Cranberry proanthocyanidins inhibit MMP production and activity.

Abstract:

:Matrix metalloproteinases (MMPs) produced by resident and inflammatory cells in response to periodontopathogens play a major role in periodontal tissue destruction. Our aim was to investigate the effects of A-type cranberry proanthocyanidins (AC-PACs) on: (i) the production of various MMPs by human monocyte-derived macrophages stimulated with Aggregatibacter actinomycetemcomitans lipopolysaccharide (LPS), and (ii) the catalytic activity of recombinant MMP-1 and MMP-9. The effects of AC-PACs on the expression of 5 protein kinases and the activity of nuclear factor-kappa B (NF-kappaB) p65 in macrophages stimulated with LPS were also monitored. Our results indicated that AC-PACs inhibited the production of MMPs in a concentration-dependent manner. Furthermore, the catalytic activity of MMP-1 and MMP-9 was also inhibited. The inhibition of MMP production was associated with reduced phosphorylation of key intracellular kinases and the inhibition of NF-kappaB p65 activity. AC-PACs thus show potential for the development of novel host-modulating strategies to inhibit MMP-mediated tissue destruction during periodontitis.

journal_name

J Dent Res

authors

La VD,Howell AB,Grenier D

doi

10.1177/0022034509339487

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

627-32

issue

7

eissn

0022-0345

issn

1544-0591

pii

88/7/627

journal_volume

88

pub_type

杂志文章
  • Ca2+- and Mg2+-activated ATP hydrolysis in human tooth pulp.

    abstract::ATP-degrading enzyme activities in pulps of healthy and carious human teeth were quantitatively analyzed using the bioluminescence method. The patterns of both Ca2+- and MG2+-activated ATP hydrolysis resembled each other. Increased enzyme activities were observed during injured states. ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345810600020601

    authors: Le Bell Y

    更新日期:1981-02-01 00:00:00

  • Oral Implants: The Paradigm Shift in Restorative Dentistry.

    abstract::The discovery of the phenomenon "osseointegration," or functional ankylosis, has led to the development of oral implants with high clinical performance. Consequently, the placement of titanium implants has changed the paradigms of restorative dentistry. Implants are used to prevent placing reconstructions anchored on ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034519853574

    authors: Lang NP

    更新日期:2019-11-01 00:00:00

  • Bayesian analysis of clustered interval-censored data.

    abstract::The recording of multiple interval-censored failure times is common in dental research. Modeling multilevel data has been a difficult task. This paper aims to use the Bayesian approach to analyze a set of multilevel clustered interval-censored data from a clinical study to investigate the effectiveness of silver diami...

    journal_title:Journal of dental research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1177/154405910508400907

    authors: Wong MC,Lam KF,Lo EC

    更新日期:2005-09-01 00:00:00

  • The seven-year outcome of an early orthodontic treatment strategy.

    abstract::The benefits of early orthodontic treatment are continuously discussed, but studies are few. We examined whether definite need for orthodontic treatment could be eliminated in public health care by systematically focusing on early intervention. One age cohort living in a rural Finnish municipality (N = 85) was regular...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910808700604

    authors: Kerosuo H,Väkiparta M,Nyström M,Heikinheimo K

    更新日期:2008-06-01 00:00:00

  • Electromyographic heterogeneity in the human temporalis and masseter muscles during static biting, open/close excursions, and chewing.

    abstract::The human temporalis and masseter muscles are not activated homogeneously during static bite force tasks. In this study, we studied the possible existence of regional differences in these muscles under dynamic conditions. Electromyographic (EMG) activity was recorded by means of bipolar fine-wire electrodes. Six elect...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345950740061201

    authors: Blanksma NG,van Eijden TM

    更新日期:1995-06-01 00:00:00

  • Impact of endodontic treatments on the rigidity of the root.

    abstract::The destabilizing effect of endodontic treatment upon teeth is still controversial. The purpose of this study was to investigate the effects of different steps of endodontic treatments upon the rigidity of teeth. Extracted untreated central maxillary anterior teeth were loaded (3.75 N), and deformations of the root we...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/154405910608500416

    authors: Lang H,Korkmaz Y,Schneider K,Raab WH

    更新日期:2006-04-01 00:00:00

  • Loss of Discoidin Domain Receptor 1 Predisposes Mice to Periodontal Breakdown.

