Abstract：
:The effect of inflammation on the distribution of chondroitin sulfate and dermatan sulfate proteoglycans was assessed after normal and inflamed human gingivae were stained with monoclonal antibodies against these extracellular matrix macromolecules. The tissues were obtained following periodontal surgery and reacted with specific antibodies after pre-treatment with chondroitinase ACII or chondroitinase ABC, and staining was visualized by the immunoperoxidase technique. The results indicated that these two proteoglycans were present in both the 4-sulfated and 6-sulfated isomeric forms. While chondroitin sulfate appeared to be uniformly distributed throughout the connective tissue, dermatan sulfate showed greater intensity of staining in the areas immediately subjacent to the epithelium. Positive staining for chondroitin sulfate was noted in the intercellular spaces of the epithelium. In inflamed tissues, there was significant staining associated with 4-sulfated dermatan sulfate and chondroitin sulfate, but this had lost the structured pattern of staining noted in normal sections. The 6-sulfated isomeric forms were greatly reduced in inflamed tissues and tended to show a predilection to be localized within the perivascular tissues. In the inflamed tissues, there was intense staining for chondroitin sulfate associated with the infiltrating inflammatory cells. These findings corroborate earlier biochemical studies on normal and inflamed gingival tissues. The specific tissue localization of dermatan sulfate and chondroitin sulfate in tissues damaged by inflammation indicates that, as opposed to the large loss of collagenous material noted during inflammation, there is not a corresponding large loss of proteoglycan. Indeed, at specific inflammatory foci, the intensity of staining for these macromolecules may intensify.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Bartold PMdoi
10.1177/00220345920710090801keywords:
subject
Has Abstractpub_date
1992-09-01 00:00:00pages
1587-93issue
9eissn
0022-0345issn
1544-0591journal_volume
71pub_type
杂志文章abstract：:Mandibular prognathism (MP) is a recognizable phenotype associated with dentoskeletal class III malocclusion. MP is a complex genetic trait, although familial recurrence also suggests the contribution of single inherited variations. To date, the genetic causes of MP have been investigated using linkage analysis or ass...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515572190
更新日期：2015-04-01 00:00:00
abstract：:The color of an unshaded body porcelain was determined at three thicknesses on white, gray, and three chromatic backings. Spectral absorption and scattering coefficients of the porcelain were determined from the diffuse reflectance at one thickness on the white and gray backings. These optical coefficients, when utili...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640061801
更新日期：1985-06-01 00:00:00
abstract：:Previous studies have demonstrated that antibodies against cholinoreceptors of exocrine glands correlate with dry mouth in persons with primary Sjögren syndrome (pSS). The aim of the present investigation was to establish if serum IgG antibodies (pSS IgG) were able to interact with cholinoreceptors in rat submandibula...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600905
更新日期：2007-09-01 00:00:00
abstract：:The type of attachment that is used in oral rehabilitation by means of implant-retained mandibular overdentures may influence the retention and the stability of the denture. In this study, we examined the hypothesis that a better retention and stability of the denture improve the oral function. Eighteen edentulous sub...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/154405910208100305
更新日期：2002-03-01 00:00:00
abstract：:Sintered samples of modifying porcelains of various colors and manufacturers were analyzed using reflectance spectrophotometry. Color designations are reported according to practices of the Commission Internationale de l'Eclairage (International Commission for Illumination), and color names were assigned based on a me...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610030801
更新日期：1982-03-01 00:00:00
abstract：:Artificial white spot lesions have been prepared on bovine enamel surfaces by the controlled addition of lactate buffer containing methylhydroxydiphosphonate ions. The rates of remineralization have been measured using a constant composition method in solutions of calcium phosphate of low supersaturation. Deposition o...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630061001
更新日期：1984-06-01 00:00:00
abstract：:Recent advances in molecular biology have facilitated analyses of the oral microbiome ("Who are they?"); however, its functions (e.g., metabolic activities) are poorly understood ("What are they doing?"). This review aims to summarize our current understanding of the metabolism of the oral microbiome. Saccharolytic ba...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034515606045
