Abstract:
:Biological evaluation procedures for the acceptance of new dental materials include testing for mucous membrane irritation and inflammation, with the hamster cheek pouch used as a model system. Previous reports have indicated both a low 14-day implant retention rate and poor differentiation between positive and negative controls, requiring the establishment of a new standard procedure for hamster cheek pouch implantations. Groups of 10 female golden Syrian hamsters were implanted with uniform discs (6 mm in diameter and 1 mm thick) of white base-plate gutta percha (GP), gray welding-rod polyvinyl chloride (PVC), low-density polyethylene (LDPE), or test alloys, under Nembutal anesthesia. Each animal's right cheek pouch was everted and cleaned, and the implant was loosely placed at the bottom of the pouch. The pouch was closed by a double-suture technique. Contralateral (left) cheek pouches served as controls for the physical state of each animal. A collar (cable tie) was placed tightly around the animal's neck at a level between the sutures and the implant. Cheek pouches were assessed after 14 days. Implants were kept in contact with oral mucosa longer using the double-suture-plus-collar technique than in hamsters without collars (14-day retention rates of 48.0% and 6.7%, respectively). Average severity indices (ASI) of 5.4 and 1.7 were obtained for PVC and GP, respectively, as compared with 1.6 for contralateral control pouches. LDPE was not a suitable negative control material (ASI = 2.6). Positive and negative controls were clearly delineated when PVC and GP were the control materials.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Roy M,Wishe HIdoi
10.1177/00220345860650111801subject
Has Abstractpub_date
1986-11-01 00:00:00pages
1365-70issue
11eissn
0022-0345issn
1544-0591journal_volume
65pub_type
杂志文章abstract::The human dentition is a complex adaptive system that is influenced by genetic, epigenetic, and environmental factors. Within this system, is sexual dimorphism related to the growth promotion of the Y chromosome, or to hormonal influences, or both? This study is the first to investigate both primary and permanent toot...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513484934
更新日期:2013-05-01 00:00:00
abstract::A series of in vitro studies have been performed to study the release of tin and fluoride from an experimental prophylactic cup and the influence of this release on the fluoride content of enamel. It has been found that the release of fluoride from the prophy cup during a simulated prophylaxis results in a significant...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550030801
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abstract::Rotational freedom of the implant-abutment connection influences its screw joint stability; for optimization, influential factors need to be evaluated based on a previously developed closed formula. The underlying hypothesis is that the manufacturing tolerances, geometric pattern, and dimensions of the index do not in...
journal_title:Journal of dental research
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更新日期:2009-08-01 00:00:00
abstract::We previously demonstrated that an anti-caries DNA vaccine intranasally administered with recombinant flagellin protein as a mucosal adjuvant enhanced salivary IgA response and conferred better protection against caries. However, the relatively weak immunogenicity of DNA vaccines and the necessity for a large quantity...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512457684
更新日期:2012-10-01 00:00:00
abstract::Periodontitis is a chronic infectious disease driven by dysbiosis, an imbalance between commensal bacteria and the host organism. Periodontitis is a leading cause of tooth loss in adults and occurs in about 50% of the US population. In addition to the clinical challenges associated with treating periodontitis, the pro...
