[De-escalation of therapy in ANCA-associated vasculitides].

abstract：:Sjögren's syndrome is a systemic inflammatory rheumatic disorder of unknown origin with so far inadequate therapy options. Management of Sjögren's syndrome is still primarily palliative using local symptomatic measures, and if appropriate glucocorticoids, NSAIDs and immunosuppressive drugs. New clues to the pathogenes...

journal_title：Zeitschrift fur Rheumatologie

authors： Feist E,Dörner T,Hansen A

更新日期：2007-12-01 00:00:00

abstract：:Systemic disease demands systemic thinkers. In this mission statement we define rheumatology, describe the role of the German Society of Rheumatology and the rheumatologist's spirit to their discipline. Rheumatologists are dedicated to improving the quality of life of their acute, chronic, and rehabilitative patients ...

journal_title：Zeitschrift fur Rheumatologie

authors： Lorenz HM,Aringer M,Braun J,Hoyer BF,Krause A,Meyer-Olson D,Mucke J,Rudwaleit M,Schneider M,Sewerin P,Späthling-Mestekemper S,Specker C,Voormann A,Wagner U,Wendler J,Schulze-Koops H

更新日期：2020-12-01 00:00:00

abstract：:Rehabilitation activities belong to tertiary prevention. The latter includes all measures that aim at avoiding the progression of a physical disability to a handicap, or those that diminish the extent of the handicap. Complex rehabilitation programs represent a cooperation of medical, occupational, and social reintegr...

journal_title：Zeitschrift fur Rheumatologie

authors： Wessel G,Leistner K

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:To assess the relative efficacy and safety of apremilast, secukinumab, and ustekinumab at different doses in patients with active psoriatic arthritis (PsA). METHOD:A Bayesian network meta-analysis was conducted, which included randomized controlled trials (RCTs) that examined the efficacy and safety of aprem...

journal_title：Zeitschrift fur Rheumatologie

authors： Song GG,Lee YH

更新日期：2018-09-01 00:00:00

abstract：:Blastocysts hominis, a protozoon considered to be a nonpathogen intestinal commensal, is now discussed to be a cause of intestinal infection under certain circumstances, e.g., immunosuppression. There are two published cases of Blastocysts infection complicated by arthritis which was classified as "reactive" in one ca...

journal_title：Zeitschrift fur Rheumatologie

authors： Krüger K,Kamilli I,Schattenkirchner M

更新日期：1994-03-01 00:00:00

abstract：:Systemic sclerosis (SSc, scleroderma) is a multisystem disease with a bad prognosis. No drugs have been shown to cure this disease. In view of its pathogenesis, in which immune responses are presumed to play an important role, immune suppressive therapies are widely applied in the treatment of SSc. Recent placebo-cont...

journal_title：Zeitschrift fur Rheumatologie

authors： van den Hoogen FH

更新日期：2006-07-01 00:00:00

abstract：:Aortic aneurysm and dissection are rare complications of systemic lupus erythematosus (SLE). The incidence, etiology, risk factors, and outcomes of this entity were largely unknown.The study materials were based on the publications of aortic aneurysm or dissection due to SLE published between 2000 and 2017.A total of ...

journal_title：Zeitschrift fur Rheumatologie

authors： Yuan SM

更新日期：2019-04-01 00:00:00

abstract：:278 patients with ankylosing spondylitis have been studied in order to find a basis for prognosis by setting a mobility function index of the vertebral column. This index does not depend on manifestation age or on the blood sedimentation rate. It increases with progression of x-ray findings. A coincidence of impaired ...

journal_title：Zeitschrift fur Rheumatologie

authors： Schöffel J,Pohl W

更新日期：1975-11-01 00:00:00

abstract：:Autoinflammatory syndromes are characterized by periodic febrile attacks in combination with increased inflammatory markers. The dysregulation of different cellular signaling pathways leads to an excessive immune response, which can in turn promote multisystemic inflammatory processes. Due to overlapping symptoms, var...

journal_title：Zeitschrift fur Rheumatologie

authors： Schnappauf O

更新日期：2020-09-01 00:00:00

abstract：:In fibromyalgia as well as in low back pain we frequently find disturbances of the posture of vertebral column clinically and radiologically. Also, reduction in the mobility of whole spine and localized movement impairments in both conditions was present. It is likely that the disturbances are responsible for the firs...

