authors： Montgomery EH,White RR

更新日期：1986-02-01 00:00:00

abstract：:The aim of this study was to examine the association between the bone mass (bone mineral content [BMC]) and hypomineralized second primary molars (HSPMs)/molar incisor hypomineralization (MIH) in 6-y-old children. This cross-sectional study was embedded in the Generation R Study, a population-based prospective cohort ...

journal_title：Journal of dental research

authors： van der Tas JT,Elfrink ME,Vucic S,Heppe DH,Veerkamp JS,Jaddoe VW,Rivadeneira F,Hofman A,Moll HA,Wolvius EB

更新日期：2016-04-01 00:00:00

abstract：:The initiator of calculus matrix calcification, in vitro, was isolated. Crude phospholipid, known to contain the factor, was separated into five fractions by column chromatography. A single protein-containing fraction induced apatite formation during incubation. The nucleating fraction was indentified as a proteolipid...

journal_title：Journal of dental research

authors： Ennever J,Vocel JJ,Riggan LJ,Paloski SB

更新日期：1977-02-01 00:00:00

abstract：:Hemifacial microsomia (HFM) is a congenital disorder marked by facial asymmetry. Whether facial asymmetry accounts for asymmetrical dental development is unknown. There are few data on dental development relative to mandibular development or severity of HFM, or on development over time. We hypothesized that when mandi...

journal_title：Journal of dental research

authors： Ongkosuwito EM,de Gijt P,Wattel E,Carels CE,Kuijpers-Jagtman AM

更新日期：2010-12-01 00:00:00

abstract：:Gingival overgrowth is a common side-effect of the administration of cyclosporin A (CSA), phenytoin, and calcium blockers. To identify the signaling mechanisms possibly involved in the overgrowth, we examined how CSA affects the activities of MAP kinases and transcription factors in human gingival fibroblasts (HGF). T...

journal_title：Journal of dental research

authors： Bostrom A,Bharath H,Saulewicz A,Narayanan AS

更新日期：2005-06-01 00:00:00

abstract：:Excessive mechanical stress (MS) during hyperocclusion is known to result in disappearance of the alveolar hard line, enlargement of the periodontal ligament (PDL) space, and destruction of alveolar bone, leading to occlusal traumatism. We hypothesized that MS induces expression of osteoclastogenesis-associated chemok...

journal_title：Journal of dental research

authors： Goto KT,Kajiya H,Nemoto T,Tsutsumi T,Tsuzuki T,Sato H,Okabe K

更新日期：2011-06-01 00:00:00

abstract：:Mutans streptococci (MS) are generally considered to be the principal etiological agent of dental caries. MS have two important virulence factors: cell- surface protein PAc and glucosyltransferases (GTFs). GTFs have two functional domains: an N-terminal catalytic sucrose-binding domain (CAT) and a C-terminal glucan-bi...

journal_title：Journal of dental research

authors： Niu Y,Sun J,Fan M,Xu QA,Guo J,Jia R,Li Y

更新日期：2009-05-01 00:00:00

abstract：:Silver cations generated by passing low intensity direct current through pure silver electrodes were found to be sufficiently antibacterial to cause sterilization of samples of infected dentin. The optimal procedure involved a 5 microA current applied for 20 minutes with the anode then left in contact with the sample....

journal_title：Journal of dental research

authors： Thibodeau EA,Handelman SL,Marquis RE

更新日期：1978-09-01 00:00:00

abstract：:Eighteen different Streptococcus strains including S mutans, sanguis, mitis, salivarius, bovis, and 2F2, were assayed for their relative adsorption to synthetic hydroxyapatite and for quantities of lactic acid produced while in the adsorbed state. The results indicated that all S mutans and some S sanguis have an enha...

journal_title：Journal of dental research

authors： Berry CW,Henry CA

更新日期：1977-10-01 00:00:00

abstract：:The rate of F absorption from the stomach is pH-dependent, with greater absorption at low pH. Since the rate of absorption is also strongly influenced by the rapidity of gastric emptying, we have compared the relative importance of gastric acidity and gastric emptying in overall F absorption. Male rats (350 g, n = 85)...

journal_title：Journal of dental research

authors： Messer HH,Ophaug RH

更新日期：1993-03-01 00:00:00

abstract：:The cariostatic effect of resin-modified glass ionomer (RMGI) on secondary root caries is well-documented. However, this beneficial effect may be dependent upon the mode of cavity surface treatment. To investigate this relationship, we studied 4 cavity surface treatments prior to the placement of RMGI: no treatment (N...

journal_title：Journal of dental research

authors： AL-Helal AS,Armstrong SR,Xie XJ,Wefel JS

更新日期：2003-02-01 00:00:00

abstract：:We tested whether orthodontic tooth movement (OTM) could be blocked by local administration of echistatin or an arginine-glycine-aspartic acid (RGD) peptide, agents known to perturb bone remodeling, adjacent to maxillary molars in rats. These molecules were incorporated into ethylene-vinyl acetate (ELVAX), a non-biode...

journal_title：Journal of dental research

authors： Dolce C,Vakani A,Archer L,Morris-Wiman JA,Holliday LS

更新日期：2003-09-01 00:00:00

abstract：:Adhesive bonding of resins to dentin surfaces requires the removal of the layer of debris caused by the cutting. Certain isotonic acidic solutions can do this rapidly. Five solutions were evaluated using cell cultures and pulp studies in monkeys. At concentrations above 10%, each solution caused the cultured human epi...

journal_title：Journal of dental research

authors： Mjör IA,Hensten-Pettersen A,Bowen RL

更新日期：1982-08-01 00:00:00