Abstract：
:Cementum is known to be growth-hormone (GH)-responsive, but to what extent is unclear. This study examines the effects of extremes of GH status on cementogenesis in three lines of genetically modified mice; GH excess (giant), GH antagonist excess (dwarf), and GH receptor-deleted (GHR-KO) (dwarf). Age-matched mandibular molar tissues were processed for light microscope histology. Digital images of sections of first molar teeth were captured for morphometric analysis of lingual root cementum. Cross-sectional area of the cellular cementum was a sensitive guide to GH status, being reduced nearly 10-fold in GHR-KO mice, three-fold in GH antagonist mice, and increased almost two-fold in giant mice (p < 0.001). Cellular cementum length was similarly influenced by GH status, but to a lesser extent. Acellular cementum was generally unaffected. This study reveals cellular cementum to be a highly responsive GH target tissue, which may have therapeutic applications in assisting regeneration of the periodontium.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Smid JR,Rowland JE,Young WG,Daley TJ,Coschigano KT,Kopchick JJ,Waters MJdoi
10.1177/154405910408300107keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
35-9issue
1eissn
0022-0345issn
1544-0591journal_volume
83pub_type
杂志文章abstract：:Temporomandibular joint (TMJ) disorders, including degenerative TMJ disease, occur primarily in women of reproductive age. Previous studies showed elevated estrogen levels in subjects with TMJ disorders relative to controls and the presence of estrogen receptors α and β (ERα and ERβ) in TMJ fibrocartilage. Additionall...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518767108
更新日期：2018-08-01 00:00:00
abstract：:Squamous cell carcinoma (SCC) of the head and neck is the sixth most frequent cancer worldwide. The survival rate is among the lowest of the major cancers and has not improved significantly in the past two decades. Extensive local invasion and regional lymph node metastasis are, in large part, responsible for the poor...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780061001
更新日期：1999-06-01 00:00:00
abstract：:Disks of dentin taken from extracted human teeth demonstrated the optical property of the magnification/reduction effect. When images were transmitted from a pulpal-to-occlusal direction, the images were magnified. When the disks were inverted, the images were reduced in size. The images were slightly distorted but cl...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550041601
更新日期：1976-07-01 00:00:00
abstract：:Patients with restorations cemented with a reinforced zinc oxide-eugenol cement and a zinc phosphate cement were recalled after a four- to seven-year interval. No significant differences in clinical success were observed between restoration luted with the two cements. No significant difference in the incidence of cari...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550022201
更新日期：1976-03-01 00:00:00
abstract：:Dendritic cells, such as Langerhans cells (LC), in different ectodermal compartments may have different functional capabilities. The present study was undertaken to compare oral Langerhans cells (LC) with those of the epidermis in terms of their ability to co-stimulate T-cells in vitro. A Mixed Epithelial Cell Lymphoc...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780030701
更新日期：1999-03-01 00:00:00
abstract：:Stereologic studies of trabecular architecture suggest that the pig mandibular condyle is strongest when loaded supero-inferiorly, and that stress is concentrated in the antero-inferior region (Teng and Herring, 1995). To test these hypotheses, we investigated the uni-axial mechanical properties of 22 pig mandibular c...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750110501
更新日期：1996-11-01 00:00:00
abstract：:The biogenetic formation of mineral crystals, one aspect of biomineralization, is a multistep process of apatite formation throughout the growth of dentin tissue. An important step is the transformation of the non-mineralized predentin matrix to mineralizing dentin matrix and its biological control. In this study, the...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770081401
更新日期：1998-08-01 00:00:00
abstract：:The aim of the present study was to describe the patterns of dental fluorosis in the primary and the permanent dentition of children born and reared in two different fluoridated areas, one in which powdered milk suspended in tap water was commonly used (Narssaq, Greenland: 1.1 ppm fluoride in the water) and one in whi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670050501
更新日期：1988-05-01 00:00:00
abstract：:Selected strains of oral Streptococcus and Actinomyces have been tested for their ability to grow in the presence of mercury. Strains were tested for growth on a semi-defined medium with low mercury-binding characteristics. Sensitivities were initially measured on agar plates, and subsequently, selected strains were g...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720091201
更新日期：1993-09-01 00:00:00
abstract：:In sham-operated and TPTX animals, F treatment did not affect final body weight, or serum Ca and P. In sham-treated rats, serum iPTH was not affected by F treatment. At the periosteum, F increased bone formation rate and bone and matrix apposition rates. At the endosteum, F treatment decreased forming surface, bone fo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560031601
更新日期：1977-03-01 00:00:00
abstract：:The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts and cementoblasts. We hypothesized that stem cells may be present in the DF and be capable of differentiating into cells of the periodontium. Stem cells ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700801
更新日期：2008-08-01 00:00:00
abstract：:Four disclosant dyes were tested for antimicrobial activity against 27 oral reference strains and five non-oral human pathogens. Erythrosine and fluorescein inhibited most gram-positive and gram-negative organisms associated with dental plaque, and were bactericidal to selected strains. Fast green and brilliant blue d...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620071601
更新日期：1983-07-01 00:00:00
abstract：:Periodontitis is increasingly associated with increased risk of cardiovascular and other systemic diseases. The Gram-negative anaerobe, Porphyromonas gingivalis, is a key periodontal pathogen, and several lines of evidence link the presence of this bacterium in the circulation with vascular disease. The outer membrane...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520943187
更新日期：2020-12-01 00:00:00
abstract：:Although proanthocyanidins (PACs) modify dentin, the effectiveness of different PAC sources and the correlation with their specific chemical composition are still unknown. This study describes the chemical profiling of natural PAC-rich extracts from 7 plants using ultra high pressure/performance liquid chromatography ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514523783
