Abstract：
:Autoimmune responses to heat-shock protein 60 (HSP60) contribute to the progression of atherosclerosis, whereas immunization with HSP60 may induce atheroprotective responses. We assessed the capacity of an atheroprotective vaccine that targeted a recombinant HSP60 from Porphyromonas gingivalis (rGroEL) to induce a protective mucosal immune response. Female apolipoprotein E-deficient spontaneously hyperlipidemic (Apoe(shl)) mice received sublingual delivery of rGroEL prior to P. gingivalis 381 injection. The animals were euthanized 16 weeks later. Sublingual immunization with rGroEL induced significant rGroEL-specific serum IgG responses. Antigen-specific cells isolated from spleen produced significantly high levels of IL-10 and IFN-γ after antigen re-stimulation in vitro. Flow cytometric analysis indicated that the frequencies of both IL-10(+) and IFN-γ(+) CD4(+) Foxp3(+) cells increased significantly in submandibular glands (SMG). Furthermore, sublingual immunization with rGroEL significantly reduced atherosclerosis lesion formation in the aortic sinus and decreased serum CRP, MCP-1, and ox-LDL levels. These findings suggest that sublingual immunization with rGroEL is associated with the increase of IFNγ(+) or IL-10(+) Foxp3(+) cells in SMG and a systemic humoral response, which could be an effective strategy for the prevention of naturally occurring or P. gingivalis-accelerated atherosclerosis.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Hagiwara M,Kurita-Ochiai T,Kobayashi R,Hashizume-Takizawa T,Yamazaki K,Yamamoto Mdoi
10.1177/0022034514523784subject
Has Abstractpub_date
2014-04-01 00:00:00pages
382-7issue
4eissn
0022-0345issn
1544-0591pii
0022034514523784journal_volume
93pub_type
杂志文章abstract：:We have isolated a specific cell wall antigen of high molecular weight which appears to be unique to virulent strains of A viscosus and A naeslundii. The antigen is composed of two parts: a polysaccharide moiety containing 6-DOT as the major sugar and determinant of serologic specificity, and a small peptide bearing s...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/002203457605500111011
更新日期：1976-01-01 00:00:00
abstract：:Dental enamel formation is a remarkable example of a biomineralization process. The exact mechanisms involved in this process remain partly obscure. Some of the genes encoding specific enamel proteins have been indicated as candidate genes for amelogenesis imperfecta. Mutational analyses within studied families have s...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910508401206
更新日期：2005-12-01 00:00:00
abstract：:Inferior alveolar nerve (IAN) injury induces persistent ectopic pain which spreads to a wide area in the orofacial region. Its exact mechanism remains unclear. We investigated the involvement of nitric oxide (NO) in relation to ectopic orofacial pain caused by IAN transection (IANX). We assessed the changes in mechani...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034513509280
更新日期：2013-12-01 00:00:00
abstract：:Cardiovascular disease is a common cause of morbidity and premature mortality. Cardiovascular disease can be prevented when risk factors are identified early. Calcified carotid artery atheromas (CCAAs), detected in panoramic radiographs, and periodontitis have both been associated with increased risk of cardiovascular...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519885362
更新日期：2020-01-01 00:00:00
abstract：:Biological evaluation procedures for the acceptance of new dental materials include testing for mucous membrane irritation and inflammation, with the hamster cheek pouch used as a model system. Previous reports have indicated both a low 14-day implant retention rate and poor differentiation between positive and negati...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345860650111801
更新日期：1986-11-01 00:00:00
abstract：:The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n ...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510381903
更新日期：2010-12-01 00:00:00
abstract：:Adhesive bonding of resins to dentin surfaces requires the removal of the layer of debris caused by the cutting. Certain isotonic acidic solutions can do this rapidly. Five solutions were evaluated using cell cultures and pulp studies in monkeys. At concentrations above 10%, each solution caused the cultured human epi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345820610081001
更新日期：1982-08-01 00:00:00
abstract：:Mutations and common polymorphisms in interferon regulatory factor 6 ( IRF6) are associated with both syndromic and nonsyndromic forms of cleft lip/palate (CLP). To date, much of the focus on this transcription factor has been on identifying its direct targets and the gene regulatory network in which it operates. Nota...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034517723615
更新日期：2017-10-01 00:00:00
