Abstract:
:Bisphosphonates are a class of agents used to treat osteoporosis and malignant bone metastases. The efficacy of these agents in treating and preventing the significant skeletal complications associated with these conditions has had a major positive impact for patients and is responsible for their widespread use in medicine. Despite these benefits, osteonecrosis of the jaws has recently emerged as a significant complication in a subset of patients receiving these drugs. Based on a growing number of case reports and institutional reviews, bisphosphonate therapy may cause exposed and necrotic bone that is isolated to the jaw. This complication usually presents following simple dento-alveolar surgery, and can cause a significant adverse effect on the quality of life for most patients. The pathogenesis for this complication appears to be related to the profound inhibition of osteoclast function and bone remodeling.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Ruggiero SL,Drew SJdoi
10.1177/154405910708601101subject
Has Abstractpub_date
2007-11-01 00:00:00pages
1013-21issue
11eissn
0022-0345issn
1544-0591pii
86/11/1013journal_volume
86pub_type
杂志文章,评审abstract::A water-soluble lipopolysaccharide from Salmonella enteritidis and a phenol-soluble lipopolysaccharide from Leptotrichia buccalis were applied topically to the healthy marginal gingivae of beagle dogs. Saline was applied to contralateral areas as an internal control. Increases in vascular permeability were monitored b...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650020301
更新日期:1986-02-01 00:00:00
abstract::Mercury emitted from dental amalgam may select for increased numbers of antibiotic- or mercury-resistant commensal bacteria in patients and increase their risk for bacterial diseases that are resistant to common therapies. We hypothesized that the presence of dental amalgams would increase the level of mercury-, tetra...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/154405910808700502
更新日期:2008-05-01 00:00:00
abstract::Three dental amalgams were investigated to determine if their abrasion resistance was significantly affected by different packing pressures. Abrasive wear tests were performed on a machine designed to test materials under conditions similar to masticatory function. The results show that the abrasion resistance of the ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560060901
更新日期:1977-06-01 00:00:00
abstract::Two copper-free amalgams expanded excessively after storage in air at 60 degrees C for about five yr. One expanded significantly at 37 degrees C and slightly at 23 degrees C. High silver content, absence of copper, and presence of small amounts of zinc, or all three, seemed to promote very high expansions at 60 degree...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345820610063301
更新日期:1982-06-01 00:00:00
abstract::Better understanding of dental caries and other oral conditions has guided new strategies to prevent disease and manage its consequences at individual and public health levels. This article discusses advances in prevention and minimal intervention dentistry over the last century by focusing on some milestones within s...
journal_title:Journal of dental research
pub_type: 历史文章,杂志文章
doi:10.1177/0022034519837252
更新日期:2019-06-01 00:00:00
abstract::The aim of this study was to assess the effect of chewing gum containing phosphoryl oligosaccharides of calcium (POs-Ca) and a low concentration of fluoride (F) on the hardness of enamel subsurface lesions, utilizing a double-blind, randomized, and controlled in situ model. Fifteen individuals wore removable lingual a...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/0022034512439716
更新日期:2012-04-01 00:00:00
abstract::To determine the 'hard palate representing' area in the primary somatosensory cortex, we recorded somatosensory-evoked magnetic fields from the cortex in ten healthy volunteers, using magnetoencephalography. Following electrical stimulation of 3 sites on the hard palate (the first and third transverse palatine ridges,...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708600313
更新日期:2007-03-01 00:00:00
abstract::We analyzed the flow rate and composition of paraffin-stimulated whole saliva samples from 35 adult diabetic patients and their age- and sex-matched, non-diabetic, clinically healthy controls. All patients had insulin-dependent diabetes (IDDM) with a mean (+/- S.D.) duration of 14.0 +/- 9.1 years. The saliva analysis ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650011101
更新日期:1986-01-01 00:00:00
abstract::The human temporalis and masseter muscles are not activated homogeneously during static bite force tasks. In this study, we studied the possible existence of regional differences in these muscles under dynamic conditions. Electromyographic (EMG) activity was recorded by means of bipolar fine-wire electrodes. Six elect...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345950740061201
更新日期:1995-06-01 00:00:00
abstract::An infrared spectroscopic study has been made of the development of crystallinity (hopeite) in dental zinc phosphate cements. Crystallization in the bulk of a cement is prevented only by the incorporation, in the liquid, of aluminum which forms complexes with phosphoric acid. The development of surface crystallinity i...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570021801
更新日期:1978-02-01 00:00:00
abstract::Stem cells from exfoliated deciduous teeth (SHED) possess multipotent differentiation and immunomodulatory properties. They have been used for orofacial bone regeneration and autoimmune disease treatment. In this study, we show that acetylsalicylic acid (ASA) treatment is able to significantly improve SHED-mediated os...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514557672
更新日期:2015-01-01 00:00:00
abstract::Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). We hypothesized that these enzymes regulate the tiss...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034508330861
更新日期:2009-03-01 00:00:00
abstract::Glass-ionomer cements (GICs) are regarded as aqueous gels made up of polyalkenoic acid salts containing ion-leachable glass fillers. The consequence of water permeation across the GIC-dentin interface is unknown. This study used SEM, field-emission/environmental SEM (FE-ESEM), and TEM to examine the ultrastructure of ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408300403
更新日期:2004-04-01 00:00:00
abstract::Eugenol, in the 100 percent concentration in commercial use, was applied to a circumscribed area, 3 mm in diameter, of rat labial mucosa for 1 minute. Reaction periods of 15 minutes, 1, 2, 4 and 6 hours were then permitted. Using routine histological procedures for processing the experimental tissues, it was observed ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570110901
