abstract：:The revised S2 guidelines for treatment of giant cell arteritis have recently been published. Glucocorticosteroids remain the standard first line treatment. For severe or relapsing courses of the disease, the IL‑6 antagonist tocilizumab, a potent antibody, is now available as a therapeutic option; however, how long th...

journal_title：Zeitschrift fur Rheumatologie

authors： Henes J

更新日期：2020-12-22 00:00:00

abstract：:Transmitting a substantial amount of basic knowledge in Rheumatology to all medical students is essential for the future medical care of patients with rheumatic diseases for two reasons: on the one hand, future general practitioners will need to master the patterns of rheumatic diseases to recognize them fast enough i...

journal_title：Zeitschrift fur Rheumatologie

authors： Aringer M,Baerwald C,Bergner R,Feuchtenberger M,Gebhardt C,Hagen M,Keyßer G,Lorenz HM,Witte T

更新日期：2020-12-02 00:00:00

abstract：:Systemic disease demands systemic thinkers. In this mission statement we define rheumatology, describe the role of the German Society of Rheumatology and the rheumatologist's spirit to their discipline. Rheumatologists are dedicated to improving the quality of life of their acute, chronic, and rehabilitative patients ...

journal_title：Zeitschrift fur Rheumatologie

authors： Lorenz HM,Aringer M,Braun J,Hoyer BF,Krause A,Meyer-Olson D,Mucke J,Rudwaleit M,Schneider M,Sewerin P,Späthling-Mestekemper S,Specker C,Voormann A,Wagner U,Wendler J,Schulze-Koops H

更新日期：2020-12-01 00:00:00

abstract：:Rheumatology training is reorganized with the implementation of the revision of the training regulations for German physicians (MWBO) to become a specialist in internal medicine and rheumatology. This article focusses on novel aspects including far-reaching waiver of reference numbers, the professionally recommended t...

journal_title：Zeitschrift fur Rheumatologie

authors： Fleck M,Berliner MN,Krause A

更新日期：2020-11-30 00:00:00

abstract：:For a long time, most of the infectious diseases seemed to have become under control. In particular, vaccinations have contributed to this development. In recent years newly occurring bacterial infections caused by multidrug-resistant pathogens and viral infections, such as the chikungunya virus, influenza epidemics a...

journal_title：Zeitschrift fur Rheumatologie

authors： Kneitz C,Müller-Ladner U

更新日期：2020-11-01 00:00:00

abstract：:Still's disease covers a range of disorders from systemic juvenile idiopathic arthritis (SJIA) up to adult onset Still's disease (AOSD). The overlapping clinical features suggest that SJIA and AOSD are different manifestations of a phenotypic continuum in different age stages. Still's disease is clinically characteriz...

journal_title：Zeitschrift fur Rheumatologie

authors： Föll D,Wittkowski H,Hinze C

更新日期：2020-09-01 00:00:00

abstract：:Behçet's disease (BD) is a recurrent, multisystemic, inflammatory blood vessel disorder that can result in mouth, genital, and skin ulcers; arthritis; and eye and intestinal inflammation. We describe a 21-year-old Korean female patient with intestinal BD refractory to conventional medical treatment and biologic drugs....

journal_title：Zeitschrift fur Rheumatologie

authors： Kim HJ,Kim KT,Lee SG,Kim Y

更新日期：2020-09-01 00:00:00

abstract：:A few days after the SARS-CoV-2 infection was declared a pandemic, the German Society for Rheumatology (DGRh) compiled first recommendations for the care of patients with inflammatory rheumatic diseases (IRD). These first recommendations were based on an expert consensus and were largely non-evidence-based. Now that t...

journal_title：Zeitschrift fur Rheumatologie

authors： Schulze-Koops H,Iking-Konert C,Leipe J,Hoyer BF,Holle J,Moosig F,Aries P,Burmester G,Fiehn C,Krause A,Lorenz HM,Schneider M,Sewerin P,Voormann A,Wagner U,Krüger K,Specker C,Kommission Pharmakotherapie.,Vorstand der De

更新日期：2020-09-01 00:00:00

abstract：:Autoinflammatory syndromes are characterized by periodic febrile attacks in combination with increased inflammatory markers. The dysregulation of different cellular signaling pathways leads to an excessive immune response, which can in turn promote multisystemic inflammatory processes. Due to overlapping symptoms, var...