journal_title：Zeitschrift fur Rheumatologie

authors： Müller W,Kelemen J,Stratz T

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to determine which disease-related factors and non-disease features can explain the presence of systemic lupus erythematosus (SLE)-related fatigue in Turkish patients. METHODS:This cross-sectional study was carried out with 99 SLE patients and 71 healthy controls. To assess fatigue a...

journal_title：Zeitschrift fur Rheumatologie

authors： Yilmaz-Oner S,Ilhan B,Can M,Alibaz-Oner F,Polat-Korkmaz O,Ozen G,Mumcu G,Kremers HM,Tuglular S,Direskeneli H

更新日期：2017-12-01 00:00:00

abstract：:The name of Sir Alfred Baring Garrod is linked with the first detection of uric acid in blood and its accumulation in sufferers from gout as well as the formulation of the term rheumatoid arthritis. The disease concept formulated by him initially (especially in Germany) caused confusion and much discussion but has now...

journal_title：Zeitschrift fur Rheumatologie

authors： Keitel W

更新日期：2009-12-01 00:00:00

abstract：:Based on the most recent studies, it clearly appears that long-term hormone replacement therapy (HRT) prevents fractures but does not improve established coronary artery disease. In addition, HRT leads to a small increase in breast cancer incidence and to a decrease in colorectal cancer incidence. HRT increases the in...

journal_title：Zeitschrift fur Rheumatologie

authors： Uebelhart B,Frey D,Uebelhart D

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease affecting a broad range of different organ systems and, hence, presenting with multiple symptomatic domains, which considerably reduces the quality of life of patients. Within the last decade the prognosis of the disease has been...

journal_title：Zeitschrift fur Rheumatologie

authors： Schneider M,Haupt M

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Patients with an inflammatory disease have an elevated risk for periprosthetic joint infections due to impairment of the immune system caused by the disease itself in combination with disease-modifying antirheumatic drugs (DMARD). These infections can cause life-threatening sepsis. Unfortunately recommendati...

journal_title：Zeitschrift fur Rheumatologie

authors： Illgner U,Uekötter A,Bause L

更新日期：2014-06-01 00:00:00

abstract：:30 patients with hepatitis, 50 patients with gynecological diseases, and 100 with urological diseases were investigated with regards to lumbago to find out whether there is a correlation between the internal disease and the signs of low back pain. The patients were compared with a control group of 33 healthy people. T...

journal_title：Zeitschrift fur Rheumatologie

authors： Tilscher H,Bogner G,Landsiedl F

更新日期：1977-05-01 00:00:00

abstract：:Assessment of disease consequences (outcome) requires reliable, valid, and sensitive instruments. Psychometrically sound generic health-status instruments such as the SF-36 have been validated for many languages and are available in German. Instead, most disease specific instruments have been developed in English and ...

journal_title：Zeitschrift fur Rheumatologie

authors： Stucki G,Stucki S,Sangha O

更新日期：1997-10-01 00:00:00

abstract：:An attempt is made to compile the pharmacological data on the leading non-steroidal anti-inflammatory drugs. They concern the pharmacodynamics, the pharmacokinetics and the unwanted effects of these compounds. From these data a few suggestions for rational use are made: Ibuprofen and diclofenac present as drugs with s...

journal_title：Zeitschrift fur Rheumatologie

authors： Brune K

更新日期：1987-01-01 00:00:00

abstract：:The revised S2 guidelines for treatment of giant cell arteritis have recently been published. Glucocorticosteroids remain the standard first line treatment. For severe or relapsing courses of the disease, the IL‑6 antagonist tocilizumab, a potent antibody, is now available as a therapeutic option; however, how long th...

journal_title：Zeitschrift fur Rheumatologie

authors： Henes J

更新日期：2020-12-22 00:00:00

abstract：:Ha(La)-antibodies are detected by counterimmunoelectrophoresis (CIE) in sera of systemic lupus erythematosus (SLE) patients, but not in sera of patients with progressive systemic scleroderma (PSS) (n = 38), rheumatoid arthritis (n = 91), ankylosing spondylitis (n = 97), and other rheumatic diseases (n = 452). This ant...

