Abstract:
:Potentially significant associations between periodontal disease and chronic kidney disease (CKD) have been reported in recent studies. The aim of this cross-sectional study was to investigate the association between serum antibody to the periodontal pathogen Porphyromonas gingivalis (P. gingivalis) and CKD in 215 Japanese individuals, aged 79 yrs. Serum antibody levels to P. gingivalis were measured by enzyme-linked immunosorbent assay. An elevated serum antibody response was defined as the upper quartile and was compared with the bottom three quartiles. Participants were classified as having CKD when their glomerular filtration rate was between 15 and 59 mL/min/1.73 m(2). A multivariable logistic regression model was used to evaluate the association between elevated antibody status and the presence of CKD. Study participants with an elevated serum antibody to P. gingivalis were 2.6 times more likely to have CKD. The adjusted odds ratio of CKD for participants in the highest quartile of serum antibody to P. gingivalis was 2.59 (95% confidence interval, 1.05-6.34) when compared with others in lower quartiles after simultaneous adjustment for other covariates. In conclusion, the present study suggests that elevated serum antibody to P. gingivalis was significantly associated with decreased kidney function in a community-based cohort of elderly Japanese.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Iwasaki M,Taylor GW,Manz MC,Kaneko N,Imai S,Yoshihara A,Miyazaki Hdoi
10.1177/0022034512455063subject
Has Abstractpub_date
2012-09-01 00:00:00pages
828-33issue
9eissn
0022-0345issn
1544-0591pii
0022034512455063journal_volume
91pub_type
杂志文章abstract::Pulpal blood flow was determined in 32 dogs ranging in age from 6 weeks to 18 months by the isotope fractionation method incorporating diffusible and nondiffusible tracers. Dogs were placed into selected age groups by the developmental status of the canine teeth. For the teeth sampled, the maxillary first, second, and...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345770560102601
更新日期:1977-10-01 00:00:00
abstract::Previously, we reported that the rate (R) of hydroxyapatite dissolution in acetic, lactic, and phosphoric acid solutions is a function of the degree of saturation with respect to the dissolving mineral, DS (defined as the ratio of the mean ionic activity product for hydroxyapatite [Ca5OH(PO4)3] in solution to its solu...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345990780070701
更新日期:1999-07-01 00:00:00
abstract::Bone and dentin share similar biochemical compositions and physiological properties. Dentin, a major tooth component, is formed by odontoblasts; in contrast, bone is produced by osteoblasts. Osterix (Osx), a zinc finger-containing transcription factor, has been identified as an essential regulator of osteoblast differ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514565647
更新日期:2015-03-01 00:00:00
abstract::Jaw displacement tremor was investigated. Both tremor amplitude and tremor frequency were found to increase with increasing muscle activation. Co-contraction of jaw elevator and jaw depressor muscles was employed in order to vary muscle activation levels without the teeth being in occlusion. Reproducibility of tremor ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670080401
更新日期:1988-08-01 00:00:00
abstract::The aim of this study was to test effects of preventive regimes using fluoride and chlorhexidine to prevent caries and periodontal diseases in 34 patients with overdentures. The patients, who were treated with immediate overdentures, were distributed at random into three experimental groups. In these groups, different...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/00220345870660101301
更新日期:1987-10-01 00:00:00
abstract::Cell kinetics of rat molar periodontal ligament (PDL) during orthodontically-induced osteogenesis revealed: 1) primary growth fraction of 59%, 2) proliferating cells from throughout the PDL migrate toward the bone surface, 3) preosteoblasts, capable of forming osteoblasts without synthesizing DNA, are present in the P...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345810600021501
更新日期:1981-02-01 00:00:00
abstract::The goal of the present investigation was to study whether periodic use of fluoride-gel treatments resulted in an increased prevalence of dental fluorosis. 269 children, from 14 to 16 years of age, who had received semi-annual or quarterly fluoride-gel treatments were examined for possible fluoride-induced enamel chan...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640081101
更新日期:1985-08-01 00:00:00