journal_title：Zeitschrift fur Rheumatologie

authors： Schnappauf O

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Reliable data on the course and treatment of pediatric COVID-19 ("corona virus disease 2019") in immunosuppressed patients with rheumatic diseases are missing. AIM:Delineation of individual strategies of the members of the Society for Pediatric Rheumatology (GKJR) in cases of COVID-19. METHODS:In May 2020 ...

journal_title：Zeitschrift fur Rheumatologie

authors： Janda A,Schuetz C,Heeg M,Minden K,Hedrich CM,Kallinich T,Hinze C,Schulz A,Speth F

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Patients with rheumatoid arthritis (RA) tend to be less physically active. Physical activity has been shown to have a positive impact on disease activity and quality of life and is recommended by the European League Against Rheumatism (EULAR) as an integral component of standard treatment. OBJECTIVE:A cross...

journal_title：Zeitschrift fur Rheumatologie

authors： Beider S,Flohr S,Gehlert S,Witte T,Ernst D

更新日期：2020-06-25 00:00:00

abstract：:The painter Max Slevogt (1868-1932), together with Lovis Corinth and Max Liebermann, was one of the most important representatives of German impressionism. Slevogt, a gourmet who appreciated fine food and good wines, suffered from acute recurrent gouty arthritis starting at the age of 27 years. His medical history is ...

journal_title：Zeitschrift fur Rheumatologie

authors： Zeidler H

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:To investigate the association between HLA‑G polymorphisms and systemic lupus erythematosus (SLE) susceptibility as well as the relationship between circulating soluble HLA‑G (sHLA‑G) levels and SLE. METHODS:A meta-analysis was performed to investigate the relationships between HLA‑G 14-bp insertion (I)/dele...

journal_title：Zeitschrift fur Rheumatologie

authors： Bae SC,Lee YH

更新日期：2020-04-09 00:00:00

abstract：AIM:The aim of this study was to compare demographic characteristics, disease activity, functional status, and quality of life between ankylosing spondylitis (AS) with neuropatic pain (NP) and AS without NP (Non-NP). METHODS:The MEDLINE via PubMed, Cochrane, Scopus, and Embase database, from the earliest available dat...

journal_title：Zeitschrift fur Rheumatologie

authors： Kim TW,Son SM,Lee JS

更新日期：2020-02-01 00:00:00

abstract：:In order to reduce the prognostically relevant time interval between the initial manifestation of a rheumatic and musculoskeletal disease and diagnosis as well as the consecutive initiation of an appropriate treatment, several rheumatological centers in Germany have improved the access to initial rheumatologic evaluat...

journal_title：Zeitschrift fur Rheumatologie

authors： Benesova K,Lorenz HM,Lion V,Voigt A,Krause A,Sander O,Schneider M,Feuchtenberger M,Nigg A,Leipe J,Briem S,Tiessen E,Haas F,Rihl M,Meyer-Olson D,Baraliakos X,Braun J,Schwarting A,Dreher M,Witte T,Assmann G,Hoeper

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:The relative efficacy and safety of tofacitinib and baricitinib were assessed in patients with rheumatoid arthritis (RA) with an inadequate response to disease-modifying anti-rheumatic drugs (DMARDs) or biologics. METHODS:We performed a Bayesian network meta-analysis to combine direct and indirect evidence ...

journal_title：Zeitschrift fur Rheumatologie

authors： Bae SC,Lee YH

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Early detection of patients with axial spondylarthritis (axSpA) in primary care is difficult. The combination of various parameters indicative of inflammatory back pain (AWARE criteria) was found to be beneficial in an initial study. OBJECTIVE:Review of the criteria for the identification of young patients ...

journal_title：Zeitschrift fur Rheumatologie

authors： Braun J,Mosch T,Fischer I,Kiltz U

更新日期：2019-08-01 00:00:00

abstract：:Systemic sclerosis is a rare rheumatologic disease that is characterised by skin and organ fibrosis as well as vascular changes and the occurrence of specific autoantibodies. It has a high morbidity and mortality while its manifestations show significant heterogeneity in patients. Thus, diagnosis and follow-up of pati...

journal_title：Zeitschrift fur Rheumatologie

authors： Becker MO,Distler O,Maurer B

更新日期：2019-06-01 00:00:00

abstract：:Aortic aneurysm and dissection are rare complications of systemic lupus erythematosus (SLE). The incidence, etiology, risk factors, and outcomes of this entity were largely unknown.The study materials were based on the publications of aortic aneurysm or dissection due to SLE published between 2000 and 2017.A total of ...

