Abstract：
:An in vitro model has been developed for measurement of initial attachment of 3H-labeled human gingival fibroblasts (HGF) and periodontal ligament cells (HPDL cells) to sieved dentin powder. Reproducible attachment was obtained and was closely related to the number of plated cells, the amount of dentin powder, the temperature, and the time (from 0 to 6 h) of incubation. HGF and HPDL cells had a high affinity for untreated dentin. Heat-denatured BSA coating of the dentin fully inhibited cell attachment, while a fibronectin coating had no significant effect. A surface conditioning of the dentin grains by 3% citric acid or by 2.5% minocycline-HCl increased the initial attachment of HPDL cells significantly (p < 0.05). Minocycline-HCl was more efficient than citric acid in that respect. In addition, HGF attachment to untreated dentin was highly significantly improved (p < 0.005) by a pre-incubation of the cells with 50 micrograms/mL of minocycline, and there was also indication (p = 0.067) of improvement by the presence of minocycline in the attachment medium, with a maximum of efficacy at 110 micrograms/mL. These results suggest that minocycline-HCl directly influenced the attachment properties of fibroblastic cells and that citric acid and minocycline-HCl could act by different mechanisms. HGF and HPDL cells originating from the same patient displayed no significant difference in their attachment to dentin in this model.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Rompen EH,Kohl J,Nusgens B,Lapiere CMdoi
10.1177/00220345930720030901subject
Has Abstractpub_date
1993-03-01 00:00:00pages
607-12issue
3eissn
0022-0345issn
1544-0591journal_volume
72pub_type
杂志文章abstract：:In this study, the effects of eugenol on human polymorphonuclear (PMN) cell migration and chemiluminescence were examined in vitro. Utilizing zymosan-activated serum or crude Bacteroides sonicate fractions as chemotractants, we found that eugenol inhibits PMN migration at 6.6 X 10(-2) to 6.6 X 10(-5) mol/L (P less tha...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345870660031401
更新日期：1987-03-01 00:00:00
abstract：:Samples of plaque and surface enamel were collected from 80 boys aged 14 years living in five communities in Ohio (USA). Mean (+/- SE) strontium concentrations in plaque were 1.43 +/- 0.18 micrograms/g (wet) and 12.34 +/- 1.63 micrograms/g (dry). For surface enamel, the mean concentration was 421 +/- 31 micrograms Sr/...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640121201
更新日期：1985-12-01 00:00:00
abstract：:Dental composites develop residual stresses during polymerization due to shrinkage. These stresses may change with time because of relaxation and water sorption in the oral environment. This phenomenon is likely dependent on the composition of the materials, specifically their hydrophilic characteristics, and could re...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513513905
更新日期：2014-02-01 00:00:00
abstract：:In this study, the differences in lesion remineralization and fluoride uptake after brushing with a 300 ppm F or a 1000 ppm F dentifrice (as NaF) were investigated. Twenty volunteers with partial dentures in their lower jaws were divided into two groups. Bovine enamel slabs with artificial lesions were mounted in the ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650120601
更新日期：1986-12-01 00:00:00
abstract：:Although a large body of scientific literature shows that background color and luminance affect color perception, previous measurements of tooth color difference thresholds have not taken the effects of viewing context into account. The present study tested the hypothesis that differences in skin/gingival color influe...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510376772
更新日期：2010-11-01 00:00:00
abstract：:Phosphorylated extracellular matrix proteins, including matrix extracellular phosphoprotein (MEPE), are involved in the formation and mineralization of dental tissues. In this study, we evaluated the potential of Dentonin, a synthetic peptide derived from MEPE, to promote the formation of reparative dentin. Agarose be...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600818
更新日期：2007-08-01 00:00:00
abstract：:Evidence that dental status affects diet is equivocal. The hypothesis of this study was that diet was affected by dental status. The objective was to assess the relationship between numbers of teeth and diet and nutritional status in US adult civilians without prostheses. We examined 6985 NHANES (1988-1994) participan...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708601206
更新日期：2007-12-01 00:00:00
abstract：:Silver cations generated by passing low intensity direct current through pure silver electrodes were found to be sufficiently antibacterial to cause sterilization of samples of infected dentin. The optimal procedure involved a 5 microA current applied for 20 minutes with the anode then left in contact with the sample....