abstract：:Due, in part, to the unique structure of the tooth, dental pain is initiated via distinct mechanisms. Here we review recent advances in our understanding of inflammatory tooth pain and discuss 3 hypotheses proposed to explain dentinal hypersensitivity: The first hypothesis, supported by functional expression of temper...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/0022034513501877
更新日期：2013-11-01 00:00:00
abstract：:In 1984, a four-year mixed-longitudinal study of oral health was begun in Morogoro Town and Morogoro District, Tanzania. Its main goal was to detect a possible upward trend in prevalence of caries in child cohorts in this developing country. The sample consisted of 722 seven- to nine-year-olds in 1984, 833 seven- to 1...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345890680121101
更新日期：1989-12-01 00:00:00
abstract：:Although the occlusal vertical dimension (OVD) is strictly controlled, the neuronal mechanism of its regulation is still unclear. We hypothesize that neurons in the trigeminal mesencephalic nucleus (MesV) play an important role in the regulation of the OVD, because the MesV receives the projection from jaw-closing mus...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910308200715
更新日期：2003-07-01 00:00:00
abstract：:Two independent cross-over studies investigated the possibility of enhanced early enamel lesion remineralization with the use of chewing gum. The first study involved a sorbitol-containing chewing gum, and the second, which had an identical protocol, tested a sucrose-containing chewing gum. In each study, 12 volunteer...
journal_title：Journal of dental research
pub_type： 临床试验,杂志文章
doi：10.1177/00220345920710120801
更新日期：1992-12-01 00:00:00
abstract：:The microstructure of the set glass-polyalkenoate cement has not been undertaken beyond a study where an Electron Probe Micro Analyser was used. The purpose of this investigation was to determine the ion distribution in matrix parts of the set cement by means of Secondary Ion Mass Spectrometry (SIMS). Among the techni...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345990780011301
更新日期：1999-01-01 00:00:00
abstract：:Light propagation in human dentin exhibits a strong directional dependence featuring the long-known optical magnification property. We hypothesized that this anisotropic effect is caused by multiple scattering at the dentin tubules, and not by fiberoptic effects, as had been previously assumed. We performed measuremen...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/154405910608501017
更新日期：2006-10-01 00:00:00
abstract：:The diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection relies on the detection of viral RNA by real-time reverse transcription polymerase chain reaction (rRT-PCR) performed with respiratory specimens, especially nasopharyngeal swabs. However, this procedure requires specialized medical...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520969670
更新日期：2021-02-01 00:00:00
abstract：:Nearly 100% of patients experience trauma to the trigeminal nerve during orthognathic surgery, impairing sensation and sensory function on the face. In a recent randomized clinical trial, people who performed sensory re-training exercises reported less difficulty related to residual numbness and decreased lip sensitiv...
journal_title：Journal of dental research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/154405910708600616
更新日期：2007-06-01 00:00:00
abstract：:Bisphosphonates are a class of agents used to treat osteoporosis and malignant bone metastases. The efficacy of these agents in treating and preventing the significant skeletal complications associated with these conditions has had a major positive impact for patients and is responsible for their widespread use in med...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/154405910708601101
更新日期：2007-11-01 00:00:00
abstract：:When measured once, psychological stress predicts development of painful temporomandibular disorder (TMD). However, a single measurement fails to characterize the dynamic nature of stress over time. Moreover, effects of stress on pain likely vary according to biological susceptibility. We hypothesized that temporal es...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034515595043
更新日期：2015-09-01 00:00:00
abstract：:The flexure moduli of elasticity of solid and multi-stranded orthodontic wires were determined. Results for the solid wires approximated their tensile values, but the differences were statistically significant for the stainless steel, chromium-cobalt-nickel, and nickel-titanium alloys. The flexure moduli of the multi-...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345830620072201
更新日期：1983-07-01 00:00:00
abstract：:The impact of osteoporosis on implant treatment is still a matter of debate in the scientific community, as it may possibly lead to higher failure rates. As long-term controlled trials are missing, the aim of this study was to verify the long-term outcome of implants placed in patients with systemic osteoporosis. Post...
