Abstract:
:Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduce the incidence of oral cancer. In 2000, in Keelung, we randomly assigned a total of 7975 individuals, aged 15 years or older and with high-risk oral habits, to either the toluidine-blue-screened (TBS) group or the visual screening group. Results showed 5% more oral premalignant lesions and 79% more oral submucous fibrosis detected in the TBS group than in the control group. After a five-year follow-up ascertaining oral cancer development through linkage to the National Cancer Registry, the incidence rate in the TBS group (28.0 x 10(-5)) was non-significantly 21% lower than that in the control group (35.4 x 10(-5)).
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Su WW,Yen AM,Chiu SY,Chen THdoi
10.1177/0022034510373763subject
Has Abstractpub_date
2010-09-01 00:00:00pages
933-7issue
9eissn
0022-0345issn
1544-0591pii
0022034510373763journal_volume
89pub_type
杂志文章,随机对照试验abstract::Intra-oral wounds, like wounds in children, demonstrate privileged healing when compared with adult wounds at extra-oral sites. This study investigated whether this preferential healing is related to an increased ability of oral mucosal fibroblasts to reorganize extracellular matrix (ECM) when compared with their derm...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750060601
更新日期:1996-06-01 00:00:00
abstract::This study investigated the relevance between pulp vitality and autophagy in aged human dental pulp cells (HDPCs) and whether peroxisome proliferator-activated receptor gamma (PPARγ) affects autophagy regulation for homeostasis in the aging progress. In vivo experiments were used in human and Sprague-Dawley rat teeth ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515573833
更新日期:2015-05-01 00:00:00
abstract::The flexure moduli of elasticity of solid and multi-stranded orthodontic wires were determined. Results for the solid wires approximated their tensile values, but the differences were statistically significant for the stainless steel, chromium-cobalt-nickel, and nickel-titanium alloys. The flexure moduli of the multi-...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620072201
更新日期:1983-07-01 00:00:00
abstract::Because bone reconstruction in irradiated sites is less than ideal, we applied a regenerative gene therapy method in which a cell-signaling virus was localized to biomaterial scaffolds to regenerate wounds compromised by radiation therapy. Critical-sized defects were created in rat calvariae previously treated with ra...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509352151
更新日期:2010-01-01 00:00:00
abstract::Enamel fluorosis can occur following either an acute or chronic exposure to fluoride during tooth formation. Fluorosed enamel is characterized by a retention of amelogenins in the early-maturation stage, and by the formation of a more porous enamel with a subsurface hypomineralization. The mechanisms by which fluoride...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/00220345920710051701
更新日期:1992-05-01 00:00:00
abstract::The objectives of this study were 1) to provide an estimate of the value of the intraclass correlation coefficient (ICC) for dental caries data at tooth and surface level, 2) to provide an estimate of the design effect (DE) to be used in the determination of sample size estimates for future dental surveys, and 3) to e...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514559408
更新日期:2015-02-01 00:00:00
abstract::Khat-chewing has been associated with oral lesions including oral cancer, but the mechanisms leading to their development are not known. We hypothesized that khat interferes with the physiological processes of the oral mucosa, such as cell proliferation and differentiation, and aimed at investigating the effects of kh...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509354980
更新日期:2010-03-01 00:00:00
abstract::Human saliva contains a number of phosphorylated acidic proline-rich proteins (APRP). Monkey parotid saliva contains a similar protein with the same phosphorylated sequences as the human proteins. A crude protein kinase was prepared from Macaca fascicularis parotid glands which phosphorylated human APRP. The enzyme wa...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650030601
更新日期:1986-03-01 00:00:00
abstract::Solder microstructures were found to be influenced by those of the castings. A tendency of solder to match the microstructures contacted during its solidification was demonstrated. Several different types of defects were identified in the soldered joints. Tentative correlations of the observed microstructures and defe...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580031401
更新日期:1979-03-01 00:00:00
abstract::Extracellular microcapsules have been demonstrated on cells of most serotypes of Streptococcus mutans by electron microscopy, using bacterial strains of the various serotypes and peroxidase labeled or unlabeled immune serum. A correlation was noted between the amount of capsular substance on the strains of S mutans ex...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560021101
更新日期:1977-02-01 00:00:00
abstract::Teeth undergo postnatal organogenesis relatively late in life and only complete full maturation a few years after the crown first erupts in the oral cavity. At this stage, development can be arrested if the tooth organ is damaged by either trauma or caries. Regenerative endodontic procedures (REPs) are a treatment alt...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034517693606
更新日期:2017-06-01 00:00:00
abstract::A simple in vitro method has been described for quantitatively measuring the rate at which isotopically labeled substances permeate through dentin in occlusal cavity preparations. The presence or absence of pulp tissue had only a minor effect on the kinetics of permeation. As the dentin was made thinner there was a re...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560011601
更新日期:1977-01-01 00:00:00
abstract::In this study, the effects of eugenol on human polymorphonuclear (PMN) cell migration and chemiluminescence were examined in vitro. Utilizing zymosan-activated serum or crude Bacteroides sonicate fractions as chemotractants, we found that eugenol inhibits PMN migration at 6.6 X 10(-2) to 6.6 X 10(-5) mol/L (P less tha...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660031401
更新日期:1987-03-01 00:00:00
abstract::Samples of a base mental alloy were cast and welded together using a conventional welding procedure. The joints were loaded and placed either in a corrosive environment or in air for varying time periods. The tensile and shear strength of the joints was unaffected by the corrosive environment, and the joints, despite ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600021101
更新日期:1981-02-01 00:00:00
abstract::The aim of this study was to test effects of preventive regimes using fluoride and chlorhexidine to prevent caries and periodontal diseases in 34 patients with overdentures. The patients, who were treated with immediate overdentures, were distributed at random into three experimental groups. In these groups, different...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/00220345870660101301
更新日期:1987-10-01 00:00:00
abstract::Short-chain carboxylic acids (e.g., lactic acid, propionic acid, butyric acid) are metabolic by-products of bacterial metabolism which can accumulate in the gingival crevice. It is of no small consequence, therefore, that 1- to 5-mM concentrations of these acids exhibit significant biological activity, including the a...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345970760010801
更新日期:1997-01-01 00:00:00
abstract::Mercury emitted from dental amalgam may select for increased numbers of antibiotic- or mercury-resistant commensal bacteria in patients and increase their risk for bacterial diseases that are resistant to common therapies. We hypothesized that the presence of dental amalgams would increase the level of mercury-, tetra...
