Abstract：
:The temporomandibular joint (TMJ) undergoes degenerative changes among patients who suffer from arthritis, and yet the pathogenesis of TMJ osteoarthritis and rheumatoid arthritis is poorly understood. We hypothesized that sustained inflammation in the TMJ induces structural abnormalities, and accordingly characterized the disc and synovium in a novel model with double injections of complete Freund's adjuvant (CFA), using behavioral, morphological, cellular, and molecular assessments. Thirty-five days following double CFA injections in seven-week-old female Sprague-Dawley rats, the disc in the CFA-induced inflammation group demonstrated multiple degenerative changes, including marked thickening, opacity, and deformation. The discs in the CFA group further showed significantly greater wet and net weights, and elevated collagen, aggrecan, and total glycosaminoglycan contents. The synovium in the CFA-induced inflammation group showed marked infiltration of mononucleated cells and accumulated sub-synovial adipose tissue. Both the disc and synovium had significantly higher iNOS and IL-1β mRNA expression than controls (saline injections). These findings are consistent with our hypothesis that sustained TMJ inflammation, even within the presently observed 35 days, may be a predisposing factor for structural abnormalities. Insight into TMJ inflammation and degeneration is anticipated to improve our understanding of the pathogenesis of TMJ arthritis and help design clinically relevant strategies for tissue engineering.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Wang XD,Kou XX,Mao JJ,Gan YH,Zhou YHdoi
10.1177/0022034512441946subject
Has Abstractpub_date
2012-05-01 00:00:00pages
499-505issue
5eissn
0022-0345issn
1544-0591pii
0022034512441946journal_volume
91pub_type
杂志文章abstract：:The destabilizing effect of endodontic treatment upon teeth is still controversial. The purpose of this study was to investigate the effects of different steps of endodontic treatments upon the rigidity of teeth. Extracted untreated central maxillary anterior teeth were loaded (3.75 N), and deformations of the root we...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608500416
更新日期：2006-04-01 00:00:00
abstract：:Previous studies show that both activin and Bmp4 act as crucial mesenchymal odontogenic signals during early tooth development. Remarkably, mice lacking activin-βA ( Inhba-/-) and mice with neural crest-specific inactivation of Bmp4 ( Bmp4ncko/ncko) both exhibit bud-stage developmental arrest of the mandibular molar t...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517713710
更新日期：2017-09-01 00:00:00
abstract：:In an attempt to determine the degree of co-activation present in selected cervical muscles during clenching, we instructed 12 male subjects to produce four brief maximum voluntary contraction (MVC) efforts (clenching) in a position of maximum intercuspation. Surface EMG activity was recorded bilaterally from the mass...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720110701
更新日期：1993-11-01 00:00:00
abstract：:Erupting first permanent molars of 5 1/2 to 6 1/2 year-olds are eminently suited for the clinical testing of potential caries-inhibiting techniques. Due to the rapid onset of caries in these teeth, accurate monitoring of new materials/regimes can be instituted and meaningful data obtained within one year of trial comm...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/002203457705600301011
更新日期：1977-10-01 00:00:00
abstract：:The initiator of calculus matrix calcification, in vitro, was isolated. Crude phospholipid, known to contain the factor, was separated into five fractions by column chromatography. A single protein-containing fraction induced apatite formation during incubation. The nucleating fraction was indentified as a proteolipid...