journal_title：Zeitschrift fur Rheumatologie

authors： Lakomek HJ,Wagener S,Schwochau M,Krüskemper HL

更新日期：1988-03-01 00:00:00

abstract：:Still's disease covers a range of disorders from systemic juvenile idiopathic arthritis (SJIA) up to adult onset Still's disease (AOSD). The overlapping clinical features suggest that SJIA and AOSD are different manifestations of a phenotypic continuum in different age stages. Still's disease is clinically characteriz...

journal_title：Zeitschrift fur Rheumatologie

authors： Föll D,Wittkowski H,Hinze C

更新日期：2020-09-01 00:00:00

abstract：:We report on a 60 year old patient with peripheral neuropathy, neurogenic muscular atrophy, skin ulcers, arthritis and weakness. Detection of cryoglobulins in association with typical clinical symptoms, exclusion of hepatitis C and any other disease led to a rare diagnosis: essential cryoglobulinemic vasculitis. The c...

journal_title：Zeitschrift fur Rheumatologie

authors： Strunk J,Taborski U,Neeck G

更新日期：2002-12-01 00:00:00

abstract：:Self-administered patient-centered questionnaires have been shown to be practical, reliable and valid in terms of evaluating functional limitations in rheumatic diseases. In systemic sclerosis a modified version of the HAQ and condition-specific questionnaires have been used. The Health Assessment Questionnaire (HAQ) ...

journal_title：Zeitschrift fur Rheumatologie

authors： Sigl T,Ewert T,Stucki G

更新日期：2004-12-01 00:00:00

abstract：:Due to their anti-inflammatory effects and their capacity to affect the synthesis of most cytokines and the Th1/Th2 balance, endogenous glucocorticoids contribute to control the basal operation of immune cells. Immune processes result in the production of cytokines, such as IL-1, IL-2, IL-6, IL-11, IL-12, TNF-alpha, a...

journal_title：Zeitschrift fur Rheumatologie

authors： Besedovsky HO,del Rey A

更新日期：2000-01-01 00:00:00

abstract：:NSAIDs, including acetylsalicylic acid, are frequently classified as peripherally-acting analgesics. This is based on the fact that these substances, among other effects, inhibit the biosynthesis of prostaglandines. A few solid arguments, however, stand against an exclusively peripheral mode of the analgesic action of...

journal_title：Zeitschrift fur Rheumatologie

authors： Jurna I

更新日期：1991-01-01 00:00:00

abstract：:This article gives a comprehensive overview of diffuse interstitial lung diseases especially those associated with connective tissue diseases. Interstitial lung diseases (ILD) represent a heterogeneous group of diseases of very different and partially unknown etiologies. Therefore, an exact classification of the ILD i...

journal_title：Zeitschrift fur Rheumatologie

authors： Koller HK,Burghuber OC

更新日期：2003-04-01 00:00:00

abstract：:The present study examined relations between irrational attitudes and pain experience in patients with rheumatoid arthritis (RA). 128 patients with definite RA from a rheumatic treatment center were studied by administration of the Irrational Attitudes Questionnaire (15) and a revised form of the Multidimensional Pain...

journal_title：Zeitschrift fur Rheumatologie

authors： Klages U

更新日期：1990-05-01 00:00:00

abstract：:Biomarkers form the basis for patient stratification and the development of individualized treatment strategies. As the understanding of the pathophysiological processes underlying rheumatic diseases increases, novel biomarkers will become available and established markers can be used more efficiently. Autoantibodies ...

journal_title：Zeitschrift fur Rheumatologie

authors： Scherer HU,Burmester GR,Häupl T

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Sex-specific differences in the prevalence and severity of immune disorders are well-known phenomena; however, it is only recently that we have begun to understand the possible causes of such differences. MATERIAL AND METHODS:A literature search on this topic was carried out and the results are summarized. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Riemekasten G,Siegert E

更新日期：2014-09-01 00:00:00

abstract：:New strategies including the blockade of TNFalpha showed excellent therapeutic effects even in so far refractory rheumatic diseases. Moreover, these approaches provided us with important informations about the pathogenic role of the mediators involved and distinct autoimmune cellular subsets. Here, we discuss recent d...

journal_title：Zeitschrift fur Rheumatologie

authors： Feist E,Burmester GR,Dörner T

更新日期：2003-08-01 00:00:00