journal_title:Journal of dental research
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doi:10.1177/0022034515611876
更新日期:2016-02-01 00:00:00
abstract::Previous studies have demonstrated that antibodies against cholinoreceptors of exocrine glands correlate with dry mouth in persons with primary Sjögren syndrome (pSS). The aim of the present investigation was to establish if serum IgG antibodies (pSS IgG) were able to interact with cholinoreceptors in rat submandibula...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708600905
更新日期:2007-09-01 00:00:00
abstract::The composition of the degradable glasses used in commercial dental glass-ionomer cements determines their leaching behavior and hence the properties of the cement. The objective of the present study was to assess if the composition and leaching in acetic acid solutions are reflected in the x-ray diffraction character...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345010800081601
更新日期:2001-08-01 00:00:00
abstract::Adhesive bonding of resins to dentin surfaces requires the removal of the layer of debris caused by the cutting. Certain isotonic acidic solutions can do this rapidly. Five solutions were evaluated using cell cultures and pulp studies in monkeys. At concentrations above 10%, each solution caused the cultured human epi...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345820610081001
更新日期:1982-08-01 00:00:00
abstract::IL-18 is a pro-inflammatory cytokine that is important in the regulation of T-cells and is elevated in inflammatory disorders such as periodontal disease. Vasoactive intestinal peptide (VIP) modulates immune responses to the periodontal pathogen Porphyromonas gingivalis (Pg). Our objective was to investigate the effec...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708600915
更新日期:2007-09-01 00:00:00
abstract::Reporting the economic burden of oral diseases is important to evaluate the societal relevance of preventing and addressing oral diseases. In addition to treatment costs, there are indirect costs to consider, mainly in terms of productivity losses due to absenteeism from work. The purpose of the present study was to e...
journal_title:Journal of dental research
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更新日期:2015-10-01 00:00:00
abstract::microRNAs could be mechanosensitive and emerge as critical posttranscriptional regulators in the bone-remodeling process. During orthodontic tooth movement (OTM), the application of mechanical force induces alveolar bone remodeling, but whether microRNAs respond to orthodontic force and contribute to OTM is unknown. m...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034516657043
更新日期:2016-11-01 00:00:00
abstract::Better understanding of dental caries and other oral conditions has guided new strategies to prevent disease and manage its consequences at individual and public health levels. This article discusses advances in prevention and minimal intervention dentistry over the last century by focusing on some milestones within s...
journal_title:Journal of dental research
pub_type: 历史文章,杂志文章
doi:10.1177/0022034519837252
更新日期:2019-06-01 00:00:00
abstract::The effect of different doses of polyadenylic and polyuridylic acids (poly A:U) was studied in control rats and in rats exposed to hypoxia. In the control rats, administration of different doses of poly A:U did not change the thickness of the epiphyseal plate or increase the incorporation of 3H-phenylalanine as judged...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550041701
更新日期:1976-07-01 00:00:00
abstract::Periodontal disease is a bacterial infection that results in inflammatory destruction of tissues that support the teeth, including connective tissue and bone. In this study, we report that transgenic mice that overexpress the 17-kDa form of IL-1alpha in the basal layer of oral mucosal epithelium develop a syndrome tha...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408301010
更新日期:2004-10-01 00:00:00
abstract::We investigated whether oral health, represented by missing teeth, was associated with an increased risk of cardiovascular disease, including myocardial infarction (MI), heart failure (HF), stroke, and all-cause mortality. Subjects who underwent routine dental examinations and health checkups provided by the Korean Na...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034518814829
更新日期:2019-02-01 00:00:00
abstract::A new type of hydraulic cement has been developed. This cement consists of a mixture of cement powder and setting agent powder and therefore has only to be kneaded with a little amount of water when being used. ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345790580050601
更新日期:1979-05-01 00:00:00
abstract::Deciduous teeth were collected from children who received professional prophylaxis with an acidulated phosphate-fluoride (APF) or placebo paste and were analyzed to determine fluoride uptake. Enamel fluoride level was increased by the APF paste approximately 300 ppm at a depth of 2.5 micrometers during the first month...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550064901
更新日期:1976-11-01 00:00:00