journal_title：Zeitschrift fur Rheumatologie

authors： Yuan SM

更新日期：2019-04-01 00:00:00

abstract：:Due to the wide range of positive effects and the clear evidence of effectiveness, physical activity is one of the most important treatments for inflammatory rheumatic diseases. Because of the frequent overlap of disease and age-related aspects in older patients, the implementation of the German national physical acti...

journal_title：Zeitschrift fur Rheumatologie

authors： Golla A,Mattukat K,Mau W

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is characterized by heterogeneous clinical symptoms. Peripheral skin fibrosis can be a common symptom. Nevertheless, a variety of diseases with different etiologies are associated with a thickening of the skin and make the initial diagnosis of systemic sclerosis more difficult. OBJE...

journal_title：Zeitschrift fur Rheumatologie

authors： Jendrek ST,Kahle B,Riemekasten G

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Familial Mediterranean fever (FMF) in Germany is a rare, genetically linked disease of childhood and adolescence, which is characterized by recurrent febrile episodes and clinical signs of peritonitis, pleuritis and arthritis. Treatment with colchicine is effective and well-tolerated in the majority of patie...

journal_title：Zeitschrift fur Rheumatologie

authors： Kallinich T,Blank N,Braun T,Feist E,Kiltz U,Neudorf U,Oommen PT,Weseloh C,Wittkowski H,Braun J

更新日期：2019-02-01 00:00:00

abstract：: ...

journal_title：Zeitschrift fur Rheumatologie

authors：

更新日期：2019-02-01 00:00:00

abstract：:The knee joint is often involved in rheumatoid arthritis. Despite ever-improving medical antirheumatic therapies, surgical treatment continues to play an important role in optimal multidisciplinary care. The aim of the present work is to process current orthopedic surgical therapy procedures on the knee joint accordin...

journal_title：Zeitschrift fur Rheumatologie

authors： Maderbacher G,Greimel F,Schaumburger J,Grifka J,Baier C

更新日期：2018-12-01 00:00:00

abstract：:The diagnosis of pyoderma gangraenosum was previously made as a diagnosis of exclusion. For this reason repeated attempts have been made in recent years to develop new diagnostic scores, whereby the typical clinical and anamnestic aspects were usually taken into account and the relevant differential diagnoses were exc...

journal_title：Zeitschrift fur Rheumatologie

authors： Dissemond J

更新日期：2018-12-01 00:00:00

abstract：: ...

journal_title：Zeitschrift fur Rheumatologie

authors：

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Taking part in physical education is an important element of social participation for children with chronic diseases. Nevertheless, children suffering from rheumatism mostly receive recommendations to stop sport activities either completely or partially, without underlying scientific guidelines. OBJECTIVE:T...

journal_title：Zeitschrift fur Rheumatologie

authors： Hartmann M,Merker J,Schrödl S,König M,Georgi M,Hinze C,Schwirtz A,Haas JP

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To assess the relative efficacy and safety of apremilast, secukinumab, and ustekinumab at different doses in patients with active psoriatic arthritis (PsA). METHOD:A Bayesian network meta-analysis was conducted, which included randomized controlled trials (RCTs) that examined the efficacy and safety of aprem...

journal_title：Zeitschrift fur Rheumatologie

authors： Song GG,Lee YH

更新日期：2018-09-01 00:00:00

abstract：:Alopecia universalis is an advanced form of alopecia areata, characterized by complete loss of hair on all hair-bearing areas. It is currently believed to be an autoimmune disorder. The development of alopecia during treatment with tumor necrosis factor alpha (TNF-α) inhibitors is a rarely observed adverse event. This...

journal_title：Zeitschrift fur Rheumatologie

authors： Ostojic P,Pavlov-Dolijanovic S

更新日期：2018-06-01 00:00:00

abstract：:Rheumatic diseases are among the most common chronic inflammatory disorders. Besides severe pain and progressive destruction of the joints, rheumatoid arthritis (RA), spondyloarthritides (SpA) and psoriatic arthritis (PsA) impair working ability, reduce quality of life and if treated insufficiently may enhance mortali...

journal_title：Zeitschrift fur Rheumatologie

authors： Häupl T,Skapenko A,Hoppe B,Skriner K,Burkhardt H,Poddubnyy D,Ohrndorf S,Sewerin P,Mansmann U,Stuhlmüller B,Schulze-Koops H,Burmester GR

更新日期：2018-05-01 00:00:00

abstract：AIM:To explore the circadian rhythm of serum interleukin (IL)-6 in collagen-induced arthritis (CIA) rats and compare the safety and effectiveness of methotrexate (MTX) administered traditionally and via chronotherapy. METHODS:CIA rat models were immunized with bovine type II collagen. Serum IL-6 levels in normal and C...