journal_title:Journal of dental research
pub_type: 杂志文章,随机对照试验
doi:10.1177/154405910808700502
更新日期:2008-05-01 00:00:00
abstract::A three-month study of the chemistry of the water erosion of two forms of ASPA cement has been made. The effect of varying cement consistency and cure time was investigated. The results are discussed in terms of the known chemistry and structure of the cement. The erosion behavior is compared to that of silicate, sili...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550060501
更新日期:1976-11-01 00:00:00
abstract::The clearance of glucose from saliva was compared with that from spaces located in an intra-oral appliance. The spaces (N = 8) were similar in shape and size to posterior interdental spaces and could be sampled with a microsyringe without removing the appliance from the mouth. The subjects (N = 5) rinsed their mouths ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640030301
更新日期:1985-03-01 00:00:00
abstract::Six subjects wore intra-oral devices carrying eight bovine enamel blocks which were covered with a layer of S. mutans. They rinsed their mouths for five sec, one min, or multiples of one min with a 5 or 10% glucose (G) solution. Demineralization was measured after 45 min by determining the change in iodide permeabilit...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650021001
更新日期:1986-02-01 00:00:00
abstract::In a three-year study of 145 adolescent males in a boarding school in Wisconsin, there were no statistically significant differences in dental caries experience between a group consuming phosphates added to pre-sweetened and non-presweetened ready-to-eat cereals, and the control group, or between cereal eaters and non...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章
doi:10.1177/00220345790580090201
更新日期:1979-09-01 00:00:00
abstract::Current knowledge regarding the sensitivity of the teeth to forces is based on psychophysical experiments that measured touch detection thresholds under static jaw conditions. It is not known whether jaw movements alter the perception of forces applied to the teeth, but, based on limb movement studies, it is hypothesi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510363101
更新日期:2010-04-01 00:00:00
abstract::Local administrations of prostaglandins E1 or E2 combined with orthodontic tooth movement can approximately double the rate of tooth movement in monkeys compared to that of the control. Macroscopically, no side-effect was observed in the gingiva and associated structures. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345820610121401
更新日期:1982-12-01 00:00:00
abstract::The size of a bolus determines how it will be manipulated in the mouth and swallowed. We hypothesized that mucosal sensitivity would be important for masticatory function. The accuracy of solid object size perception, spatial acuity, and food particle size reduction during mastication were measured in 22 healthy adult...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408300507
更新日期:2004-05-01 00:00:00
abstract::Although the contribution of the oral microbiota to oral malodor is well-documented, the potential role of Gram-positive micro-organisms is unclear. In the current study, we tested the hypothesis that Gram-positive micro-organisms contribute to malodor production by deglycosylating oral glycoproteins, rendering them s...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608501007
更新日期:2006-10-01 00:00:00
abstract::It was recently reported that human periapical cysts (hPCys), a commonly occurring odontogenic cystic lesion of inflammatory origin, contain mesenchymal stem cells (MSCs) with the capacity for self-renewal and multilineage differentiation. In this study, periapical inflammatory cysts were compared with dental pulp to ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034515570316
更新日期:2015-06-01 00:00:00
abstract::Secondary palatogenesis occurs when the bilateral palatal shelves (PS), arising from maxillary prominences, fuse at the midline, forming the hard and soft palate. This embryonic phenomenon involves a complex array of morphogenetic events that require coordinated proliferation, apoptosis, migration, and adhesion in the...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034517726284
更新日期:2017-10-01 00:00:00
abstract::A multiple logistic regression analysis was used to compute the odds ratios for 11 common occlusal features for asymptomatic controls (n = 147) vs. five temporomandibular disorder groups: Disc Displacement with Reduction (n = 81), Disc Displacement without Reduction (n = 48), Osteoarthrosis with Disc Displacement Hist...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720061301
更新日期:1993-06-01 00:00:00
abstract::Pure gutta-percha was heat-treated in a differential thermal analyzer. The high melting form crystallized on cooling when gutta-percha was heated to 70 C or less. Above 74 C, crystallization into the low melting form predominated. Either polymorph can be selectively crystallized by control of the heat-treatment temper...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560120301
更新日期:1977-12-01 00:00:00
abstract::Interleukin (IL)-23 is an essential cytokine involved in expansion of the Th17 lineage, which is associated with many immune-related destructive tissue diseases. We hypothesized that the IL-23-induced Th17 pathway plays a role in periodontal pathology and examined the expression of cytokines, and related molecules, in...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509339889
更新日期:2009-07-01 00:00:00