    abstract::The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors and tyrosine kinases. DDRs regulate cell functions, and their extracellular domains affect collagen fibrillogenesis and mineralization. Based on the collagenous nature of dentoalveolar tissues, we hypothesized that DDR1 plays an importan...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034519881136

    authors: Chavez MB,Kolli TN,Tan MH,Zachariadou C,Wang C,Embree MC,Lira Dos Santos EJ,Nociti FH Jr,Wang Y,Tatakis DN,Agarwal G,Foster BL

    更新日期:2019-12-01 00:00:00

  • Molecular and cellular regulatory mechanisms of tongue myogenesis.

    abstract::The tongue exerts crucial functions in our daily life. However, we know very little about the regulatory mechanisms of mammalian tongue development. In this review, we summarize recent findings of the molecular and cellular mechanisms that control tissue-tissue interactions during tongue morphogenesis. Specifically, c...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/0022034511434055

    authors: Parada C,Han D,Chai Y

    更新日期:2012-06-01 00:00:00

  • An explanation for the "two fiber axes" problem in human enamel by x-ray diffraction.

    abstract::Since Thewlis found the "two fiber axes" patterns on x-ray diffractograms of human enamel in 1934, many investigators have studied this problem. However, a definite answer has not yet been obtained. The present detailed x-ray diffraction study showed that the "two fiber axes" patterns in human enamel were caused by re...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345860650071601

    authors: Hirota F

    更新日期:1986-07-01 00:00:00

  • A comparison of antimicrobial activity of four disclosant dyes.

    abstract::Four disclosant dyes were tested for antimicrobial activity against 27 oral reference strains and five non-oral human pathogens. Erythrosine and fluorescein inhibited most gram-positive and gram-negative organisms associated with dental plaque, and were bactericidal to selected strains. Fast green and brilliant blue d...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345830620071601

    authors: Baab DA,Broadwell AH,Williams BL

    更新日期:1983-07-01 00:00:00

  • Use of human minor salivary glands in basic and applied secretion research.

    abstract::Previous findings from studies utilizing human labial and palatine minor salivary glands are reviewed. These studies took histopathological, biochemical, and ultrastructural approaches, and focused on control and diseased glands. Disease-oriented summarization are used, and control results are discussed in the context...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345870660s108

    authors: Izutsu KT,Schubert MM,Truelove EL,Johnson DE

    更新日期:1987-02-01 00:00:00

  • Identification of Bacteroides forsythus in subgingival dental plaque with the aid of a rapid PCR method.

    abstract::Bacteroides forysthus has been shown to be prevalent among patients with periodontitis. Conventional microbiological methods used to identify this bacterium, however, are laborious and time-consuming and are therefore not well-suited for screening purposes. We have developed a polymerase chain-reaction (PCR) method wh...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345970760070701

    authors: Meurman JH,Wahlfors J,Korhonen A,Alakuijala P,Väisänen P,Torkko H,Jänne J

    更新日期:1997-07-01 00:00:00

  • The secretion of protein and of some electrolytes in response to alpha- and beta- adrenergic agonists by rat parotid and submandibular salivary glands enlarged by chronic treatment with isoproterenol.

    abstract::In comparison with control rats. chronic administration of isoproterenol (IPR) caused enlargement of the parotid and submandibular glands and the synthesis of apparently new proteins, probably by acinar cells. The parotid and submandibular saliva secreted in response to methoxamine or IPR differed markedly in protein ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345800590062001

    authors: Abe K,Dawes C

    更新日期:1980-06-01 00:00:00

  • Changes in the microvasculature after mechanical pressure on the hamster cheek pouch.

    abstract::The reaction of the microvasculature in the periodontal ligament to mechanical pressure is considered a very important phenomenon with respect to the biological background to orthodontic tooth movement. For clarification of the microvascular reaction to mechanical pressure, an experimental model that incorporated a ha...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345920710060701

    authors: Iida J,Inage S,Kurihara S,Miura F

    更新日期:1992-06-01 00:00:00

  • Fusobacterium nucleatum activates the immune response through retinoic acid-inducible gene I.

