Abstract：
:Although it is known that diabetes impairs oral wound healing, relatively little is known about the cellular parameters affected, particularly in connective tissue. This study investigated the hypothesis that diabetes impairs connective tissue formation in healing gingiva, and that impaired healing is associated with factors that decrease fibroblast numbers. Full-thickness wounds were created in the palatal gingiva of type 1 and type 2 diabetic and normoglycemic mice. Five days after wounding, diabetic mice had less epithelial wound coverage, less new connective tissue formation, and reduced fibroblast density (p < 0.05). This occurred with increased numbers of caspase-3- and TUNEL-positive fibroblasts, decreased fibroblast proliferation, increased nuclear translocation of the pro-apoptotic transcription factor FOXO1, and increased numbers of polymorphonuclear leukocytes, all of which were significant (p < 0.05). The results suggest that diabetes may decrease fibroblast numbers through increased apoptosis and reduced proliferation, both of which may be mediated through increased activation of FOXO1.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Desta T,Li J,Chino T,Graves DTdoi
10.1177/0022034510362960subject
Has Abstractpub_date
2010-06-01 00:00:00pages
609-14issue
6eissn
0022-0345issn
1544-0591pii
0022034510362960journal_volume
89pub_type
杂志文章abstract：:Genetic influences are important in the determination of mandibular morphology, and growth hormone receptor (GHR) is believed to have an important influence on the growth of craniofacial bone. In this study, we used quantitative trait locus methods to evaluate the relationship between craniofacial morphology and singl...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910508401116
更新日期：2005-11-01 00:00:00
abstract：:Wavelength-independent Microradiography (WIM), described in this paper, used polychromatic, high-energy (less than or equal to 60 kV) x-rays for determination of mineral concentrations in tooth material non-destructively. This was done with the aid of a reference step-wedge made of 94% aluminum, 6% zinc. The mass atte...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690081501
更新日期：1990-08-01 00:00:00
abstract：:Khat-chewing has been associated with oral lesions including oral cancer, but the mechanisms leading to their development are not known. We hypothesized that khat interferes with the physiological processes of the oral mucosa, such as cell proliferation and differentiation, and aimed at investigating the effects of kh...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509354980
更新日期：2010-03-01 00:00:00
abstract：:The tongue exerts crucial functions in our daily life. However, we know very little about the regulatory mechanisms of mammalian tongue development. In this review, we summarize recent findings of the molecular and cellular mechanisms that control tissue-tissue interactions during tongue morphogenesis. Specifically, c...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034511434055
更新日期：2012-06-01 00:00:00
abstract：:Dispersed salivary acini isolated from the rat submandibular gland by enzymatic digestion were used to study the effects of alpha-receptor stimulation on transmembrane transport of 36Cl. In the absence of secretagogue, the tracer accumulated in the cells in a time-dependent manner until a steady-state content of 6.8 +...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670030701
更新日期：1988-03-01 00:00:00
abstract：:Ammoniacal silver stain showed that there was a decrease in nucleohistones in zinc-deficient rat buccal hyperplastic epithelium as compared to control. Autoradiographic study showed that there was decreased incorporation of 3H-arginine and 3H-lysine in the hyperplastic epithelium. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560122501
更新日期：1977-12-01 00:00:00
abstract：:Teeth to be extracted for orthodontic reasons were filled in vivo with regular and fine-cut silver amalgams containing 1% and 5% SnF2. The teeth were extracted after 15 or 30 d, and the in vivo fluoride release and uptake by the dental tissues were studied using an electron microprobe analysis technique. The obtained ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600020101
更新日期：1981-02-01 00:00:00
abstract：:When measured once, psychological stress predicts development of painful temporomandibular disorder (TMD). However, a single measurement fails to characterize the dynamic nature of stress over time. Moreover, effects of stress on pain likely vary according to biological susceptibility. We hypothesized that temporal es...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515595043
更新日期：2015-09-01 00:00:00
abstract：:Amelogenin and ameloblastin, the major enamel matrix proteins, are important for enamel mineralization. To identify their synergistic roles in enamel development, we generated Amel X(-/-)/Ambn(-/-) mice. These mice showed additional enamel defects in comparison with Amel X(-/-) or Ambn(-/-) mice. In 7-day-old Amel X(-...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034509334749
更新日期：2009-04-01 00:00:00
abstract：:Genetic studies of early-onset periodontitis (EOP) are hampered by several factors. These include delayed onset of the trait, an upper age limit of expression of the disease, and lack of phenotypic information for edentulous family members. Segregation analyses of families with EOP support a major locus hypothesis but...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790031201
更新日期：2000-03-01 00:00:00
abstract：:We have previously reported the clinical and radiographic findings of a trial in dogs of a new dental implant system after a functional period of eight months. The present report consists of the corresponding qualitative and quantitative histological data. The implant system was fabricated from Ti-6A1-4V and employed ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670090801
更新日期：1988-09-01 00:00:00
abstract：:The etiology and pathogenesis of craniofacial birth defects are multifactorial and include both genetic and environmental factors. Despite the identification of numerous genes associated with congenital craniofacial anomalies, our understanding of their etiology remains incomplete, and many affected individuals have a...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520969109
更新日期：2020-11-06 00:00:00
abstract：:Early childhood caries (ECC) is a chronic disease affecting the oral health of children globally. This disease is multifactorial, but a primary factor is cariogenic microorganisms such as Streptococcus mutans. Biosynthetic gene clusters (BGCs) encode small molecules with diverse biological activities that influence th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520914519
更新日期：2020-07-01 00:00:00