更新日期:1978-11-01 00:00:00
abstract::A sintered hydroxyapatite (HAP) ceramic for use in wear studies was prepared from a commercial tricalcium phosphate. The sintered HAP had physical properties close to those of human enamel. The coefficient of friction and wear of the sintered HAP ceramic as characterized by tangential force, track width, and surface f...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570070401
更新日期:1978-07-01 00:00:00
abstract::The rate of F absorption from the stomach is pH-dependent, with greater absorption at low pH. Since the rate of absorption is also strongly influenced by the rapidity of gastric emptying, we have compared the relative importance of gastric acidity and gastric emptying in overall F absorption. Male rats (350 g, n = 85)...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720031101
更新日期:1993-03-01 00:00:00
abstract::This 24-mo randomized controlled trial was based on a double-blind parallel design, and it compared the effectiveness of 2 fluoride application protocols in arresting dentine caries in primary teeth. Three-year-old children with active dentine caries were recruited and randomly allocated to 2 treatment groups. Childre...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034520952031
更新日期:2021-01-01 00:00:00
abstract::Artificial white spot lesions have been prepared on bovine enamel surfaces by the controlled addition of lactate buffer containing methylhydroxydiphosphonate ions. The rates of remineralization have been measured using a constant composition method in solutions of calcium phosphate of low supersaturation. Deposition o...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630061001
更新日期:1984-06-01 00:00:00
abstract::Degradation of dentin matrix components within caries dentin has been correlated with the activity of host-derived proteases, such as matrix metalloproteases (MMPs) and cysteine cathepsins (CTs). Since this relationship has not been fully established, we hypothesized that the abundance of MMPs and CTs in caries-affect...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513516979
更新日期:2014-03-01 00:00:00
abstract::The whisker pad area (WP) is innervated by the second branch of the trigeminal nerve and experiences allodynia and hyperalgesia following transection of the mental nerve (MN; the third branch of the trigeminal nerve). However, the mechanisms of this extra-territorial pain remain unclear. The ionotropic P2X(7) ATP rece...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512474668
更新日期:2013-03-01 00:00:00
abstract::Stress-induced changes imparted in a 'dentin-bonded-crown' material during sintering, annealing, pre-cementation surface modification, and resin coating have been visualized by profilometry. The hypothesis tested was that operative techniques modify the stressing pattern throughout the material thickness. We polished ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509354049
更新日期:2010-01-01 00:00:00
abstract::A complex feedback mechanism between parathyroid hormone (PTH), 1,25(OH)2D3 (1,25D), and fibroblast growth factor 23 (FGF-23) maintains mineral homeostasis, in part by regulating calcium and phosphate absorption/reabsorption. Previously, we showed that 1,25D regulates mineral homeostasis by repressing dentin matrix pr...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515599726
更新日期:2015-10-01 00:00:00
abstract::Components of resin materials may damage DNA, leading to genetic alterations in mammalian cells. Here, monomers were analyzed for the induction of chromosomal aberrations indicated by micronuclei induced in V79 cells. A dose-related increase in the numbers of micronuclei was observed with triethyleneglycol dimethacryl...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345010800070401
更新日期:2001-07-01 00:00:00
abstract::An indirect extrusion capillary viscometer has been developed. This has been tested for nonsetting Newtonian fluids and was found to give results close to, but slightly lower than the actual viscosity. The same apparatus has been successfully applied to a non-Newtonian fluid to determine the dependence of viscosity on...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550021001
更新日期:1976-03-01 00:00:00
abstract::It has often been hypothesized that a large tongue leads to an enlargement of the mandible and therefore contributes to the development of mandibular prognathism. We examined (1) whether the tongue volume in human subjects with mandibular prognathism was larger than that in subjects with good occlusion and (2) whether...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750120701
更新日期:1996-12-01 00:00:00
abstract::The dental pulp in human primary teeth is densely innervated by a plethora of nerve endings at the coronal pulp-dentin interface. This study analyzed how the physiological root resorption (PRR) process affects dental pulp innervation before exfoliation of primary teeth. Forty-four primary canine teeth, classified into...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515593055
更新日期:2015-10-01 00:00:00
abstract::Odontoblasts, with their strategic arrangement along the outermost compartment of the dentin-pulp complex, have been suggested to have sensory function. In addition to their primary role in dentin formation, growing evidence shows that odontoblasts are capable of sensing mechanical stimulation. Previously, we found th...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034518759947
更新日期:2018-08-01 00:00:00
abstract::It is shown that the creep behavior of a commercial dispersant-amalgam containing copper is improved by the addition of a manganese-containing alloy. This improvement is apparently obtained without any serious changes in corrosion resistance, provided that no more than 20% of the Mn alloy is added. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570090601
更新日期:1978-09-01 00:00:00
abstract::In cases of pulp exposure due to deep dental caries or severe traumatic injuries, existing pulp-capping materials have a limited ability to reconstruct dentin-pulp complexes and can result in pulpectomy because of their low potentials to accelerate dental pulp cell activities, such as migration, proliferation, and dif...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034516653085
更新日期:2016-10-01 00:00:00
abstract::Porcine dentin sialophosphoprotein (DSPP) is the most abundant non-collagenous protein in dentin. It is processed by proteases into 3 independent proteins: dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP). We fractionated DPP and DSP along with TGF-β activity by ion exchange (IE) c...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514534690
更新日期:2014-07-01 00:00:00