    abstract::Retinoic acid-inducible gene I (RIG-I) is a cytosolic pattern recognition receptor involved in the sensing of RNA viruses and the initiation of antiviral responses. Fusobacterium nucleatum, a Gram-negative anaerobic bacterium associated with periodontal disease, is capable of invading cells. We hypothesized that F. nu...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034513516346

    authors: Lee P,Tan KS

    更新日期:2014-02-01 00:00:00

  • Fluoride deposition in human enamel in vivo from professionally applied fluoride prophylaxis paste.

    abstract::Deciduous teeth were collected from children who received professional prophylaxis with an acidulated phosphate-fluoride (APF) or placebo paste and were analyzed to determine fluoride uptake. Enamel fluoride level was increased by the APF paste approximately 300 ppm at a depth of 2.5 micrometers during the first month...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345760550064901

    authors: Mellberg JR,Nicholson CR,Ripa LW,Barenie J

    更新日期:1976-11-01 00:00:00

  • Ceramic whisker reinforcement of dental resin composites.

    abstract::Resin composites currently available are not suitable for use as large stress-bearing posterior restorations involving cusps due to their tendencies toward excessive fracture and wear. The glass fillers in composites provide only limited reinforcement because of the brittleness and low strength of glass. The aim of th...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345990780021101

    authors: Xu HH,Martin TA,Antonucci JM,Eichmiller FC

    更新日期:1999-02-01 00:00:00

  • X-ray diffraction study of acid-degradable glasses.

    abstract::The composition of the degradable glasses used in commercial dental glass-ionomer cements determines their leaching behavior and hence the properties of the cement. The objective of the present study was to assess if the composition and leaching in acetic acid solutions are reflected in the x-ray diffraction character...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345010800081601

    authors: De Maeyer EA,Verbeeck RM

    更新日期:2001-08-01 00:00:00

  • Antibodies against mycobacterial antigens in the synovial fluid of patients with temporomandibular disorders.

    abstract::In the absence of active pulmonary disease, mycobacterial infection frequently causes arthritis and can be considered to initiate autoimmune diseases such as rheumatoid arthritis. Temporomandibular disorder (TMD) is a disease in which pain and impaired mandibular movement appear to arise directly from degenerative or ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345000790100401

    authors: Adachi N,Matsumoto S,Tokuhisa M,Kobayashi K,Yamada T

    更新日期:2000-10-01 00:00:00

  • The relation between caries prevalence and strontium concentrations in drinking water, plaque, and surface enamel.

    abstract::Samples of plaque and surface enamel were collected from 80 boys aged 14 years living in five communities in Ohio (USA). Mean (+/- SE) strontium concentrations in plaque were 1.43 +/- 0.18 micrograms/g (wet) and 12.34 +/- 1.63 micrograms/g (dry). For surface enamel, the mean concentration was 421 +/- 31 micrograms Sr/...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345850640121201

    authors: Curzon ME

    更新日期:1985-12-01 00:00:00

  • Comparison of the reproducibility of EMG signals recorded from human masseter and lateral pterygoid muscles.

    abstract::EMG recordings of the left and right masseter and lateral pterygoid muscles were repeated three times in 15 young adults to test the reproducibility of the signals. Two tests were made on the same day (morning and afternoon) and one test three days later (morning). Needle and hook electrodes were used for the masseter...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345860650031401

    authors: Dahan J,Boitte C

    更新日期:1986-03-01 00:00:00

  • Dental amalgam and antibiotic- and/or mercury-resistant bacteria.

    abstract::Mercury emitted from dental amalgam may select for increased numbers of antibiotic- or mercury-resistant commensal bacteria in patients and increase their risk for bacterial diseases that are resistant to common therapies. We hypothesized that the presence of dental amalgams would increase the level of mercury-, tetra...

    journal_title:Journal of dental research

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/154405910808700502

    authors: Roberts MC,Leroux BG,Sampson J,Luis HS,Bernardo M,Leitão J

    更新日期:2008-05-01 00:00:00

  • Susceptibility of some plaque microorganisms to chemotherapeutic agents.