更新日期：2015-12-01 00:00:00
abstract：:The reaction of the microvasculature in the periodontal ligament to mechanical pressure is considered a very important phenomenon with respect to the biological background to orthodontic tooth movement. For clarification of the microvascular reaction to mechanical pressure, an experimental model that incorporated a ha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345920710060701
更新日期：1992-06-01 00:00:00
abstract：:Breastfeeding is important for health and development. Yet, the interaction between breastfeeding duration and usage of fluoridated water on caries experience has not been investigated. This study examined exposure to fluoridation as an effect modifier of the association between breastfeeding duration and caries. The ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519843487
更新日期：2019-07-01 00:00:00
abstract：:Mastication as a mild but life-long exercise has been examined as a possibility for maintaining brain function in the elderly. Little is known, however, about the cerebral circulatory response during masticatory movement. The aim of this study was to develop a monitoring system for circulation dynamics during masticat...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510383692
更新日期：2011-01-01 00:00:00
abstract：:Previous investigations have shown a clear association between the presence of the enzyme aspartate aminotransferase (AST) in gingival crevicular fluid (GCF) and clinical evidence of periodontal disease in humans, as well as in the beagle dog model. This paper describes a 26-week study that uses the beagle dog model o...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700061501
更新日期：1991-06-01 00:00:00
abstract：:Ten dental casting alloys were tested for alloy-element release into cell-culture medium, and this release was related to alloy composition, alloy microstructure, and alloy cytotoxicity (previously determined). Cell-culture medium was analyzed for alloy elements by flame atomic absorption. Concentrations of elements i...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700060301
更新日期：1991-06-01 00:00:00
abstract：:Continuous etching of aggressive all-in-one adhesives occurs in wet dentin tubules after polymerization of the adhesives. This study challenged the hypothesis that unpolymerized acidic monomers from an aggressive all-in-one self-etching adhesive continue to etch beyond dentin hybrid layers. Dentin surfaces bonded with...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034510363665
更新日期：2010-05-01 00:00:00
abstract：:Bacteria attach to teeth and oral mucosal surfaces in a surprisingly selective manner, and attachment appears to be the first step in the colonization process. Attachment is thought to involve lectin-like and/or hydrophobic ligands, called adhesins, often present in bacterial surface appendages which interact with rec...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630030401
更新日期：1984-03-01 00:00:00
abstract：:At the present time, peri-implantitis has become a global burden that occurs with a frequency from 1% to 47% at implant level. Therefore, we aimed herein at assessing the impact of peri-implant maintenance therapy (PIMT) on the prevention of peri-implant diseases. Electronic and manual literature searches were conduct...
journal_title：Journal of dental research
pub_type： 杂志文章,meta分析,评审
doi：10.1177/0022034515622432
更新日期：2016-04-01 00:00:00
abstract：:This study describes the formation of a calcium polyacrylate-hydroxyapatite cement. Our hypothesis was that calcium phosphates would rapidly hydrolyze in the presence of polyacrylic acid (PAA) to form a cement. PAA, tetracalcium phosphate (TetCP), and dicalcium phosphate (DCP) were reacted together and formed calcium ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730030501
更新日期：1994-03-01 00:00:00
abstract：:Soft lining materials undergo two processes when immersed in water. Plasticizers and other soluble materials are leached into the water, and water is absorbed by the polymer. The balance between these two processes affects both the compliance and dimensional stability of the materials. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620061601
更新日期：1983-06-01 00:00:00
abstract：:Defects in the enamelin gene (ENAM) cause amelogenesis imperfecta (AI). Our objective was to identify the genetic etiology of enamel hypoplasia in a Caucasian proband. Our hypothesis was that ENAM was defective. The proband and his father have an AG insertion (g.13185_13186insAG; p.422FsX448) in ENAM previously identi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510365662
更新日期：2010-07-01 00:00:00