abstract::An infrared spectroscopic study has been made of the development of crystallinity (hopeite) in dental zinc phosphate cements. Crystallization in the bulk of a cement is prevented only by the incorporation, in the liquid, of aluminum which forms complexes with phosphoric acid. The development of surface crystallinity i...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570021801
更新日期:1978-02-01 00:00:00
abstract::Amelogenin and ameloblastin, the major enamel matrix proteins, are important for enamel mineralization. To identify their synergistic roles in enamel development, we generated Amel X(-/-)/Ambn(-/-) mice. These mice showed additional enamel defects in comparison with Amel X(-/-) or Ambn(-/-) mice. In 7-day-old Amel X(-...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034509334749
更新日期:2009-04-01 00:00:00
abstract::Setting reactions and compressive strengths of a self-hardening calcium phosphate cement (CPC) were investigated. The CPC consists of tetracalcium phosphate (TTCP) and anhydrous dicalcium phosphate (DCPA). The cement specimens were prepared by mixing 0.7 g of the powder (TTCP 72.9 wt% + DCPA 27.1 wt%) with 0.175 mL of...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690121201
更新日期:1990-12-01 00:00:00
abstract::The distribution, genetic relatedness, and peptidase activity in hydrolyzing N-benzoyl-L-arginine-p-nitroanilide by Capnocytophaga species isolated from calculus- and non-calculus-formers were determined in this study. The proportion and prevalence of Capnocytophaga species were higher in plaque samples from the calcu...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700070601
更新日期:1991-07-01 00:00:00
abstract::Radiation therapy for head and neck cancer results in severe secondary side-effects in salivary glands. We previously demonstrated that the administration of IGF1 preserves or restores salivary gland function following radiation. Based on these findings, we propose to study the effect of IGF1 on human head and neck ca...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510388037
更新日期:2011-03-01 00:00:00
abstract::A quantitative microprobe analysis was conducted on three commercial amalgams to determine the nature of the phases present. The presence of tin in the Ag-Hg phase (gamma1) was confirmed and Cu-3Sn was found in the original alloy particles. In the dispersant amalgam studied, little Sn-Hg phase (gamma-2) was found and ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract::A three-month study of the chemistry of the water erosion of two forms of ASPA cement has been made. The effect of varying cement consistency and cure time was investigated. The results are discussed in terms of the known chemistry and structure of the cement. The erosion behavior is compared to that of silicate, sili...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550060501
更新日期:1976-11-01 00:00:00
abstract::The kinetics of subsurface demineralization of tooth sections has been studied in real-time by scanning microradiography (SMR). Demineralization was carried out: (1) with a large volume of solution buffered to pH = 4 to maintain a constant composition; and (2) in a small constant volume (approximately 3 mL), buffered ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720051401
更新日期:1993-05-01 00:00:00
abstract::Adhesion of restorative and protective materials to dentin is an important requirement for operative and preventive dentistry. Wettability and roughness are dentin substrate conditions that are critical to establishing good adhesion. This study examined superficial and deep dentin for variations in water contact angle...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345990780091001
更新日期:1999-09-01 00:00:00
abstract::The aim of this meta-analysis was to examine the clinical effectiveness of miniscrew implants (MI) used for anchorage reinforcement compared with that of conventional orthodontic means, as well as to assess the success rates of MIs and the possible risk factors affecting their clinical effectiveness. Literature search...
journal_title:Journal of dental research
pub_type: 杂志文章,meta分析,评审
doi:10.1177/0022034511409236
更新日期:2011-08-01 00:00:00
abstract::The complexity of the periodontal microbiota resembles that of the gastro-intestinal tract, where infectious diseases are treatable via probiotics. In the oropharyngeal region, probiotic or replacement therapies have shown some benefit in the prevention of dental caries, otitis media, and pharyngitis, but their effect...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910708601111
更新日期:2007-11-01 00:00:00
abstract::Amylase activity in various tissues--i.e., submandibular/sublingual and parotid glands, the pancreas, saliva, and serum--in rats was measured after injection of isoproterenol, pilocarpine, and acetylcholine. All agents reduced amylase activity in the parotid gland and increased the enzyme activity in the submandibular...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620011201
更新日期:1983-01-01 00:00:00
abstract::Samples of human dental plaque were pooled from several "white spot" smooth tooth surface areas as well as from several clinically-sound tooth surface areas in each of 12 caries-positive college students. Each of the two samples from each subject was used for the determination of: (1) pH-lowering potential in vitro in...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700120501
更新日期:1991-12-01 00:00:00