Abstract：
:Not only are teeth essential for mastication, but also missing teeth are considered a social handicap due to speech and aesthetic problems, with a resulting high impact on emotional well-being. Several treatment procedures are currently available for tooth replacement with mostly inert prosthetic materials and implants. Natural tooth substitution based on copying the developmental process of tooth formation is particularly challenging and creates a rapidly developing area of molecular dentistry. In any approach, functional interactions among the tooth, the surrounding bone, and the periodontium must be established. Therefore, recent research in craniofacial genetics searches for mechanisms responsible for correct cell and tissue interactions, not only within a specific structure, but also in the context of supporting structures. A tooth crown that is not functionally anchored to roots and bone is useless. This review aims to summarize the developmental and tissue homeostatic aspects of the tooth-bone interface, from the initial patterning toward tooth eruption and lifelong interactions between the tooth and its surrounding alveolar bone.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Fleischmannova J,Matalova E,Sharpe PT,Misek I,Radlanski RJdoi
10.1177/0022034509355440subject
Has Abstractpub_date
2010-02-01 00:00:00pages
108-15issue
2eissn
0022-0345issn
1544-0591pii
0022034509355440journal_volume
89pub_type
杂志文章,评审abstract：:Bacteroides forysthus has been shown to be prevalent among patients with periodontitis. Conventional microbiological methods used to identify this bacterium, however, are laborious and time-consuming and are therefore not well-suited for screening purposes. We have developed a polymerase chain-reaction (PCR) method wh...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345970760070701
更新日期：1997-07-01 00:00:00
abstract：:Understanding the mechanical properties of human teeth is important to clinical tooth preparation and to the development of "tooth-like" restorative materials. Previous studies have focused on the macroscopic fracture behavior of enamel and dentin. In the present study, we performed indentation studies to understand t...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345980770030601
更新日期：1998-03-01 00:00:00
abstract：:Setting reactions and compressive strengths of a self-hardening calcium phosphate cement (CPC) were investigated. The CPC consists of tetracalcium phosphate (TTCP) and anhydrous dicalcium phosphate (DCPA). The cement specimens were prepared by mixing 0.7 g of the powder (TTCP 72.9 wt% + DCPA 27.1 wt%) with 0.175 mL of...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345900690121201
更新日期：1990-12-01 00:00:00
abstract：:A procedure for measuring nasal airway resistance using posterior rhinorheometry is described. Baseline nasal airway resistances +/- 1 S.D. at an airflow of 0.5 L/sec were found to be 1.077 +/- 0.683 cm H2O for inhalation and 1.359 +/- 0.792 cm H2O for exhalation. Application of either cold water (4 to 6 C) or warm wa...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560110301
更新日期：1977-11-01 00:00:00
abstract：:This study indicated that a clear relationship exists between silicon and fluoride. We have also demonstrated a probable surface enamel silicon effect that increases fluoride uptake. The complex set of relationships described in the surface chemistry of calcium, tin, and zirconium with fluoride, hydroxide, phosphate, ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345760550050601
更新日期：1976-09-01 00:00:00
abstract：:Growing evidence suggests that individual genetic susceptibility may influence the host's response to infections. The aim of this project was to study whether gene polymorphisms of inflammatory markers are associated with the presence of viable periodontopathogenic bacteria. We extracted genomic DNA from 45 young adul...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600505
更新日期：2007-05-01 00:00:00
abstract：:Debonding rates of 164 resin-bonded prostheses (RBP) placed from 1974 to 1985 were examined at recall. The yearly debond rates were calculated, the cumulative probability of failure was determined for the debonded RBPs, and Weibull distribution parameters were determined. For perforated prostheses, there was a high in...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345930720081401
更新日期：1993-08-01 00:00:00
abstract：:The kinetics of growth of calcium phosphates on synthetic hydroxyapatite (HAP), human enamel, whole dentin, and human calculus has been studied at 37 C at pH values from 4.97 to 5.10 held constant by the pH-stat addition of base. Following an initial induction period, dicalcium phosphate dihydrate (DCPD) crystallizati...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570010901
