Abstract:
:For restoring cavitated dental lesions, whether carious or not, a large number of material combinations are available. We aimed to systematically review and synthesize data of comparative dental restorative trials. A systematic review was performed. Randomized controlled trials published between 2005 and 2015 were included that compared the survival of ≥2 restorative and/or adhesive materials (i.e., no need for restorative reintervention). Pairwise and Bayesian network meta-analyses were performed, with separate evaluations for cervical cavitated lesions and load-bearing posterior cavitated lesions in permanent and primary teeth. A total of 11,070 restorations (5,330 cervical, 5,740 load bearing) had been placed in 3,633 patients in the included trials. Thirty-six trials investigated restoration of cervical lesions (all in permanent teeth) and 36 of load-bearing lesions (8 in primary and 28 in permanent teeth). Resin-modified glass ionomer cements had the highest chance of survival in cervical cavitated lesions; composites or compomers placed via 2-step self-etch and 3-step etch-and-rinse adhesives were ranked next. Restorations placed with 2-step etch-and-rinse or 1-step self-etch adhesives performed worst. For load-bearing restorations, conventional composites had the highest probability of survival, while siloranes were found least suitable. Ambiguity remains regarding which adhesive strategy to use in load-bearing cavitated lesions. Most studies showed high risk of bias, and several comparisons were prone for publication bias. If prioritized for survival, resin-modified glass ionomer cements might be recommended to restore cervical lesions. For load-bearing ones, conventional or bulk fill composites seem most suitable. The available evidence is quantitatively and qualitatively insufficient for further recommendations, especially with regard to adhesive strategies in posterior load-bearing situations. Moreover, different material classifications might yield different findings on the same materials. Future trials should aim for sufficient power, longer follow-up times, and high internal validity to prove or refute differences between certain material combinations. An agreed material classification for future syntheses is desirable.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Schwendicke F,Göstemeyer G,Blunck U,Paris S,Hsu LY,Tu YKdoi
10.1177/0022034516631285subject
Has Abstractpub_date
2016-06-01 00:00:00pages
613-22issue
6eissn
0022-0345issn
1544-0591pii
0022034516631285journal_volume
95pub_type
杂志文章,meta分析,评审abstract::Dental porcelains rely on the high-thermal-expansion mineral leucite to elevate their bulk thermal expansion to levels compatible with dental PFM alloys. The microcracks that form around these leucite particles when cooled during porcelain manufacture are a potential source of change in bulk porcelain thermal expansio...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750070801
更新日期:1996-07-01 00:00:00
abstract::The resin-dentin interdiffusion zone produced by a dentin-adhesive system that removes the smear layer and concurrently decalcifies superficial dentin was morphologically examined by both scanning and transmission electron microscopy. Cross-sectioned resin-bonded dentin discs were etched with an argon-ion beam to make...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345930720020501
更新日期:1993-02-01 00:00:00
abstract::A three-month study of the chemistry of the water erosion of two forms of ASPA cement has been made. The effect of varying cement consistency and cure time was investigated. The results are discussed in terms of the known chemistry and structure of the cement. The erosion behavior is compared to that of silicate, sili...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550060501
更新日期:1976-11-01 00:00:00
abstract::Chondroitin sulfate is up-regulated in granulation tissue during wound healing. To investigate the role of chondroitin sulfate in the wound-healing process after surgical repair of cleft palate, we isolated and cultured rabbit palatal fibroblasts. Treatment with chondroitin-6-sulfate resulted in a dose-dependent incre...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910408301111
更新日期:2004-11-01 00:00:00
abstract::The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510381903
更新日期:2010-12-01 00:00:00
abstract::The initiator of calculus matrix calcification, in vitro, was isolated. Crude phospholipid, known to contain the factor, was separated into five fractions by column chromatography. A single protein-containing fraction induced apatite formation during incubation. The nucleating fraction was indentified as a proteolipid...