journal_title：Zeitschrift fur Rheumatologie

authors： Wang X,Yan X,Wang F,Ge F,Li Z

更新日期：2018-04-01 00:00:00

abstract：:Big data analysis raises the expectation that computerized algorithms may extract new knowledge from otherwise unmanageable vast data sets. What are the algorithms behind the big data discussion? In principle, high throughput technologies in molecular research already introduced big data and the development and applic...

journal_title：Zeitschrift fur Rheumatologie

authors： Bonin-Andresen M,Smiljanovic B,Stuhlmüller B,Sörensen T,Grützkau A,Häupl T

更新日期：2018-04-01 00:00:00

abstract：:The treatment of rheumatic diseases with bioloics has significantly improved the prognosis of patients. Currently, there are 13 preparations available in Germany for the treatment of patients with inflammatory rheumatic diseases. These original preparations generally have-depending on the individual country-15 years o...

journal_title：Zeitschrift fur Rheumatologie

authors： Braun J,Lorenz HM,Müller-Ladner U,Schneider M,Schulze-Koops H,Specker C,Strangfeld A,Wagner U,Dörner T

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to determine which disease-related factors and non-disease features can explain the presence of systemic lupus erythematosus (SLE)-related fatigue in Turkish patients. METHODS:This cross-sectional study was carried out with 99 SLE patients and 71 healthy controls. To assess fatigue a...

journal_title：Zeitschrift fur Rheumatologie

authors： Yilmaz-Oner S,Ilhan B,Can M,Alibaz-Oner F,Polat-Korkmaz O,Ozen G,Mumcu G,Kremers HM,Tuglular S,Direskeneli H

更新日期：2017-12-01 00:00:00

abstract：:Low back pain (LBP) in patients with rheumatoid arthritis (RA) has so far been of little concern in clinical investigations. The main focus of scientific publications on spinal problems in RA was the cervical spine. In a recent study, we could demonstrate that LBP in RA patients leads to a significantly higher degree ...

journal_title：Zeitschrift fur Rheumatologie

authors： Kothe R

更新日期：2017-12-01 00:00:00

abstract：:Systemic juvenile idiopathic arthritis (sJIA) is characterized by fever, arthritis, and other signs of systemic inflammation. Historically, sJIA was named Still's disease after George Frederic Still, who first reported patients. Individuals who manifest after the 16th birthday are diagnosed with adult onset Still's di...

journal_title：Zeitschrift fur Rheumatologie

authors： Hedrich CM,Günther C,Aringer M

更新日期：2017-09-01 00:00:00

abstract：:The histopathological synovitis score evaluates in a graded approach, as is largely usual for diagnostic histopathological scores, the immunological and inflammatory changes caused by synovitis. A synovitis score of between 1 and ≤ 4 is classified as low-grade (osteoarthritis-related synovitis, post-traumatic synoviti...

journal_title：Zeitschrift fur Rheumatologie

authors： Krenn V,Perino G,Rüther W,Krenn VT,Huber M,Hügle T,Najm A,Müller S,Boettner F,Pessler F,Waldstein W,Kriegsmann J,Häupl T,Wienert S,Krukemeyer MG,Sesselmann S,Tikhilov R,Morawietz L

更新日期：2017-08-01 00:00:00

abstract：:Ocular manifestation of sarcoidosis occurs in up to 60% of patients with confirmed systemic sarcoidosis and represents one of the most common forms of noninfectious uveitis. In known pulmonary sarcoidosis, ocular involvement can occur in up to 80% of cases. Sarcoidosis can also present only in the eye, without a syste...

journal_title：Zeitschrift fur Rheumatologie

authors： Springer-Wanner C,Brauns T

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Up to now indirect immunofluorescence (IIF) followed by an antigen-specific assay specific for proteinase 3 (PR3) or myeloperoxidase (MPO) has been the standard method for the detection of antineutrophil cytoplasmic antibodies (ANCA). The development of more sensitive and highly specific PR3-ANCA and MPO-ANC...

journal_title：Zeitschrift fur Rheumatologie

authors： Csernok E,Kempiners N,Hellmich B

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Since the introduction of biologic treatment in rheumatoid arthritis (RA), disease activity and treatment modalities have changed substantially. The current provision and developments in recent years are analyzed with annual data from the National Database of the Collaborative Arthritis Centers in Germany. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Albrecht K,Huscher D,Eidner T,Kleinert S,Späthling-Mestekemper S,Bischoff S,Zink A

更新日期：2017-02-01 00:00:00