abstract::Investigators have used chemotherapeutic agents topically for plaque control without knowing the drug concentration necessary to inhibit the growth of odontopathic microorganisms. S mutans, S sanguis, A viscosus and A naeslundii are important components of the plaque flora. The minimal inhibitory concentrations (MIC) ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550040401
更新日期:1976-07-01 00:00:00
abstract::Evidence that dental status affects diet is equivocal. The hypothesis of this study was that diet was affected by dental status. The objective was to assess the relationship between numbers of teeth and diet and nutritional status in US adult civilians without prostheses. We examined 6985 NHANES (1988-1994) participan...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708601206
更新日期:2007-12-01 00:00:00
abstract::A previously reported technique for staining areas of degradation in dental composite restorations was evaluated in 51 removed restorations. The staining reagent was silver nitrate, which penetrated the degraded subsurface as ionic silver and was subsequently developed into colored deposits of metallic silver. Several...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700031201
更新日期:1991-03-01 00:00:00
abstract::The objective of this study was to assess the relative effects of age and oral hygiene on the progression of periodontitis by estimating incidence from age-specific prevalence. This study analyzed data from a representative national sample of 14,690 dentate Americans, aged from 15 to 74, seen in the first National Hea...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660010201
更新日期:1987-01-01 00:00:00
abstract::Four classes of elastomeric impression materials (polysulfide, polyether, silicone, and agar-agar) were evaluated on the basis of linear dimensional stability as a function of time between taking and pouring an impression of mounted teeth. Four polysulfide materials produced dies which were larger than the teeth and g...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345800590071001
更新日期:1980-07-01 00:00:00
abstract::The purpose of the study was to determine the exposure times needed to harden a light-activated composite cement through various thicknesses of porcelain. A negative exponential model was developed with which the relative hardness of a composite could be predicted from the product of the exposure time and the square r...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345890680030801
更新日期:1989-03-01 00:00:00
abstract::In the rat parotid acinar cell, methacholine caused an increase in [Ca2+]i as determined by quin-2 fluorescence. The increase in [Ca2+]i was initially independent of, and subsequently dependent on, the presence of extracellular Ca2+, indicating mobilization of intracellular Ca2+, as well as activation of Ca2+ entry. M...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345870660022701
更新日期:1987-02-01 00:00:00
abstract::Levels of mutans streptococci in plaque samples from margins of Class II amalgam (Dispersalloy), composite (P-10), and glass-ionomer (Ketac Silver) restorations were compared. Fifty-one children, each having one of the restorations in a permanent first molar, were part of an inter-individual comparison, giving 17 rest...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690030601
更新日期:1990-03-01 00:00:00
abstract::The rate of F absorption from the stomach is pH-dependent, with greater absorption at low pH. Since the rate of absorption is also strongly influenced by the rapidity of gastric emptying, we have compared the relative importance of gastric acidity and gastric emptying in overall F absorption. Male rats (350 g, n = 85)...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720031101
更新日期:1993-03-01 00:00:00
abstract::Soft lining materials undergo two processes when immersed in water. Plasticizers and other soluble materials are leached into the water, and water is absorbed by the polymer. The balance between these two processes affects both the compliance and dimensional stability of the materials. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620061601
更新日期:1983-06-01 00:00:00
abstract::Vitamin D, an anti-inflammatory mediator, has potential benefits for physical and oral health. Although it is produced endogenously, some individuals have a greater need for dietary and supplemental sources. This repeated-measures cross-sectional study assessed associations between total vitamin D intake and periodont...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513495239
更新日期:2013-08-01 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAIDs) are used to manage pain and inflammatory disorders. We hypothesized that gingival fibroblasts actively accumulate NSAIDs and enhance their levels in gingival connective tissue. Using fluorescence to monitor NSAID transport, we demonstrated that cultured gingival fibroblas...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910608500511