journal_title：Journal of dental research
pub_type： 历史文章,杂志文章
doi：10.1177/00220345770560020701
更新日期：1977-02-01 00:00:00
abstract：:Inorganic polyphosphate [Poly(P)] is especially prevalent in osteoblasts. We tested the hypothesis that Poly(P) stimulates osteoblastic differentiation and polyphosphate metabolism for bone formation. The osteoblast-like cell line, MC 3T3-E1, was cultured with Poly(P), and gene expression was evaluated by real-time re...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510363096
更新日期：2010-05-01 00:00:00
abstract：:The balance between bone resorption and bone formation is vital for maintenance and regeneration of alveolar bone and supporting structures around teeth and dental implants. Tissue regeneration in the oral cavity is regulated by multiple cell types, signaling mechanisms, and matrix interactions. A goal for periodontal...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034515618887
更新日期：2016-03-01 00:00:00
abstract：:The recording of multiple interval-censored failure times is common in dental research. Modeling multilevel data has been a difficult task. This paper aims to use the Bayesian approach to analyze a set of multilevel clustered interval-censored data from a clinical study to investigate the effectiveness of silver diami...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/154405910508400907
更新日期：2005-09-01 00:00:00
abstract：:Phosphatases are involved in bone and tooth mineralization, but their mechanisms of action are not completely understood. Tissue-nonspecific alkaline phosphatase (TNAP, ALPL) regulates inhibitory extracellular pyrophosphate through its pyrophosphatase activity to control mineral propagation in the matrix; mice without...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513490958
更新日期：2013-08-01 00:00:00
abstract：:The efficacy of a new remineralization system was determined in vivo by maintaining a low concentration of approximately 1 ppm fluoride for 48 hrs against a demineralized human tooth. Human subjects were selected who wore removable partial dentures containing two or more of the demineralized teeth with film system. Th...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345800590030501
更新日期：1980-03-01 00:00:00
abstract：:The biogenetic formation of mineral crystals, one aspect of biomineralization, is a multistep process of apatite formation throughout the growth of dentin tissue. An important step is the transformation of the non-mineralized predentin matrix to mineralizing dentin matrix and its biological control. In this study, the...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770081401
更新日期：1998-08-01 00:00:00
abstract：:During amelogenesis in the rat incisor, modulating ruffle-ended (RA) and smooth-ended (SA) ameloblasts are distributed as bands in the enamel organ of the maturation zone. This distribution of the two cell types has been shown to be precisely correlated with a banding of the underlying enamel, as shown by staining and...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680020101
更新日期：1989-02-01 00:00:00
abstract：:The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts and cementoblasts. We hypothesized that stem cells may be present in the DF and be capable of differentiating into cells of the periodontium. Stem cells ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910808700801
更新日期：2008-08-01 00:00:00
abstract：:The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors and tyrosine kinases. DDRs regulate cell functions, and their extracellular domains affect collagen fibrillogenesis and mineralization. Based on the collagenous nature of dentoalveolar tissues, we hypothesized that DDR1 plays an importan...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519881136
更新日期：2019-12-01 00:00:00
abstract：:An adhesive opaque resin for veneering on cast metal was developed with 4-methacryloxyethyl trimellitate anhydride and poly (methyl methacrylate)-coated titanium dioxide prepared by aqueous phase polymerization. The opaque resin was a modified 4-META/MMA-TBB resin. The powder consisted of 20% of the encapsulated mater...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670010501
更新日期：1988-01-01 00:00:00
abstract：:A simple in vitro method has been described for quantitatively measuring the rate at which isotopically labeled substances permeate through dentin in occlusal cavity preparations. The presence or absence of pulp tissue had only a minor effect on the kinetics of permeation. As the dentin was made thinner there was a re...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560011601
更新日期：1977-01-01 00:00:00
abstract：:Dental composites develop residual stresses during polymerization due to shrinkage. These stresses may change with time because of relaxation and water sorption in the oral environment. This phenomenon is likely dependent on the composition of the materials, specifically their hydrophilic characteristics, and could re...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513513905
更新日期：2014-02-01 00:00:00