更新日期：1978-01-01 00:00:00
abstract：:A complex feedback mechanism between parathyroid hormone (PTH), 1,25(OH)2D3 (1,25D), and fibroblast growth factor 23 (FGF-23) maintains mineral homeostasis, in part by regulating calcium and phosphate absorption/reabsorption. Previously, we showed that 1,25D regulates mineral homeostasis by repressing dentin matrix pr...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515599726
更新日期：2015-10-01 00:00:00
abstract：:In the past decade, medical genetic research has generated multiple discoveries, many of which were obtained via genome-wide association studies (GWASs). A major GWAS finding is that the majority of risk variants for complex traits map to noncoding regions. This has resulted in a paradigm shift in terms of the interpr...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034517720403
更新日期：2017-10-01 00:00:00
abstract：:Porphyromonas gingivalis dihydroceramides are found in extracts of calculus-contaminated root surfaces, diseased gingival tissue, and atherosclerotic plaques. These ceramides have been shown to promote inflammatory secretory responses in gingival fibroblasts. Little is known about their effects on the vascular system....
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910708600710
更新日期：2007-07-01 00:00:00
abstract：:The temporomandibular joint (TMJ) undergoes degenerative changes among patients who suffer from arthritis, and yet the pathogenesis of TMJ osteoarthritis and rheumatoid arthritis is poorly understood. We hypothesized that sustained inflammation in the TMJ induces structural abnormalities, and accordingly characterized...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034512441946
更新日期：2012-05-01 00:00:00
abstract：:Previous studies have clearly established the down-regulating effect of a sucrose-rich diet on primary dentinogenesis in rat molars. Earlier observation of the negative effect of a high-sucrose diet on a parotid function involved in the control of intradentinal solute movement led us to hypothesize that parotid gland ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910208100407
更新日期：2002-04-01 00:00:00
abstract：:The purpose of this study was to determine the surface roughness of enamel-to-enamel contact areas in order to provide a standard for comparison with surface characteristics of commercially available composite restorative materials. In addition, the inherent surface roughness of resin composites was evaluated profilom...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345910700091301
更新日期：1991-09-01 00:00:00
abstract：:The ability of adhesive resins to restore the physical properties of demineralized dentin has not been well-documented. The unfilled resins that are used for adhesion have relatively low moduli of elasticity and limited ability to increase dentin stiffness, although they may increase the ultimate tensile strength of d...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345950740041001
更新日期：1995-04-01 00:00:00
abstract：:Epithelial-mesenchymal interactions are required for tooth formation. Bone morphogenetic protein 4 (Bmp4) is a crucial signaling molecule during this process. For better understanding of the role of the Bmp4 gene during tooth development, we studied the mechanisms that control its temporal and spatial expression durin...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/002203450208100103
更新日期：2002-01-01 00:00:00
abstract：:Greater fluoride concentrations were obtained in enamel treated with phosphate/fluoride solutions than in that treated with TiF4 at similar pH's (1.0) and F concentrations (0.6M F and 1.6M F). However, fluoride solution without added phosphate at pH 1.0 and 1.6M F concentration produced lower fluoride concentrations i...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580021001
更新日期：1979-02-01 00:00:00
abstract：:Three strain combinations of in-bred mice representing strong and moderate histocompatibility barriers were used to determine if tooth allotransplants evoked strong or weak immunologic memory as measured by the second-set donor-strain skin graft technique. At issue was whether the anatomic site of engraftment could in...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630010901
更新日期：1984-01-01 00:00:00
abstract：:The tooth resistance measuring instrument was compared to the traditional method of the explorer examination for the detection of occlusal carious lesions. The findings of the instrument were more sensitive as compared to the traditional method when verified by a histological examination. ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570020801