更新日期:2006-05-01 00:00:00
abstract::This study describes the formation of a calcium polyacrylate-hydroxyapatite cement. Our hypothesis was that calcium phosphates would rapidly hydrolyze in the presence of polyacrylic acid (PAA) to form a cement. PAA, tetracalcium phosphate (TetCP), and dicalcium phosphate (DCP) were reacted together and formed calcium ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345940730030501
更新日期:1994-03-01 00:00:00
abstract::Biological evaluation procedures for the acceptance of new dental materials include testing for mucous membrane irritation and inflammation, with the hamster cheek pouch used as a model system. Previous reports have indicated both a low 14-day implant retention rate and poor differentiation between positive and negati...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650111801
更新日期:1986-11-01 00:00:00
abstract::The effect of low-level laser treatment on maxillary arch dimensions after palatal surgery was investigated in Beagle dogs at an age of 12 weeks. A total of 30 dogs was used, and they were assigned to either a control group (Group C, n = 6) or one of two experimental groups (Group L, n = 12; and group LL, n = 12). Aft...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700111501
更新日期:1991-11-01 00:00:00
abstract:UNLABELLED:We have previously shown that the resin monomer 2-hydroxyethylmethacrylate (HEMA) affects mouse B-lymphocyte activity, leading to increased IgG1 antibody production in vivo. In the present study, we tested, in vitro, the hypothesis that HEMA also affects human B-lymphocyte activity. The in vitro production o...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510378522
更新日期:2010-12-01 00:00:00
abstract::This study indicated that a clear relationship exists between silicon and fluoride. We have also demonstrated a probable surface enamel silicon effect that increases fluoride uptake. The complex set of relationships described in the surface chemistry of calcium, tin, and zirconium with fluoride, hydroxide, phosphate, ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550050601
更新日期:1976-09-01 00:00:00
abstract::Cell therapies utilizing mesenchymal stem cells (MSCs) could overcome limitations of traditional treatments for reconstructing craniofacial tissues. This large-scale study explored a standardized methodology for the isolation and clinical-scale expansion of alveolar bone marrow-derived MSCs (aBMSCs). We harvested 103 ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513510530
更新日期:2014-01-01 00:00:00
abstract::The effects of different doses of p-tyramine injected i.v. and i.p. on salivary flow rates and proteins secreted by the submandibular glands of rats were studied with and without various types of autonomic blockers and two enzyme inhibitors. The salivary flow rates and the amounts of protein secreted progressively inc...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720051101
更新日期:1993-05-01 00:00:00
abstract::Frequent consumption of cariogenic foods and bacterial infection are risk factors for early childhood caries (ECC). This study hypothesized that a short diet survey focused on frequency of foods, categorized by putative cariogenicity, would differentiate severe ECC (S-ECC) from caries-free children. Children's diets w...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510376543
更新日期:2010-11-01 00:00:00
abstract::In previous studies, light-cured glass-ionomer cements have been shown to evoke cytotoxic reactions. It was the purpose of this investigation (a) to determine the nature of the ingredients released into an aqueous medium from 2 light-cured glass-ionomer cements (GICs) and 3 compomers; (b) to evaluate the cytotoxicity ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345980770121001
更新日期:1998-12-01 00:00:00
abstract::The following five outlines are the results to date of the Workshop held in Rockville, Maryland, in January, 1990. The topics considered in these outlines are: (1) validation of immunological and/or nucleic acid identification probes, (2) cross-calibration of methods and/or laboratories for multi-laboratory cooperativ...
journal_title:Journal of dental research
pub_type: 指南,杂志文章
doi:10.1177/00220345910700031401
更新日期:1991-03-01 00:00:00
abstract::Mark Twain provides a humorous and insightful look into the origins of periodontal therapy and anesthesia in "Happy Memories of the Dental Chair". The main character of this story is Dr. John Riggs, the father of periodontics. Dr. Horace Wells, a pioneer in the field of anesthesia, also appears in the story. Twain pre...
journal_title:Journal of dental research
pub_type: 传,历史文章,杂志文章
doi:10.1177/0022034510366677
更新日期:2010-07-01 00:00:00