Abstract:
:The periodontal ligament (PDL) works as a suspensory ligament when external mechanical stress is placed on the teeth. PDL fibroblasts, the principal cells in the PDL, are responsible for many PDL functions. We hypothesized that mechanosensitive ion channels are present in human PDL fibroblasts, which are capable of responding to mechanical stress during normal function of the tissue. Using patch-clamp techniques, we detected mechanosensitive TREK-1 K+ channels (a member of the two-pore-domain K+ channel family), whose single-channel conductance was 104 pS in symmetrical K+-rich solutions. The open probability of the channel was low in the quiescent state, but it was strongly increased by the induction of membrane stretch. Arachidonic acid also enhanced the channel activity. RT-PCR and immunocytochemical observations showed the expression of TREK-1 K+ channels in PDL fibroblasts. The results suggest that the activation of TREK-1 K+ channels by masticatory stress contributes to the hyperpolarization of PDL fibroblasts.
journal_name
J Dent Resjournal_title
Journal of dental researchauthors
Ohara A,Saeki Y,Nishikawa M,Yamamoto Y,Yamamoto Gdoi
10.1177/154405910608500716subject
Has Abstractpub_date
2006-07-01 00:00:00pages
664-9issue
7eissn
0022-0345issn
1544-0591pii
85/7/664journal_volume
85pub_type
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journal_title:Journal of dental research
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