Abstract：
:Radiation therapy for head and neck cancer results in severe secondary side-effects in salivary glands. We previously demonstrated that the administration of IGF1 preserves or restores salivary gland function following radiation. Based on these findings, we propose to study the effect of IGF1 on human head and neck carcinoma cells. Head and neck tumor cells treated with radiation have significant reductions in tumor cell survival, as measured by MTT and crystal violet assays, regardless of IGF1 pre-treatment. Head and neck squamous carcinoma cell xenografts treated with concurrent radiation+IGF1 also exhibit significant tumor growth delay; however, growth rates are elevated compared with those in irradiated xenografts. In contrast, administration of IGF1 after radiation treatment has no effect on tumor xenograft growth rates. Analysis of these data suggests that localized delivery may be required for concurrent therapy to prevent secondary side-effects of radiotherapy, while post-therapy administration of IGF1 could be considered for the restoration of salivary function.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Victory K,Burd R,Fribley A,Sittadjody S,Arnett D,Klein RR,Limesand KHdoi
10.1177/0022034510388037subject
Has Abstractpub_date
2011-03-01 00:00:00pages
347-52issue
3eissn
0022-0345issn
1544-0591pii
0022034510388037journal_volume
90pub_type
杂志文章abstract：:Recent reports have suggested functional interactions between the masticatory and head motor systems. However, the neurophysiological mechanisms behind these phenomena have not been thoroughly investigated. In this study, the motor unit activity was recorded bilaterally from the dorsal neck splenius muscles (SPL) whil...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200515
更新日期：2003-05-01 00:00:00
abstract：:Extracellular vesicles (EVs), several tens to hundreds of nanometers in size, are vesicles secreted by cells for intercellular communication. EVs released from mesenchymal stem cells (MSC-EVs) have the potential to treat multiple diseases. This study aimed to determine the effects of MSC-EVs on bisphosphonate-related ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520906793
更新日期：2020-05-01 00:00:00
abstract：:During the 18th century, France was the leader in the field of dentistry, exemplified by Pierre Fauchard (1678-1761), who was given the title "the father of modern dentistry" for his comprehensive work, Le Chirurgien Dentiste. This paper examines an 18th century dental treatment in a barely 50-year-old male whose body...
journal_title：Journal of dental research
pub_type： 历史文章,杂志文章
doi：10.1177/0022034508329872
更新日期：2009-03-01 00:00:00
abstract：:The effects of thermal stress on the marginal leakage of resin composite restorations in bovine teeth were investigated by a method that preserved the specimens. The changes in marginal leakage of specimens with increasing numbers of thermal cycles were measured by an electrical conductivity method. Four brands of pos...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690100601
更新日期：1990-10-01 00:00:00
abstract：:The complexity of the periodontal microbiota resembles that of the gastro-intestinal tract, where infectious diseases are treatable via probiotics. In the oropharyngeal region, probiotic or replacement therapies have shown some benefit in the prevention of dental caries, otitis media, and pharyngitis, but their effect...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708601111
更新日期：2007-11-01 00:00:00
abstract：:Dendritic cells, such as Langerhans cells (LC), in different ectodermal compartments may have different functional capabilities. The present study was undertaken to compare oral Langerhans cells (LC) with those of the epidermis in terms of their ability to co-stimulate T-cells in vitro. A Mixed Epithelial Cell Lymphoc...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780030701
更新日期：1999-03-01 00:00:00
abstract：:The amount of free water in 50 samples of air-dried enamel from permanent and deciduous teeth was measured by the Karl Fischer method. Samples included both contemporary and burial specimens. The mean values obtained showed that free water constituted about 1% of enamel mass. However, the range of individual values va...
journal_title：Journal of dental research
pub_type： 历史文章,杂志文章
doi：10.1177/00220345880670051701
更新日期：1988-05-01 00:00:00
abstract：:Interfacial bond strengths of light-activated composites were measured as a function of age using a transverse strength test. Bond strength between layers decreased with the age of the initial layer and reflected the setting curves of the composites. The highly-filled composites exhibited the greatest bond strengths. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630101501
更新日期：1984-10-01 00:00:00
abstract：:The pellicle serves as a multifunctional protective layer, providing, e.g., lubrication and remineralization and also acting as a diffusion barrier. In addition, since the formation of the pellicle precedes the adhesion of micro-organisms, it is also important as a conditioning film. We present a novel approach to stu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512456704
更新日期：2012-10-01 00:00:00
abstract：:Seven ATCC strains of bacteria were examined for apatite formation in a chemically-defined calcification-supporting medium and also in a metastable calcium phosphate solution. One, E. coli, calcified in both. One, S. aureus, calcified in the solution, but not in the medium. The other five did not calcify in either. Th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600101001
更新日期：1981-10-01 00:00:00
abstract：:Frequent consumption of cariogenic foods and bacterial infection are risk factors for early childhood caries (ECC). This study hypothesized that a short diet survey focused on frequency of foods, categorized by putative cariogenicity, would differentiate severe ECC (S-ECC) from caries-free children. Children's diets w...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510376543
更新日期：2010-11-01 00:00:00
abstract：:Matrix metalloproteinases (MMPs) produced by resident and inflammatory cells in response to periodontopathogens play a major role in periodontal tissue destruction. Our aim was to investigate the effects of A-type cranberry proanthocyanidins (AC-PACs) on: (i) the production of various MMPs by human monocyte-derived ma...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509339487
更新日期：2009-07-01 00:00:00
abstract：:The objective of this study was to calculate the stress distribution induced in anterior metal-ceramic crowns fabricated with either gold-alloy or nickel-alloy copings of reduced thickness using plane stress analyses. Two-dimensional finite element models of three crown designs were subjected to a simulated biting for...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650091201
更新日期：1986-09-01 00:00:00