journal_title：Journal of dental research
pub_type： 杂志文章,随机对照试验
doi：10.1177/0022034518798804
更新日期：2019-01-01 00:00:00
abstract：:Although the tripeptides Glu-O-Phosphoserine-Tyr and Glu-O-Phosphoserine-Leu have been identified in embryonic bovine enamel proteins, 1, 2 the issue of whether both sequences occur in each of the phosphopeptides, or whether certain sequences occur in specific peptides only, has recently been resolved by isolating hom...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345790580023101
更新日期：1979-03-01 00:00:00
abstract：:Bone remodeling is a complex process regulated by several mediators. Recent work has revealed that cytokines and growth factors have significant effects on bone cell metabolism. However, little information is available concerning the production of cytokines during orthodontic tooth movement in human subjects, and ther...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345960750010801
更新日期：1996-01-01 00:00:00
abstract：:The work described considers the effects on calcified tissues of those concentrations of fluoride which are not overtly cyto-toxic, i.e., in the general region of up to 1-2 mumol/L. Plasma fluoride concentrations or those of the cellular environment are considered rather than dietary levels. The effect of fluoride ion...
journal_title：Journal of dental research
pub_type： 杂志文章,评审
doi：10.1177/00220345900690S134
更新日期：1990-02-01 00:00:00
abstract：:The relative contribution of the matrix of dentin to the physical properties of dentin is unknown but thought to be small. The objective of this study was to test the hypothesis that the demineralized matrix of dentin contributes little to the strength of dentin by measuring and comparing the ultimate tensile strength...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345940730061201
更新日期：1994-06-01 00:00:00
abstract：:Histone deacetylases (HDACs) are important regulators of gene expression that are aberrantly regulated in several inflammatory and infectious diseases. HDAC inhibitors (HDACi) suppress inflammatory activation of various cell types through epigenetic and non-epigenetic mechanisms, and ameliorate pathology in a mouse mo...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034519885088
更新日期：2020-01-01 00:00:00
abstract：:Samples of dental plaque obtained from the interproximal tooth surfaces of seven young men showed considerable variation in the prevalence and anatomic site distribution of the potentially cariogenic microorganism S mutans. Multiple application of 10% SnF2 topical solution and saline solution delivered to interproxima...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345770560010301
更新日期：1977-01-01 00:00:00
abstract：:The aim of this systematic review and network meta-analysis was to summarize the direct and indirect clinical evidence on the effectiveness of professionally applied and self-applied topical fluorides in preventing dental root caries. Controlled clinical trials with any follow-up duration were included. MEDLINE, PubMe...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034520906384
更新日期：2020-05-01 00:00:00
abstract：:Stem cells from exfoliated deciduous teeth (SHED) possess multipotent differentiation and immunomodulatory properties. They have been used for orofacial bone regeneration and autoimmune disease treatment. In this study, we show that acetylsalicylic acid (ASA) treatment is able to significantly improve SHED-mediated os...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034514557672
更新日期：2015-01-01 00:00:00
abstract：:Experiments were performed to determine the role of the immune response in rat periodontal disease. Germ-free rats were fed defined antigen-free liquid diets or a diet containing ovalbumin(OVA) as a prototype antigen. The OVA-fed rats demonstrated increased gingival lymphocytes (mainly T at early times), OVA-sensitize...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/00220345840630031801
更新日期：1984-03-01 00:00:00
abstract：:Defects in the enamelin gene (ENAM) cause amelogenesis imperfecta (AI). Our objective was to identify the genetic etiology of enamel hypoplasia in a Caucasian proband. Our hypothesis was that ENAM was defective. The proband and his father have an AG insertion (g.13185_13186insAG; p.422FsX448) in ENAM previously identi...
journal_title：Journal of dental research
pub_type： 杂志文章
doi：10.1177/0022034510365662
更新日期：2010-07-01 00:00:00