abstract：:Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) nanocomplexes incorporated into sugar-free chewing gum have been shown to remineralize enamel subsurface lesions in situ. The aim of this study was to compare the ability of CPP-ACP, with that of other forms of calcium, to be retained in supragingival plaque ...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/154405910308200311
更新日期：2003-03-01 00:00:00
abstract：:The effects of Escherichia coli endotoxin upon mouse L929 cell proliferation, DNA synthesis, protein synthesis, and proline incorporation were determined. It was found that a level of endotoxin which inhibited cell proliferation prompted a similar inhibition of DNA synthesis and overall cell protein synthesis. In cont...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580061301
更新日期：1979-06-01 00:00:00
abstract：:The recent bioengineering of complex tooth structures from pig tooth bud tissues suggests the potential for the regeneration of mammalian dental tissues. We have improved tooth bioengineering methods by comparing the utility of cultured rat tooth bud cells obtained from three- to seven-day post-natal (dpn) rats for to...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408300703
更新日期：2004-07-01 00:00:00
abstract：:Since 1935, various mechanisms have been suggested for the formation of subsurface lesions and, in particular, the surface layer covering enamel lesions. The relatively intact mineral-rich and porous surface layer is most likely caused by kinetic events. The suggested mineral-rich outer layer in sound enamel, the orga...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/00220345860650010201
更新日期：1986-01-01 00:00:00
abstract：:Relative glycogen synthetic abilities of resting cells of fresh clinical isolates of Actinomyces viscosus and Actinomyces naeslundii originating from dental plaque samples over root surface caries lesions and non-carious sites were studied under anaerobic conditions at a constant pH of 7.0, with U-(14C)-glucose used a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650060701
更新日期：1986-06-01 00:00:00
abstract：:The aim of this systematic review and network meta-analysis was to summarize the direct and indirect clinical evidence on the effectiveness of professionally applied and self-applied topical fluorides in preventing dental root caries. Controlled clinical trials with any follow-up duration were included. MEDLINE, PubMe...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520906384
更新日期：2020-05-01 00:00:00
abstract：:In the current theme of dental pulp regeneration, biological and synthetic scaffolds are becoming a potential therapy for pulp revitalization. The goal is to provide a suitable environment for cellular infiltration, proliferation, and differentiation. The extracellular matrix (ECM) represents a natural scaffold materi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518785124
更新日期：2018-12-01 00:00:00
abstract：:Dentin sialoprotein (DSP) and dentin phosphoprotein (DPP) are expressed as a single mRNA transcript coding for a large precursor protein termed dentin sialophosphoprotein (DSPP). DSP, DPP, and DSPP have been considered to be tooth-specific. To test for the expression of the dspp gene in bone, we performed Western immu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910208100607
更新日期：2002-06-01 00:00:00
abstract：:Autoimmune responses to heat-shock protein 60 (HSP60) contribute to the progression of atherosclerosis, whereas immunization with HSP60 may induce atheroprotective responses. We assessed the capacity of an atheroprotective vaccine that targeted a recombinant HSP60 from Porphyromonas gingivalis (rGroEL) to induce a pro...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514523784
更新日期：2014-04-01 00:00:00
abstract：:Bifidobacteria are aciduric bacteria that might play a role in the caries process. To test the hypothesis that Bifidobacteria behave as caries-associated organisms, as predicted by the ecological plaque hypothesis, we determined salivary levels of Bifidobacteria and caries-associated organisms for 156 older adults. Sa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510369319
更新日期：2010-09-01 00:00:00
abstract：:Bacteroides forysthus has been shown to be prevalent among patients with periodontitis. Conventional microbiological methods used to identify this bacterium, however, are laborious and time-consuming and are therefore not well-suited for screening purposes. We have developed a polymerase chain-reaction (PCR) method wh...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760070701
更新日期：1997-07-01 00:00:00
abstract：:Chondroitin sulfate is up-regulated in granulation tissue during wound healing. To investigate the role of chondroitin sulfate in the wound-healing process after surgical repair of cleft palate, we isolated and cultured rabbit palatal fibroblasts. Treatment with chondroitin-6-sulfate resulted in a dose-dependent incre...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910408301111
更新日期：2004-11-01 00:00:00