更新日期：1978-02-01 00:00:00
abstract：:Selective recruitment of periodontal ligament cells to a previously exposed root surface is believed to enhance periodontal regeneration. It has been hypothesized that competition from gingival fibroblasts may reduce the potential of periodontal regeneration. We compared the migratory responses of PDL cells and gingiv...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750041401
更新日期：1996-04-01 00:00:00
abstract：:To understand the role of betel quid (BQ) in the pathogenesis of oral submucous fibrosis (OSF) and oral cancer, we used DNA damage, cytotoxicity, and cell proliferation assays to study the pathobiological effects of aqueous extracts of three BQ constituents [betel nut (Areca catechu, BN), inflorescence of Piper betle ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730050501
更新日期：1994-05-01 00:00:00
abstract：:In the absence of active pulmonary disease, mycobacterial infection frequently causes arthritis and can be considered to initiate autoimmune diseases such as rheumatoid arthritis. Temporomandibular disorder (TMD) is a disease in which pain and impaired mandibular movement appear to arise directly from degenerative or ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345000790100401
更新日期：2000-10-01 00:00:00
abstract：:Eugenol, in the 100 percent concentration in commercial use, was applied to a circumscribed area, 3 mm in diameter, of rat labial mucosa for 1 minute. Reaction periods of 15 minutes, 1, 2, 4 and 6 hours were then permitted. Using routine histological procedures for processing the experimental tissues, it was observed ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345780570110901
更新日期：1978-11-01 00:00:00
abstract：:Insulin resistance is one of the critical pathogeneses of type 2 diabetes mellitus (T2DM). Elevated levels of plasma branched-chain amino acids (BCAAs) are associated with insulin resistance. Recent studies have demonstrated the role of Porphyromonas gingivalis in the development of insulin resistance. However, the me...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520911037
更新日期：2020-07-01 00:00:00
abstract：:The oral microbiota was compared between Romanian adolescents with a high prevalence of caries and no dental care and Swedish caries-active and caries-free adolescents in caries prevention programs and with a low prevalence of caries. Biofilm samples were analyzed by FLX+ pyrosequencing of the V1 to V4 hypervariable r...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515609554
更新日期：2016-01-01 00:00:00
abstract：:Recent studies have shown that the extent of hydrolysis by plaque of the trypsin substrate, N-benzoyl-DL-arginine-2-naphthylamide (BANA), correlates with the numbers and proportions of spirochetes in subgingival plaque samples, and appears to be an indicator of clinical disease. In this study, BANA hydrolysis by subgi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670121201
更新日期：1988-12-01 00:00:00
abstract：:The diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection relies on the detection of viral RNA by real-time reverse transcription polymerase chain reaction (rRT-PCR) performed with respiratory specimens, especially nasopharyngeal swabs. However, this procedure requires specialized medical...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520969670
更新日期：2021-02-01 00:00:00
abstract：:Local anesthetic agents may be classified according to their intrinsic anesthetic potency and duration of activity. Procaine and chloroprocaine are relatively weak, short-acting drugs. Lidocaine, mepivacaine, and prilocaine represent agents of intermediate potency and duration of action. Tetracaine, bupivacaine, and e...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345810600080903
更新日期：1981-08-01 00:00:00
abstract：:We have previously reported the clinical and radiographic findings of a trial in dogs of a new dental implant system after a functional period of eight months. The present report consists of the corresponding qualitative and quantitative histological data. The implant system was fabricated from Ti-6A1-4V and employed ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345880670090801
更新日期：1988-09-01 00:00:00
abstract：:Vitamin D, an anti-inflammatory mediator, has potential benefits for physical and oral health. Although it is produced endogenously, some individuals have a greater need for dietary and supplemental sources. This repeated-measures cross-sectional study assessed associations between total vitamin D intake and periodont...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513495239
更新日期：2013-08-01 00:00:00
