Estrogen modulates cytokine expression in human periodontal ligament cells.

Abstract:

:Although systemic bone loss accompanying estrogen deficiency has been proposed as a risk factor for periodontal disease in post-menopausal women, the mechanisms involved remain unclear. The objective of this study was to elucidate the potential bone-sparing effect of estrogen (17beta-estradiol, E(2)) via modulation of inflammatory cytokine production in human periodontal ligament (hPDL) cells. E. coli lipopolysaccharide (LPS) increased the production of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and receptor activator of NF- B ligand (RANKL) by hPDL cells at both mRNA and protein levels. E(2) treatment reversed the stimulatory effects of LPS on pro-inflammatory cytokine expression by hPDL cells. Moreover, E(2) up-regulated osteoprotegerin (OPG) expression and therefore attenuated the reduction of the OPG vs. RANKL ratio. Our results suggested that estrogen may play a significant role in modulating periodontal tissue responses to LPS, and may exert its bone-sparing effects on periodontal tissues via altering the expression of inflammatory cytokines in hPDL cells.

journal_name

J Dent Res

authors

Shu L,Guan SM,Fu SM,Guo T,Cao M,Ding Y

doi

10.1177/154405910808700214

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

142-7

issue

2

eissn

0022-0345

issn

1544-0591

pii

87/2/142

journal_volume

87

pub_type

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