journal_title:Journal of dental research
pub_type: 历史文章,杂志文章
doi:10.1177/00220345770560020701
更新日期:1977-02-01 00:00:00
abstract::Retinoic acid-inducible gene I (RIG-I) is a cytosolic pattern recognition receptor involved in the sensing of RNA viruses and the initiation of antiviral responses. Fusobacterium nucleatum, a Gram-negative anaerobic bacterium associated with periodontal disease, is capable of invading cells. We hypothesized that F. nu...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034513516346
更新日期:2014-02-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is a potent inducer of angiogenesis, vascular permeability, and edema. Up-regulation of VEGF expression in the dental pulp may result in increased intra-pulpal pressure, and contribute to pain and irreversible tissue damage. Lipoteichoic acid (LTA) is an amphiphilic molecule f...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/154405910308200612
更新日期:2003-06-01 00:00:00
abstract::Cross-sectional areas of the masseter, temporalis and medial, and lateral pterygoid muscles were determined in 16 subjects by means of computer tomography. In each subject three scans were made, intersecting the thickest part of the muscles at right angles to the fiber direction. The masseter and medial pterygoid musc...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345840630091201
更新日期:1984-09-01 00:00:00
abstract::Previously, we reported that the rate (R) of hydroxyapatite dissolution in acetic, lactic, and phosphoric acid solutions is a function of the degree of saturation with respect to the dissolving mineral, DS (defined as the ratio of the mean ionic activity product for hydroxyapatite [Ca5OH(PO4)3] in solution to its solu...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345990780070701
更新日期:1999-07-01 00:00:00
abstract::Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) nanocomplexes incorporated into sugar-free chewing gum have been shown to remineralize enamel subsurface lesions in situ. The aim of this study was to compare the ability of CPP-ACP, with that of other forms of calcium, to be retained in supragingival plaque ...
journal_title:Journal of dental research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/154405910308200311
更新日期:2003-03-01 00:00:00
abstract::In 1986, the first nationwide epidemiological survey of adult oral health and attitudes to oral health care was carried out in The Netherlands. One of the aims of this study was to evaluate the prevalence and the quality (in terms of need for replacement) of amalgam and composite restorations in the Dutch adult popula...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345900690060901
更新日期:1990-06-01 00:00:00
abstract::During porcelainization the non-preoxidized alloy develops a Be-rich reaction zone in the interface which separates a Be-depleted alloy from a Li and (to a lesser extent Na) depleted region of the ceramic. Thus, Be diffuses to the interface through the alloy Be degrees leads to Be++ + 2 e- occurs at the interface; som...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345780570021501
更新日期:1978-02-01 00:00:00
abstract::Indigenous populations around the world experience a disproportionate burden in terms of oral diseases and conditions. These inequalities are likely due to a complex web of social determinants that includes poverty, historical consequences of colonialism, social exclusion, government policies of assimilation, cultural...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/0022034518763605
更新日期:2018-07-01 00:00:00
abstract::Modulation of the phosphoinositide signal transduction pathway by arachidonic acid (AA) in collagenase-dispersed rat submandibular acinar cells was investigated. The muscarinic agonist, carbachol, stimulated PIP2 hydrolysis and the generation of IP3 to five-fold the control levels. This response was inhibited by 75% o...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345920710080101
更新日期:1992-08-01 00:00:00
abstract::The objective of this study was to calculate the stress distribution induced in anterior metal-ceramic crowns fabricated with either gold-alloy or nickel-alloy copings of reduced thickness using plane stress analyses. Two-dimensional finite element models of three crown designs were subjected to a simulated biting for...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650091201
更新日期:1986-09-01 00:00:00
abstract::The distribution, genetic relatedness, and peptidase activity in hydrolyzing N-benzoyl-L-arginine-p-nitroanilide by Capnocytophaga species isolated from calculus- and non-calculus-formers were determined in this study. The proportion and prevalence of Capnocytophaga species were higher in plaque samples from the calcu...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345910700070601
更新日期:1991-07-01 00:00:00
abstract::We analyzed the flow rate and composition of paraffin-stimulated whole saliva samples from 35 adult diabetic patients and their age- and sex-matched, non-diabetic, clinically healthy controls. All patients had insulin-dependent diabetes (IDDM) with a mean (+/- S.D.) duration of 14.0 +/- 9.1 years. The saliva analysis ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345860650011101
更新日期:1986-01-01 00:00:00
abstract::Despite the recognized link between aging and cancer, most preclinical studies in experimental tumor models are conducted with 6- to 8-wk-old rodents. The goal of the present study was to examine the impact of age on tumor incidence, growth, and microenvironmental characteristics in mouse models of head and neck squam...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034518775736
更新日期:2018-10-01 00:00:00
abstract::Dental enamel formation is a remarkable example of a biomineralization process. The exact mechanisms involved in this process remain partly obscure. Some of the genes encoding specific enamel proteins have been indicated as candidate genes for amelogenesis imperfecta. Mutational analyses within studied families have s...