abstract：:Understanding the mechanical properties of human teeth is important to clinical tooth preparation and to the development of "tooth-like" restorative materials. Previous studies have focused on the macroscopic fracture behavior of enamel and dentin. In the present study, we performed indentation studies to understand t...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770030601
更新日期：1998-03-01 00:00:00
abstract：:Jaw displacement tremor was investigated. Both tremor amplitude and tremor frequency were found to increase with increasing muscle activation. Co-contraction of jaw elevator and jaw depressor muscles was employed in order to vary muscle activation levels without the teeth being in occlusion. Reproducibility of tremor ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670080401
更新日期：1988-08-01 00:00:00
abstract：:This study indicated that a clear relationship exists between silicon and fluoride. We have also demonstrated a probable surface enamel silicon effect that increases fluoride uptake. The complex set of relationships described in the surface chemistry of calcium, tin, and zirconium with fluoride, hydroxide, phosphate, ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550050601
更新日期：1976-09-01 00:00:00
abstract：:Minimally invasive caries-removal procedures remove only caries-infected dentin and preserve caries-affected dentin that becomes remineralized. Dental cements containing calcium phosphate promote remineralization. This study evaluated the in vivo remineralization capacity of resin-based calcium-phosphate cement (Ca-P)...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034509360155
更新日期：2010-03-01 00:00:00
abstract：:A major extracellular protein of cultured adult human gingival fibroblasts was shown to be fibronectin by indirect immunofluorescence, lactoperoxidase catalyzed iodination and metabolic radiolabeling. Fibronectin preparations from these cells possessed the biological properties of agglutination of sheep red blood cell...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590031301
更新日期：1980-03-01 00:00:00
abstract：:PAX9 is a transcription factor expressed in the tooth mesenchyme during tooth morphogenesis. In Pax9-null mice, tooth development is arrested at the bud stage. In humans, heterozygous mutations in PAX9 have been associated with non-syndromic tooth agenesis, predominantly in the molars. Here, we report 2 novel mutation...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513519801
更新日期：2014-03-01 00:00:00
abstract：:In an attempt to make a dynamic study of the isoelectric point and the chargeability of human dental enamel, an electrochemical approach was utilized. Zeta potential of three kinds of the enamel was measured by a streaming potential method. As a result, these isoelectric points could be decided. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570022701
更新日期：1978-02-01 00:00:00
abstract：:A method of articulator comparison and a technique demonstrating the effects of three occlusal determinants were demonstrated and proved successful. The techniques used could be used in dental research circumstances and in dental schools as a means to study the determinants of occlusion. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550060601
更新日期：1976-11-01 00:00:00
abstract：:Mixed or parotid saliva from caries-active individuals consistently supported better growth of Streptococcus mutans (type c) than that from caries-free individuals. Electrophoretic studies revealed that certain proteins in caries-active salivas were susceptible to microbial attack, but similar proteins in caries-free ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580101501
更新日期：1979-10-01 00:00:00
abstract：:An oral radiotelemetric technique was used to determine whether a range of efficient buffers had the capacity to control the levels of hydrogen ions within dental plaque in the presence of sucrose. It was found that the buffers failed to control both the intensity and duration of the acid produced. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550052601
更新日期：1976-09-01 00:00:00
abstract：:The effect of inflammation on the distribution of chondroitin sulfate and dermatan sulfate proteoglycans was assessed after normal and inflamed human gingivae were stained with monoclonal antibodies against these extracellular matrix macromolecules. The tissues were obtained following periodontal surgery and reacted w...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345920710090801
更新日期：1992-09-01 00:00:00
abstract：:Erupting first permanent molars of 5 1/2 to 6 1/2 year-olds are eminently suited for the clinical testing of potential caries-inhibiting techniques. Due to the rapid onset of caries in these teeth, accurate monitoring of new materials/regimes can be instituted and meaningful data obtained within one year of trial comm...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/002203457705600301011
更新日期：1977-10-01 00:00:00
abstract：:After cheek pouch carcinomas were induced in hamsters by the application of dimethylbenzanthracene (DMBA) to the right pouch for 13 weeks, the animals were divided into four groups and observed for seven more weeks. The control group received no further treatment, two experimental groups had incisional biopsies perfor...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650061401
更新日期：1986-06-01 00:00:00
abstract：:Fibroblast growth factor receptor 2 (FGFR2) in craniofacial bones mediates osteoprogenitor proliferation, differentiation, and apoptosis. The distortion of proper craniofacial bone growth may cause class II and class III skeletal malocclusion and result in compromised function and aesthetics. Here, we investigated the...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519872951
更新日期：2019-11-01 00:00:00
abstract：:In order for the role of parotid amylase in starch digestion in the gastro-intestinal tracts of diabetic rats to be clarified, this study investigated the effect of parotid-duct ligation on both amylase secretion from the parotid glands and pancreas into the gastro-intestinal tract and on starch digestion in the gastr...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680091501
更新日期：1989-09-01 00:00:00
abstract：:The aim of this study was to assess the effect of chewing gum containing phosphoryl oligosaccharides of calcium (POs-Ca) and a low concentration of fluoride (F) on the hardness of enamel subsurface lesions, utilizing a double-blind, randomized, and controlled in situ model. Fifteen individuals wore removable lingual a...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034512439716
更新日期：2012-04-01 00:00:00
abstract：:Stress-induced changes imparted in a 'dentin-bonded-crown' material during sintering, annealing, pre-cementation surface modification, and resin coating have been visualized by profilometry. The hypothesis tested was that operative techniques modify the stressing pattern throughout the material thickness. We polished ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509354049
更新日期：2010-01-01 00:00:00