abstract：:Gingival epithelium is a site of active trafficking of Langerhans cells (LCs), while the lamina propria in chronic periodontitis (CP) contains CD83+ mature dendritic cells (mDCs) and CD4+ T-cells. The immune cells that contribute to the mDCs, and whether mDCs engage with T-cells in situ, are unclear. Using several imm...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200915
更新日期：2003-09-01 00:00:00
abstract：:A conceptual means of obtaining improved bonding between filler particles and the polymeric binders of composites is presented. It involves preparing glass particles that separate into two interconnected vitreous phases when heated to an appropriate temperature, and then etching these to produce a porous surface layer...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550050701
更新日期：1976-09-01 00:00:00
abstract：:We placed an MOD preparation in each of 12 permanent molars, then restored each tooth with a posterior composite resin by means of six different application techniques (I-polymerization as one complete unit; II--polymerization as one complete unit with glass inserts; III--polymerization in gingivo-occlusal increments;...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680080401
更新日期：1989-08-01 00:00:00
abstract：:Synovitis in internal derangement of the temporomandibular joint (TMJ) is accompanied by the growth of new blood vessels. Fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) are well-characterized angiogenic factors. The objective of this study was to elucidate the correlation between the ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200406
更新日期：2003-04-01 00:00:00
abstract：:The aim of this study was to examine the association between the bone mass (bone mineral content [BMC]) and hypomineralized second primary molars (HSPMs)/molar incisor hypomineralization (MIH) in 6-y-old children. This cross-sectional study was embedded in the Generation R Study, a population-based prospective cohort ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515625470
更新日期：2016-04-01 00:00:00
abstract：:Adhesion of restorative and protective materials to dentin is an important requirement for operative and preventive dentistry. Wettability and roughness are dentin substrate conditions that are critical to establishing good adhesion. This study examined superficial and deep dentin for variations in water contact angle...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780091001
更新日期：1999-09-01 00:00:00
abstract：:Symphyseal secondary cartilage is important for mandibular development, but the molecular mechanisms underlying its formation remain largely unknown. Here we asked whether Indian hedgehog (Ihh) regulates symphyseal cartilage development and growth. By embryonic days 16.5 to 18.5, Sox9-expressing chondrocytes formed wi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510397836
更新日期：2011-05-01 00:00:00
abstract：:There are no prospective studies investigating the effects of sugar-related feeding practices on changes in dental caries from early childhood to young adulthood. The aim of this study was to assess whether sugar-related feeding practices affect dental caries between the ages of 6 and 18 y. This birth cohort study was...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515625907
更新日期：2016-04-01 00:00:00
abstract：:This study contains the first part of a research project in which the applicability of fracture mechanics parameters to predict failure of a restored tooth was investigated. Fracture mechanics parameters have been used in dental research before, but were restricted to comparative studies between various brands of comp...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670060601
更新日期：1988-06-01 00:00:00
abstract：:Conservative techniques for improving the appearance of discolored teeth have become popular in the past decade. These include: in-office bleaching with 30% hydrogen peroxide, which is applied on etched enamel with a gauze pad and then exposed to a bleaching light; home bleaching with a mild form of peroxide, such as ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720011001
更新日期：1993-01-01 00:00:00
abstract：:Fibroblast cultures derived from uninjured and reparative rabbit buccal mucosa were compared in terms of extracellular glycosaminoglycan (GAG) content and cellular response to interleukin-1 (IL-1). Under identical growth conditions, proliferation of both cell lines was the same. Both lines incorporated [3H]-glucosamin...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680010801
更新日期：1989-01-01 00:00:00
abstract：:In the past decade, medical genetic research has generated multiple discoveries, many of which were obtained via genome-wide association studies (GWASs). A major GWAS finding is that the majority of risk variants for complex traits map to noncoding regions. This has resulted in a paradigm shift in terms of the interpr...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034517720403
更新日期：2017-10-01 00:00:00
abstract：:The molecular mechanisms that maintain the equilibrium of odontoblast progenitor cells in dental pulp are unknown. Here we tested whether homeostasis in dental pulp is modulated by Twist-1, a nuclear protein that partners with Runx2 during osteoblast differentiation. Our analysis of Twist-1(+/-) mice revealed phenotyp...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708601007
更新日期：2007-10-01 00:00:00