abstract：:Loss of hybrid layer integrity compromises resin-dentin bond stability. Matrix metalloproteinases (MMPs) may be partially responsible for hybrid layer degradation. Since chlorhexidine inhibits MMPs, we hypothesized that chlorhexidine would decelerate the loss of resin-dentin bonds. Class I preparations in extracted th...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/154405910708600115
更新日期：2007-01-01 00:00:00
abstract：:Tumor progression is often associated with altered glycosylation of the cell-surface proteins and lipids. The peripheral part of these cell-surface glycoconjugates often carries carbohydrate structures related to the ABO and Lewis blood-group antigens. The expression of histo-blood-group antigens in normal human tissu...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910508400103
更新日期：2005-01-01 00:00:00
abstract：:Dental porcelains rely on the high-thermal-expansion mineral leucite to elevate their bulk thermal expansion to levels compatible with dental PFM alloys. The microcracks that form around these leucite particles when cooled during porcelain manufacture are a potential source of change in bulk porcelain thermal expansio...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750070801
更新日期：1996-07-01 00:00:00
abstract：:Joining a brittle veneer to a strong ceramic core with an adhesive offers potential benefits over current fabrication methods for all-ceramic crowns. We tested the hypothesis that such joining can withstand subsurface radial cracking in the veneer, from enhanced flexure in occlusal loading, as well as in the core. Cri...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700408
更新日期：2008-04-01 00:00:00
abstract：:Dissolution of mercury from the Ag-Hg matrix phase of dental amalgam is distilled water and synthetic saliva, and the mercury evaporation from the solutions, were studied in vitro. The main objectives of the study were to evaluate the factors that affect the results of the mercury release tests, and to consider the po...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690050901
更新日期：1990-05-01 00:00:00
abstract：:In a previous experiment, we found that masseter muscle spindles show functional plasticity after 5 to 15 days under increased occlusal vertical dimension (iOVD). In the present study, we hypothesized that spindle function would eventually recover if longer observation periods were allowed. Therefore, in this study we...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500914
更新日期：2006-09-01 00:00:00
abstract：:Although systemic bone loss accompanying estrogen deficiency has been proposed as a risk factor for periodontal disease in post-menopausal women, the mechanisms involved remain unclear. The objective of this study was to elucidate the potential bone-sparing effect of estrogen (17beta-estradiol, E(2)) via modulation of...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700214
更新日期：2008-02-01 00:00:00
abstract：:The differential diagnosis of dental wear lesions affects their clinical management. We hypothesized that surface texture parameters can differentiate simulated erosion, abrasion, and erosion-abrasion lesions on human enamel and dentin. This in vitro study comprised 2 parts (both factorial 4 × 2), with 4 lesion types ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034516629941
更新日期：2016-05-01 00:00:00
abstract：:Despite recent advances revealing genetic factors influencing caries susceptibility, questions regarding the model of inheritance involved are yet to be addressed. We conducted a Complex Segregation Analysis on decayed teeth in a sample of homogenous, isolated families recruited from the Brazilian Amazon. A dominant, ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510397614
更新日期：2011-06-01 00:00:00
abstract：:The effects of demineralized dentin and bone matrix on dental ectomesenchymal cells were evaluated after observation periods of two or three weeks. Autogenous dentin and bone matrix, obtained from the crowns of primary molars or maxillary cortical bone, respectively, were demineralized with 3% acetic acid and implante...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690011301
更新日期：1990-01-01 00:00:00
abstract：:Breastfeeding is important for health and development. Yet, the interaction between breastfeeding duration and usage of fluoridated water on caries experience has not been investigated. This study examined exposure to fluoridation as an effect modifier of the association between breastfeeding duration and caries. The ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519843487
更新日期：2019-07-01 00:00:00
abstract：:The main purpose of this paper is to review the various methods used for evaluation of fluoride retention in saliva, plaque, and enamel following application of topical anti-caries treatments such as F dentifrices and F mouthwashes. Such methods monitor delivery of fluoride to the site of action, the mouth, and so can...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/002203459207100S29
更新日期：1992-04-01 00:00:00
abstract：:Since Thewlis found the "two fiber axes" patterns on x-ray diffractograms of human enamel in 1934, many investigators have studied this problem. However, a definite answer has not yet been obtained. The present detailed x-ray diffraction study showed that the "two fiber axes" patterns in human enamel were caused by re...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650071601
更新日期：1986-07-01 00:00:00
abstract：:Growing evidence suggests that individual genetic susceptibility may influence the host's response to infections. The aim of this project was to study whether gene polymorphisms of inflammatory markers are associated with the presence of viable periodontopathogenic bacteria. We extracted genomic DNA from 45 young adul...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600505
更新日期：2007-05-01 00:00:00
abstract：:The dimensional accuracy of porcelain fused to metal crown and bridge castings was determined on truncated cone-shaped steel dies. Ni-Cr castings produced in manufacturers' laboratories were consistently undersize, while precious metal castings were consistently oversize. Ni-Cr castings, produced in NBS laboratories u...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580120501
更新日期：1979-12-01 00:00:00
abstract：:Selected reference and freshly isolated strains of Streptococcus mitis (mitior) and Streptococcus sanguis were assayed for cell-associated neuraminidase activity by their ability to hydrolyze [3H-] sialyllactitol. A cell-associated neuraminidase was detected with S. mitis and S. sanguis serotype II (reclassified as S....
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630020201
更新日期：1984-02-01 00:00:00
abstract：:Previous studies have shown that fluoride affected the formation of apatite in spontaneous precipitations from unstable calcium phosphate solutions partly through its effect on the stability of such nonapatitic precursors as octacalcium phosphate, Ca8H2(PO4)6.5 H2O. The present study shows that fluoride had a comparab...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590021401
更新日期：1980-02-01 00:00:00