journal_title:Journal of dental research
pub_type: 杂志文章,评审
doi:10.1177/154405910508401206
更新日期:2005-12-01 00:00:00
abstract::Selective recruitment of periodontal ligament cells to a previously exposed root surface is believed to enhance periodontal regeneration. It has been hypothesized that competition from gingival fibroblasts may reduce the potential of periodontal regeneration. We compared the migratory responses of PDL cells and gingiv...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345960750041401
更新日期:1996-04-01 00:00:00
abstract:UNLABELLED:Excessive mechanical stress (MS) during hyperocclusion is known to result in disappearance of the alveolar hard line, enlargement of the periodontal ligament (PDL) space, and destruction of alveolar bone, leading to occlusal traumatism. We have recently reported that MS induces predominantly C-C chemokine li...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034512467803
更新日期:2013-01-01 00:00:00
abstract::The effects of oral rinses on enamel fluoride uptake, caries, and plaque pH in rats were investigated by use of (1) an acidic calcium phosphate solution (CPS) saturated with dicalcium phosphate dihydrate (DCPD) and (2) a 1% fluoride solution. Osborne-Mendel rats, 19 days of age, were randomly assigned to one of four m...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345880670061401
更新日期:1988-06-01 00:00:00
abstract::The goal of nonrestorative or non- and microinvasive caries treatment (fluoride- and nonfluoride-based interventions) is to manage the caries disease process at a lesion level and minimize the loss of sound tooth structure. The purpose of this systematic review and network meta-analysis was to summarize the available ...
journal_title:Journal of dental research
pub_type: 杂志文章,meta分析
doi:10.1177/0022034518800014
更新日期:2019-01-01 00:00:00
abstract::Although proanthocyanidins (PACs) modify dentin, the effectiveness of different PAC sources and the correlation with their specific chemical composition are still unknown. This study describes the chemical profiling of natural PAC-rich extracts from 7 plants using ultra high pressure/performance liquid chromatography ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034514523783
更新日期:2014-04-01 00:00:00
abstract::Proteolytic hydrolysis of casein and porcine or bovine glycoproteins by S mutans was demonstrated in the present study. Caseinolytic activity was found in both the soluble contents of the cells and the cellular debris after rupture of the cells. However, caseinolytic activity could not be demonstrated after growth in ...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345760550031701
更新日期:1976-05-01 00:00:00
abstract::Samples of plaque and surface enamel were collected from 80 boys aged 14 years living in five communities in Ohio (USA). Mean (+/- SE) strontium concentrations in plaque were 1.43 +/- 0.18 micrograms/g (wet) and 12.34 +/- 1.63 micrograms/g (dry). For surface enamel, the mean concentration was 421 +/- 31 micrograms Sr/...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345850640121201
更新日期:1985-12-01 00:00:00
abstract::Radiation therapy for head and neck cancer results in severe secondary side-effects in salivary glands. We previously demonstrated that the administration of IGF1 preserves or restores salivary gland function following radiation. Based on these findings, we propose to study the effect of IGF1 on human head and neck ca...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/0022034510388037
更新日期:2011-03-01 00:00:00
abstract::Chemical bonding between dental porcelains and alloys results from interdiffusion of porcelain and metal ions. An interfacial diffusion zone is created which, most likely, has properties different from those of bulk materials. The changed interface might affect experimental measurements of thermo-mechanical strain. To...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345830620051701
更新日期:1983-05-01 00:00:00
abstract::Resin composites currently available are not suitable for use as large stress-bearing posterior restorations involving cusps due to their tendencies toward excessive fracture and wear. The glass fillers in composites provide only limited reinforcement because of the brittleness and low strength of glass. The aim of th...
journal_title:Journal of dental research
pub_type: 杂志文章
doi:10.1177/00220345990780021101
更新日期:1999-02-01 00:00:00