    abstract::Investigators have used chemotherapeutic agents topically for plaque control without knowing the drug concentration necessary to inhibit the growth of odontopathic microorganisms. S mutans, S sanguis, A viscosus and A naeslundii are important components of the plaque flora. The minimal inhibitory concentrations (MIC) ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345760550040401

    authors: Newbrun E,Felton RA,Bulkacz J

    更新日期:1976-07-01 00:00:00

  • The Evolution of Dental Materials over the Past Century: Silver and Gold to Tooth Color and Beyond.

    abstract::The field of dental materials has undergone more of a revolution than an evolution over the past 100 y. The development of new products, especially in the past half century, has occurred at a staggering pace, and their introduction to the market has been equally impressive. The movement has mostly come in the area of ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/0022034518822808

    authors: Bayne SC,Ferracane JL,Marshall GW,Marshall SJ,van Noort R

    更新日期:2019-03-01 00:00:00

  • The seeded growth of calcium phosphates. The kinetics of growth of dicalcium phosphate dihydrate on enamel, dentin, and calculus.

    abstract::The kinetics of growth of calcium phosphates on synthetic hydroxyapatite (HAP), human enamel, whole dentin, and human calculus has been studied at 37 C at pH values from 4.97 to 5.10 held constant by the pH-stat addition of base. Following an initial induction period, dicalcium phosphate dihydrate (DCPD) crystallizati...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345780570010901

    authors: Barone JP,Nancollas GH

    更新日期:1978-01-01 00:00:00

  • Microbiological aspects of the chemical control of plaque and gingivitis.

    abstract::Antimicrobial agents, delivered either by mouthrinse or toothpaste, can be used to maintain plaque at levels compatible with oral health by (a) reducing existing plaque, (b) preventing the formation of new plaque, (c) selectively inhibiting those particular bacteria that are associated with disease, and (d) inhibiting...

    journal_title:Journal of dental research

    pub_type: 杂志文章,评审

    doi:10.1177/00220345920710071501

    authors: Marsh PD

    更新日期:1992-07-01 00:00:00

  • A study of in vivo fluoride uptake by dental tissues from fluoride-containing silver amalgams.

    abstract::Teeth to be extracted for orthodontic reasons were filled in vivo with regular and fine-cut silver amalgams containing 1% and 5% SnF2. The teeth were extracted after 15 or 30 d, and the in vivo fluoride release and uptake by the dental tissues were studied using an electron microprobe analysis technique. The obtained ...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345810600020101

    authors: Souganidis DJ,Athanassouli TM,Papastathopoulos DS

    更新日期:1981-02-01 00:00:00

  • Curing light-activated composite cement through porcelain.

    abstract::The purpose of the study was to determine the exposure times needed to harden a light-activated composite cement through various thicknesses of porcelain. A negative exponential model was developed with which the relative hardness of a composite could be predicted from the product of the exposure time and the square r...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345890680030801

    authors: Chan KC,Boyer DB

    更新日期:1989-03-01 00:00:00

  • The influence of functional use of endosseous dental implants on the tissue-implant interface. I. Histological aspects.

    abstract::The tissue-implant interfaces of functional and non-functional endosseous dental implants were compared histologically for up to one year post-operatively. Nonmineralized connective tissue zones (a "fibrous capsule") existed in all functional interfaces. Direct, or nearly direct, bone apposition to implants occurred i...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345790580100201

    authors: Brunski JB,Moccia AF Jr,Pollack SR,Korostoff E,Trachtenberg DI

    更新日期:1979-10-01 00:00:00

  • A comparison of the ability of intra-oral and extra-oral fibroblasts to stimulate extracellular matrix reorganization in a model of wound contraction.

    abstract::Intra-oral wounds, like wounds in children, demonstrate privileged healing when compared with adult wounds at extra-oral sites. This study investigated whether this preferential healing is related to an increased ability of oral mucosal fibroblasts to reorganize extracellular matrix (ECM) when compared with their derm...

    journal_title:Journal of dental research

    pub_type: 杂志文章

    doi:10.1177/00220345960750060601

    authors: Stephens P,Davies KJ,al-Khateeb T,Shepherd JP,Thomas DW

    更新日期:1996-06-01 00:00:00