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570091901
更新日期：1978-09-01 00:00:00
abstract：:Potassium ions in dentifrices for treating 'hypersensitive' dentin are believed to act directly on intradental nerves by raising extracellular potassium ion concentration ([K+]o) sufficiently to prevent action potential generation by axonal accommodation. However, the [K+]o necessary to block nerve conduction is not p...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345950740020301
更新日期：1995-02-01 00:00:00
abstract：:The effects of oral rinses on enamel fluoride uptake, caries, and plaque pH in rats were investigated by use of (1) an acidic calcium phosphate solution (CPS) saturated with dicalcium phosphate dihydrate (DCPD) and (2) a 1% fluoride solution. Osborne-Mendel rats, 19 days of age, were randomly assigned to one of four m...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670061401
更新日期：1988-06-01 00:00:00
abstract：:Fibroblast growth factor receptor 2 (FGFR2) in craniofacial bones mediates osteoprogenitor proliferation, differentiation, and apoptosis. The distortion of proper craniofacial bone growth may cause class II and class III skeletal malocclusion and result in compromised function and aesthetics. Here, we investigated the...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519872951
更新日期：2019-11-01 00:00:00
abstract：:Since the exposure of mutans streptococci to xylitol is known to select for xylitol-resistant (XR) natural mutants, the occurrence and long-term survival of such xylitol-resistant strains was evaluated in a cross-sectional sampling of participants of the Ylivieska xylitol study four years after the original two-year e...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345920710110401
更新日期：1992-11-01 00:00:00
abstract：:Chronic periodontitis is a multi-factorial disease involving anaerobic bacteria and the generation of an inflammatory response, including the production of metalloproteinases, pro-inflammatory cytokines, and eicosanoids. Hypochlorous acid (HOCl) and taurine-N-monochloramine (TauCl) are the end-products of the neutroph...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910408301101
更新日期：2004-11-01 00:00:00
abstract：:Four disclosant dyes were tested for antimicrobial activity against 27 oral reference strains and five non-oral human pathogens. Erythrosine and fluorescein inhibited most gram-positive and gram-negative organisms associated with dental plaque, and were bactericidal to selected strains. Fast green and brilliant blue d...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620071601
更新日期：1983-07-01 00:00:00
abstract：:The biochemical function, adenylate energy charge (AEC), correlates with the viable count of S. mutans. AEC may be used to estimate the percent viable fraction of bacteria in dental plaque samples. An interactive computer program designed to process the AEC data is described. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/002203457905800410011
更新日期：1979-11-01 00:00:00
abstract：:The inhibitory activity of 2-phosphono-butane 1,2,4 tricarboxylic acid (PBTA) in the formation of hydroxyapatite (HA) was studied in vitro and in vivo. PBTA, at 4 ppm, inhibited the spontaneous formation of HA in vitro from a supersaturated solution. PBTA, at 2 ppm, completely inhibited the crystal growth of HA; at lo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345850640011201
更新日期：1985-01-01 00:00:00
abstract：:Periodontal diseases are initiated by bacteria that accumulate in a biofilm on the tooth surface and affect the adjacent periodontal tissue. Systemic diseases such as diabetes, rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) increase susceptibility to destructive periodontal diseases. In human studie...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034518805739
更新日期：2019-02-01 00:00:00
abstract：:This 24-mo randomized controlled trial was based on a double-blind parallel design, and it compared the effectiveness of 2 fluoride application protocols in arresting dentine caries in primary teeth. Three-year-old children with active dentine caries were recruited and randomly allocated to 2 treatment groups. Childre...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520952031
更新日期：2021-01-01 00:00:00
abstract：:In an earlier paper on bench-scale simulation of the caries process, it was shown that the passage of ions through ion-permselective barriers could have profound effects on the composition of the solution within the "lesion" at steady state. As indicated in earlier papers, these changes are produced by unequal rates o...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650090201