更新日期：2014-04-01 00:00:00
abstract：:The oral microbiome consists of a planktonic microbiome residing in saliva and an adhering microbiome (the biofilm adhering to oral hard and soft tissues). Here we hypothesized that possible differences in microbial composition of the planktonic and adhering oral microbiome on teeth can be related to the forces by whi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513511822
更新日期：2014-01-01 00:00:00
abstract：:During the polymerization of multifunctional monomers for dental restorations, typical final double-bond conversions range from 55 to 75%. The low conversion results in a large amount of extractable monomer, reduced adhesion to the filler, and the potential for increased swelling. In this work, the ability to increase...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750081301
更新日期：1996-08-01 00:00:00
abstract：:A procedure for measuring nasal airway resistance using posterior rhinorheometry is described. Baseline nasal airway resistances +/- 1 S.D. at an airflow of 0.5 L/sec were found to be 1.077 +/- 0.683 cm H2O for inhalation and 1.359 +/- 0.792 cm H2O for exhalation. Application of either cold water (4 to 6 C) or warm wa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560110301
更新日期：1977-11-01 00:00:00
abstract：:Light propagation in human dentin exhibits a strong directional dependence featuring the long-known optical magnification property. We hypothesized that this anisotropic effect is caused by multiple scattering at the dentin tubules, and not by fiberoptic effects, as had been previously assumed. We performed measuremen...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608501017
更新日期：2006-10-01 00:00:00
abstract：:In the current theme of dental pulp regeneration, biological and synthetic scaffolds are becoming a potential therapy for pulp revitalization. The goal is to provide a suitable environment for cellular infiltration, proliferation, and differentiation. The extracellular matrix (ECM) represents a natural scaffold materi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034518785124
更新日期：2018-12-01 00:00:00
abstract：:Oxygen inhibits polymerization of resin-based materials. We hypothesized that compromised bonding to bleached enamel can be reversed with sodium ascorbate, an anti-oxidant. Sandblasted human enamel specimens were treated with distilled water (control) and 10% carbamide peroxide gel with or without further treatment wi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910208100709
更新日期：2002-07-01 00:00:00
abstract：:The kinetics of subsurface demineralization of tooth sections has been studied in real-time by scanning microradiography (SMR). Demineralization was carried out: (1) with a large volume of solution buffered to pH = 4 to maintain a constant composition; and (2) in a small constant volume (approximately 3 mL), buffered ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720051401
更新日期：1993-05-01 00:00:00
abstract：:Priming with tumor antigens is one of the most important strategies in cancer immunotherapy. To enhance tumor antigenicity, OK-432, a streptococcal preparation, was coupled to squamous cell carcinoma (KLN-205) by means of a 0.2% glutaraldehyde method. The purpose of this study was to investigate whether OK-432-conjuga...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200813
更新日期：2003-08-01 00:00:00
abstract：:During the past two decades, some major pitfalls in fluorine analysis have been recognized and overcome. Therefore, it is important that facts be separated from fallacies in published literature on levels and forms of fluorine (ionic, bound, covalent, etc.) in biological materials, in order that correct perceptions of...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/00220345900690S105
更新日期：1990-02-01 00:00:00
abstract：:Overgrowth of oral yeast is a common problem among the elderly. Probiotic bacteria are known to inhibit the growth of pathogenic microbes. We tested the hypothesis that cheese containing probiotic bacteria can reduce the prevalence of oral Candida. During this 16-week, randomized, double-blind, placebo-controlled stud...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/154405910708600204
更新日期：2007-02-01 00:00:00
abstract：:A multiple logistic regression analysis was used to compute the odds ratios for 11 common occlusal features for asymptomatic controls (n = 147) vs. five temporomandibular disorder groups: Disc Displacement with Reduction (n = 81), Disc Displacement without Reduction (n = 48), Osteoarthrosis with Disc Displacement Hist...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720061301
更新日期：1993-06-01 00:00:00
abstract：:Administration of indomethacin inhibited the appearance of osteoclasts and bone resorption induced by experimental tooth movement in rats. Effects were limited to groups injected within 12 h after treatment. Prostaglandin E1 or E2 solutions injected in gingiva lying near the upper first molar caused the appearance of ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590101301
更新日期：1980-10-01 00:00:00
abstract：:Jaw displacement tremor was investigated. Both tremor amplitude and tremor frequency were found to increase with increasing muscle activation. Co-contraction of jaw elevator and jaw depressor muscles was employed in order to vary muscle activation levels without the teeth being in occlusion. Reproducibility of tremor ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670080401
更新日期：1988-08-01 00:00:00
abstract：:The pellicle serves as a multifunctional protective layer, providing, e.g., lubrication and remineralization and also acting as a diffusion barrier. In addition, since the formation of the pellicle precedes the adhesion of micro-organisms, it is also important as a conditioning film. We present a novel approach to stu...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512456704
更新日期：2012-10-01 00:00:00
abstract：:Although it has been shown that patients are more satisfied with prostheses supported by implants than with conventional dentures, there have been few direct comparisons of the various designs of implant-supported prostheses. This within-subject crossover clinical trial was designed to compare two forms of removable p...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345970760100901
更新日期：1997-10-01 00:00:00
abstract：:Vitamin D, an anti-inflammatory mediator, has potential benefits for physical and oral health. Although it is produced endogenously, some individuals have a greater need for dietary and supplemental sources. This repeated-measures cross-sectional study assessed associations between total vitamin D intake and periodont...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513495239
更新日期：2013-08-01 00:00:00
