Osteonecrosis of the jaws and bisphosphonate therapy.

Abstract:

:Bisphosphonates are a class of agents used to treat osteoporosis and malignant bone metastases. The efficacy of these agents in treating and preventing the significant skeletal complications associated with these conditions has had a major positive impact for patients and is responsible for their widespread use in medicine. Despite these benefits, osteonecrosis of the jaws has recently emerged as a significant complication in a subset of patients receiving these drugs. Based on a growing number of case reports and institutional reviews, bisphosphonate therapy may cause exposed and necrotic bone that is isolated to the jaw. This complication usually presents following simple dento-alveolar surgery, and can cause a significant adverse effect on the quality of life for most patients. The pathogenesis for this complication appears to be related to the profound inhibition of osteoclast function and bone remodeling.

journal_name

J Dent Res

authors

Ruggiero SL,Drew SJ

doi

10.1177/154405910708601101

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

1013-21

issue

11

eissn

0022-0345

issn

1544-0591

pii

86/11/1013

journal_volume

86

pub_type

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