更新日期：1986-09-01 00:00:00
abstract：:Impacted human third molar teeth were examined, both with the light and electron microscope, to determine the extent of the odontoblast process. The odontoblast process was found to be limited to the inner third of coronal dentin and inner half of mid-root dentin. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/002203457905800412011
更新日期：1979-11-01 00:00:00
abstract：:The oral cavity contains a rich consortium of exopolysaccharide-producing microbes. These extracellular polysaccharides comprise a major component of the oral biofilm. Together with extracellular proteins, DNA, and lipids, they form the biofilm matrix, which contributes to bacterial colonization, biofilm formation and...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034519845001
更新日期：2019-07-01 00:00:00
abstract：:The oral microbiome is one of the most stable ecosystems in the body and yet the reasons for this are still unclear. As well as being stable, it is also highly diverse which can be ascribed to the variety of niches available in the mouth. Previous studies have focused on the microflora in disease-either caries or peri...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034520915486
更新日期：2020-06-01 00:00:00
abstract：:The intent of this article is to review the numerous factors that affect the mechanical properties of particle- or fiber-filler-containing indirect dental resin composite materials. The focus will be on the effects of degradation due to aging in different media, mainly water and water and ethanol, cyclic loading, and ...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910808700802
更新日期：2008-08-01 00:00:00
abstract：:The importance of assessing the impact of treatments for chronic conditions on an individual's quality of life has been well-established. In this randomized clinical trial, oral-health-related quality of life, measured with the Oral Health Impact Profile (OHIP), was compared between two groups of edentulous patients. ...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/00220345000790090401
更新日期：2000-09-01 00:00:00
abstract：:The regulation of blood flow of the dental pulp was investigated in dogs and rats anesthetized with sodium pentobarbital. Pulpal blood flow was altered by variations of local and systemic hemodynamics. Variation in pulpal hemodynamics was attained by means of close intra-arterial injections of adrenergic agonists (NE ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/002203458506400415
更新日期：1985-04-01 00:00:00
abstract：:The whisker pad area (WP) is innervated by the second branch of the trigeminal nerve and experiences allodynia and hyperalgesia following transection of the mental nerve (MN; the third branch of the trigeminal nerve). However, the mechanisms of this extra-territorial pain remain unclear. The ionotropic P2X(7) ATP rece...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512474668
更新日期：2013-03-01 00:00:00
abstract：:Composite resin restorations in cavities are generally associated with the development of a contraction gap during the first minutes after insertion. Enamel-Bond-Concise composite restoration were placed on both approximal sides of extracted pre-molars. The cervical walls of all cavities extended beyond the enamel-cem...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630051501
更新日期：1984-05-01 00:00:00
abstract：:In this study, we first investigated the expressions of Jagged1, Notch2, the receptor activator of nuclear factor-kappa B ligand (RANKL), and interleukin (IL)-6 in areas of root resorption during experimental tooth movement in rats in vivo. We then assessed the effects of compression force (CF) with or without GSI (an...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514555364
更新日期：2015-01-01 00:00:00
abstract：:Studies on mechanisms underlying the differentiation of dental pulp stem cells are critical for the understanding of the biology of odontogenesis and for dental tissue engineering. Here, we tested the hypothesis that stem cells from exfoliated deciduous teeth (SHED) differentiate into functional odontoblasts and endot...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510368647
更新日期：2010-08-01 00:00:00
abstract：:Submandibular glands from young adult and aged male and female rats have been examined and various descriptive parameters obtained. Several sex differences were observed with tissue from young and old animals. Sex differences were found in the gland contents of DNA, protein, and sialic acid and in some protein compone...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600051501
更新日期：1981-05-01 00:00:00
